hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08251.1

Complex Portal: CPX-19264

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
DCAF8L2	DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)	2	UniProt NCBI
DCAF16	DDB1- and CUL4-associated factor 16	4	UniProt NCBI
CRBN	Protein cereblon	5	UniProt NCBI
RBX1	E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]	5	UniProt NCBI
CUL4A	Cullin-4A (CUL-4A)	5	UniProt NCBI
CUL4B	Cullin-4B (CUL-4B)	5	UniProt NCBI
DDB1	DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)	5	UniProt NCBI
BRWD3	Bromodomain and WD repeat-containing protein 3	5	UniProt NCBI
DDA1	DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0080008	2.63820074065e-16	0.888888888889	CRBN DDA1 DDB1 CUL4B DCAF8L2 RBX1 CUL4A DCAF16	Cul4-RING E3 ubiquitin ligase complex
CORUM:6875	5.38212907005e-12	0.444444444444	RBX1 CRBN DDB1 CUL4A	CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase
CORUM:1162	2.69032781214e-11	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)
GO:0031461	1.20622726729e-10	0.888888888889	CRBN DDA1 DDB1 CUL4B DCAF8L2 RBX1 CUL4A DCAF16	cullin-RING ubiquitin ligase complex
GO:0031464	2.26671487374e-09	0.555555555556	RBX1 DDB1 CRBN CUL4B CUL4A	Cul4A-RING E3 ubiquitin ligase complex
GO:0000151	6.86557546883e-09	0.888888888889	CRBN DDA1 DDB1 CUL4B DCAF8L2 RBX1 CUL4A DCAF16	ubiquitin ligase complex
CORUM:391	1.31072783286e-08	0.333333333333	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:2722	1.31072783286e-08	0.333333333333	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:2172	5.24129669272e-08	0.333333333333	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)
CORUM:1214	1.30992062401e-07	0.333333333333	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
REAC:R-HSA-8951664	2.38603660464e-07	0.666666666667	DDB1 DDA1 CUL4B DCAF16 RBX1 CUL4A	Neddylation
CORUM:1211	2.61903437064e-07	0.333333333333	RBX1 DDB1 CUL4B	Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)
REAC:R-HSA-110314	4.2755177006e-07	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Recognition of DNA damage by PCNA-containing replication complex
WP:WP4753	7.38691399834e-07	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Nucleotide excision repair
REAC:R-HSA-5696394	1.14908181818e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	DNA Damage Recognition in GG-NER
KEGG:03420	1.40136691549e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Nucleotide excision repair
REAC:R-HSA-5696400	1.5751787127e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Dual Incision in GG-NER
REAC:R-HSA-5696395	1.74050956917e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Formation of Incision Complex in GG-NER
REAC:R-HSA-73893	2.76977126814e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	DNA Damage Bypass
CORUM:726	2.87561751823e-06	0.333333333333	RBX1 CUL4A DDB1	DDB2 complex
CORUM:727	2.87561751823e-06	0.333333333333	RBX1 CUL4A DDB1	CSA complex
CORUM:728	2.87561751823e-06	0.333333333333	RBX1 CUL4A DDB1	CSA-POLIIa complex
REAC:R-HSA-6781823	4.19823601739e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Formation of TC-NER Pre-Incision Complex
WP:WP5114	6.46155621312e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Nucleotide excision repair in xeroderma pigmentosum
REAC:R-HSA-6782210	9.20935842442e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	9.82061910807e-06	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Dual incision in TC-NER
REAC:R-HSA-6781827	2.08422022609e-05	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
GO:1990234	2.64549591363e-05	0.888888888889	CRBN DDA1 DDB1 CUL4B DCAF8L2 RBX1 CUL4A DCAF16	transferase complex
REAC:R-HSA-5696399	2.82551309181e-05	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Global Genome Nucleotide Excision Repair (GG-NER)
WP:WP4946	3.78060926198e-05	0.444444444444	RBX1 CUL4A DDB1 CUL4B	DNA repair pathways full network
GO:0140535	4.18736299862e-05	0.888888888889	CRBN DDA1 DDB1 CUL4B DCAF8L2 RBX1 CUL4A DCAF16	intracellular protein-containing complex
KEGG:04120	4.2792504245e-05	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Ubiquitin mediated proteolysis
GO:0031465	8.06911104389e-05	0.333333333333	RBX1 DDB1 CUL4B	Cul4B-RING E3 ubiquitin ligase complex
REAC:R-HSA-5696398	8.18366619652e-05	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Nucleotide Excision Repair
CORUM:6487	8.20609246787e-05	0.222222222222	CUL4B DDB1	CUL4B-DDB1-TLE2 complex
CORUM:6488	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4A-DDB1-EED complex
CORUM:6489	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4A-DDB1-WDR5 complex
CORUM:6490	8.20609246787e-05	0.222222222222	CUL4B DDB1	CUL4B-DDB1-WDR26 complex
CORUM:6491	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4A-DDB1-RBBP5 complex
CORUM:6492	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4A-DDB1-WDR5B complex
CORUM:223	8.20609246787e-05	0.222222222222	RBX1 CUL4A	CAND1-CUL4A-RBX1 complex
CORUM:6494	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4A-DDB1-WDR61 complex
CORUM:224	8.20609246787e-05	0.222222222222	RBX1 CUL4B	CAND1-CUL4B-RBX1 complex
CORUM:6495	8.20609246787e-05	0.222222222222	CUL4B DDB1	CUL4B-DDB1-GRWD1 complex
CORUM:6550	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4B-DDB1-TLE1 complex
CORUM:6553	8.20609246787e-05	0.222222222222	CUL4B DDB1	CUL4B-DDB1-TLE3 complex
CORUM:6493	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4A-DDB1-WDR57 complex
CORUM:6486	8.20609246787e-05	0.222222222222	CUL4A DDB1	CUL4A-DDB1-DTL complex
CORUM:6291	0.000164069436391	0.222222222222	CUL4A DDB1	Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A)
KEGG:05170	0.00017832070469	0.444444444444	RBX1 CUL4A DDB1 CUL4B	Human immunodeficiency virus 1 infection
CORUM:6482	0.000273361732609	0.222222222222	CUL4B DDB1	CUL4B-DDB1-DTL-CSN complex
WP:WP4541	0.0020456158253	0.333333333333	RBX1 CUL4A DDB1	Hippo Merlin signaling dysregulation
GO:0010498	0.00221420903646	0.666666666667	DDB1 DDA1 CUL4B RBX1 CUL4A CRBN	proteasomal protein catabolic process
GO:0034644	0.00395198876289	0.444444444444	RBX1 CUL4A DDB1 CUL4B	cellular response to UV
REAC:R-HSA-73894	0.00517868236837	0.444444444444	RBX1 CUL4A DDB1 CUL4B	DNA Repair
REAC:R-HSA-597592	0.00564787922656	0.666666666667	DDB1 DDA1 CUL4B DCAF16 RBX1 CUL4A	Post-translational protein modification
GO:1902494	0.00573478933095	0.888888888889	CRBN DDA1 DDB1 CUL4B DCAF8L2 RBX1 CUL4A DCAF16	catalytic complex
GO:0016567	0.00730404922177	0.666666666667	DDB1 DDA1 CUL4B RBX1 CUL4A CRBN	protein ubiquitination
GO:0071482	0.00827392856677	0.444444444444	RBX1 CUL4A DDB1 CUL4B	cellular response to light stimulus
CORUM:929	0.0151941738882	0.222222222222	CUL4A DDB1	CEN complex
GO:0032446	0.0156608922208	0.666666666667	DDB1 DDA1 CUL4B RBX1 CUL4A CRBN	protein modification by small protein conjugation
GO:0051603	0.0183571145865	0.666666666667	DDB1 DDA1 CUL4B RBX1 CUL4A CRBN	proteolysis involved in protein catabolic process
GO:0009411	0.0255085593346	0.444444444444	RBX1 CUL4A DDB1 CUL4B	response to UV
GO:0070647	0.0280697756258	0.666666666667	DDB1 DDA1 CUL4B RBX1 CUL4A CRBN	protein modification by small protein conjugation or removal
GO:0043161	0.0348321198689	0.555555555556	DDA1 RBX1 CRBN DDB1 CUL4A	proteasome-mediated ubiquitin-dependent protein catabolic process
REAC:R-HSA-392499	0.0367270844403	0.666666666667	DDB1 DDA1 CUL4B DCAF16 RBX1 CUL4A	Metabolism of proteins
GO:0071478	0.0375139355743	0.444444444444	RBX1 CUL4A DDB1 CUL4B	cellular response to radiation
GO:0043687	0.0413349003112	0.666666666667	DDB1 DDA1 CUL4B RBX1 CUL4A CRBN	post-translational protein modification

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CUL4A	CUL4B	0.999	0.374		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only
DDB1	DDA1	0.999	0.2	structurally_consistent (dimer)	hein_WMM bioplex_WMM Guru bioplex3_WMM boldt hein () fraction boldt_WMM
CUL4A	DDA1	0.999	0.12		hein_WMM bioplex_WMM bioplex3_WMM hein ()
CUL4A	RBX1	0.998	0.878		hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
CUL4B	DDB1	0.998	0.272	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM
CRBN	CUL4B	0.997	0.136	structurally_consistent (Q16531)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CUL4B	DCAF16	0.997	0.128		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CUL4A	BRWD3	0.996			hein_WMM bioplex_WMM bioplex3_WMM hein ()
CUL4B	RBX1	0.996	0.138		hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
CUL4A	DDB1	0.995	0.628	structurally_consistent (dimer)	hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM
CUL4B	DDA1	0.994	0.092	structurally_consistent (Q16531)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein ()
DDB1	BRWD3	0.991			hein_WMM bioplex_WMM bioplex3_WMM hein ()
BRWD3	DDA1	0.989			hein_WMM bioplex_WMM bioplex3_WMM WMM_only
CRBN	CUL4A	0.985	0.228		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CRBN	DDB1	0.983	0.307	mixed_interface	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
DDB1	RBX1	0.969	0.638		hein_WMM bioplex3_HEK293 bioplex3_WMM boldt hein () boldt_WMM
DDB1	DCAF16	0.962	0.260682464455		hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM
CUL4B	BRWD3	0.955			hein_WMM bioplex_WMM bioplex3_WMM hein ()
BRWD3	RBX1	0.941			hein_WMM hein ()
CUL4A	DCAF16	0.927	0.198		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
DCAF16	DDA1	0.849	0.122		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RBX1	DDA1	0.785	0.306		hein_WMM WMM_only
CRBN	RBX1	0.75	0.3		bioplex3_HEK293 bioplex3_WMM WMM_only
CRBN	DCAF16	0.545	0.13		bioplex_WMM bioplex3_WMM WMM_only
RBX1	DCAF16	0.461	0.274		hein_WMM bioplex3_WMM WMM_only
CRBN	DDA1	0.058	0.034		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
DCAF8L2	huMAP3_00263.1 huMAP3_00860.1 huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11100.1 huMAP3_11271.1 huMAP3_12806.1 huMAP3_13329.1 huMAP3_14528.1
DCAF16	huMAP3_02953.1 huMAP3_03628.1 huMAP3_07590.1 huMAP3_08251.1 huMAP3_08550.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1 huMAP3_14809.1
CRBN	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
RBX1	huMAP3_02231.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
CUL4A	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
CUL4B	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
DDB1	huMAP3_02229.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11271.1 huMAP3_14528.1
BRWD3	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
DDA1	huMAP3_02953.1 huMAP3_05150.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08251.1

Complex Portal: CPX-19264