hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08269.1
Complex Portal: CPX-24407
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACTR3B | Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4) | 4 | UniProt NCBI |
| ARPC2 | Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) | 5 | UniProt NCBI |
| ACTR2 | Actin-related protein 2 (Actin-like protein 2) | 5 | UniProt NCBI |
| CHURC1 | Protein Churchill | 4 | UniProt NCBI |
| ACTR3 | Actin-related protein 3 (Actin-like protein 3) | 5 | UniProt NCBI |
| ARPC4 | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:27 | 3.35999837607e-11 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Arp2/3 protein complex |
| KEGG:05100 | 1.0290744588e-09 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Bacterial invasion of epithelial cells |
| KEGG:04666 | 2.44607296805e-09 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Fc gamma R-mediated phagocytosis |
| KEGG:05135 | 8.52974211494e-09 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Yersinia infection |
| KEGG:04530 | 2.23152734084e-08 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Tight junction |
| GO:0005885 | 4.97036464355e-08 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Arp2/3 protein complex |
| KEGG:05130 | 5.31278037476e-08 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-5663213 | 6.7073660844e-08 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-3928662 | 1.06711884519e-07 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | EPHB-mediated forward signaling |
| KEGG:04810 | 1.23436381825e-07 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Regulation of actin cytoskeleton |
| KEGG:05132 | 2.48146923028e-07 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Salmonella infection |
| KEGG:05131 | 2.65327655033e-07 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Shigellosis |
| KEGG:04144 | 2.8969997442e-07 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | Endocytosis |
| REAC:R-HSA-9664417 | 4.22631019131e-07 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Leishmania phagocytosis |
| REAC:R-HSA-9664422 | 4.22631019131e-07 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664407 | 4.22631019131e-07 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Parasite infection |
| REAC:R-HSA-2029482 | 5.29930924667e-07 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 2.05309631721e-06 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-2682334 | 2.51636763457e-06 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | EPH-Ephrin signaling |
| REAC:R-HSA-8856828 | 1.83684769807e-05 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Clathrin-mediated endocytosis |
| REAC:R-HSA-9658195 | 1.94986624605e-05 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Leishmania infection |
| REAC:R-HSA-9824443 | 1.94986624605e-05 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Parasitic Infection Pathways |
| GO:0034314 | 3.59286130889e-05 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Arp2/3 complex-mediated actin nucleation |
| GO:0051015 | 5.79224844498e-05 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | actin filament binding |
| GO:0045010 | 5.85430293603e-05 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | actin nucleation |
| REAC:R-HSA-195258 | 0.000440361429128 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | RHO GTPase Effectors |
| GO:0035861 | 0.000502392288512 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | site of double-strand break |
| GO:0003779 | 0.000684514612873 | 0.833333333333 | ARPC4 ARPC2 ACTR3 ACTR3B ACTR2 | actin binding |
| GO:0005200 | 0.000999031924798 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | structural constituent of cytoskeleton |
| GO:0090734 | 0.00165931249978 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | site of DNA damage |
| REAC:R-HSA-422475 | 0.0030564769327 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Axon guidance |
| GO:0010592 | 0.00339409783315 | 0.5 | ARPC2 ACTR3 ACTR2 | positive regulation of lamellipodium assembly |
| REAC:R-HSA-9675108 | 0.00353370301704 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Nervous system development |
| REAC:R-HSA-199991 | 0.00605429919172 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00750133147239 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Vesicle-mediated transport |
| GO:0010591 | 0.00777254411354 | 0.5 | ARPC2 ACTR3 ACTR2 | regulation of lamellipodium assembly |
| GO:1902745 | 0.00860399003151 | 0.5 | ARPC2 ACTR3 ACTR2 | positive regulation of lamellipodium organization |
| REAC:R-HSA-194315 | 0.0087987737143 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00959411672385 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| WP:WP2272 | 0.0117481700727 | 0.333333333333 | ARPC2 ARPC4 | Pathogenic Escherichia coli infection |
| WP:WP3680 | 0.0170615762461 | 0.333333333333 | ACTR2 ACTR3 | Physico chemical features and toxicity associated pathways |
| GO:1902743 | 0.0219369042126 | 0.5 | ARPC2 ACTR3 ACTR2 | regulation of lamellipodium organization |
| REAC:R-HSA-1266738 | 0.02903341132 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Developmental Biology |
| REAC:R-HSA-5663205 | 0.0303849890339 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Infectious disease |
| REAC:R-HSA-168249 | 0.0338175140237 | 0.666666666667 | ARPC4 ARPC2 ACTR3 ACTR2 | Innate Immune System |
| GO:0030032 | 0.0421653429605 | 0.5 | ARPC2 ACTR3 ACTR2 | lamellipodium assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ACTR3 | ARPC4 | 1.0 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| ACTR2 | ACTR3 | 1.0 | 0.938 |
structurally_consistent (O15144)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| ACTR2 | ARPC4 | 1.0 | 0.932 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| ACTR3B | ARPC4 | 1.0 | 0.902 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| ACTR2 | ARPC2 | 1.0 | 0.99 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM hein () gupta_WMM fraction treiber_WMM |
| ARPC2 | ARPC4 | 1.0 | 0.978 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| ARPC2 | ACTR3 | 1.0 | 0.966 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
| ACTR3B | ACTR2 | 0.999 | 0.884 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| ACTR3B | ARPC2 | 0.999 | 0.866 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ACTR3B | CHURC1 | 0.998 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CHURC1 | ACTR2 | 0.997 | 0.114 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CHURC1 | ACTR3 | 0.993 | 0.094 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACTR3B | ACTR3 | 0.992 | 0.826 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CHURC1 | ARPC4 | 0.968 | 0.064 |
mutually_exclusive (P61160)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CHURC1 | ARPC2 | 0.962 | 0.08 |
structurally_consistent (P61160)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
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