hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08271.1
Complex Portal: CPX-15699
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRAS | Ras-related protein R-Ras (EC 3.6.5.-) (p23) | 5 | UniProt NCBI |
| RAB1A | Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) | 5 | UniProt NCBI |
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) | 5 | UniProt NCBI |
| RAP1A | Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1) | 5 | UniProt NCBI |
| RRAS2 | Ras-related protein R-Ras2 (EC 3.6.5.-) (Ras-like protein TC21) (Teratocarcinoma oncogene) | 5 | UniProt NCBI |
| RAP1B | Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4223 | 3.06194136757e-06 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | Ras signaling |
| KEGG:04024 | 3.16534717686e-06 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | cAMP signaling pathway |
| KEGG:04014 | 5.84525187305e-06 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | Ras signaling pathway |
| WP:WP382 | 1.07905696272e-05 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | MAPK signaling pathway |
| KEGG:04010 | 1.78654941634e-05 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | MAPK signaling pathway |
| GO:0003924 | 5.97436292687e-05 | 1.0 | RAB1A RAP1B RRAS2 RAC3 RAP1A | GTPase activity |
| KEGG:04520 | 9.46922201828e-05 | 0.6 | RAP1A RAC3 RAP1B | Adherens junction |
| WP:WP185 | 0.000114104439854 | 0.6 | RAP1A RAC3 RAP1B | Integrin mediated cell adhesion |
| KEGG:04062 | 0.000403047923682 | 0.6 | RAP1A RAC3 RAP1B | Chemokine signaling pathway |
| GO:0017111 | 0.000472922240731 | 1.0 | RAB1A RAP1B RRAS2 RAC3 RAP1A | ribonucleoside triphosphate phosphatase activity |
| REAC:R-HSA-8875555 | 0.000683310775372 | 0.4 | RAP1A RAP1B | MET activates RAP1 and RAC1 |
| KEGG:04015 | 0.000687014133415 | 0.6 | RAP1A RAC3 RAP1B | Rap1 signaling pathway |
| KEGG:04510 | 0.0007776530092 | 0.6 | RAP1A RAC3 RAP1B | Focal adhesion |
| REAC:R-HSA-354194 | 0.000835043279679 | 0.4 | RAP1A RAP1B | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| GO:0016818 | 0.000848322261204 | 1.0 | RAB1A RAP1B RRAS2 RAC3 RAP1A | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 0.000848322261204 | 1.0 | RAB1A RAP1B RRAS2 RAC3 RAP1A | hydrolase activity, acting on acid anhydrides |
| GO:0016462 | 0.000848322261204 | 1.0 | RAB1A RAP1B RRAS2 RAC3 RAP1A | pyrophosphatase activity |
| REAC:R-HSA-372708 | 0.00100191474811 | 0.4 | RAP1A RAP1B | p130Cas linkage to MAPK signaling for integrins |
| WP:WP1981 | 0.00100346979189 | 0.4 | RAP1A RAP1B | Thyroxine thyroid hormone production |
| WP:WP306 | 0.00100625954708 | 0.6 | RAP1A RAC3 RAP1B | Focal adhesion |
| REAC:R-HSA-392517 | 0.0013810496636 | 0.4 | RAP1A RAP1B | Rap1 signalling |
| WP:WP313 | 0.00254884296025 | 0.4 | RAP1A RAP1B | Hepatocyte growth factor receptor signaling |
| WP:WP2636 | 0.00290547066497 | 0.4 | RAP1A RAP1B | Common pathways underlying drug addiction |
| REAC:R-HSA-354192 | 0.00318398402781 | 0.4 | RAP1A RAP1B | Integrin signaling |
| GO:0005525 | 0.00492038984684 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | GTP binding |
| REAC:R-HSA-76009 | 0.00572567861867 | 0.4 | RAP1A RAP1B | Platelet Aggregation (Plug Formation) |
| KEGG:04720 | 0.00645863473927 | 0.4 | RAP1A RAP1B | Long-term potentiation |
| REAC:R-HSA-6802948 | 0.0065872694687 | 0.4 | RAP1A RAP1B | Signaling by high-kinase activity BRAF mutants |
| GO:0032561 | 0.00776216760564 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | guanyl ribonucleotide binding |
| GO:0019001 | 0.00792260312428 | 0.8 | RAP1A RAP1B RAC3 RRAS2 | guanyl nucleotide binding |
| REAC:R-HSA-5674135 | 0.00849065158197 | 0.4 | RAP1A RAP1B | MAP2K and MAPK activation |
| REAC:R-HSA-8875878 | 0.00849065158197 | 0.4 | RAP1A RAP1B | MET promotes cell motility |
| WP:WP2032 | 0.00867145853418 | 0.4 | RAP1A RAP1B | Thyroid stimulating hormone TSH signaling pathway |
| REAC:R-HSA-9656223 | 0.00900400267976 | 0.4 | RAP1A RAP1B | Signaling by RAF1 mutants |
| WP:WP4205 | 0.00931707261303 | 0.4 | RAP1A RAP1B | MET in type 1 papillary renal cell carcinoma |
| KEGG:05211 | 0.00937366158534 | 0.4 | RAP1A RAP1B | Renal cell carcinoma |
| REAC:R-HSA-6802955 | 0.0106339701454 | 0.4 | RAP1A RAP1B | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 0.0106339701454 | 0.4 | RAP1A RAP1B | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 0.0106339701454 | 0.4 | RAP1A RAP1B | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802949 | 0.0106339701454 | 0.4 | RAP1A RAP1B | Signaling by RAS mutants |
| KEGG:04972 | 0.0115077320087 | 0.4 | RAP1A RAP1B | Pancreatic secretion |
| GO:2000301 | 0.0140440992017 | 0.4 | RAP1A RAP1B | negative regulation of synaptic vesicle exocytosis |
| KEGG:04670 | 0.0164241113683 | 0.4 | RAP1A RAP1B | Leukocyte transendothelial migration |
| KEGG:04611 | 0.0213229262457 | 0.4 | RAP1A RAP1B | Platelet activation |
| KEGG:04722 | 0.0222006100833 | 0.4 | RAP1A RAP1B | Neurotrophin signaling pathway |
| REAC:R-HSA-6802952 | 0.0232374901507 | 0.4 | RAP1A RAP1B | Signaling by BRAF and RAF1 fusions |
| WP:WP2263 | 0.0259300596317 | 0.4 | RAP1A RAP1B | Androgen receptor network in prostate cancer |
| KEGG:04934 | 0.0346393491085 | 0.4 | RAP1A RAP1B | Cushing syndrome |
| REAC:R-HSA-6806834 | 0.035336387757 | 0.4 | RAP1A RAP1B | Signaling by MET |
| REAC:R-HSA-6802957 | 0.0374197925333 | 0.4 | RAP1A RAP1B | Oncogenic MAPK signaling |
| GO:0019003 | 0.0379355065545 | 0.6 | RAP1A RAP1B RRAS2 | GDP binding |
| WP:WP3929 | 0.0420114386662 | 0.4 | RAP1A RAP1B | Chemokine signaling pathway |
| WP:WP51 | 0.046989062869 | 0.4 | RRAS2 RAC3 | Regulation of actin cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RRAS | RRAS2 | 0.997 | 0.562 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RRAS2 | RAP1B | 0.992 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RRAS2 | RAP1A | 0.99 | 0.1 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RAC3 | RAP1A | 0.988 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RAB1A | RAC3 | 0.972 | 0.188 | hein_WMM bioplex3_WMM WMM_only | |
| RAP1B | RAP1A | 0.97 | 0.882 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| RAC3 | RRAS2 | 0.969 | 0.154333988212 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RAC3 | RAP1B | 0.961 | 0.0863339882122 |
mutually_exclusive (P52306)
|
hein_WMM bioplex_WMM bioplex3_WMM fraction |
| RAB1A | RRAS2 | 0.961 | 0.268 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RAB1A | RAP1A | 0.951 | 0.676 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| RAB1A | RAP1B | 0.926 | 0.478 | hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| RRAS | RAP1B | 0.654 | 0.182 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RRAS | RAP1A | 0.499 | 0.274 | hein_WMM bioplex3_WMM WMM_only | |
| RAC3 | RRAS | 0.061 | 0.128 | hein_WMM bioplex3_WMM WMM_only | |
| RAB1A | RRAS | 0.043 | 0.152 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes