hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08278.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INTS11 | Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68) | 5 | UniProt NCBI |
| INTS6 | Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1) | 5 | UniProt NCBI |
| INTS4 | Integrator complex subunit 4 (Int4) | 5 | UniProt NCBI |
| FOXC1 | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | 5 | UniProt NCBI |
| INTS1 | Integrator complex subunit 1 (Int1) | 5 | UniProt NCBI |
| INTS12 | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1153 | 1.04067593972e-13 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | Integrator complex |
| CORUM:1155 | 1.6910019057e-13 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | Integrator-RNAPII complex |
| GO:0032039 | 6.27716685072e-10 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | integrator complex |
| REAC:R-HSA-6807505 | 2.76846766863e-09 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | RNA polymerase II transcribes snRNA genes |
| GO:0016180 | 3.54959615011e-09 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | snRNA processing |
| GO:0016073 | 1.40035891182e-07 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | snRNA metabolic process |
| CORUM:1154 | 1.02759689435e-06 | 0.5 | INTS11 INTS6 INTS4 | DSS1 complex |
| GO:0034243 | 1.13580597682e-06 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | regulation of transcription elongation by RNA polymerase II |
| GO:0032784 | 3.11424510658e-06 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | regulation of DNA-templated transcription elongation |
| GO:0006368 | 3.84341603452e-06 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | transcription elongation by RNA polymerase II |
| GO:0006354 | 8.610395678e-06 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | DNA-templated transcription elongation |
| GO:0034470 | 0.00228495154828 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | ncRNA processing |
| GO:0034472 | 0.00254971303757 | 0.5 | INTS12 INTS6 INTS1 | snRNA 3'-end processing |
| REAC:R-HSA-73857 | 0.00300615431734 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.00558415609329 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | Gene expression (Transcription) |
| GO:0034660 | 0.0153805016953 | 0.833333333333 | INTS11 INTS1 INTS6 INTS12 INTS4 | ncRNA metabolic process |
| WP:WP5345 | 0.0226781844519 | 0.333333333333 | INTS11 INTS4 | 1p36 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| INTS1 | INTS12 | 1.0 | 0.49 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| INTS12 | INTS4 | 1.0 | 0.614 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| INTS11 | INTS4 | 0.998 | 0.494 | hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction |
| INTS6 | INTS4 | 0.993 | 0.886 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| INTS6 | INTS11 | 0.99 | 0.56 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FOXC1 | INTS1 | 0.985 | 0.088 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| INTS1 | INTS4 | 0.981 | 0.774 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| FOXC1 | INTS6 | 0.965 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FOXC1 | INTS12 | 0.962 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| INTS6 | INTS1 | 0.955 | 0.728 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| INTS6 | INTS12 | 0.954 | 0.48 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| INTS12 | INTS11 | 0.86 | 0.432 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FOXC1 | INTS4 | 0.737 | 0.086 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| INTS1 | INTS11 | 0.709 | 0.476 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FOXC1 | INTS11 | 0.282 | 0.046 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes