hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08278.1

Complex Portal: CPX-14432

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
INTS11	Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68)	5	UniProt NCBI
INTS6	Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1)	5	UniProt NCBI
INTS4	Integrator complex subunit 4 (Int4)	5	UniProt NCBI
FOXC1	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)	5	UniProt NCBI
INTS1	Integrator complex subunit 1 (Int1)	5	UniProt NCBI
INTS12	Integrator complex subunit 12 (Int12) (PHD finger protein 22)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1153	1.04067593972e-13	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	Integrator complex
CORUM:1155	1.6910019057e-13	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	Integrator-RNAPII complex
GO:0032039	6.27716685072e-10	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	integrator complex
REAC:R-HSA-6807505	2.76846766863e-09	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	RNA polymerase II transcribes snRNA genes
GO:0016180	3.54959615011e-09	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	snRNA processing
GO:0016073	1.40035891182e-07	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	snRNA metabolic process
CORUM:1154	1.02759689435e-06	0.5	INTS11 INTS4 INTS6	DSS1 complex
GO:0034243	1.13580597682e-06	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	regulation of transcription elongation by RNA polymerase II
GO:0032784	3.11424510658e-06	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	regulation of DNA-templated transcription elongation
GO:0006368	3.84341603452e-06	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	transcription elongation by RNA polymerase II
GO:0006354	8.610395678e-06	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	DNA-templated transcription elongation
GO:0034470	0.00228495154828	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	ncRNA processing
GO:0034472	0.00254971303757	0.5	INTS1 INTS6 INTS12	snRNA 3'-end processing
REAC:R-HSA-73857	0.00300615431734	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	RNA Polymerase II Transcription
REAC:R-HSA-74160	0.00558415609329	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	Gene expression (Transcription)
GO:0034660	0.0153805016953	0.833333333333	INTS12 INTS1 INTS11 INTS4 INTS6	ncRNA metabolic process
WP:WP5345	0.0226781844519	0.333333333333	INTS11 INTS4	1p36 copy number variation syndrome

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
INTS1	INTS12	1.0	0.49		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo fraction
INTS12	INTS4	1.0	0.614		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
INTS11	INTS4	0.998	0.494	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction
INTS6	INTS4	0.993	0.886		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
INTS6	INTS11	0.99	0.56		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
FOXC1	INTS1	0.985	0.088		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
INTS1	INTS4	0.981	0.774		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
FOXC1	INTS6	0.965	0.1		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
FOXC1	INTS12	0.962	0.148		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
INTS6	INTS1	0.955	0.728	structurally_consistent (Q9H0H0)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
INTS6	INTS12	0.954	0.48		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
INTS12	INTS11	0.86	0.432		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
FOXC1	INTS4	0.737	0.086		hein_WMM bioplex3_WMM youn_WMM WMM_only
INTS1	INTS11	0.709	0.476		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
FOXC1	INTS11	0.282	0.046		hein_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
INTS11	huMAP3_06382.1 huMAP3_06989.1 huMAP3_08278.1 huMAP3_09230.1 huMAP3_10641.1 huMAP3_12564.1 huMAP3_15286.1
INTS6	huMAP3_01810.1 huMAP3_04137.1 huMAP3_04823.1 huMAP3_06989.1 huMAP3_08147.1 huMAP3_08278.1 huMAP3_08985.1 huMAP3_09230.1 huMAP3_09363.1 huMAP3_10641.1 huMAP3_10684.1 huMAP3_12564.1 huMAP3_13510.1 huMAP3_15286.1
INTS4	huMAP3_06382.1 huMAP3_06914.1 huMAP3_06989.1 huMAP3_08278.1 huMAP3_08985.1 huMAP3_09230.1 huMAP3_09363.1 huMAP3_10641.1 huMAP3_12564.1 huMAP3_13510.1 huMAP3_15286.1
FOXC1	huMAP3_00847.1 huMAP3_04823.1 huMAP3_06695.1 huMAP3_06989.1 huMAP3_07998.1 huMAP3_08278.1 huMAP3_09230.1 huMAP3_09709.1 huMAP3_10333.1 huMAP3_10641.1 huMAP3_13510.1
INTS1	huMAP3_04823.1 huMAP3_06382.1 huMAP3_06989.1 huMAP3_08278.1 huMAP3_09230.1 huMAP3_09363.1 huMAP3_10641.1
INTS12	huMAP3_04823.1 huMAP3_06382.1 huMAP3_06914.1 huMAP3_06989.1 huMAP3_08278.1 huMAP3_09230.1 huMAP3_09363.1 huMAP3_10153.1 huMAP3_10641.1 huMAP3_12564.1 huMAP3_15286.1