hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08289.1

Complex Portal: CPX-10751

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	5	UniProt NCBI
MEX3B	RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195)	5	UniProt NCBI
PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	5	UniProt NCBI
MEX3C	RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C)	5	UniProt NCBI
PNISR	Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)	5	UniProt NCBI
PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	5	UniProt NCBI
AHCYL1	S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)	5	UniProt NCBI
CHD9	Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein)	5	UniProt NCBI
PLCD3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)	5	UniProt NCBI
GRM3	Metabotropic glutamate receptor 3 (mGluR3)	5	UniProt NCBI
DIP2C	Disco-interacting protein 2 homolog C (DIP2 homolog C)	3	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8847453	3.28565687076e-07	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	Synthesis of PIPs in the nucleus
WP:WP5411	1.99966829504e-06	0.363636363636	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Phosphatidyl inositol phosphate pathway
WP:WP4971	1.99966829504e-06	0.363636363636	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Phosphoinositides metabolism
KEGG:00562	5.85403646388e-06	0.363636363636	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Inositol phosphate metabolism
REAC:R-HSA-6811555	6.88572370608e-06	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	PI5P Regulates TP53 Acetylation
GO:0016309	1.58598067776e-05	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:1902633	1.58598067776e-05	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
GO:1902635	1.58598067776e-05	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
KEGG:04070	1.73732336667e-05	0.363636363636	PLCD3 PIP4K2C PIP4K2A PIP4K2B	Phosphatidylinositol signaling system
REAC:R-HSA-6804758	0.000329950651236	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	Regulation of TP53 Activity through Acetylation
GO:0016308	0.000886327111509	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	1-phosphatidylinositol-4-phosphate 5-kinase activity
REAC:R-HSA-1660499	0.00130859353099	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	Synthesis of PIPs at the plasma membrane
REAC:R-HSA-1483255	0.00476386518789	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	PI Metabolism
REAC:R-HSA-6811558	0.00517368811151	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
REAC:R-HSA-199418	0.00678991252121	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	Negative regulation of the PI3K/AKT network
REAC:R-HSA-9006925	0.00817206080952	0.363636363636	AHCYL1 PIP4K2C PIP4K2A PIP4K2B	Intracellular signaling by second messengers
GO:2000786	0.0107228250299	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	positive regulation of autophagosome assembly
WP:WP51	0.010736478227	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	Regulation of actin cytoskeleton
KEGG:04810	0.0181775804342	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	Regulation of actin cytoskeleton
GO:0044090	0.0242342063386	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	positive regulation of vacuole organization
GO:0052742	0.0278578876014	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	phosphatidylinositol kinase activity
GO:0046627	0.0361493524666	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	negative regulation of insulin receptor signaling pathway
GO:1900077	0.0408476954791	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	negative regulation of cellular response to insulin stimulus
REAC:R-HSA-5633007	0.0443476855597	0.272727272727	PIP4K2C PIP4K2A PIP4K2B	Regulation of TP53 Activity
CORUM:6371	0.049976851631	0.0909090909091	GRM3	mGluR3-mGluR8 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PIP4K2B	PIP4K2C	1.0	0.014
PIP4K2A	PIP4K2C	1.0	0.0883043478261
PIP4K2A	PIP4K2B	1.0	0.318
PIP4K2A	PLCD3	0.999	0.068	structurally_consistent (dimer)
PLCD3	PIP4K2C	0.994	0.15	structurally_consistent (O43865) structurally_consistent (dimer)
PIP4K2A	PNISR	0.99	0.024
PIP4K2A	DIP2C	0.99	0.106
PIP4K2A	GRM3	0.983
PIP4K2A	MEX3B	0.978	0.098
PIP4K2A	AHCYL1	0.974	0.048
CHD9	PIP4K2A	0.972	0.088
PIP4K2A	MEX3C	0.96	0.106
AHCYL1	PLCD3	0.951	0.082	structurally_consistent (dimer)
PIP4K2B	PLCD3	0.95	0.068	structurally_consistent (O43865) structurally_consistent (dimer)
PLCD3	PNISR	0.902	0.066
PIP4K2C	DIP2C	0.87	0.094
PLCD3	DIP2C	0.851	0.138
CHD9	PNISR	0.786	0.174
CHD9	PLCD3	0.754	0.134
GRM3	MEX3C	0.572
MEX3B	GRM3	0.572
GRM3	DIP2C	0.557
PIP4K2B	AHCYL1	0.552	0.042	structurally_consistent (dimer)
PNISR	GRM3	0.502
PIP4K2C	MEX3B	0.473	0.17
AHCYL1	PIP4K2C	0.347	0.046	structurally_consistent (dimer)
MEX3C	DIP2C	0.333	0.094
PIP4K2B	GRM3	0.333
PNISR	DIP2C	0.333	0.104
MEX3B	DIP2C	0.333	0.098
CHD9	GRM3	0.303
AHCYL1	MEX3B	0.276	0.178
AHCYL1	MEX3C	0.276	0.132
MEX3B	MEX3C	0.265	0.226
PIP4K2B	DIP2C	0.265	0.04
CHD9	AHCYL1	0.262	0.158
PIP4K2C	MEX3C	0.244	0.08
AHCYL1	DIP2C	0.241	0.1792
PIP4K2B	MEX3B	0.213	0.068
PIP4K2B	MEX3C	0.213	0.098
PLCD3	MEX3B	0.193	0.116
PLCD3	MEX3C	0.193	0.072
AHCYL1	GRM3	0.18
PNISR	MEX3C	0.172	0.076
MEX3B	PNISR	0.172	0.088
CHD9	DIP2C	0.164	0.082
CHD9	MEX3C	0.164	0.178
CHD9	MEX3B	0.164	0.126
CHD9	PIP4K2C	0.162	0.04
PIP4K2C	GRM3	0.143
PLCD3	GRM3	0.142
CHD9	PIP4K2B	0.127	0.096
AHCYL1	PNISR	0.088	0.032
PIP4K2B	PNISR	0.082	0.022
PIP4K2C	PNISR	0.075	0.054

Related Complexes

Genename	Complexes
PIP4K2A	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1 huMAP3_14693.1
MEX3B	huMAP3_01974.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06171.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10957.1 huMAP3_12269.1 huMAP3_15202.1
PIP4K2B	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
MEX3C	huMAP3_03481.1 huMAP3_04419.1 huMAP3_05647.1 huMAP3_07288.1 huMAP3_07979.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10957.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13857.1 huMAP3_14640.1 huMAP3_14693.1
PNISR	huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10611.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12028.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13857.1 huMAP3_13971.1
PIP4K2C	huMAP3_01275.1 huMAP3_04301.1 huMAP3_05601.1 huMAP3_05855.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
AHCYL1	huMAP3_00550.1 huMAP3_02291.1 huMAP3_03410.1 huMAP3_03481.1 huMAP3_06847.1 huMAP3_07110.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08739.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09280.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10844.1 huMAP3_10957.1 huMAP3_13428.1 huMAP3_13742.1 huMAP3_14337.1
CHD9	huMAP3_00526.1 huMAP3_00550.1 huMAP3_04960.1 huMAP3_08289.1 huMAP3_08914.1 huMAP3_09657.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_11590.1 huMAP3_12211.1 huMAP3_13428.1 huMAP3_13786.1
PLCD3	huMAP3_00550.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08739.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1
GRM3	huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10611.1 huMAP3_10957.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1 huMAP3_14693.1
DIP2C	huMAP3_03481.1 huMAP3_05647.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08831.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10957.1 huMAP3_11633.1 huMAP3_11729.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08289.1

Complex Portal: CPX-10751