List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_08306.1

Confidence: High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
LRP2	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	5	UniProt   NCBI
LRP1	Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]	5	UniProt   NCBI
LRP8	Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)	5	UniProt   NCBI
LRPAP1	Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04979	3.65228974203e-06	0.75	LRP2 LRP1 LRPAP1	Cholesterol metabolism
REAC:R-HSA-975634	1.38374083551e-05	0.75	LRP2 LRP1 LRP8	Retinoid metabolism and transport
REAC:R-HSA-6806667	1.72814889866e-05	0.75	LRP2 LRP1 LRP8	Metabolism of fat-soluble vitamins
REAC:R-HSA-2187338	0.000106339832101	0.75	LRP2 LRP1 LRP8	Visual phototransduction
GO:0005041	0.000139871762976	0.75	LRP2 LRP1 LRP8	low-density lipoprotein particle receptor activity
GO:0045056	0.000174830724535	0.75	LRP2 LRP1 LRPAP1	transcytosis
GO:0030228	0.000215165225046	0.75	LRP2 LRP1 LRP8	lipoprotein particle receptor activity
REAC:R-HSA-196854	0.000880808650283	0.75	LRP2 LRP1 LRP8	Metabolism of vitamins and cofactors
GO:0097242	0.00190418300832	0.75	LRP2 LRP1 LRPAP1	amyloid-beta clearance
REAC:R-HSA-9709957	0.002052480752	0.75	LRP2 LRP1 LRP8	Sensory Perception
WP:WP5304	0.00464837292584	0.5	LRP1 LRPAP1	Cholesterol metabolism
GO:0038024	0.00508133939815	0.75	LRP2 LRP1 LRP8	cargo receptor activity
GO:1905167	0.00842684400117	0.5	LRP2 LRP1	positive regulation of lysosomal protein catabolic process
GO:0001523	0.0112187083505	0.75	LRP2 LRP1 LRP8	retinoid metabolic process
GO:0016101	0.0124631389739	0.75	LRP2 LRP1 LRP8	diterpenoid metabolic process
GO:0006721	0.0183580179548	0.75	LRP2 LRP1 LRP8	terpenoid metabolic process
CORUM:7535	0.0249718442456	0.25	LRP1	CD44-LRP1 complex
GO:1904352	0.0280843539964	0.5	LRP2 LRP1	positive regulation of protein catabolic process in the vacuole
GO:1900223	0.042122686785	0.5	LRP1 LRPAP1	positive regulation of amyloid-beta clearance
GO:0006897	0.0467824894143	1.0	LRP2 LRP1 LRPAP1 LRP8	endocytosis
CORUM:2709	0.049938562206	0.25	LRP1	MMP-9-TIMP-1-LRP complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
LRP2	LRPAP1	0.99	0.092	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
LRP8	LRPAP1	0.979	0.058	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
LRPAP1	LRP1	0.96	0.112	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
LRP2	LRP1	0.575	0.254	bioplex_WMM     bioplex3_WMM     WMM_only
LRP8	LRP1	0.111	0.152	bioplex_WMM     bioplex3_WMM     WMM_only
LRP8	LRP2	0.066	0.086	bioplex_WMM     bioplex3_WMM     gupta_WMM     WMM_only





Related Complexes

Genename	Complexes
LRP2	huMAP3_01857.1 huMAP3_02751.1 huMAP3_05672.1 huMAP3_06423.1 huMAP3_06436.1 huMAP3_07892.1 huMAP3_08306.1 huMAP3_10228.1 huMAP3_10712.1
LRP1	huMAP3_02751.1 huMAP3_05672.1 huMAP3_06423.1 huMAP3_08306.1 huMAP3_10228.1 huMAP3_10712.1 huMAP3_11525.1 huMAP3_13632.1
LRP8	huMAP3_00485.1 huMAP3_02751.1 huMAP3_05013.1 huMAP3_05672.1 huMAP3_05926.1 huMAP3_06423.1 huMAP3_06930.1 huMAP3_07676.1 huMAP3_08247.1 huMAP3_08306.1 huMAP3_10228.1 huMAP3_10712.1 huMAP3_10755.1 huMAP3_13100.1
LRPAP1	huMAP3_02751.1 huMAP3_05672.1 huMAP3_06423.1 huMAP3_08306.1 huMAP3_10228.1 huMAP3_10712.1 huMAP3_13192.1