hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08307.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| CARTPT | Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)] | 5 | UniProt NCBI |
| ORC5 | Origin recognition complex subunit 5 | 5 | UniProt NCBI |
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | 5 | UniProt NCBI |
| ALKBH4 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1034 | 1.12081835382e-08 | 0.6 | ORC5 ORC2 ORC3 | ORC 2-5 complex (origin recognition 2-5 complex) |
| CORUM:1038 | 2.80175822576e-08 | 0.6 | ORC5 ORC2 ORC3 | ORC 1-5 complex (origin recognition 1-5 complex) |
| CORUM:1031 | 5.60294116544e-08 | 0.6 | ORC5 ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:1033 | 5.60294116544e-08 | 0.6 | ORC5 ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:389 | 5.60294116544e-08 | 0.6 | ORC5 ORC2 ORC3 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68689 | 1.7467401872e-07 | 0.6 | ORC5 ORC2 ORC3 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113507 | 2.61984124802e-07 | 0.6 | ORC5 ORC2 ORC3 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-113510 | 4.79663279828e-06 | 0.6 | ORC5 ORC2 ORC3 | E2F mediated regulation of DNA replication |
| WP:WP466 | 1.3807096837e-05 | 0.6 | ORC5 ORC2 ORC3 | DNA replication |
| REAC:R-HSA-68962 | 1.69745830215e-05 | 0.6 | ORC5 ORC2 ORC3 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 2.22069549267e-05 | 0.6 | ORC5 ORC2 ORC3 | Activation of ATR in response to replication stress |
| CORUM:1032 | 4.09448956317e-05 | 0.4 | ORC3 ORC2 | ORC 2-4 complex (origin recognition 2-4 complex) |
| WP:WP45 | 4.999634375e-05 | 0.6 | ORC5 ORC2 ORC3 | G1 to S cell cycle control |
| GO:0005664 | 5.37995977657e-05 | 0.6 | ORC5 ORC2 ORC3 | nuclear origin of replication recognition complex |
| GO:0000808 | 5.37995977657e-05 | 0.6 | ORC5 ORC2 ORC3 | origin recognition complex |
| CORUM:5251 | 8.18785830799e-05 | 0.4 | ORC3 ORC2 | Ku-ORC complex |
| REAC:R-HSA-68616 | 9.08085842447e-05 | 0.6 | ORC5 ORC2 ORC3 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-68949 | 0.000169658686915 | 0.6 | ORC5 ORC2 ORC3 | Orc1 removal from chromatin |
| GO:0003688 | 0.000211268761872 | 0.6 | ORC5 ORC2 ORC3 | DNA replication origin binding |
| WP:WP179 | 0.000302523176006 | 0.6 | ORC5 ORC2 ORC3 | Cell cycle |
| REAC:R-HSA-69052 | 0.00036336263669 | 0.6 | ORC5 ORC2 ORC3 | Switching of origins to a post-replicative state |
| KEGG:04110 | 0.000516961308947 | 0.6 | ORC5 ORC2 ORC3 | Cell cycle |
| REAC:R-HSA-69239 | 0.000844385297839 | 0.6 | ORC5 ORC2 ORC3 | Synthesis of DNA |
| REAC:R-HSA-68867 | 0.00110198471879 | 0.6 | ORC5 ORC2 ORC3 | Assembly of the pre-replicative complex |
| REAC:R-HSA-69206 | 0.00110198471879 | 0.6 | ORC5 ORC2 ORC3 | G1/S Transition |
| REAC:R-HSA-69002 | 0.00159480598718 | 0.6 | ORC5 ORC2 ORC3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 0.00159480598718 | 0.6 | ORC5 ORC2 ORC3 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69242 | 0.00201875981781 | 0.6 | ORC5 ORC2 ORC3 | S Phase |
| REAC:R-HSA-69481 | 0.00201875981781 | 0.6 | ORC5 ORC2 ORC3 | G2/M Checkpoints |
| REAC:R-HSA-69306 | 0.00264594341422 | 0.6 | ORC5 ORC2 ORC3 | DNA Replication |
| GO:0006270 | 0.00475337188383 | 0.6 | ORC5 ORC2 ORC3 | DNA replication initiation |
| REAC:R-HSA-69620 | 0.0108605941756 | 0.6 | ORC5 ORC2 ORC3 | Cell Cycle Checkpoints |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ALKBH4 | ORC3 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ALKBH4 | ORC2 | 0.999 | 0.02 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ORC2 | ORC3 | 0.995 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | |
| ORC2 | ORC5 | 0.994 | 0.456 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| ORC2 | CARTPT | 0.958 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ORC3 | CARTPT | 0.95 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ORC3 | ORC5 | 0.692 | youn_WMM gupta_WMM fraction treiber_WMM |
Related Complexes