hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08325.1
Complex Portal: CPX-16660
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPAIN | RPA-interacting protein (hRIP) | 5 | UniProt NCBI |
| RPA4 | Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) | 5 | UniProt NCBI |
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | 5 | UniProt NCBI |
| RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | 5 | UniProt NCBI |
| HMCES | Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) | 5 | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03430 | 1.64931336911e-06 | 0.6 | RPA4 RPA1 RPA3 | Mismatch repair |
| KEGG:03030 | 6.64052632759e-06 | 0.6 | RPA4 RPA1 RPA3 | DNA replication |
| KEGG:03440 | 9.18507275524e-06 | 0.6 | RPA4 RPA1 RPA3 | Homologous recombination |
| CORUM:5229 | 1.36501667663e-05 | 0.4 | RPA3 RPA1 | RPA complex |
| WP:WP466 | 1.3807096837e-05 | 0.6 | RPA4 RPA1 RPA3 | DNA replication |
| REAC:R-HSA-68962 | 1.69745830215e-05 | 0.6 | RPA4 RPA1 RPA3 | Activation of the pre-replicative complex |
| KEGG:03460 | 1.71122661794e-05 | 0.6 | RPA4 RPA1 RPA3 | Fanconi anemia pathway |
| KEGG:03420 | 2.86326141069e-05 | 0.6 | RPA4 RPA1 RPA3 | Nucleotide excision repair |
| GO:0005657 | 8.87760174517e-05 | 0.8 | RPA4 RPA1 HMCES RPA3 | replication fork |
| CORUM:2738 | 0.000136445626745 | 0.4 | RPA3 RPA1 | BLM complex II |
| CORUM:2222 | 0.000136445626745 | 0.4 | RPA3 RPA1 | BLM complex II |
| GO:0005662 | 0.000274621184043 | 0.6 | RPA4 RPA1 RPA3 | DNA replication factor A complex |
| CORUM:248 | 0.000490935356523 | 0.4 | RPA3 RPA1 | BRAFT complex |
| CORUM:1004 | 0.000490935356523 | 0.4 | RPA3 RPA1 | RC complex during S-phase of cell cycle |
| GO:0003697 | 0.000556087531591 | 0.8 | RPA4 RPA1 HMCES RPA3 | single-stranded DNA binding |
| CORUM:1005 | 0.000613585186048 | 0.4 | RPA3 RPA1 | RC complex during G2/M-phase of cell cycle |
| CORUM:244 | 0.000749834781753 | 0.4 | RPA3 RPA1 | BRAFT complex |
| REAC:R-HSA-3371511 | 0.00100191474811 | 0.4 | RPA3 RPA1 | HSF1 activation |
| HPA:0210053 | 0.00106395420268 | 1.0 | RPA1 RPA4 RPAIN HMCES RPA3 | fallopian tube; glandular cells[High] |
| REAC:R-HSA-69206 | 0.00110198471879 | 0.6 | RPA4 RPA1 RPA3 | G1/S Transition |
| REAC:R-HSA-69166 | 0.0013810496636 | 0.4 | RPA3 RPA1 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358606 | 0.0013810496636 | 0.4 | RPA3 RPA1 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-5358565 | 0.0013810496636 | 0.4 | RPA3 RPA1 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| GO:0043601 | 0.00147736290187 | 0.6 | RPA4 RPA1 RPA3 | nuclear replisome |
| WP:WP531 | 0.00148385269311 | 0.4 | RPA3 RPA1 | DNA mismatch repair |
| REAC:R-HSA-5358508 | 0.001593300657 | 0.4 | RPA3 RPA1 | Mismatch Repair |
| REAC:R-HSA-69183 | 0.001593300657 | 0.4 | RPA3 RPA1 | Processive synthesis on the lagging strand |
| REAC:R-HSA-453279 | 0.00159480598718 | 0.6 | RPA4 RPA1 RPA3 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69002 | 0.00159480598718 | 0.6 | RPA4 RPA1 RPA3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-110312 | 0.0018206657072 | 0.4 | RPA3 RPA1 | Translesion synthesis by REV1 |
| REAC:R-HSA-5656121 | 0.0018206657072 | 0.4 | RPA3 RPA1 | Translesion synthesis by POLI |
| GO:0030894 | 0.00194127795747 | 0.6 | RPA4 RPA1 RPA3 | replisome |
| REAC:R-HSA-174437 | 0.00206313859056 | 0.4 | RPA3 RPA1 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-5655862 | 0.00206313859056 | 0.4 | RPA3 RPA1 | Translesion synthesis by POLK |
| REAC:R-HSA-174414 | 0.00259338296865 | 0.4 | RPA3 RPA1 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-110320 | 0.00259338296865 | 0.4 | RPA3 RPA1 | Translesion Synthesis by POLH |
| REAC:R-HSA-69306 | 0.00264594341422 | 0.6 | RPA4 RPA1 RPA3 | DNA Replication |
| HPA:0610833 | 0.00276998008335 | 1.0 | RPA1 RPA4 RPAIN HMCES RPA3 | urinary bladder; urothelial cells[High] |
| REAC:R-HSA-69186 | 0.00288114202251 | 0.4 | RPA3 RPA1 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 0.00318398402781 | 0.4 | RPA3 RPA1 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-110373 | 0.00454605723789 | 0.4 | RPA3 RPA1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 0.00454605723789 | 0.4 | RPA3 RPA1 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| WP:WP4753 | 0.00528162918062 | 0.4 | RPA3 RPA1 | Nucleotide excision repair |
| REAC:R-HSA-110314 | 0.0065872694687 | 0.4 | RPA3 RPA1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 0.00704059925156 | 0.4 | RPA3 RPA1 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 0.00750894366662 | 0.4 | RPA3 RPA1 | DNA strand elongation |
| REAC:R-HSA-174417 | 0.00849065158197 | 0.4 | RPA3 RPA1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-9709570 | 0.00849065158197 | 0.4 | RPA3 RPA1 | Impaired BRCA2 binding to RAD51 |
| GO:0043596 | 0.00875197805683 | 0.6 | RPA4 RPA1 RPA3 | nuclear replication fork |
| REAC:R-HSA-5685938 | 0.00900400267976 | 0.4 | RPA3 RPA1 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-73933 | 0.00900400267976 | 0.4 | RPA3 RPA1 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-6783310 | 0.00900400267976 | 0.4 | RPA3 RPA1 | Fanconi Anemia Pathway |
| REAC:R-HSA-176187 | 0.00953234360475 | 0.4 | RPA3 RPA1 | Activation of ATR in response to replication stress |
| REAC:R-HSA-110313 | 0.0106339701454 | 0.4 | RPA3 RPA1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5693616 | 0.0112072433688 | 0.4 | RPA3 RPA1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| WP:WP45 | 0.0117576408425 | 0.4 | RPA3 RPA1 | G1 to S cell cycle control |
| REAC:R-HSA-9675136 | 0.0117954816348 | 0.4 | RPA3 RPA1 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 0.0117954816348 | 0.4 | RPA3 RPA1 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-5696400 | 0.0123986787504 | 0.4 | RPA3 RPA1 | Dual Incision in GG-NER |
| REAC:R-HSA-5693579 | 0.0130168285242 | 0.4 | RPA3 RPA1 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5696395 | 0.0130168285242 | 0.4 | RPA3 RPA1 | Formation of Incision Complex in GG-NER |
| WP:WP5114 | 0.0153080129813 | 0.4 | RPA3 RPA1 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-73893 | 0.0163316506439 | 0.4 | RPA3 RPA1 | DNA Damage Bypass |
| REAC:R-HSA-9675135 | 0.0177620315324 | 0.4 | RPA3 RPA1 | Diseases of DNA repair |
| HPA:0030072 | 0.0188314494581 | 1.0 | RPA1 RPA4 RPAIN HMCES RPA3 | appendix; lymphoid tissue[>=Medium] |
| REAC:R-HSA-180786 | 0.0192520251047 | 0.4 | RPA3 RPA1 | Extension of Telomeres |
| GO:0006310 | 0.0196468946878 | 0.8 | RPA4 RPA1 HMCES RPA3 | DNA recombination |
| HPA:0270352 | 0.0208261420727 | 1.0 | RPA1 RPA4 RPAIN HMCES RPA3 | kidney; cells in glomeruli[>=Medium] |
| WP:WP2446 | 0.0212523049113 | 0.4 | RPA3 RPA1 | Retinoblastoma gene in cancer |
| REAC:R-HSA-6782210 | 0.0294410858888 | 0.4 | RPA3 RPA1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 0.0303866302294 | 0.4 | RPA3 RPA1 | Dual incision in TC-NER |
| REAC:R-HSA-3371453 | 0.0313469851718 | 0.4 | RPA3 RPA1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-5685942 | 0.0323221445549 | 0.4 | RPA3 RPA1 | HDR through Homologous Recombination (HRR) |
| HPA:0130242 | 0.0355835654206 | 1.0 | RPA1 RPA4 RPAIN HMCES RPA3 | colon; peripheral nerve/ganglion[>=Medium] |
| WP:WP4946 | 0.0366585107731 | 0.4 | RPA3 RPA1 | DNA repair pathways full network |
| REAC:R-HSA-912446 | 0.0384836492499 | 0.4 | RPA3 RPA1 | Meiotic recombination |
| REAC:R-HSA-73884 | 0.0428866281036 | 0.4 | RPA3 RPA1 | Base Excision Repair |
| REAC:R-HSA-6781827 | 0.0440242300692 | 0.4 | RPA3 RPA1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HPA:0380512 | 0.0457288865022 | 1.0 | RPA1 RPA4 RPAIN HMCES RPA3 | placenta; decidual cells[>=Medium] |
| HPA:0351182 | 0.0492303149675 | 1.0 | RPA1 RPA4 RPAIN HMCES RPA3 | pancreas; pancreatic endocrine cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPA3 | RPA2 | 1.0 | 0.958 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| RPA1 | RPA2 | 1.0 | 0.802 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| RPA3 | RPA1 | 1.0 | 0.658 |
mutually_exclusive (Q13156)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM |
| RPA1 | RPAIN | 0.999 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA2 | RPAIN | 0.999 | 0.208 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA1 | RPA4 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPAIN | RPA4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RPA3 | RPA4 | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA3 | RPAIN | 0.989 | 0.288 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HMCES | RPA1 | 0.988 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HMCES | RPA4 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| HMCES | RPA2 | 0.965 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA3 | HMCES | 0.957 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA2 | RPA4 | 0.931 |
mutually_exclusive (P35244)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HMCES | RPAIN | 0.643 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes