hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08329.1
Complex Portal: CPX-11015
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RBMXL3 | RNA-binding motif protein, X-linked-like-3 | 2 | UniProt NCBI |
| CBARP | Voltage-dependent calcium channel beta subunit-associated regulatory protein | 5 | UniProt NCBI |
| CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | 5 | UniProt NCBI |
| CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-112308 | 0.000215205765992 | 0.5 | CACNB2 CACNB1 | Presynaptic depolarization and calcium channel opening |
| REAC:R-HSA-5576893 | 0.000461028962628 | 0.5 | CACNB2 CACNB1 | Phase 2 - plateau phase |
| REAC:R-HSA-5576892 | 0.00282403231951 | 0.5 | CACNB2 CACNB1 | Phase 0 - rapid depolarisation |
| REAC:R-HSA-419037 | 0.00359044851421 | 0.5 | CACNB2 CACNB1 | NCAM1 interactions |
| WP:WP5356 | 0.00405547408869 | 0.5 | CACNB2 CACNB1 | Affected pathways in Duchenne muscular dystrophy |
| WP:WP2118 | 0.00434689671613 | 0.5 | CACNB2 CACNB1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05412 | 0.0056793701001 | 0.5 | CACNB2 CACNB1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:04260 | 0.00637013094617 | 0.5 | CACNB2 CACNB1 | Cardiac muscle contraction |
| KEGG:05410 | 0.00710024614077 | 0.5 | CACNB2 CACNB1 | Hypertrophic cardiomyopathy |
| KEGG:05414 | 0.00710024614077 | 0.5 | CACNB2 CACNB1 | Dilated cardiomyopathy |
| REAC:R-HSA-375165 | 0.008795277704 | 0.5 | CACNB2 CACNB1 | NCAM signaling for neurite out-growth |
| KEGG:04921 | 0.0171315137194 | 0.5 | CACNB2 CACNB1 | Oxytocin signaling pathway |
| KEGG:04261 | 0.017422762868 | 0.5 | CACNB2 CACNB1 | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-5576891 | 0.0363250695065 | 0.5 | CACNB2 CACNB1 | Cardiac conduction |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RBMXL3 | CACNB1 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CACNB2 | CACNB1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CBARP | CACNB1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CBARP | CACNB2 | 0.754 | 0.09 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| CBARP | RBMXL3 | 0.478 | bioplex3_WMM WMM_only | ||
| CACNB2 | RBMXL3 | 0.214 | bioplex3_WMM WMM_only |
Related Complexes