hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08333.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNRC6C | Trinucleotide repeat-containing gene 6C protein | 5 | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | 5 | UniProt NCBI |
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 1.63310749402e-08 | 1.0 | AGO1 TNRC6C AGO2 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 2.61297199043e-08 | 1.0 | AGO1 TNRC6C AGO2 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-9768778 | 2.61297199043e-08 | 1.0 | AGO1 TNRC6C AGO2 | Regulation of NPAS4 mRNA translation |
| REAC:R-HSA-8943723 | 3.91945798564e-08 | 1.0 | AGO1 TNRC6C AGO2 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-9768759 | 5.59922569377e-08 | 1.0 | AGO1 TNRC6C AGO2 | Regulation of NPAS4 gene expression |
| REAC:R-HSA-8934593 | 3.1728945598e-07 | 1.0 | AGO1 TNRC6C AGO2 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9634815 | 1.5285886144e-06 | 1.0 | AGO1 TNRC6C AGO2 | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9022692 | 1.70496422375e-06 | 1.0 | AGO1 TNRC6C AGO2 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 2.09737662446e-06 | 1.0 | AGO1 TNRC6C AGO2 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-9024446 | 4.26427696795e-06 | 1.0 | AGO1 TNRC6C AGO2 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 1.09306217585e-05 | 1.0 | AGO1 TNRC6C AGO2 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-4086398 | 1.09306217585e-05 | 1.0 | AGO1 TNRC6C AGO2 | Ca2+ pathway |
| REAC:R-HSA-1912408 | 3.28021305227e-05 | 1.0 | AGO1 TNRC6C AGO2 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5628897 | 3.68984307198e-05 | 1.0 | AGO1 TNRC6C AGO2 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-5687128 | 3.98104946827e-05 | 1.0 | AGO1 TNRC6C AGO2 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912422 | 5.85958968853e-05 | 1.0 | AGO1 TNRC6C AGO2 | Pre-NOTCH Expression and Processing |
| GO:0035278 | 6.5361627932e-05 | 1.0 | AGO1 TNRC6C AGO2 | miRNA-mediated gene silencing by inhibition of translation |
| REAC:R-HSA-211000 | 0.000124543577107 | 1.0 | AGO1 TNRC6C AGO2 | Gene Silencing by RNA |
| REAC:R-HSA-9018519 | 0.000155553488805 | 1.0 | AGO1 TNRC6C AGO2 | Estrogen-dependent gene expression |
| REAC:R-HSA-6807070 | 0.00018710512559 | 1.0 | AGO1 TNRC6C AGO2 | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.000191325541956 | 1.0 | AGO1 TNRC6C AGO2 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-426486 | 0.00024538606603 | 0.666666666667 | AGO2 AGO1 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-8939211 | 0.000484435674982 | 1.0 | AGO1 TNRC6C AGO2 | ESR-mediated signaling |
| REAC:R-HSA-157118 | 0.000650538571597 | 1.0 | AGO1 TNRC6C AGO2 | Signaling by NOTCH |
| REAC:R-HSA-8878171 | 0.000720184073787 | 1.0 | AGO1 TNRC6C AGO2 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 0.000933885521422 | 1.0 | AGO1 TNRC6C AGO2 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006931 | 0.00115769357143 | 1.0 | AGO1 TNRC6C AGO2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-5683057 | 0.00118616050146 | 1.0 | AGO1 TNRC6C AGO2 | MAPK family signaling cascades |
| GO:0035195 | 0.00118621742692 | 1.0 | AGO1 TNRC6C AGO2 | miRNA-mediated post-transcriptional gene silencing |
| REAC:R-HSA-9006925 | 0.001430872794 | 1.0 | AGO1 TNRC6C AGO2 | Intracellular signaling by second messengers |
| REAC:R-HSA-203927 | 0.00172341693863 | 0.666666666667 | AGO2 AGO1 | MicroRNA (miRNA) biogenesis |
| REAC:R-HSA-195721 | 0.00201681309877 | 1.0 | AGO1 TNRC6C AGO2 | Signaling by WNT |
| GO:0035194 | 0.00225170808226 | 1.0 | AGO1 TNRC6C AGO2 | regulatory ncRNA-mediated post-transcriptional gene silencing |
| REAC:R-HSA-3700989 | 0.00297633187542 | 1.0 | AGO1 TNRC6C AGO2 | Transcriptional Regulation by TP53 |
| GO:0016441 | 0.00328922780564 | 1.0 | AGO1 TNRC6C AGO2 | post-transcriptional gene silencing |
| REAC:R-HSA-2559585 | 0.00359505378021 | 0.666666666667 | TNRC6C AGO1 | Oncogene Induced Senescence |
| REAC:R-HSA-8853884 | 0.00453384142373 | 0.666666666667 | TNRC6C AGO1 | Transcriptional Regulation by VENTX |
| GO:0031047 | 0.0128843147861 | 1.0 | AGO1 TNRC6C AGO2 | regulatory ncRNA-mediated gene silencing |
| GO:0017148 | 0.0169989253844 | 1.0 | AGO1 TNRC6C AGO2 | negative regulation of translation |
| REAC:R-HSA-8936459 | 0.0214696523361 | 0.666666666667 | TNRC6C AGO1 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| GO:0000956 | 0.0219076797621 | 1.0 | AGO1 TNRC6C AGO2 | nuclear-transcribed mRNA catabolic process |
| CORUM:1387 | 0.0249718442456 | 0.333333333333 | AGO2 | TTP-AGO2 complex |
| GO:0034249 | 0.0276806494292 | 1.0 | AGO1 TNRC6C AGO2 | negative regulation of amide metabolic process |
| REAC:R-HSA-5578749 | 0.0278082114556 | 0.666666666667 | AGO2 AGO1 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-2559580 | 0.0384822430974 | 0.666666666667 | TNRC6C AGO1 | Oxidative Stress Induced Senescence |
| GO:0070578 | 0.0393180950424 | 0.666666666667 | AGO2 AGO1 | RISC-loading complex |
| WP:WP2805 | 0.0496447587094 | 0.333333333333 | AGO2 | exRNA mechanism of action and biogenesis |
| CORUM:5360 | 0.0499402709677 | 0.333333333333 | AGO2 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AGO1 | AGO2 | 0.993 | 0.212 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| TNRC6C | AGO1 | 0.969 | 0.242171075838 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction |
| TNRC6C | AGO2 | 0.734 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes