hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08342.1
Complex Portal: CPX-25100
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GYG1 | Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) | 5 | UniProt NCBI |
| PPP1R3B | Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) | 4 | UniProt NCBI |
| AMY2A | Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) | 5 | UniProt NCBI |
| GYS1 | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | 5 | UniProt NCBI |
| GBE1 | 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme) | 5 | UniProt NCBI |
| PPP1R3D | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00500 | 2.14152523635e-06 | 0.6 | GYG1 GBE1 AMY2A | Starch and sucrose metabolism |
| GO:0009250 | 4.72375798258e-06 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | glucan biosynthetic process |
| GO:0005978 | 4.72375798258e-06 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | glycogen biosynthetic process |
| GO:0044042 | 1.95582475037e-05 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | glucan metabolic process |
| GO:0005977 | 1.95582475037e-05 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | glycogen metabolic process |
| GO:0000271 | 2.34110134044e-05 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | polysaccharide biosynthetic process |
| GO:0006112 | 3.5523826943e-05 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | energy reserve metabolic process |
| GO:0005976 | 6.84426164966e-05 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | polysaccharide metabolic process |
| GO:0005975 | 0.000211369707937 | 1.0 | GBE1 GYG1 AMY2A PPP1R3D PPP1R3B | carbohydrate metabolic process |
| WP:WP5173 | 0.000458099292948 | 0.4 | GYG1 GBE1 | Disorders of galactose metabolism |
| REAC:R-HSA-3229121 | 0.0013810496636 | 0.4 | GYG1 GBE1 | Glycogen storage diseases |
| REAC:R-HSA-3322077 | 0.0013810496636 | 0.4 | GYG1 GBE1 | Glycogen synthesis |
| GO:0016051 | 0.00139398670092 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | carbohydrate biosynthetic process |
| WP:WP500 | 0.00389862536801 | 0.4 | GYG1 GBE1 | Glycogen synthesis and degradation |
| REAC:R-HSA-8982491 | 0.00418294558639 | 0.4 | GYG1 GBE1 | Glycogen metabolism |
| WP:WP4861 | 0.00456408083355 | 0.4 | PPP1R3B PPP1R3D | Endoplasmic reticulum stress response in coronavirus infection |
| REAC:R-HSA-5663084 | 0.0065872694687 | 0.4 | GYG1 GBE1 | Diseases of carbohydrate metabolism |
| GO:0015980 | 0.0130363720333 | 0.8 | GYG1 GBE1 PPP1R3D PPP1R3B | energy derivation by oxidation of organic compounds |
| KEGG:04931 | 0.0213229262457 | 0.4 | PPP1R3B PPP1R3D | Insulin resistance |
| KEGG:04910 | 0.0351932106204 | 0.4 | PPP1R3B PPP1R3D | Insulin signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PPP1R3B | GYG1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PPP1R3B | PPP1R3D | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| PPP1R3B | GYS1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| AMY2A | GYG1 | 0.985 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| AMY2A | GYS1 | 0.98 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP1R3D | GYG1 | 0.98 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| GYS1 | GBE1 | 0.978 | 0.098 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GYG1 | GBE1 | 0.978 | 0.048 |
structurally_consistent (P13807)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PPP1R3D | GYS1 | 0.977 | 0.044 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| GYG1 | GYS1 | 0.962 | 0.044 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PPP1R3B | GBE1 | 0.002 | bioplex3_HCT116 WMM_only | ||
| AMY2A | GBE1 | 0.002 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes