hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08344.1
Complex Portal: CPX-17798
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAGOHB | Protein mago nashi homolog 2 | 5 | UniProt NCBI |
| MAGOH | Protein mago nashi homolog | 5 | UniProt NCBI |
| PNN | Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein) | 5 | UniProt NCBI |
| RBM8A | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03015 | 6.2790160285e-08 | 1.0 | PNN MAGOHB RBM8A MAGOH | mRNA surveillance pathway |
| KEGG:03013 | 9.59218740742e-08 | 1.0 | PNN MAGOHB RBM8A MAGOH | Nucleocytoplasmic transport |
| GO:0035145 | 1.27484697239e-07 | 1.0 | PNN MAGOHB RBM8A MAGOH | exon-exon junction complex |
| GO:1903503 | 3.84480164306e-07 | 0.75 | RBM8A MAGOHB MAGOH | ATPase inhibitor complex |
| GO:1990501 | 3.84480164306e-07 | 0.75 | RBM8A MAGOHB MAGOH | exon-exon junction subcomplex mago-y14 |
| CORUM:773 | 5.12628525639e-06 | 0.5 | RBM8A MAGOH | Y14-Magoh complex |
| CORUM:763 | 5.12628525639e-06 | 0.5 | RBM8A MAGOH | Y14-Magoh complex |
| REAC:R-HSA-72163 | 6.33792055023e-06 | 1.0 | PNN MAGOHB RBM8A MAGOH | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 7.27540598206e-06 | 1.0 | PNN MAGOHB RBM8A MAGOH | mRNA Splicing |
| CORUM:1293 | 1.53774525569e-05 | 0.5 | RBM8A MAGOH | IPO13-RBM8A-MAGOH complex |
| REAC:R-HSA-72203 | 2.20624569728e-05 | 1.0 | PNN MAGOHB RBM8A MAGOH | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:740 | 3.07520988333e-05 | 0.5 | RBM8A MAGOH | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:744 | 3.07520988333e-05 | 0.5 | RBM8A MAGOH | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:754 | 3.07520988333e-05 | 0.5 | RBM8A MAGOH | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14) |
| CORUM:769 | 3.07520988333e-05 | 0.5 | RBM8A MAGOH | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| REAC:R-HSA-72187 | 3.67150180564e-05 | 0.75 | RBM8A MAGOHB MAGOH | mRNA 3'-end processing |
| CORUM:1181 | 5.11275535434e-05 | 0.75 | PNN MAGOH RBM8A | C complex spliceosome |
| CORUM:755 | 5.12488211613e-05 | 0.5 | RBM8A MAGOH | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM) |
| REAC:R-HSA-73856 | 5.55513549806e-05 | 0.75 | RBM8A MAGOHB MAGOH | RNA Polymerase II Transcription Termination |
| GO:0071013 | 5.85691538001e-05 | 1.0 | PNN MAGOHB RBM8A MAGOH | catalytic step 2 spliceosome |
| GO:2000622 | 6.34131776058e-05 | 0.75 | RBM8A MAGOHB MAGOH | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| REAC:R-HSA-159236 | 7.65476877178e-05 | 0.75 | RBM8A MAGOHB MAGOH | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| CORUM:6742 | 7.68662167609e-05 | 0.5 | RBM8A MAGOH | SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex |
| CORUM:785 | 0.000107602882996 | 0.5 | RBM8A MAGOH | Exon junction complex |
| KEGG:03040 | 0.000108396031683 | 0.75 | RBM8A MAGOHB MAGOH | Spliceosome |
| REAC:R-HSA-72202 | 0.000110531761496 | 0.75 | RBM8A MAGOHB MAGOH | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-927802 | 0.000335499618459 | 0.75 | RBM8A MAGOHB MAGOH | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-975957 | 0.000335499618459 | 0.75 | RBM8A MAGOHB MAGOH | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-8953854 | 0.000868181971164 | 1.0 | PNN MAGOHB RBM8A MAGOH | Metabolism of RNA |
| GO:0005681 | 0.000883719448116 | 1.0 | PNN MAGOHB RBM8A MAGOH | spliceosomal complex |
| REAC:R-HSA-9010553 | 0.00104173974765 | 0.75 | RBM8A MAGOHB MAGOH | Regulation of expression of SLITs and ROBOs |
| GO:0000184 | 0.00209449363787 | 0.75 | RBM8A MAGOHB MAGOH | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| REAC:R-HSA-376176 | 0.00211233137107 | 0.75 | RBM8A MAGOHB MAGOH | Signaling by ROBO receptors |
| GO:0000398 | 0.005365870902 | 1.0 | PNN MAGOHB RBM8A MAGOH | mRNA splicing, via spliceosome |
| GO:0000377 | 0.005365870902 | 1.0 | PNN MAGOHB RBM8A MAGOH | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00569790407237 | 1.0 | PNN MAGOHB RBM8A MAGOH | RNA splicing, via transesterification reactions |
| GO:0006397 | 0.0135620900865 | 1.0 | PNN MAGOHB RBM8A MAGOH | mRNA processing |
| GO:0006406 | 0.0175369202004 | 0.75 | RBM8A MAGOHB MAGOH | mRNA export from nucleus |
| GO:0008380 | 0.0193524071449 | 1.0 | PNN MAGOHB RBM8A MAGOH | RNA splicing |
| GO:0051028 | 0.0228491864842 | 0.75 | RBM8A MAGOHB MAGOH | mRNA transport |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | RBM8A MAGOHB MAGOH | Axon guidance |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | RBM8A MAGOHB MAGOH | Nervous system development |
| HPA:0090183 | 0.0296286402726 | 0.75 | PNN MAGOH RBM8A | cerebellum; cells in granular layer[High] |
| GO:0006405 | 0.0378152735667 | 0.75 | RBM8A MAGOHB MAGOH | RNA export from nucleus |
| CORUM:351 | 0.047170241778 | 0.5 | RBM8A MAGOH | Spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAGOH | RBM8A | 1.0 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM | |
| PNN | RBM8A | 0.999 | 0.874 |
mutually_exclusive (P38919)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| MAGOH | MAGOHB | 0.994 | hein_WMM bioplex3_WMM hein () gupta_WMM | ||
| RBM8A | MAGOHB | 0.983 | 0.946 |
mutually_exclusive (Q96J01)
structurally_consistent (dimer) |
hein_WMM bioplex3_WMM hein () gupta_WMM |
| MAGOH | PNN | 0.982 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | ||
| PNN | MAGOHB | 0.97 | 0.766 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes