hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08346.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| IBTK | Inhibitor of Bruton tyrosine kinase (IBtk) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
| IBA57 | Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4566 | 0.0020866894725 | 0.5 | EIF4A1 EIF4A2 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-429947 | 0.00282403231951 | 0.5 | EIF4A1 EIF4A2 | Deadenylation of mRNA |
| WP:WP107 | 0.00299043061896 | 0.5 | EIF4A1 EIF4A2 | Translation factors |
| REAC:R-HSA-429914 | 0.0151515389193 | 0.5 | EIF4A1 EIF4A2 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-72702 | 0.0174510452107 | 0.5 | EIF4A1 EIF4A2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0174510452107 | 0.5 | EIF4A1 EIF4A2 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0180511544442 | 0.5 | EIF4A1 EIF4A2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REAC:R-HSA-1169408 | 0.0218635493976 | 0.5 | EIF4A1 EIF4A2 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.0260384914588 | 0.5 | EIF4A1 EIF4A2 | Antiviral mechanism by IFN-stimulated genes |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM |
| IBTK | EIF4A1 | 0.995 | 0.227272727273 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 fraction |
| EIF4A1 | IBA57 | 0.974 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| IBTK | EIF4A2 | 0.792 | 0.046 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| IBTK | IBA57 | 0.146 | 0.10648 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EIF4A2 | IBA57 | 0.105 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes