hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08350.1
Complex Portal: CPX-22507
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRAGD | Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-) | 5 | UniProt NCBI |
| SLC38A9 | Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11) | 5 | UniProt NCBI |
| RPTOR | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | 5 | UniProt NCBI |
| LAMTOR2 | Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3) | 5 | UniProt NCBI |
| LAMTOR1 | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | 5 | UniProt NCBI |
| RRAGC | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | 5 | UniProt NCBI |
| RRAGA | Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1) | 5 | UniProt NCBI |
| LAMTOR4 | Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed] | 5 | UniProt NCBI |
| LAMTOR3 | Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1) | 5 | UniProt NCBI |
| LAMTOR5 | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | 5 | UniProt NCBI |
| SMYD5 | Histone-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.372) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H4]-lysine20 N-trimethyltransferase SMYD5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-166208 | 4.57165420253e-26 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | mTORC1-mediated signalling |
| REAC:R-HSA-380972 | 4.66750671469e-25 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 2.6104958675e-23 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | MTOR signalling |
| REAC:R-HSA-9639288 | 4.53699502624e-22 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Amino acids regulate mTORC1 |
| GO:0071230 | 5.89551366613e-22 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to amino acid stimulus |
| REAC:R-HSA-8943724 | 1.00451938154e-21 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Regulation of PTEN gene transcription |
| GO:0071229 | 1.56579741468e-21 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to acid chemical |
| GO:0043200 | 2.85741674985e-21 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to amino acid |
| GO:1990877 | 7.20228030652e-21 | 0.727272727273 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | FNIP-folliculin RagC/D GAP |
| GO:0001101 | 8.61548981679e-21 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to acid chemical |
| GO:1902773 | 2.64035394183e-20 | 0.727272727273 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | GTPase activator complex |
| REAC:R-HSA-5628897 | 3.34669505605e-20 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | TP53 Regulates Metabolic Genes |
| GO:0032008 | 8.0328966374e-19 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | positive regulation of TOR signaling |
| GO:0150005 | 2.0575963047e-18 | 0.727272727273 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | enzyme activator complex |
| REAC:R-HSA-1632852 | 4.46227300394e-18 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Macroautophagy |
| KEGG:04150 | 4.63388314782e-18 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | mTOR signaling pathway |
| REAC:R-HSA-6807070 | 9.11622644892e-18 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | PTEN Regulation |
| REAC:R-HSA-9612973 | 1.42877394558e-17 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Autophagy |
| GO:0038202 | 2.27838271947e-17 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | TORC1 signaling |
| REAC:R-HSA-9711097 | 3.31683282907e-17 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Cellular response to starvation |
| GO:1904263 | 8.19713431328e-17 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | positive regulation of TORC1 signaling |
| GO:0032006 | 7.29530028606e-16 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | regulation of TOR signaling |
| GO:0071986 | 1.70843062971e-15 | 0.545454545455 | LAMTOR3 LAMTOR1 LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | Ragulator complex |
| REAC:R-HSA-1257604 | 2.15416759757e-15 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | PIP3 activates AKT signaling |
| GO:0031929 | 2.20823351986e-15 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | TOR signaling |
| REAC:R-HSA-9006925 | 9.09953691303e-15 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Intracellular signaling by second messengers |
| GO:1903432 | 1.34126217524e-14 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | regulation of TORC1 signaling |
| REAC:R-HSA-3700989 | 1.0715032096e-13 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Transcriptional Regulation by TP53 |
| CORUM:6888 | 1.10262353551e-11 | 0.454545454545 | LAMTOR3 LAMTOR4 LAMTOR5 LAMTOR2 LAMTOR1 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| GO:0071417 | 1.8333822725e-11 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to organonitrogen compound |
| GO:0032045 | 4.61766170172e-11 | 0.545454545455 | LAMTOR3 LAMTOR1 LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | guanyl-nucleotide exchange factor complex |
| GO:1901699 | 6.57674564031e-11 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to nitrogen compound |
| REAC:R-HSA-2262752 | 2.25254025102e-10 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Cellular responses to stress |
| REAC:R-HSA-8953897 | 2.48074204379e-10 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Cellular responses to stimuli |
| GO:0010243 | 4.5357968468e-10 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to organonitrogen compound |
| GO:1901698 | 1.89164734537e-09 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to nitrogen compound |
| GO:0098852 | 3.24083986294e-09 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 RPTOR LAMTOR2 | lytic vacuole membrane |
| GO:0005765 | 3.24083986294e-09 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 RPTOR LAMTOR2 | lysosomal membrane |
| GO:0005764 | 4.22151891627e-09 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | lysosome |
| GO:0000323 | 4.22151891627e-09 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | lytic vacuole |
| GO:0005774 | 6.49779229556e-09 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 RPTOR LAMTOR2 | vacuolar membrane |
| REAC:R-HSA-212436 | 7.37775532608e-09 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Generic Transcription Pathway |
| GO:0005773 | 1.11110909948e-08 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | vacuole |
| GO:1901701 | 1.7173476332e-08 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to oxygen-containing compound |
| REAC:R-HSA-73857 | 2.20543046166e-08 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | RNA Polymerase II Transcription |
| GO:1902533 | 3.37715212145e-08 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | positive regulation of intracellular signal transduction |
| REAC:R-HSA-74160 | 7.69459173595e-08 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Gene expression (Transcription) |
| GO:1901700 | 1.57050041081e-07 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to oxygen-containing compound |
| GO:0071495 | 2.24752421298e-07 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to endogenous stimulus |
| GO:0009719 | 5.27845342841e-07 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to endogenous stimulus |
| WP:WP1471 | 8.31071633117e-07 | 0.363636363636 | RRAGC RRAGD RRAGA RPTOR | Target of rapamycin signaling |
| GO:0009967 | 1.66181670164e-06 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | positive regulation of signal transduction |
| GO:0071310 | 2.72665564258e-06 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to organic substance |
| GO:0010647 | 3.89996087715e-06 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | positive regulation of cell communication |
| GO:0023056 | 4.07471903013e-06 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | positive regulation of signaling |
| REAC:R-HSA-162582 | 6.34479072702e-06 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | Signal Transduction |
| GO:1902531 | 8.07685936393e-06 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | regulation of intracellular signal transduction |
| GO:0061462 | 8.67923442929e-06 | 0.454545454545 | LAMTOR4 LAMTOR5 LAMTOR1 RRAGA RRAGC | protein localization to lysosome |
| GO:0060090 | 2.6994499503e-05 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 LAMTOR5 RPTOR LAMTOR2 RRAGD | molecular adaptor activity |
| GO:0010033 | 2.95639491954e-05 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to organic substance |
| CORUM:5226 | 3.41979277617e-05 | 0.181818181818 | LAMTOR3 LAMTOR2 | p14-Mp1-ERK2 complex |
| GO:0005085 | 4.16767853696e-05 | 0.545454545455 | LAMTOR3 LAMTOR1 LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | guanyl-nucleotide exchange factor activity |
| GO:1990131 | 6.34131776058e-05 | 0.272727272727 | RRAGD RRAGA RRAGC | Gtr1-Gtr2 GTPase complex |
| GO:0072665 | 7.00968258654e-05 | 0.454545454545 | LAMTOR4 LAMTOR5 LAMTOR1 RRAGA RRAGC | protein localization to vacuole |
| GO:0048584 | 8.55623524134e-05 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | positive regulation of response to stimulus |
| GO:0031902 | 9.14075853742e-05 | 0.454545454545 | LAMTOR3 LAMTOR4 LAMTOR5 LAMTOR2 LAMTOR1 | late endosome membrane |
| GO:0070887 | 9.41592664541e-05 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | cellular response to chemical stimulus |
| CORUM:5222 | 0.000102551658964 | 0.181818181818 | LAMTOR3 LAMTOR2 | p14-Mp1-MEK1 complex |
| GO:0005770 | 0.000137010355036 | 0.545454545455 | LAMTOR3 LAMTOR1 LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | late endosome |
| KEGG:04140 | 0.000198190184799 | 0.363636363636 | RRAGC RRAGD RRAGA RPTOR | Autophagy - animal |
| GO:0035556 | 0.000396792670502 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | intracellular signal transduction |
| KEGG:05131 | 0.000875119124953 | 0.363636363636 | RRAGC RRAGD RRAGA RPTOR | Shigellosis |
| GO:0042221 | 0.0010618254138 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | response to chemical |
| GO:0009966 | 0.00142290110999 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | regulation of signal transduction |
| GO:0098588 | 0.00202956453663 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 SLC38A9 LAMTOR5 RPTOR LAMTOR2 | bounding membrane of organelle |
| GO:0031669 | 0.00333838549681 | 0.454545454545 | RRAGC LAMTOR1 RRAGD RRAGA RPTOR | cellular response to nutrient levels |
| GO:0023051 | 0.00355736257568 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | regulation of signaling |
| GO:0010646 | 0.00360428654475 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | regulation of cell communication |
| GO:0060589 | 0.00396944759162 | 0.545454545455 | LAMTOR3 LAMTOR1 LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | nucleoside-triphosphatase regulator activity |
| GO:0030695 | 0.00396944759162 | 0.545454545455 | LAMTOR3 LAMTOR1 LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | GTPase regulator activity |
| GO:0031668 | 0.00438286217972 | 0.454545454545 | RRAGC LAMTOR1 RRAGD RRAGA RPTOR | cellular response to extracellular stimulus |
| WP:WP5224 | 0.00595185726333 | 0.272727272727 | RRAGD RRAGA RRAGC | 2q37 copy number variation syndrome |
| GO:0010507 | 0.00776238405979 | 0.363636363636 | RRAGC RRAGD RRAGA RPTOR | negative regulation of autophagy |
| HPA:0590053 | 0.00916668965142 | 0.636363636364 | LAMTOR3 LAMTOR1 RRAGC LAMTOR4 LAMTOR5 LAMTOR2 RRAGD | thyroid gland; glandular cells[High] |
| GO:0071496 | 0.0108866080362 | 0.454545454545 | RRAGC LAMTOR1 RRAGD RRAGA RPTOR | cellular response to external stimulus |
| GO:0031667 | 0.0154949106367 | 0.454545454545 | RRAGC LAMTOR1 RRAGD RRAGA RPTOR | response to nutrient levels |
| HPA:0630052 | 0.0165000435065 | 0.818181818182 | LAMTOR3 LAMTOR1 RRAGC RRAGA LAMTOR4 LAMTOR5 RPTOR LAMTOR2 RRAGD | cervix; glandular cells[>=Medium] |
| GO:0009991 | 0.0197658794876 | 0.454545454545 | RRAGC LAMTOR1 RRAGD RRAGA RPTOR | response to extracellular stimulus |
| HPA:0570741 | 0.0203131147945 | 0.727272727273 | LAMTOR3 LAMTOR1 RRAGA RPTOR LAMTOR4 LAMTOR5 LAMTOR2 RRAGD | testis; cells in seminiferous ducts[>=Low] |
| GO:0048583 | 0.0210705025756 | 0.909090909091 | LAMTOR3 LAMTOR1 RPTOR RRAGA RRAGC LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 RRAGD | regulation of response to stimulus |
| GO:0140535 | 0.0236729393562 | 0.636363636364 | LAMTOR3 LAMTOR1 RPTOR LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | intracellular protein-containing complex |
| GO:0043495 | 0.0408476954791 | 0.272727272727 | LAMTOR1 RRAGA RRAGC | protein-membrane adaptor activity |
| GO:0030234 | 0.0472638763972 | 0.636363636364 | LAMTOR3 LAMTOR1 RPTOR LAMTOR4 SLC38A9 LAMTOR5 LAMTOR2 | enzyme regulator activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LAMTOR1 | LAMTOR4 | 1.0 | 0.916 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAMTOR1 | RRAGA | 1.0 | 0.254 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LAMTOR2 | LAMTOR1 | 1.0 | 0.872 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAMTOR2 | LAMTOR5 | 0.999 | 0.516 |
mutually_exclusive (Q5VZM2)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGC | RRAGA | 0.999 | 0.207777777778 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RRAGD | RRAGA | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RRAGA | LAMTOR5 | 0.999 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLC38A9 | RRAGA | 0.999 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LAMTOR2 | LAMTOR3 | 0.999 | 0.944 |
mutually_exclusive (Q5VZM2)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGD | LAMTOR5 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RRAGC | LAMTOR1 | 0.998 | 0.262 |
mutually_exclusive (Q9NQL2)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LAMTOR4 | LAMTOR5 | 0.998 | 0.582 |
mutually_exclusive (Q5VZM2)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LAMTOR4 | LAMTOR3 | 0.998 | 0.912 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAMTOR2 | LAMTOR4 | 0.998 | 0.836 |
mutually_exclusive (Q5VZM2)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LAMTOR1 | LAMTOR3 | 0.998 | 0.816 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| SLC38A9 | LAMTOR1 | 0.998 | 0.250911392405 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRAGC | LAMTOR2 | 0.998 | 0.112 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC38A9 | LAMTOR3 | 0.997 | 0.134 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRAGC | LAMTOR4 | 0.997 | 0.164 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC38A9 | LAMTOR2 | 0.997 | 0.194 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAMTOR1 | LAMTOR5 | 0.997 | 0.696 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| RRAGD | LAMTOR4 | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RRAGC | LAMTOR3 | 0.997 | 0.224 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAMTOR3 | LAMTOR5 | 0.997 | 0.332 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRAGD | LAMTOR3 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SLC38A9 | LAMTOR4 | 0.996 | 0.092 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC38A9 | LAMTOR5 | 0.995 | 0.15 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRAGC | LAMTOR5 | 0.995 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRAGD | LAMTOR1 | 0.994 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRAGA | LAMTOR3 | 0.994 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LAMTOR2 | RRAGA | 0.99 | 0.144 |
mutually_exclusive (Q5VZM2)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RRAGA | LAMTOR4 | 0.988 | 0.266 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RPTOR | RRAGA | 0.988 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RPTOR | LAMTOR4 | 0.986 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC38A9 | RRAGC | 0.984 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| RPTOR | LAMTOR5 | 0.981 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAMTOR1 | SMYD5 | 0.975 | 0.108 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RRAGC | RRAGD | 0.973 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RPTOR | LAMTOR3 | 0.965 | 0.052 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RRAGD | LAMTOR2 | 0.965 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| SLC38A9 | RRAGD | 0.959 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RRAGD | RPTOR | 0.73 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| LAMTOR1 | RPTOR | 0.559 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LAMTOR2 | RPTOR | 0.549 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC38A9 | RPTOR | 0.387 | 0.158244897959 | bioplex_WMM bioplex3_WMM WMM_only | |
| RRAGC | RPTOR | 0.359 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| LAMTOR2 | SMYD5 | 0.076 | 0.036 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SMYD5 | LAMTOR3 | 0.066 | 0.026 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SMYD5 | LAMTOR4 | 0.025 | 0.028 | bioplex3_HEK293 WMM_only |
Related Complexes