hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08354.1
Complex Portal: CPX-21662
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL17A1 | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | 5 | UniProt NCBI |
| COL4A4 | Collagen alpha-4(IV) chain | 5 | UniProt NCBI |
| COL6A3 | Collagen alpha-3(VI) chain | 5 | UniProt NCBI |
| LAIR2 | Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306) | 4 | UniProt NCBI |
| COL3A1 | Collagen alpha-1(III) chain | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 5.68914662089e-06 | 0.75 | COL17A1 COL4A4 COL3A1 | Collagen chain trimerization |
| KEGG:04974 | 1.79251891439e-05 | 0.75 | COL17A1 COL4A4 COL3A1 | Protein digestion and absorption |
| REAC:R-HSA-2022090 | 2.27017011202e-05 | 0.75 | COL17A1 COL4A4 COL3A1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 2.57917427086e-05 | 0.75 | COL17A1 COL4A4 COL3A1 | Collagen degradation |
| REAC:R-HSA-1650814 | 3.0932996971e-05 | 0.75 | COL17A1 COL4A4 COL3A1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 8.33911915483e-05 | 0.75 | COL17A1 COL4A4 COL3A1 | Collagen formation |
| REAC:R-HSA-198933 | 0.000205891416993 | 0.75 | COL17A1 COL3A1 LAIR2 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| REAC:R-HSA-1474228 | 0.000261669015753 | 0.75 | COL17A1 COL4A4 COL3A1 | Degradation of the extracellular matrix |
| GO:0030020 | 0.00140301566648 | 0.75 | COL17A1 COL4A4 COL3A1 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-1474244 | 0.00270393678592 | 0.75 | COL17A1 COL4A4 COL3A1 | Extracellular matrix organization |
| REAC:R-HSA-419037 | 0.00359044851421 | 0.5 | COL3A1 COL4A4 | NCAM1 interactions |
| REAC:R-HSA-375165 | 0.008795277704 | 0.5 | COL3A1 COL4A4 | NCAM signaling for neurite out-growth |
| KEGG:05146 | 0.00909742323246 | 0.5 | COL3A1 COL4A4 | Amoebiasis |
| KEGG:04933 | 0.00931062778609 | 0.5 | COL3A1 COL4A4 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-186797 | 0.0115164156767 | 0.5 | COL3A1 COL4A4 | Signaling by PDGF |
| REAC:R-HSA-3000171 | 0.0115164156767 | 0.5 | COL3A1 COL4A4 | Non-integrin membrane-ECM interactions |
| KEGG:04926 | 0.014352694406 | 0.5 | COL3A1 COL4A4 | Relaxin signaling pathway |
| HP:0001030 | 0.0155098335254 | 0.5 | COL17A1 COL3A1 | Fragile skin |
| REAC:R-HSA-3000178 | 0.0168610262513 | 0.5 | COL3A1 COL4A4 | ECM proteoglycans |
| HP:0001075 | 0.0176079483787 | 0.5 | COL17A1 COL3A1 | Atrophic scars |
| REAC:R-HSA-216083 | 0.0199119958937 | 0.5 | COL3A1 COL4A4 | Integrin cell surface interactions |
| HP:0200020 | 0.0222019103471 | 0.5 | COL17A1 COL4A4 | Corneal erosion |
| HP:0002293 | 0.0259951101914 | 0.5 | COL17A1 COL3A1 | Alopecia of scalp |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COL4A4 | LAIR2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL6A3 | LAIR2 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL17A1 | LAIR2 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LAIR2 | COL3A1 | 0.974 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| COL17A1 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL4A4 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL3A1 | 0.25 | bioplex3_WMM WMM_only | ||
| COL6A3 | COL3A1 | 0.214 | 0.366 | bioplex3_WMM WMM_only | |
| COL17A1 | COL3A1 | 0.214 | bioplex3_WMM WMM_only |
Related Complexes