hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08362.1
Complex Portal: CPX-22151
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OSBPL3 | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | 5 | UniProt NCBI |
| ZFPL1 | Zinc finger protein-like 1 (Zinc finger protein MCG4) | 5 | UniProt NCBI |
| PITPNM1 | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | 5 | UniProt NCBI |
| OSBP | Oxysterol-binding protein 1 | 5 | UniProt NCBI |
| OSBP2 | Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) | 5 | UniProt NCBI |
| SLC22A15 | Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1) | 5 | UniProt NCBI |
| PITPNM3 | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | 5 | UniProt NCBI |
| VAPA | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | 5 | UniProt NCBI |
| OSBPL6 | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005319 | 8.57350790432e-07 | 0.666666666667 | OSBP PITPNM1 PITPNM3 OSBP2 OSBPL6 OSBPL3 | lipid transporter activity |
| GO:0097038 | 7.86258774297e-06 | 0.444444444444 | OSBPL3 OSBP OSBPL6 OSBP2 | perinuclear endoplasmic reticulum |
| GO:0015248 | 4.92672936912e-05 | 0.444444444444 | OSBPL3 OSBP OSBPL6 OSBP2 | sterol transporter activity |
| REAC:R-HSA-192105 | 5.0612044968e-05 | 0.333333333333 | OSBPL3 OSBP OSBPL6 | Synthesis of bile acids and bile salts |
| REAC:R-HSA-556833 | 9.40411082062e-05 | 0.666666666667 | OSBP VAPA PITPNM3 OSBPL6 OSBPL3 PITPNM1 | Metabolism of lipids |
| REAC:R-HSA-194068 | 0.000138707470455 | 0.333333333333 | OSBPL3 OSBP OSBPL6 | Bile acid and bile salt metabolism |
| GO:0032934 | 0.000584421737577 | 0.444444444444 | OSBPL3 OSBP OSBPL6 OSBP2 | sterol binding |
| REAC:R-HSA-1483226 | 0.000798060792831 | 0.222222222222 | PITPNM1 PITPNM3 | Synthesis of PI |
| GO:0005215 | 0.00188245805208 | 0.777777777778 | OSBP PITPNM3 OSBP2 OSBPL6 PITPNM1 OSBPL3 SLC22A15 | transporter activity |
| GO:0005496 | 0.0020721506318 | 0.444444444444 | OSBPL3 OSBP OSBPL6 OSBP2 | steroid binding |
| GO:0008610 | 0.00673624890584 | 0.666666666667 | OSBP VAPA PITPNM3 OSBPL6 OSBPL3 PITPNM1 | lipid biosynthetic process |
| REAC:R-HSA-8957322 | 0.0108901888715 | 0.333333333333 | OSBPL3 OSBP OSBPL6 | Metabolism of steroids |
| GO:0006699 | 0.0123615112794 | 0.333333333333 | OSBPL3 OSBP OSBPL6 | bile acid biosynthetic process |
| GO:0008206 | 0.0262477173145 | 0.333333333333 | OSBPL3 OSBP OSBPL6 | bile acid metabolic process |
| REAC:R-HSA-1660661 | 0.0443583465173 | 0.222222222222 | VAPA OSBP | Sphingolipid de novo biosynthesis |
| REAC:R-HSA-1430728 | 0.0452440709483 | 0.666666666667 | OSBP VAPA PITPNM3 OSBPL6 OSBPL3 PITPNM1 | Metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VAPA | OSBPL3 | 0.999 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| VAPA | ZFPL1 | 0.999 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| VAPA | OSBPL6 | 0.999 | 0.140194444444 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| VAPA | OSBP2 | 0.997 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ZFPL1 | OSBPL3 | 0.996 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VAPA | OSBP | 0.992 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| VAPA | PITPNM3 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| OSBPL6 | OSBPL3 | 0.985 | 0.082 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| VAPA | PITPNM1 | 0.983 | 0.11 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ZFPL1 | PITPNM3 | 0.979 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZFPL1 | OSBPL6 | 0.96 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLC22A15 | VAPA | 0.957 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| OSBP | OSBP2 | 0.94 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| PITPNM3 | OSBPL3 | 0.909 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SLC22A15 | PITPNM1 | 0.902 | bioplex3_WMM WMM_only | ||
| PITPNM1 | OSBP2 | 0.897 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC22A15 | ZFPL1 | 0.889 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PITPNM1 | PITPNM3 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PITPNM3 | OSBP2 | 0.778 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PITPNM1 | OSBPL6 | 0.737 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| OSBP2 | OSBPL6 | 0.737 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only | |
| PITPNM1 | OSBP | 0.731 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC22A15 | OSBP2 | 0.722 | bioplex3_WMM WMM_only | ||
| PITPNM1 | OSBPL3 | 0.72 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC22A15 | PITPNM3 | 0.717 | bioplex3_WMM WMM_only | ||
| OSBP2 | OSBPL3 | 0.714 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| OSBP | PITPNM3 | 0.677 | bioplex_WMM bioplex3_WMM WMM_only | ||
| OSBP | OSBPL6 | 0.653 | 0.148 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PITPNM3 | OSBPL6 | 0.644 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PITPNM1 | ZFPL1 | 0.563 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only | |
| OSBP | OSBPL3 | 0.509 | 0.082 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | |
| ZFPL1 | OSBP2 | 0.475 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC22A15 | OSBPL6 | 0.343 | bioplex3_WMM WMM_only | ||
| SLC22A15 | OSBP | 0.323 | bioplex3_WMM WMM_only | ||
| SLC22A15 | OSBPL3 | 0.245 | bioplex3_WMM WMM_only | ||
| OSBP | ZFPL1 | 0.227 | 0.11 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes