hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08365.1
Complex Portal: CPX-18509
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CWC22 | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | 5 | UniProt NCBI |
| SAP18 | Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18) | 5 | UniProt NCBI |
| SETD2 | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | 5 | UniProt NCBI |
| RSBN1L | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | 3 | UniProt NCBI |
| SNIP1 | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | 5 | UniProt NCBI |
| EPB41L2 | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | 5 | UniProt NCBI |
| PRPF4B | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | 5 | UniProt NCBI |
| NKTR | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | 5 | UniProt NCBI |
| ACIN1 | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | 5 | UniProt NCBI |
| RNPS1 | RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2) | 5 | UniProt NCBI |
| VANGL1 | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | 5 | UniProt NCBI |
| GPATCH8 | G patch domain-containing protein 8 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:760 | 2.5725558439e-08 | 0.25 | RNPS1 SAP18 ACIN1 | Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18, RNPS1, Acinus-L |
| REAC:R-HSA-72163 | 1.47221997734e-06 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 1.80802915765e-06 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | mRNA Splicing |
| REAC:R-HSA-72203 | 9.39234395669e-06 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0061574 | 8.45465618902e-05 | 0.25 | RNPS1 SAP18 ACIN1 | ASAP complex |
| CORUM:351 | 0.000209900402146 | 0.333333333333 | CWC22 RNPS1 PRPF4B ACIN1 | Spliceosome |
| GO:0000377 | 0.00144841757832 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.00144841757832 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.00158319444835 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | RNA splicing, via transesterification reactions |
| REAC:R-HSA-8953854 | 0.0020263217605 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | Metabolism of RNA |
| KEGG:03015 | 0.00256393573202 | 0.25 | RNPS1 SAP18 ACIN1 | mRNA surveillance pathway |
| KEGG:03013 | 0.00350089201053 | 0.25 | RNPS1 SAP18 ACIN1 | Nucleocytoplasmic transport |
| HPA:0160051 | 0.00366868798146 | 1.0 | PRPF4B SNIP1 CWC22 RSBN1L NKTR SAP18 EPB41L2 VANGL1 SETD2 RNPS1 ACIN1 GPATCH8 | endometrium 1; glandular cells[>=Low] |
| HPA:0160000 | 0.00545121734432 | 1.0 | PRPF4B SNIP1 CWC22 RSBN1L NKTR SAP18 EPB41L2 VANGL1 SETD2 RNPS1 ACIN1 GPATCH8 | endometrium 1 |
| HPA:0150051 | 0.0055037503734 | 1.0 | PRPF4B SNIP1 CWC22 RSBN1L NKTR SAP18 EPB41L2 VANGL1 SETD2 RNPS1 ACIN1 GPATCH8 | duodenum; glandular cells[>=Low] |
| GO:0006397 | 0.00570511239629 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | mRNA processing |
| HPA:0030052 | 0.00765065267907 | 0.916666666667 | PRPF4B SNIP1 CWC22 RSBN1L NKTR SAP18 EPB41L2 VANGL1 SETD2 ACIN1 GPATCH8 | appendix; glandular cells[>=Medium] |
| GO:0008380 | 0.00963205879678 | 0.5 | SNIP1 CWC22 PRPF4B SAP18 RNPS1 ACIN1 | RNA splicing |
| GO:0048025 | 0.0117710605412 | 0.25 | RNPS1 SAP18 ACIN1 | negative regulation of mRNA splicing, via spliceosome |
| GO:0050686 | 0.0171362685288 | 0.25 | RNPS1 SAP18 ACIN1 | negative regulation of mRNA processing |
| HPA:0150000 | 0.0171575698741 | 1.0 | PRPF4B SNIP1 CWC22 RSBN1L NKTR SAP18 EPB41L2 VANGL1 SETD2 RNPS1 ACIN1 GPATCH8 | duodenum |
| HPA:0150052 | 0.0217314017844 | 0.916666666667 | GPATCH8 SNIP1 CWC22 PRPF4B NKTR SAP18 EPB41L2 VANGL1 SETD2 RNPS1 ACIN1 | duodenum; glandular cells[>=Medium] |
| GO:0035145 | 0.0239182536024 | 0.25 | RNPS1 SAP18 ACIN1 | exon-exon junction complex |
| GO:0048024 | 0.0242643828416 | 0.333333333333 | CWC22 RNPS1 SAP18 ACIN1 | regulation of mRNA splicing, via spliceosome |
| GO:0033119 | 0.0278917334495 | 0.25 | RNPS1 SAP18 ACIN1 | negative regulation of RNA splicing |
| HPA:0220052 | 0.0490709150621 | 0.916666666667 | PRPF4B SNIP1 CWC22 RSBN1L NKTR SAP18 EPB41L2 VANGL1 SETD2 ACIN1 GPATCH8 | gallbladder; glandular cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| ACIN1 | SAP18 | 1.0 | ||
| RNPS1 | GPATCH8 | 0.999 | 0.376 | |
| RNPS1 | SAP18 | 0.999 |
structurally_consistent (dimer)
|
|
| CWC22 | EPB41L2 | 0.998 | 0.066 | |
| ACIN1 | RNPS1 | 0.998 | 0.92 |
mutually_exclusive (P61326)
|
| SETD2 | SAP18 | 0.998 | ||
| RNPS1 | SNIP1 | 0.996 | 0.742 |
mutually_exclusive (P49760)
|
| CWC22 | RNPS1 | 0.996 | 0.318 | |
| ACIN1 | NKTR | 0.996 | 0.362 | |
| RNPS1 | SETD2 | 0.994 | 0.126 | |
| RNPS1 | NKTR | 0.994 | 0.316 | |
| ACIN1 | SNIP1 | 0.992 | 0.642 | |
| RNPS1 | PRPF4B | 0.99 | 0.824 |
mutually_exclusive (O00422)
|
| RNPS1 | RSBN1L | 0.988 | 0.092 | |
| SAP18 | PRPF4B | 0.986 |
structurally_consistent (dimer)
|
|
| NKTR | SAP18 | 0.985 | ||
| RNPS1 | VANGL1 | 0.982 | 0.116 | |
| VANGL1 | SAP18 | 0.974 | ||
| EPB41L2 | ACIN1 | 0.973 | 0.092 | |
| EPB41L2 | RNPS1 | 0.967 | 0.068 | |
| CWC22 | ACIN1 | 0.964 | 0.304 | |
| GPATCH8 | SAP18 | 0.963 | ||
| RSBN1L | PRPF4B | 0.947 | 0.172 | |
| SETD2 | GPATCH8 | 0.929 | 0.084 | |
| NKTR | GPATCH8 | 0.928 | 0.178 | |
| CWC22 | GPATCH8 | 0.903 | 0.184 | |
| NKTR | SNIP1 | 0.889 | 0.217 | |
| ACIN1 | GPATCH8 | 0.886 | 0.35 | |
| EPB41L2 | SAP18 | 0.835 | ||
| NKTR | PRPF4B | 0.828 | 0.242 | |
| VANGL1 | GPATCH8 | 0.802 | 0.082 | |
| VANGL1 | PRPF4B | 0.801 | 0.11 | |
| ACIN1 | PRPF4B | 0.775 | 0.666 | |
| CWC22 | PRPF4B | 0.768 | 0.41 | |
| SETD2 | PRPF4B | 0.737 | 0.294 | |
| NKTR | SETD2 | 0.641 | 0.204 | |
| NKTR | RSBN1L | 0.594 | 0.106 | |
| EPB41L2 | GPATCH8 | 0.583 | 0.044 | |
| VANGL1 | SETD2 | 0.58 | 0.116 | |
| CWC22 | RSBN1L | 0.551 | 0.038 | |
| CWC22 | NKTR | 0.508 | 0.206 | |
| ACIN1 | SETD2 | 0.468 | 0.166 | |
| EPB41L2 | VANGL1 | 0.463 | 0.222 | |
| GPATCH8 | PRPF4B | 0.434 | 0.256 | |
| SNIP1 | PRPF4B | 0.432 | 0.58 | |
| CWC22 | SNIP1 | 0.415 | 0.432 | |
| CWC22 | SAP18 | 0.391 | ||
| ACIN1 | VANGL1 | 0.369 | 0.198 | |
| RSBN1L | GPATCH8 | 0.33 | 0.056 | |
| CWC22 | VANGL1 | 0.294 | 0.094 | |
| CWC22 | SETD2 | 0.288 | 0.144 | |
| GPATCH8 | SNIP1 | 0.277 | 0.326 | |
| NKTR | VANGL1 | 0.271 | 0.13 | |
| ACIN1 | RSBN1L | 0.201 | 0.226 | |
| SNIP1 | SAP18 | 0.194 | ||
| RSBN1L | SETD2 | 0.172 | 0.158 | |
| VANGL1 | RSBN1L | 0.096 | 0.068 | |
| RSBN1L | SAP18 | 0.076 | ||
| EPB41L2 | NKTR | 0.022 | 0.054 | |
| SETD2 | SNIP1 | 0.019 | 0.222 | |
| RSBN1L | SNIP1 | 0.016 | 0.14 | |
| EPB41L2 | SETD2 | 0.015 | 0.024 | |
| VANGL1 | SNIP1 | 0.006 | 0.194 | |
| EPB41L2 | RSBN1L | 0.004 | 0.04 | |
| EPB41L2 | PRPF4B | 0.003 | 0.054 |
Related Complexes