hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08365.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
CWC22	Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)	5	UniProt NCBI
SAP18	Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)	5	UniProt NCBI
SETD2	Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)	5	UniProt NCBI
RSBN1L	Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein)	3	UniProt NCBI
SNIP1	Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1)	5	UniProt NCBI
EPB41L2	Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)	5	UniProt NCBI
PRPF4B	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)	5	UniProt NCBI
NKTR	NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)	5	UniProt NCBI
ACIN1	Apoptotic chromatin condensation inducer in the nucleus (Acinus)	5	UniProt NCBI
RNPS1	RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)	5	UniProt NCBI
VANGL1	Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)	5	UniProt NCBI
GPATCH8	G patch domain-containing protein 8	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:760	2.5725558439e-08	0.25	SAP18 RNPS1 ACIN1	Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18, RNPS1, Acinus-L
REAC:R-HSA-72163	1.47221997734e-06	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	mRNA Splicing - Major Pathway
REAC:R-HSA-72172	1.80802915765e-06	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	mRNA Splicing
REAC:R-HSA-72203	9.39234395669e-06	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	Processing of Capped Intron-Containing Pre-mRNA
GO:0061574	8.45465618902e-05	0.25	SAP18 RNPS1 ACIN1	ASAP complex
CORUM:351	0.000209900402146	0.333333333333	ACIN1 RNPS1 CWC22 PRPF4B	Spliceosome
GO:0000377	0.00144841757832	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398	0.00144841757832	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	mRNA splicing, via spliceosome
GO:0000375	0.00158319444835	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	RNA splicing, via transesterification reactions
REAC:R-HSA-8953854	0.0020263217605	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	Metabolism of RNA
KEGG:03015	0.00256393573202	0.25	SAP18 RNPS1 ACIN1	mRNA surveillance pathway
KEGG:03013	0.00350089201053	0.25	SAP18 RNPS1 ACIN1	Nucleocytoplasmic transport
HPA:0160051	0.00366868798146	1.0	RSBN1L SAP18 RNPS1 SETD2 VANGL1 SNIP1 EPB41L2 ACIN1 NKTR GPATCH8 PRPF4B CWC22	endometrium 1; glandular cells[>=Low]
HPA:0160000	0.00545121734432	1.0	RSBN1L SAP18 RNPS1 SETD2 VANGL1 SNIP1 EPB41L2 ACIN1 NKTR GPATCH8 PRPF4B CWC22	endometrium 1
HPA:0150051	0.0055037503734	1.0	RSBN1L SAP18 RNPS1 SETD2 VANGL1 SNIP1 EPB41L2 ACIN1 NKTR GPATCH8 PRPF4B CWC22	duodenum; glandular cells[>=Low]
GO:0006397	0.00570511239629	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	mRNA processing
HPA:0030052	0.00765065267907	0.916666666667	RSBN1L SAP18 SETD2 VANGL1 SNIP1 EPB41L2 ACIN1 NKTR GPATCH8 PRPF4B CWC22	appendix; glandular cells[>=Medium]
GO:0008380	0.00963205879678	0.5	SAP18 RNPS1 SNIP1 CWC22 ACIN1 PRPF4B	RNA splicing
GO:0048025	0.0117710605412	0.25	SAP18 RNPS1 ACIN1	negative regulation of mRNA splicing, via spliceosome
GO:0050686	0.0171362685288	0.25	SAP18 RNPS1 ACIN1	negative regulation of mRNA processing
HPA:0150000	0.0171575698741	1.0	RSBN1L SAP18 RNPS1 SETD2 VANGL1 SNIP1 EPB41L2 ACIN1 NKTR GPATCH8 PRPF4B CWC22	duodenum
HPA:0150052	0.0217314017844	0.916666666667	SAP18 SETD2 RNPS1 VANGL1 SNIP1 EPB41L2 ACIN1 NKTR GPATCH8 PRPF4B CWC22	duodenum; glandular cells[>=Medium]
GO:0035145	0.0239182536024	0.25	SAP18 RNPS1 ACIN1	exon-exon junction complex
GO:0048024	0.0242643828416	0.333333333333	SAP18 RNPS1 CWC22 ACIN1	regulation of mRNA splicing, via spliceosome
GO:0033119	0.0278917334495	0.25	SAP18 RNPS1 ACIN1	negative regulation of RNA splicing
HPA:0220052	0.0490709150621	0.916666666667	RSBN1L SAP18 SETD2 VANGL1 SNIP1 EPB41L2 ACIN1 NKTR GPATCH8 PRPF4B CWC22	gallbladder; glandular cells[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD
ACIN1	SAP18	1.0
RNPS1	GPATCH8	0.999	0.376
RNPS1	SAP18	0.999
CWC22	EPB41L2	0.998	0.066
ACIN1	RNPS1	0.998	0.92
SETD2	SAP18	0.998
RNPS1	SNIP1	0.996	0.742
CWC22	RNPS1	0.996	0.318
ACIN1	NKTR	0.996	0.362
RNPS1	SETD2	0.994	0.126
RNPS1	NKTR	0.994	0.316
ACIN1	SNIP1	0.992	0.642
RNPS1	PRPF4B	0.99	0.824
RNPS1	RSBN1L	0.988	0.092
SAP18	PRPF4B	0.986
NKTR	SAP18	0.985
RNPS1	VANGL1	0.982	0.116
VANGL1	SAP18	0.974
EPB41L2	ACIN1	0.973	0.092
EPB41L2	RNPS1	0.967	0.068
CWC22	ACIN1	0.964	0.304
GPATCH8	SAP18	0.963
RSBN1L	PRPF4B	0.947	0.172
SETD2	GPATCH8	0.929	0.084
NKTR	GPATCH8	0.928	0.178
CWC22	GPATCH8	0.903	0.184
NKTR	SNIP1	0.889	0.217
ACIN1	GPATCH8	0.886	0.35
EPB41L2	SAP18	0.835
NKTR	PRPF4B	0.828	0.242
VANGL1	GPATCH8	0.802	0.082
VANGL1	PRPF4B	0.801	0.11
ACIN1	PRPF4B	0.775	0.666
CWC22	PRPF4B	0.768	0.41
SETD2	PRPF4B	0.737	0.294
NKTR	SETD2	0.641	0.204
NKTR	RSBN1L	0.594	0.106
EPB41L2	GPATCH8	0.583	0.044
VANGL1	SETD2	0.58	0.116
CWC22	RSBN1L	0.551	0.038
CWC22	NKTR	0.508	0.206
ACIN1	SETD2	0.468	0.166
EPB41L2	VANGL1	0.463	0.222
GPATCH8	PRPF4B	0.434	0.256
SNIP1	PRPF4B	0.432	0.58
CWC22	SNIP1	0.415	0.432
CWC22	SAP18	0.391
ACIN1	VANGL1	0.369	0.198
RSBN1L	GPATCH8	0.33	0.056
CWC22	VANGL1	0.294	0.094
CWC22	SETD2	0.288	0.144
GPATCH8	SNIP1	0.277	0.326
NKTR	VANGL1	0.271	0.13
ACIN1	RSBN1L	0.201	0.226
SNIP1	SAP18	0.194
RSBN1L	SETD2	0.172	0.158
VANGL1	RSBN1L	0.096	0.068
RSBN1L	SAP18	0.076
EPB41L2	NKTR	0.022	0.054
SETD2	SNIP1	0.019	0.222
RSBN1L	SNIP1	0.016	0.14
EPB41L2	SETD2	0.015	0.024
VANGL1	SNIP1	0.006	0.194
EPB41L2	RSBN1L	0.004	0.04
EPB41L2	PRPF4B	0.003	0.054

Related Complexes

Genename	Complexes
CWC22	huMAP3_00373.1 huMAP3_00489.1 huMAP3_07467.1 huMAP3_08365.1 huMAP3_08647.1 huMAP3_09637.1 huMAP3_09803.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11077.1 huMAP3_11931.1 huMAP3_12350.1
SAP18	huMAP3_05319.1 huMAP3_05722.1 huMAP3_05740.1 huMAP3_06219.1 huMAP3_07248.1 huMAP3_07561.1 huMAP3_08302.1 huMAP3_08365.1 huMAP3_08467.1 huMAP3_08769.1 huMAP3_09226.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
SETD2	huMAP3_02739.1 huMAP3_03484.1 huMAP3_05722.1 huMAP3_08365.1 huMAP3_08769.1 huMAP3_08851.1 huMAP3_09520.1 huMAP3_09637.1 huMAP3_09923.1 huMAP3_11073.1
RSBN1L	huMAP3_02403.1 huMAP3_02739.1 huMAP3_03128.1 huMAP3_06097.1 huMAP3_07248.1 huMAP3_08365.1 huMAP3_08715.1 huMAP3_08769.1 huMAP3_09607.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11073.1
SNIP1	huMAP3_03772.1 huMAP3_06391.1 huMAP3_06799.1 huMAP3_07248.1 huMAP3_07561.1 huMAP3_08365.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10139.1 huMAP3_10564.1 huMAP3_11073.1
EPB41L2	huMAP3_00373.1 huMAP3_00489.1 huMAP3_00734.1 huMAP3_08365.1 huMAP3_08647.1 huMAP3_09637.1 huMAP3_09803.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11077.1 huMAP3_11493.1
PRPF4B	huMAP3_05807.1 huMAP3_07248.1 huMAP3_08365.1 huMAP3_08467.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_11073.1
NKTR	huMAP3_00489.1 huMAP3_01312.1 huMAP3_02739.1 huMAP3_04339.1 huMAP3_05069.1 huMAP3_05740.1 huMAP3_06097.1 huMAP3_06219.1 huMAP3_06799.1 huMAP3_07248.1 huMAP3_07309.1 huMAP3_07835.1 huMAP3_08302.1 huMAP3_08365.1 huMAP3_08769.1 huMAP3_09226.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1 huMAP3_11261.1
ACIN1	huMAP3_00373.1 huMAP3_00489.1 huMAP3_02739.1 huMAP3_03253.1 huMAP3_05722.1 huMAP3_06097.1 huMAP3_06219.1 huMAP3_07248.1 huMAP3_08365.1 huMAP3_08745.1 huMAP3_08769.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10564.1 huMAP3_11073.1
RNPS1	huMAP3_00373.1 huMAP3_00489.1 huMAP3_02739.1 huMAP3_03253.1 huMAP3_05722.1 huMAP3_06097.1 huMAP3_07248.1 huMAP3_07267.1 huMAP3_07291.1 huMAP3_08365.1 huMAP3_08745.1 huMAP3_08769.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10564.1 huMAP3_11073.1
VANGL1	huMAP3_00489.1 huMAP3_06097.1 huMAP3_08365.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_12350.1
GPATCH8	huMAP3_02739.1 huMAP3_05319.1 huMAP3_05722.1 huMAP3_05740.1 huMAP3_07248.1 huMAP3_07737.1 huMAP3_08302.1 huMAP3_08365.1 huMAP3_08467.1 huMAP3_08769.1 huMAP3_09095.1 huMAP3_09226.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10789.1 huMAP3_11073.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08365.1