hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08377.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDK3 | Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) | 5 | UniProt NCBI |
| CDK2 | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | 5 | UniProt NCBI |
| MIDEAS | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | 4 | UniProt NCBI |
| E2F5 | Transcription factor E2F5 (E2F-5) | 5 | UniProt NCBI |
| CCNB1 | G2/mitotic-specific cyclin-B1 | 5 | UniProt NCBI |
| GMNN | Geminin | 5 | UniProt NCBI |
| E2F4 | Transcription factor E2F4 (E2F-4) | 5 | UniProt NCBI |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | 5 | UniProt NCBI |
| CCNE2 | G1/S-specific cyclin-E2 | 5 | UniProt NCBI |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | 5 | UniProt NCBI |
| CDK1 | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | 5 | UniProt NCBI |
| CCNE1 | G1/S-specific cyclin-E1 | 5 | UniProt NCBI |
| CDK5R1 | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-453279 | 2.54968464773e-10 | 0.7 | GMNN CCNE2 CDKN1B CDKN1C CDK1 E2F5 E2F4 | Mitotic G1 phase and G1/S transition |
| WP:WP179 | 4.41989421211e-09 | 0.6 | CDKN1B CDK1 CDKN1C E2F4 E2F5 CCNE2 | Cell cycle |
| KEGG:04110 | 1.12522596331e-08 | 0.6 | CDKN1B CDK1 CDKN1C E2F4 E2F5 CCNE2 | Cell cycle |
| REAC:R-HSA-69231 | 1.48511481524e-08 | 0.5 | CDKN1B CCNE2 E2F5 CDKN1C E2F4 | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 1.48511481524e-08 | 0.5 | CDKN1B CCNE2 E2F5 CDKN1C E2F4 | G1 Phase |
| REAC:R-HSA-69206 | 2.17278183766e-08 | 0.6 | GMNN CDK1 CDKN1B E2F4 E2F5 CCNE2 | G1/S Transition |
| REAC:R-HSA-1538133 | 3.96199240718e-07 | 0.4 | CCNE2 E2F5 CDK1 E2F4 | G0 and Early G1 |
| REAC:R-HSA-69278 | 1.98415441168e-06 | 0.7 | GMNN CCNE2 CDKN1B CDKN1C CDK1 E2F5 E2F4 | Cell Cycle, Mitotic |
| WP:WP5180 | 3.3838359376e-06 | 0.4 | GMNN E2F5 CDKN1B E2F4 | DYRK1A involvement regarding cell proliferation in brain development |
| REAC:R-HSA-6791312 | 3.92400217121e-06 | 0.4 | CDKN1B E2F4 CDK1 CCNE2 | TP53 Regulates Transcription of Cell Cycle Genes |
| WP:WP45 | 6.77606940351e-06 | 0.4 | CDKN1B CDKN1C CDK1 CCNE2 | G1 to S cell cycle control |
| REAC:R-HSA-1640170 | 8.32723293103e-06 | 0.7 | GMNN CCNE2 CDKN1B CDKN1C CDK1 E2F5 E2F4 | Cell Cycle |
| REAC:R-HSA-69242 | 8.33609419719e-06 | 0.5 | GMNN CCNE2 E2F5 CDKN1B E2F4 | S Phase |
| REAC:R-HSA-1362300 | 2.52442876408e-05 | 0.3 | E2F5 CDK1 E2F4 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-9661069 | 3.77006103587e-05 | 0.3 | CDKN1B CDKN1C CCNE2 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
| REAC:R-HSA-9659787 | 3.77006103587e-05 | 0.3 | CDKN1B CDKN1C CCNE2 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects |
| REAC:R-HSA-69202 | 4.55060268174e-05 | 0.4 | CDKN1B CCNE2 E2F5 E2F4 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 5.01675451915e-05 | 0.4 | CDKN1B CCNE2 E2F5 E2F4 | Cyclin A:Cdk2-associated events at S phase entry |
| KEGG:04218 | 8.15646166788e-05 | 0.4 | CCNE2 E2F5 CDK1 E2F4 | Cellular senescence |
| REAC:R-HSA-69205 | 0.000161586017522 | 0.3 | E2F5 CDK1 E2F4 | G1/S-Specific Transcription |
| CORUM:2975 | 0.000307240465423 | 0.2 | E2F5 E2F4 | SMAD3-E2F4/5-p107-DP1 complex |
| CORUM:5117 | 0.000307240465423 | 0.2 | E2F5 E2F4 | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) |
| REAC:R-HSA-3700989 | 0.000355451955011 | 0.5 | CDKN1B CDK5R1 E2F4 CDK1 CCNE2 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-9687139 | 0.000360527139754 | 0.3 | CDKN1B CDKN1C CCNE2 | Aberrant regulation of mitotic cell cycle due to RB1 defects |
| REAC:R-HSA-9675126 | 0.000427697670043 | 0.3 | CDKN1B CDKN1C CCNE2 | Diseases of mitotic cell cycle |
| CORUM:1474 | 0.000460692494101 | 0.2 | E2F5 E2F4 | SMAD3/4-E2F4/5-p107-DP1 complex |
| CORUM:5118 | 0.000460692494101 | 0.2 | E2F5 E2F4 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) |
| WP:WP1530 | 0.000969904252276 | 0.3 | CDKN1B CCNE2 CDK1 | miRNA regulation of DNA damage response |
| WP:WP707 | 0.000969904252276 | 0.3 | CDKN1B CCNE2 CDK1 | DNA damage response |
| GO:0000307 | 0.00185320096161 | 0.4 | CDK5R1 CDK3 CDK1 CCNE2 | cyclin-dependent protein kinase holoenzyme complex |
| WP:WP2446 | 0.00225531384444 | 0.3 | CDKN1B CCNE2 CDK1 | Retinoblastoma gene in cancer |
| WP:WP4658 | 0.00249995876317 | 0.3 | CDKN1B CDKN1C CCNE2 | Small cell lung cancer |
| WP:WP2431 | 0.00258523259283 | 0.3 | CDKN1B E2F5 CDK1 | Spinal cord injury |
| GO:1904029 | 0.00283002173584 | 0.4 | CDKN1B CDK5R1 CDKN1C CCNE2 | regulation of cyclin-dependent protein kinase activity |
| WP:WP4970 | 0.00433420215397 | 0.2 | CDKN1B CDKN1C | Galanin receptor pathway |
| REAC:R-HSA-212436 | 0.00465548020126 | 0.6 | CDKN1B CCNE2 CDK5R1 E2F4 E2F5 CDK1 | Generic Transcription Pathway |
| WP:WP366 | 0.00596292421694 | 0.3 | E2F5 CDK1 E2F4 | TGF beta signaling pathway |
| REAC:R-HSA-6804116 | 0.00790724004214 | 0.2 | CDKN1B CCNE2 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| GO:0051726 | 0.00867855843311 | 0.7 | GMNN CDK1 CDKN1B CDKN1C CDK5R1 CDK3 CCNE2 | regulation of cell cycle |
| REAC:R-HSA-73857 | 0.0087488365386 | 0.6 | CDKN1B CCNE2 CDK5R1 E2F4 E2F5 CDK1 | RNA Polymerase II Transcription |
| KEGG:05203 | 0.0114751192385 | 0.3 | CDKN1B CCNE2 CDK1 | Viral carcinogenesis |
| REAC:R-HSA-6804114 | 0.0137668647983 | 0.2 | E2F4 CDK1 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| REAC:R-HSA-1362277 | 0.0154820698392 | 0.2 | E2F5 E2F4 | Transcription of E2F targets under negative control by DREAM complex |
| REAC:R-HSA-74160 | 0.0179061878456 | 0.6 | CDKN1B CCNE2 CDK5R1 E2F4 E2F5 CDK1 | Gene expression (Transcription) |
| WP:WP3941 | 0.025806598747 | 0.2 | CDKN1B CDKN1C | Oxidative damage response |
| GO:0030332 | 0.0297425210859 | 0.3 | CDKN1B CDK3 CDK1 | cyclin binding |
| WP:WP1971 | 0.0319043985122 | 0.2 | CDKN1B CDK1 | Integrated cancer pathway |
| WP:WP3878 | 0.0335282776025 | 0.2 | CDK5R1 CDK1 | ATM signaling in development and disease |
| KEGG:04115 | 0.0418172146224 | 0.2 | CCNE2 CDK1 | p53 signaling pathway |
| WP:WP5144 | 0.0441033585523 | 0.2 | CDKN1B CCNE2 | NRP1 triggered signaling pathways in pancreatic cancer |
| CORUM:5543 | 0.0499436884912 | 0.1 | CDK1 | CCNB1-CDC2 complex |
| CORUM:2628 | 0.0499436884912 | 0.1 | CDK3 | CCNC-CDK3 complex |
| CORUM:1656 | 0.0499436884912 | 0.1 | CDKN1B | p27-cyclinE-CDK2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| CCNB1 | CDKN1B | 1.0 | 0.26236 |
| CDKN1B | CCNE1 | 1.0 | 0.102 |
| CDKN1B | CDK1 | 1.0 | 0.158 |
| CCNB1 | CDK2 | 0.999 | 0.161 |
| CDK2 | CCNE2 | 0.999 | |
| CDKN1B | CDK2 | 0.999 | 0.1424 |
| CDKN1B | CDKN1C | 0.999 | 0.158 |
| CCNE1 | CCNE2 | 0.999 | |
| CCNB1 | CDK1 | 0.999 | 0.3 |
| CCNB1 | CCNE1 | 0.998 | 0.102 |
| CDK2 | CDKN1C | 0.998 | 0.172 |
| CDK2 | CCNE1 | 0.998 | 0.15 |
| CDK1 | CDK2 | 0.998 | 0.288 |
| CDKN1B | CCNE2 | 0.997 | |
| CDK3 | CDK2 | 0.997 | |
| CDK1 | CDKN1C | 0.996 | 0.298 |
| GMNN | CDK2 | 0.996 | 0.193555555556 |
| CCNB1 | CCNE2 | 0.992 | |
| CDKN1B | GMNN | 0.992 | 0.148 |
| CDK3 | CCNE2 | 0.991 | |
| CDKN1B | CDK3 | 0.99 | |
| MIDEAS | CDKN1C | 0.987 | 0.06 |
| CCNB1 | CDK3 | 0.984 | |
| CDK2 | CDK5R1 | 0.984 | |
| CDKN1B | MIDEAS | 0.983 | 0.094 |
| CDK3 | CDKN1C | 0.982 | |
| CDK3 | CCNE1 | 0.982 | |
| CDK1 | GMNN | 0.976 | 0.142 |
| E2F4 | GMNN | 0.974 | 0.072 |
| E2F4 | E2F5 | 0.974 | |
| CCNB1 | CDKN1C | 0.973 | 0.12 |
| GMNN | CDK3 | 0.967 | |
| MIDEAS | CDK2 | 0.966 | 0.038 |
| E2F5 | CDK2 | 0.965 | |
| E2F4 | CDK2 | 0.962 | 0.284 |
| GMNN | E2F5 | 0.961 | |
| CDK1 | CCNE1 | 0.955 | 0.254946428571 |
| CDK1 | CCNE2 | 0.936 | |
| GMNN | CDKN1C | 0.92 | 0.126 |
| CCNE2 | CDKN1C | 0.92 | |
| GMNN | CCNE1 | 0.855 | 0.099 |
| MIDEAS | GMNN | 0.77 | 0.024 |
| E2F4 | CDK1 | 0.752 | 0.286385542169 |
| CDK3 | E2F5 | 0.675 | |
| CCNB1 | E2F5 | 0.634 | |
| E2F4 | CDKN1C | 0.634 | 0.074 |
| E2F4 | CDKN1B | 0.587 | 0.178 |
| CDK1 | MIDEAS | 0.466 | 0.0484553571429 |
| E2F5 | CCNE1 | 0.455 | |
| E2F4 | CCNB1 | 0.416 | 0.164 |
| CCNE1 | CDKN1C | 0.413 | 0.056 |
| E2F4 | CCNE2 | 0.384 | |
| E2F5 | CCNE2 | 0.384 | |
| GMNN | CCNE2 | 0.367 | |
| E2F4 | CCNE1 | 0.362 | 0.124 |
| CCNB1 | GMNN | 0.358 | 0.246 |
| E2F4 | CDK3 | 0.325 | |
| CDK1 | CDK3 | 0.32 | |
| MIDEAS | CCNE1 | 0.232 | 0.152 |
| CDKN1B | E2F5 | 0.188 | |
| E2F5 | CDKN1C | 0.188 | |
| CDK1 | E2F5 | 0.118 | |
| MIDEAS | CCNE2 | 0.063 | |
| MIDEAS | CDK3 | 0.06 | |
| CDK3 | CDK5R1 | 0.055 | |
| CDKN1B | CDK5R1 | 0.043 | |
| CCNB1 | CDK5R1 | 0.043 | |
| E2F4 | MIDEAS | 0.042 | 0.088 |
| CCNB1 | MIDEAS | 0.028 | 0.06 |
| CDK1 | CDK5R1 | 0.016 |
Related Complexes