hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08389.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | 5 | UniProt NCBI |
| CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | 5 | UniProt NCBI |
| UNG | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | 5 | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 1.20999690042e-11 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | CaMK IV-mediated phosphorylation of CREB |
| GO:0005954 | 2.63126310092e-11 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | calcium- and calmodulin-dependent protein kinase complex |
| REAC:R-HSA-442982 | 9.61275315334e-11 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-9617324 | 2.2855497008e-10 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-438066 | 2.2855497008e-10 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9620244 | 2.93856390102e-10 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Long-term potentiation |
| WP:WP4875 | 3.02595256605e-10 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Disruption of postsynaptic signaling by CNV |
| REAC:R-HSA-442742 | 7.02470422744e-10 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-3371571 | 8.50358932796e-10 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | HSF1-dependent transactivation |
| REAC:R-HSA-5576892 | 1.02043071936e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Phase 0 - rapid depolarisation |
| WP:WP4756 | 1.10934052335e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Renin angiotensin aldosterone system RAAS |
| REAC:R-HSA-399719 | 1.21479847542e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 1.21479847542e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| WP:WP4008 | 1.57983428636e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | NO cGMP PKG mediated neuroprotection |
| REAC:R-HSA-9022692 | 2.28084415729e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Regulation of MECP2 expression and activity |
| REAC:R-HSA-5673000 | 2.63174325842e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | RAF activation |
| REAC:R-HSA-111997 | 2.63174325842e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | CaM pathway |
| REAC:R-HSA-111933 | 2.63174325842e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Calmodulin induced events |
| REAC:R-HSA-111996 | 3.4532927412e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Ca-dependent events |
| REAC:R-HSA-9656223 | 5.02820934175e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Signaling by RAF1 mutants |
| REAC:R-HSA-1489509 | 5.65673550947e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | DAG and IP3 signaling |
| KEGG:04971 | 6.87946087076e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Gastric acid secretion |
| REAC:R-HSA-9609736 | 7.08856517497e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-6802949 | 7.08856517497e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Signaling by RAS mutants |
| REAC:R-HSA-6802955 | 7.08856517497e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-9649948 | 7.08856517497e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Signaling downstream of RAS mutants |
| REAC:R-HSA-936837 | 7.08856517497e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Ion transport by P-type ATPases |
| REAC:R-HSA-6802946 | 7.08856517497e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Signaling by moderate kinase activity BRAF mutants |
| KEGG:04720 | 7.42981774043e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Long-term potentiation |
| KEGG:05031 | 9.28013604904e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Amphetamine addiction |
| REAC:R-HSA-5578775 | 9.72511000838e-09 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Ion homeostasis |
| REAC:R-HSA-112043 | 1.07488057987e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | PLC beta mediated events |
| WP:WP4341 | 1.42486485001e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04911 | 1.5905985445e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Insulin secretion |
| REAC:R-HSA-112040 | 1.71286585035e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | G-protein mediated events |
| KEGG:04912 | 1.91326892896e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | GnRH signaling pathway |
| KEGG:05214 | 1.91326892896e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Glioma |
| KEGG:04750 | 2.03100855536e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Inflammatory mediator regulation of TRP channels |
| KEGG:04713 | 2.55709437226e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Circadian entrainment |
| KEGG:04925 | 2.70321405067e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Aldosterone synthesis and secretion |
| REAC:R-HSA-8986944 | 2.81204239973e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Transcriptional Regulation by MECP2 |
| KEGG:04012 | 3.01414712223e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | ErbB signaling pathway |
| REAC:R-HSA-6802952 | 3.52714096473e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Signaling by BRAF and RAF1 fusions |
| WP:WP673 | 3.97976151956e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | ErbB signaling pathway |
| KEGG:04740 | 4.10914021365e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Olfactory transduction |
| KEGG:04916 | 4.31719794599e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Melanogenesis |
| KEGG:04725 | 5.73621464289e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Cholinergic synapse |
| KEGG:04922 | 6.56442584798e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Glucagon signaling pathway |
| REAC:R-HSA-438064 | 7.82066131547e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Post NMDA receptor activation events |
| KEGG:04066 | 8.84380684533e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | HIF-1 signaling pathway |
| KEGG:04722 | 9.21229879722e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Neurotrophin signaling pathway |
| REAC:R-HSA-6802957 | 9.3307566535e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Oncogenic MAPK signaling |
| WP:WP428 | 9.76659081482e-08 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Wnt signaling |
| KEGG:04114 | 1.08025707832e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Oocyte meiosis |
| REAC:R-HSA-877300 | 1.23206013755e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Interferon gamma signaling |
| KEGG:04728 | 1.30699795334e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Dopaminergic synapse |
| REAC:R-HSA-111885 | 1.36981732435e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Opioid Signalling |
| WP:WP5083 | 1.43260435161e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Neuroinflammation and glutamatergic signaling |
| WP:WP536 | 1.48566377204e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Calcium regulation in cardiac cells |
| REAC:R-HSA-442755 | 1.51881499823e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Activation of NMDA receptors and postsynaptic events |
| KEGG:04921 | 1.80284632839e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Oxytocin signaling pathway |
| KEGG:04261 | 1.86555402677e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Adrenergic signaling in cardiomyocytes |
| GO:0004683 | 1.92476895832e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | calmodulin-dependent protein kinase activity |
| REAC:R-HSA-3371556 | 1.94443140795e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Cellular response to heat stress |
| REAC:R-HSA-5576891 | 1.94443140795e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Cardiac conduction |
| KEGG:04148 | 2.20397674971e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Efferocytosis |
| KEGG:04934 | 2.27683548524e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Cushing syndrome |
| WP:WP289 | 2.80268749988e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Myometrial relaxation and contraction pathways |
| KEGG:04217 | 3.29938543974e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Necroptosis |
| KEGG:05152 | 4.2673120168e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Tuberculosis |
| KEGG:04310 | 4.7598316091e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Wnt signaling pathway |
| KEGG:04360 | 5.29380205286e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Axon guidance |
| KEGG:04024 | 5.87148623437e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | cAMP signaling pathway |
| KEGG:04020 | 8.27170798963e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Calcium signaling pathway |
| REAC:R-HSA-983712 | 9.0089560572e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Ion channel transport |
| KEGG:05417 | 9.93696627528e-07 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Lipid and atherosclerosis |
| KEGG:05205 | 1.03898794845e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Proteoglycans in cancer |
| KEGG:05415 | 1.03898794845e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Diabetic cardiomyopathy |
| REAC:R-HSA-397014 | 1.94562459934e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Muscle contraction |
| REAC:R-HSA-112314 | 2.40002357025e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Neurotransmitter receptors and postsynaptic signal transmission |
| KEGG:05012 | 3.06224672918e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Parkinson disease |
| REAC:R-HSA-913531 | 3.6254700184e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Interferon Signaling |
| REAC:R-HSA-418594 | 4.63613481436e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | G alpha (i) signalling events |
| REAC:R-HSA-112315 | 6.59592838137e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Transmission across Chemical Synapses |
| REAC:R-HSA-5673001 | 8.00607557463e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 8.6291533952e-06 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | MAPK1/MAPK3 signaling |
| REAC:R-HSA-5683057 | 1.50136248309e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | MAPK family signaling cascades |
| REAC:R-HSA-9006925 | 1.92889821679e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Intracellular signaling by second messengers |
| KEGG:05022 | 2.83416050578e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-112316 | 3.09235191422e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Neuronal System |
| KEGG:05200 | 3.82134789115e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Pathways in cancer |
| GO:0005516 | 4.60223703929e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | calmodulin binding |
| REAC:R-HSA-388396 | 7.14075066073e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | GPCR downstream signalling |
| REAC:R-HSA-5663202 | 7.45851366062e-05 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-372790 | 0.000120408247398 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Signaling by GPCR |
| REAC:R-HSA-442729 | 0.000215205765992 | 0.5 | CAMK2B CAMK2G | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde |
| REAC:R-HSA-382551 | 0.00031930939946 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Transport of small molecules |
| GO:0051924 | 0.000380561950422 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | regulation of calcium ion transport |
| WP:WP5231 | 0.000436026474737 | 0.5 | CAMK2B CAMK2A | Hippocampal synaptogenesis and neurogenesis |
| GO:0030666 | 0.000477938945882 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | endocytic vesicle membrane |
| REAC:R-HSA-1280215 | 0.000544985136876 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Cytokine Signaling in Immune system |
| REAC:R-HSA-2262752 | 0.00108429068544 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.00112698633356 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Cellular responses to stimuli |
| GO:0043502 | 0.00209449363787 | 0.75 | CAMK2B CAMK2D CAMK2G | regulation of muscle adaptation |
| GO:0010959 | 0.00263891757684 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | regulation of metal ion transport |
| GO:0006816 | 0.00354721473264 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | calcium ion transport |
| REAC:R-HSA-212436 | 0.00439089268099 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Generic Transcription Pathway |
| GO:0030139 | 0.00459925423944 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | endocytic vesicle |
| GO:0043500 | 0.00473512798232 | 0.75 | CAMK2B CAMK2D CAMK2G | muscle adaptation |
| GO:0043269 | 0.0047455440478 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | regulation of monoatomic ion transport |
| REAC:R-HSA-73857 | 0.00681752083972 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | RNA Polymerase II Transcription |
| GO:0010663 | 0.00842684400117 | 0.5 | CAMK2A CAMK2D | positive regulation of striated muscle cell apoptotic process |
| GO:0010666 | 0.00842684400117 | 0.5 | CAMK2A CAMK2D | positive regulation of cardiac muscle cell apoptotic process |
| GO:0014733 | 0.00842684400117 | 0.5 | CAMK2B CAMK2G | regulation of skeletal muscle adaptation |
| REAC:R-HSA-74160 | 0.0112707156575 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Gene expression (Transcription) |
| GO:0004674 | 0.0129230406112 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | protein serine/threonine kinase activity |
| HPA:0100133 | 0.0134599376677 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | cerebral cortex; neuronal cells[High] |
| WP:WP4549 | 0.0151597078239 | 0.5 | CAMK2B CAMK2A | Fragile X syndrome |
| REAC:R-HSA-1643685 | 0.0193799289378 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Disease |
| REAC:R-HSA-168256 | 0.032293648674 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | Immune System |
| GO:0004672 | 0.0405345893876 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | protein kinase activity |
| GO:0043501 | 0.042122686785 | 0.5 | CAMK2B CAMK2G | skeletal muscle adaptation |
| HPA:0100212 | 0.047031419915 | 1.0 | CAMK2B CAMK2D CAMK2G CAMK2A | cerebral cortex; neuropil[>=Medium] |
| CORUM:5655 | 0.049938562206 | 0.25 | CAMK2A | Ternary complex (LRRC7, CAMK2a, ACTN4) |
| CORUM:6517 | 0.049938562206 | 0.25 | CAMK2A | SERCA2a-alphaKAP-CaM-CaMKII complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAMK2D | CAMK2G | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| CAMK2B | CAMK2D | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| CAMK2B | CAMK2G | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| CAMK2D | CAMK2A | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| CAMK2A | CAMK2G | 0.998 | 0.51 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| CAMK2B | CAMK2A | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| UNG | CAMK2D | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UNG | CAMK2B | 0.284 | bioplex_WMM bioplex3_WMM WMM_only | |
| UNG | CAMK2G | 0.275 | 0.034 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| UNG | CAMK2A | 0.164 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes