hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08407.1
Complex Portal: CPX-13379
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAPKAPK2 | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | 5 | UniProt NCBI |
| MAPK11 | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | 5 | UniProt NCBI |
| PHF3 | PHD finger protein 3 | 3 | UniProt NCBI |
| MAPKAPK3 | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-171007 | 1.68324973574e-07 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | p38MAPK events |
| REAC:R-HSA-167044 | 5.10480886775e-07 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Signalling to RAS |
| REAC:R-HSA-450302 | 1.59826617962e-06 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-187687 | 3.64404491129e-06 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Signalling to ERKs |
| KEGG:04370 | 7.13131503768e-06 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | VEGF signaling pathway |
| REAC:R-HSA-450294 | 3.87912301308e-05 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | MAP kinase activation |
| REAC:R-HSA-448424 | 5.2908776296e-05 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Interleukin-17 signaling |
| REAC:R-HSA-168142 | 0.000123764584817 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 0.000123764584817 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.000123764584817 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 0.000133147800117 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.000138011947324 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.000138011947324 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-4420097 | 0.000148092217351 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-168138 | 0.000158650980172 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.000169699262125 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.000181248084935 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.000181248084935 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-194138 | 0.000193308465722 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Signaling by VEGF |
| REAC:R-HSA-166058 | 0.000193308465722 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.000193308465722 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.000205891416993 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.000205891416993 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-187037 | 0.000205891416993 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-2559580 | 0.000277029845738 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-166520 | 0.000335499618459 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Signaling by NTRKs |
| REAC:R-HSA-166016 | 0.000422025999557 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll Like Receptor 4 (TLR4) Cascade |
| WP:WP382 | 0.000461288756706 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | MAPK signaling pathway |
| REAC:R-HSA-168898 | 0.000650875640662 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Toll-like Receptor Cascades |
| KEGG:04010 | 0.000800866642312 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | MAPK signaling pathway |
| WP:WP722 | 0.000828175715845 | 0.5 | MAPKAPK2 MAPKAPK3 | Serotonin HTR1 group and FOS pathway |
| REAC:R-HSA-2559583 | 0.00122110889015 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Cellular Senescence |
| WP:WP314 | 0.00178944501344 | 0.5 | MAPKAPK2 MAPKAPK3 | Fas ligand pathway and stress induction of heat shock proteins |
| WP:WP2637 | 0.0022974831852 | 0.5 | MAPKAPK2 MAPK11 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-450282 | 0.00444848198459 | 0.5 | MAPKAPK2 MAPK11 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04625 | 0.00888666878999 | 0.5 | MAPKAPK2 MAPK11 | C-type lectin receptor signaling pathway |
| KEGG:04722 | 0.0123049375309 | 0.5 | MAPKAPK2 MAPK11 | Neurotrophin signaling pathway |
| REAC:R-HSA-449147 | 0.0141224671799 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Signaling by Interleukins |
| REAC:R-HSA-198725 | 0.0146019089592 | 0.5 | MAPKAPK2 MAPK11 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-9006934 | 0.0183118305735 | 0.75 | MAPKAPK3 MAPKAPK2 MAPK11 | Signaling by Receptor Tyrosine Kinases |
| KEGG:04148 | 0.0189154103852 | 0.5 | MAPKAPK2 MAPK11 | Efferocytosis |
| KEGG:04218 | 0.0240987471983 | 0.5 | MAPKAPK2 MAPK11 | Cellular senescence |
| REAC:R-HSA-450531 | 0.0346321697685 | 0.5 | MAPKAPK2 MAPK11 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| KEGG:05167 | 0.0346546128597 | 0.5 | MAPKAPK2 MAPK11 | Kaposi sarcoma-associated herpesvirus infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAPKAPK2 | MAPK11 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAPKAPK3 | MAPK11 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MAPKAPK2 | MAPKAPK3 | 0.997 | 0.226 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHF3 | MAPKAPK2 | 0.995 | 0.048 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PHF3 | MAPKAPK3 | 0.675 | 0.09 | bioplex3_WMM WMM_only | |
| PHF3 | MAPK11 | 0.675 | bioplex3_WMM WMM_only |
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