hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08413.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHD1L | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | 5 | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | 5 | UniProt NCBI |
| RNF146 | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | 5 | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5696395 | 1.60766305396e-05 | 0.75 | CHD1L PARP2 XPC | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-5696399 | 0.000128399139144 | 0.75 | CHD1L PARP2 XPC | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 0.000284930280132 | 0.75 | CHD1L PARP2 XPC | Nucleotide Excision Repair |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | CHD1L PARP2 XPC | DNA Repair |
| WP:WP5114 | 0.00666804419641 | 0.5 | CHD1L XPC | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-5696394 | 0.00718390333861 | 0.5 | XPC PARP2 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696400 | 0.00837722051003 | 0.5 | CHD1L PARP2 | Dual Incision in GG-NER |
| WP:WP4946 | 0.0159973744593 | 0.5 | XPC PARP2 | DNA repair pathways full network |
| GO:0160004 | 0.0168521501606 | 0.5 | CHD1L PARP2 | poly-ADP-D-ribose modification-dependent protein binding |
| GO:0072572 | 0.042122686785 | 0.5 | RNF146 PARP2 | poly-ADP-D-ribose binding |
| GO:0160002 | 0.042122686785 | 0.5 | CHD1L PARP2 | ADP-D-ribose modification-dependent protein binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF146 | PARP2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| XPC | PARP2 | 0.993 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF146 | CHD1L | 0.988 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| XPC | CHD1L | 0.988 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| XPC | RNF146 | 0.984 | 0.182 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PARP2 | CHD1L | 0.966 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes