List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_08422.1

Confidence: High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
RPAIN	RPA-interacting protein (hRIP)	5	UniProt   NCBI
RPA4	Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)	5	UniProt   NCBI
HLTF	Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)	5	UniProt   NCBI
MACROD1	ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)	5	UniProt   NCBI
RPA2	Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)	5	UniProt   NCBI
RPA3	Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)	5	UniProt   NCBI
HMCES	Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)	5	UniProt   NCBI
RPA1	Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03430	6.19370988527e-06	0.428571428571	RPA3 RPA4 RPA1	Mismatch repair
CORUM:5229	2.05265451394e-05	0.285714285714	RPA3 RPA1	RPA complex
KEGG:03030	2.49040513548e-05	0.428571428571	RPA3 RPA4 RPA1	DNA replication
KEGG:03440	3.44327359757e-05	0.428571428571	RPA3 RPA4 RPA1	Homologous recombination
KEGG:03460	6.40906373235e-05	0.428571428571	RPA3 RPA4 RPA1	Fanconi anemia pathway
WP:WP466	6.94071614722e-05	0.428571428571	RPA3 RPA4 RPA1	DNA replication
REAC:R-HSA-68962	7.07065782066e-05	0.428571428571	RPA3 RPA4 RPA1	Activation of the pre-replicative complex
KEGG:03420	0.000107138625731	0.428571428571	RPA3 RPA4 RPA1	Nucleotide excision repair
CORUM:2222	0.000205125012531	0.285714285714	RPA3 RPA1	BLM complex II
CORUM:2738	0.000205125012531	0.285714285714	RPA3 RPA1	BLM complex II
WP:WP2446	0.000613160783256	0.428571428571	HLTF RPA1 RPA3	Retinoblastoma gene in cancer
GO:0005657	0.000617288463902	0.571428571429	RPA3 RPA4 RPA1 HMCES	replication fork
CORUM:1004	0.000737776422886	0.285714285714	RPA3 RPA1	RC complex during S-phase of cell cycle
CORUM:248	0.000737776422886	0.285714285714	RPA3 RPA1	BRAFT complex
CORUM:1005	0.000922010129722	0.285714285714	RPA3 RPA1	RC complex during G2/M-phase of cell cycle
GO:0005662	0.000960187650128	0.428571428571	RPA3 RPA4 RPA1	DNA replication factor A complex
CORUM:244	0.00112664416828	0.285714285714	RPA3 RPA1	BRAFT complex
REAC:R-HSA-3371511	0.00250948572249	0.285714285714	RPA3 RPA1	HSF1 activation
REAC:R-HSA-69166	0.00345846977329	0.285714285714	RPA3 RPA1	Removal of the Flap Intermediate
REAC:R-HSA-5358565	0.00345846977329	0.285714285714	RPA3 RPA1	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
REAC:R-HSA-5358606	0.00345846977329	0.285714285714	RPA3 RPA1	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
GO:0003697	0.00385096114287	0.571428571429	RPA3 RPA4 RPA1 HMCES	single-stranded DNA binding
REAC:R-HSA-69183	0.00398963152505	0.285714285714	RPA3 RPA1	Processive synthesis on the lagging strand
REAC:R-HSA-5358508	0.00398963152505	0.285714285714	RPA3 RPA1	Mismatch Repair
WP:WP531	0.00448488924583	0.285714285714	RPA3 RPA1	DNA mismatch repair
REAC:R-HSA-69206	0.00454464074576	0.428571428571	RPA3 RPA4 RPA1	G1/S Transition
REAC:R-HSA-110312	0.00455853850403	0.285714285714	RPA3 RPA1	Translesion synthesis by REV1
REAC:R-HSA-5656121	0.00455853850403	0.285714285714	RPA3 RPA1	Translesion synthesis by POLI
GO:0006974	0.00462209623318	0.857142857143	RPA1 HMCES MACROD1 RPA3 HLTF RPA4	DNA damage response
GO:0043601	0.00516068999797	0.428571428571	RPA3 RPA4 RPA1	nuclear replisome
REAC:R-HSA-5655862	0.00516516478082	0.285714285714	RPA3 RPA1	Translesion synthesis by POLK
REAC:R-HSA-174437	0.00516516478082	0.285714285714	RPA3 RPA1	Removal of the Flap Intermediate from the C-strand
REAC:R-HSA-174414	0.0064914715634	0.285714285714	RPA3 RPA1	Processive synthesis on the C-strand of the telomere
REAC:R-HSA-110320	0.0064914715634	0.285714285714	RPA3 RPA1	Translesion Synthesis by POLH
REAC:R-HSA-69002	0.00656553805866	0.428571428571	RPA3 RPA4 RPA1	DNA Replication Pre-Initiation
REAC:R-HSA-453279	0.00656553805866	0.428571428571	RPA3 RPA4 RPA1	Mitotic G1 phase and G1/S transition
GO:0030894	0.00677983410628	0.428571428571	RPA3 RPA4 RPA1	replisome
REAC:R-HSA-69186	0.00721110026367	0.285714285714	RPA3 RPA1	Lagging Strand Synthesis
REAC:R-HSA-5651801	0.00796834465067	0.285714285714	RPA3 RPA1	PCNA-Dependent Long Patch Base Excision Repair
REAC:R-HSA-69306	0.0108625713199	0.428571428571	RPA3 RPA4 RPA1	DNA Replication
REAC:R-HSA-5696397	0.0113729617035	0.285714285714	RPA3 RPA1	Gap-filling DNA repair synthesis and ligation in GG-NER
REAC:R-HSA-110373	0.0113729617035	0.285714285714	RPA3 RPA1	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
WP:WP4753	0.0159344117177	0.285714285714	RPA3 RPA1	Nucleotide excision repair
REAC:R-HSA-110314	0.0164719839916	0.285714285714	RPA3 RPA1	Recognition of DNA damage by PCNA-containing replication complex
REAC:R-HSA-5656169	0.0176039638163	0.285714285714	RPA3 RPA1	Termination of translesion DNA synthesis
REAC:R-HSA-69190	0.0187732752758	0.285714285714	RPA3 RPA1	DNA strand elongation
REAC:R-HSA-9709570	0.0212237900738	0.285714285714	RPA3 RPA1	Impaired BRCA2 binding to RAD51
REAC:R-HSA-174417	0.0212237900738	0.285714285714	RPA3 RPA1	Telomere C-strand (Lagging Strand) Synthesis
HPA:0210053	0.0224192435307	0.714285714286	RPA3 HMCES RPAIN RPA1 RPA4	fallopian tube; glandular cells[High]
REAC:R-HSA-73933	0.0225049419259	0.285714285714	RPA3 RPA1	Resolution of Abasic Sites (AP sites)
REAC:R-HSA-5685938	0.0225049419259	0.285714285714	RPA3 RPA1	HDR through Single Strand Annealing (SSA)
REAC:R-HSA-6783310	0.0225049419259	0.285714285714	RPA3 RPA1	Fanconi Anemia Pathway
REAC:R-HSA-176187	0.0238233224402	0.285714285714	RPA3 RPA1	Activation of ATR in response to replication stress
REAC:R-HSA-110313	0.0265716665994	0.285714285714	RPA3 RPA1	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
REAC:R-HSA-5693616	0.028001578843	0.285714285714	RPA3 RPA1	Presynaptic phase of homologous DNA pairing and strand exchange
REAC:R-HSA-9701190	0.0294686169459	0.285714285714	RPA3 RPA1	Defective homologous recombination repair (HRR) due to BRCA2 loss of function
REAC:R-HSA-9675136	0.0294686169459	0.285714285714	RPA3 RPA1	Diseases of DNA Double-Strand Break Repair
GO:0043596	0.0305188440994	0.428571428571	RPA3 RPA4 RPA1	nuclear replication fork
REAC:R-HSA-5696400	0.030972755234	0.285714285714	RPA3 RPA1	Dual Incision in GG-NER
REAC:R-HSA-5693579	0.0325139680435	0.285714285714	RPA3 RPA1	Homologous DNA Pairing and Strand Exchange
REAC:R-HSA-5696395	0.0325139680435	0.285714285714	RPA3 RPA1	Formation of Incision Complex in GG-NER
WP:WP45	0.035404281131	0.285714285714	RPA3 RPA1	G1 to S cell cycle control
REAC:R-HSA-73893	0.0407752524289	0.285714285714	RPA3 RPA1	DNA Damage Bypass
REAC:R-HSA-9675135	0.0443383907933	0.285714285714	RPA3 RPA1	Diseases of DNA repair
WP:WP5114	0.0460572054326	0.285714285714	RPA3 RPA1	Nucleotide excision repair in xeroderma pigmentosum
REAC:R-HSA-180786	0.0480490075434	0.285714285714	RPA3 RPA1	Extension of Telomeres



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
RPA3	RPA2	1.0	0.958	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     boldt     youn_WMM     Malo     bioplex3_HCT116     gupta_WMM     fraction     boldt_WMM
RPA1	RPA2	1.0	0.802	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     boldt     youn_WMM     hein ()     Malo     bioplex3_HCT116     gupta_WMM     fraction     boldt_WMM
RPA3	RPA1	1.0	0.658	hein_WMM     bioplex_WMM     Guru     bioplex3_WMM     boldt     youn_WMM     hein ()     Malo     gupta_WMM     fraction     boldt_WMM
RPA1	RPAIN	0.999	0.196	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RPA2	RPAIN	0.999	0.208	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RPA1	RPA4	0.998		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RPAIN	RPA4	0.997		bioplex3_WMM     bioplex3_HCT116     WMM_only
RPA3	RPA4	0.995		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RPA3	RPAIN	0.989	0.288	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
HMCES	RPA1	0.988	0.08	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
MACROD1	RPA2	0.978	0.026	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
HLTF	RPA2	0.977	0.07	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM
HLTF	RPA1	0.972	0.204166666667	bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     youn_WMM     treiber_WMM     WMM_only
HMCES	RPA4	0.969		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
HMCES	RPA2	0.965	0.166	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
HLTF	RPA3	0.957	0.048	bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     youn_WMM     WMM_only
RPA3	HMCES	0.957	0.072	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RPA2	RPA4	0.931		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
MACROD1	RPA1	0.841	0.052	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
MACROD1	RPA3	0.734	0.052	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
HMCES	RPAIN	0.643	0.034	bioplex_WMM     bioplex3_WMM     WMM_only
HLTF	RPAIN	0.283	0.078	bioplex_WMM     bioplex3_WMM     WMM_only
HLTF	HMCES	0.072	0.046	bioplex_WMM     bioplex3_WMM     WMM_only
HLTF	MACROD1	0.067	0.036	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
HLTF	RPA4	0.024		bioplex3_WMM     bioplex3_HCT116     WMM_only





Related Complexes

Genename	Complexes
RPAIN	huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
RPA4	huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
HLTF	huMAP3_01511.1 huMAP3_02570.1 huMAP3_06287.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_09858.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
MACROD1	huMAP3_01511.1 huMAP3_03503.1 huMAP3_07481.1 huMAP3_08422.1 huMAP3_08778.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13399.1 huMAP3_13854.1 huMAP3_14846.1
RPA2	huMAP3_03503.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1
RPA3	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1
HMCES	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13227.1 huMAP3_13854.1 huMAP3_14723.1
RPA1	huMAP3_02103.1 huMAP3_07481.1 huMAP3_08325.1 huMAP3_08422.1 huMAP3_09432.1 huMAP3_10578.1 huMAP3_13854.1 huMAP3_14846.1