hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08442.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NXF2 | Nuclear RNA export factor 2 (Cancer/testis antigen 39) (CT39) (TAP-like protein 2) (TAPL-2) | 5 | UniProt NCBI |
| NUP42 | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | 5 | UniProt NCBI |
| NUP62 | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | 5 | UniProt NCBI |
| NUP88 | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | 5 | UniProt NCBI |
| GLE1 | mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) | 5 | UniProt NCBI |
| RAE1 | mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) | 5 | UniProt NCBI |
| NXT1 | NTF2-related export protein 1 (Protein p15) | 5 | UniProt NCBI |
| NXF1 | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-159236 | 8.23286121537e-15 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 1.99078581113e-14 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | Transport of Mature Transcript to Cytoplasm |
| KEGG:03013 | 3.18116426777e-14 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | Nucleocytoplasmic transport |
| REAC:R-HSA-159227 | 1.24161324729e-10 | 0.714285714286 | NXF1 NUP62 RAE1 NUP42 NUP88 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-72203 | 1.46246312693e-10 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-159230 | 1.47137351502e-10 | 0.714285714286 | NXF1 NUP62 RAE1 NUP42 NUP88 | Transport of the SLBP Dependant Mature mRNA |
| GO:0051168 | 3.52201533793e-10 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | nuclear export |
| REAC:R-HSA-159231 | 3.66497485291e-10 | 0.714285714286 | NXF1 NUP62 RAE1 NUP42 NUP88 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 4.20346129105e-10 | 0.714285714286 | NXF1 NUP62 RAE1 NUP42 NUP88 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| GO:0005643 | 9.72619733609e-09 | 0.857142857143 | GLE1 RAE1 NUP88 NXT1 NUP62 NUP42 | nuclear pore |
| WP:WP3998 | 9.85767521815e-09 | 0.714285714286 | NUP62 GLE1 RAE1 NUP42 NUP88 | Prader Willi and Angelman syndrome |
| GO:0006405 | 1.12685593968e-08 | 0.857142857143 | GLE1 RAE1 NXF1 NXT1 NUP62 NUP88 | RNA export from nucleus |
| GO:0006913 | 1.56560155962e-08 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | nucleocytoplasmic transport |
| GO:0051169 | 1.56560155962e-08 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | nuclear transport |
| KEGG:05014 | 4.06653947287e-08 | 0.857142857143 | GLE1 RAE1 NXF1 NXT1 NUP62 NUP88 | Amyotrophic lateral sclerosis |
| GO:0050657 | 4.65038977351e-08 | 0.857142857143 | GLE1 RAE1 NXF1 NXT1 NUP62 NUP88 | nucleic acid transport |
| GO:0050658 | 4.65038977351e-08 | 0.857142857143 | GLE1 RAE1 NXF1 NXT1 NUP62 NUP88 | RNA transport |
| GO:0051236 | 5.51041937092e-08 | 0.857142857143 | GLE1 RAE1 NXF1 NXT1 NUP62 NUP88 | establishment of RNA localization |
| REAC:R-HSA-170822 | 7.27986463037e-08 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 7.27986463037e-08 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168274 | 8.44325418323e-08 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 8.44325418323e-08 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168333 | 8.44325418323e-08 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-8953854 | 9.25548869944e-08 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | Metabolism of RNA |
| REAC:R-HSA-180910 | 1.11818286144e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 1.11818286144e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Nuclear import of Rev protein |
| REAC:R-HSA-165054 | 1.277713074e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-4085377 | 1.277713074e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3301854 | 1.4537101986e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 1.64726720638e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 1.64726720638e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 1.85951185977e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 2.34474893536e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | NS1 Mediated Effects on Host Pathways |
| GO:0006403 | 2.40939570538e-07 | 0.857142857143 | GLE1 RAE1 NXF1 NXT1 NUP62 NUP88 | RNA localization |
| REAC:R-HSA-168325 | 3.24295323063e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Viral Messenger RNA Synthesis |
| GO:0015931 | 3.52298201497e-07 | 0.857142857143 | GLE1 RAE1 NXF1 NXT1 NUP62 NUP88 | nucleobase-containing compound transport |
| REAC:R-HSA-4615885 | 3.97050332478e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 4.37701397548e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 6.32195304736e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 8.85160190125e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | snRNP Assembly |
| REAC:R-HSA-194441 | 8.85160190125e-07 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 1.20724098212e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | tRNA processing in the nucleus |
| GO:0006406 | 1.67816461195e-06 | 0.714285714286 | GLE1 NXT1 NXF1 NUP88 RAE1 | mRNA export from nucleus |
| REAC:R-HSA-70171 | 2.39259094536e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Glycolysis |
| REAC:R-HSA-3371453 | 2.39259094536e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-1169408 | 2.54653200545e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 2.54653200545e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMOylation of chromatin organization proteins |
| GO:0051028 | 2.62550964059e-06 | 0.714285714286 | GLE1 NXT1 NXF1 NUP88 RAE1 | mRNA transport |
| REAC:R-HSA-5619102 | 3.23754553505e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 3.43026641569e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 3.63144818167e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 5.2974479806e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Glucose metabolism |
| REAC:R-HSA-3371556 | 7.13183221125e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 9.40454269709e-06 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-72306 | 1.32285423695e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | tRNA processing |
| REAC:R-HSA-9610379 | 1.32285423695e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | HCMV Late Events |
| REAC:R-HSA-9705671 | 2.177889083e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-211000 | 2.68824488605e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 2.87672068396e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | HCMV Early Events |
| REAC:R-HSA-68875 | 3.07490358825e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Mitotic Prophase |
| REAC:R-HSA-162909 | 3.39109081881e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 3.97128087888e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 4.09568344531e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-5619115 | 5.50598372696e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Disorders of transmembrane transporters |
| REAC:R-HSA-9609646 | 5.66464039369e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | HCMV Infection |
| REAC:R-HSA-162587 | 5.66464039369e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | HIV Life Cycle |
| CORUM:1348 | 6.1565588648e-05 | 0.285714285714 | GLE1 NUP42 | GLE1-NUPL2-NUP155 complex |
| GO:0005635 | 6.30993918979e-05 | 0.857142857143 | GLE1 RAE1 NUP88 NXT1 NUP62 NUP42 | nuclear envelope |
| REAC:R-HSA-168255 | 6.68945697214e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Influenza Infection |
| REAC:R-HSA-3108232 | 8.69731520059e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 9.85510200968e-05 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SUMOylation |
| REAC:R-HSA-913531 | 0.000131012054451 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Interferon Signaling |
| REAC:R-HSA-9705683 | 0.00017454112665 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SARS-CoV-2-host interactions |
| REAC:R-HSA-162906 | 0.000333081909557 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | HIV Infection |
| KEGG:03015 | 0.000418965008626 | 0.428571428571 | GLE1 NXF1 NXT1 | mRNA surveillance pathway |
| GO:0071705 | 0.00057569858342 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | nitrogen compound transport |
| GO:0046907 | 0.000594741825979 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | intracellular transport |
| REAC:R-HSA-71387 | 0.000598471160784 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Metabolism of carbohydrates |
| GO:0140513 | 0.000698274170384 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | nuclear protein-containing complex |
| REAC:R-HSA-9694516 | 0.000772937908588 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SARS-CoV-2 Infection |
| KEGG:05164 | 0.00166242587361 | 0.428571428571 | NXT1 RAE1 NXF1 | Influenza A |
| GO:0071702 | 0.00237775127455 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | organic substance transport |
| REAC:R-HSA-9679506 | 0.0027504989814 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | SARS-CoV Infections |
| REAC:R-HSA-68886 | 0.00308249436511 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | M Phase |
| GO:0051649 | 0.00341941525307 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | establishment of localization in cell |
| GO:0016973 | 0.00445787546995 | 0.428571428571 | GLE1 NXF1 NXT1 | poly(A)+ mRNA export from nucleus |
| REAC:R-HSA-69278 | 0.0103191476058 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Cell Cycle, Mitotic |
| REAC:R-HSA-1280215 | 0.0183128073795 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Cytokine Signaling in Immune system |
| GO:0031975 | 0.0205605899593 | 0.857142857143 | GLE1 RAE1 NUP88 NXT1 NUP62 NUP42 | envelope |
| GO:0031967 | 0.0205605899593 | 0.857142857143 | GLE1 RAE1 NUP88 NXT1 NUP62 NUP42 | organelle envelope |
| REAC:R-HSA-1640170 | 0.0231929958906 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Cell Cycle |
| KEGG:03008 | 0.0265381810008 | 0.285714285714 | NXT1 NXF1 | Ribosome biogenesis in eukaryotes |
| REAC:R-HSA-9824446 | 0.0320441838438 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Viral Infection Pathways |
| REAC:R-HSA-2262752 | 0.0357359015554 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Cellular responses to stress |
| GO:0033036 | 0.0367544883741 | 1.0 | GLE1 RAE1 NXF1 NUP88 NXT1 NUP62 NUP42 | macromolecule localization |
| REAC:R-HSA-8953897 | 0.037098775361 | 0.571428571429 | NUP62 RAE1 NUP42 NUP88 | Cellular responses to stimuli |
| HP:0001989 | 0.0497326121949 | 0.285714285714 | GLE1 NUP88 | Fetal akinesia sequence |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUP62 | NUP88 | 1.0 | 0.738 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| NXF1 | NXT1 | 1.0 | 0.358 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| RAE1 | NUP62 | 1.0 | 0.528 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| NUP42 | NXT1 | 0.998 | 0.16 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP42 | GLE1 | 0.998 | 0.36 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXT1 | NUP62 | 0.998 | 0.25 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RAE1 | GLE1 | 0.998 | 0.212 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXT1 | NUP88 | 0.997 | 0.264 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| NUP42 | RAE1 | 0.994 | 0.522 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXT1 | RAE1 | 0.994 | 0.242 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXF1 | GLE1 | 0.992 | 0.294 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| NXF1 | NUP62 | 0.992 | 0.558 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXF1 | NUP42 | 0.991 | 0.564 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXF1 | RAE1 | 0.99 | 0.652 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| NXT1 | GLE1 | 0.99 | 0.204 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RAE1 | NUP88 | 0.985 | 0.402 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| NXF1 | NUP88 | 0.984 | 0.622 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXT1 | NXF2 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| GLE1 | NUP88 | 0.969 | 0.34 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP42 | NUP62 | 0.966 | 0.384 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NXF2 | GLE1 | 0.964 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| NUP42 | NXF2 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| RAE1 | NXF2 | 0.937 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| NUP42 | NUP88 | 0.936 | 0.514 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| NUP62 | GLE1 | 0.868 | 0.146 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXF2 | NUP62 | 0.631 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| NXF2 | NUP88 | 0.285 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| NXF1 | NXF2 | 0.232 | bioplex3_HEK293 bioplex () bioplex_WMM |
Related Complexes