hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08446.1
Complex Portal: CPX-13056
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4566 | 0.000349022354971 | 1.0 | EIF4A1 EIF4A2 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-429947 | 0.000471618243588 | 1.0 | EIF4A1 EIF4A2 | Deadenylation of mRNA |
| WP:WP107 | 0.000500549133471 | 1.0 | EIF4A1 EIF4A2 | Translation factors |
| REAC:R-HSA-429914 | 0.00253751120191 | 1.0 | EIF4A1 EIF4A2 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-72702 | 0.00292369135789 | 1.0 | EIF4A1 EIF4A2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.00292369135789 | 1.0 | EIF4A1 EIF4A2 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.00302450830127 | 1.0 | EIF4A1 EIF4A2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REAC:R-HSA-1169408 | 0.00366529395832 | 1.0 | EIF4A1 EIF4A2 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.00436759503844 | 1.0 | EIF4A1 EIF4A2 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-156827 | 0.010244026704 | 1.0 | EIF4A1 EIF4A2 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.0104319904967 | 1.0 | EIF4A1 EIF4A2 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72737 | 0.0117955823749 | 1.0 | EIF4A1 EIF4A2 | Cap-dependent Translation Initiation |
| REAC:R-HSA-72613 | 0.0117955823749 | 1.0 | EIF4A1 EIF4A2 | Eukaryotic Translation Initiation |
| REAC:R-HSA-913531 | 0.0260158976762 | 1.0 | EIF4A1 EIF4A2 | Interferon Signaling |
| GO:0016281 | 0.0365196561665 | 1.0 | EIF4A1 EIF4A2 | eukaryotic translation initiation factor 4F complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM |
Related Complexes