hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08461.1
Complex Portal: CPX-21694
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMED4 | Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) | 5 | UniProt NCBI |
| TMED3 | Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26) | 5 | UniProt NCBI |
| GOLGB1 | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | 5 | UniProt NCBI |
| FGF3 | Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2) | 5 | UniProt NCBI |
| TMED10 | Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) | 5 | UniProt NCBI |
| TMED2 | Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1) | 5 | UniProt NCBI |
| TMED9 | Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25) | 5 | UniProt NCBI |
| TMED1 | Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1) | 5 | UniProt NCBI |
| TMED5 | Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28) | 5 | UniProt NCBI |
| CTXN1 | Cortexin-1 | 2 | UniProt NCBI |
| CHST8 | Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005793 | 4.02303516034e-12 | 0.8 | TMED5 TMED10 TMED1 TMED2 TMED3 GOLGB1 TMED9 TMED4 | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0007030 | 3.61925504463e-11 | 0.8 | TMED5 TMED10 TMED1 TMED2 TMED3 GOLGB1 TMED9 TMED4 | Golgi organization |
| GO:0030134 | 3.4234759588e-10 | 0.7 | TMED10 TMED1 TMED2 TMED3 TMED5 TMED9 TMED4 | COPII-coated ER to Golgi transport vesicle |
| GO:0006888 | 1.09879726416e-08 | 0.7 | TMED10 TMED1 TMED2 TMED3 TMED5 TMED9 TMED4 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-948021 | 1.18784329271e-07 | 0.6 | TMED3 TMED10 TMED2 CHST8 GOLGB1 TMED9 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6807878 | 6.52827455595e-07 | 0.5 | TMED2 TMED10 TMED3 TMED9 GOLGB1 | COPI-mediated anterograde transport |
| GO:0030135 | 1.01170158919e-06 | 0.7 | TMED10 TMED1 TMED2 TMED3 TMED5 TMED9 TMED4 | coated vesicle |
| GO:0010256 | 1.28089876504e-06 | 0.8 | TMED5 TMED10 TMED1 TMED2 TMED3 GOLGB1 TMED9 TMED4 | endomembrane system organization |
| REAC:R-HSA-446203 | 2.37666556341e-06 | 0.6 | TMED3 TMED10 TMED2 CHST8 GOLGB1 TMED9 | Asparagine N-linked glycosylation |
| GO:0048193 | 3.89038908753e-06 | 0.7 | TMED10 TMED1 TMED2 TMED3 TMED5 TMED9 TMED4 | Golgi vesicle transport |
| REAC:R-HSA-199977 | 4.892551932e-06 | 0.5 | TMED2 TMED10 TMED3 TMED9 GOLGB1 | ER to Golgi Anterograde Transport |
| GO:0005794 | 4.39247775541e-05 | 0.9 | TMED5 TMED10 TMED1 TMED2 TMED3 GOLGB1 TMED9 CHST8 TMED4 | Golgi apparatus |
| REAC:R-HSA-6811434 | 7.56889212085e-05 | 0.4 | TMED9 TMED2 TMED3 TMED10 | COPI-dependent Golgi-to-ER retrograde traffic |
| GO:0048205 | 0.0002304395259 | 0.3 | TMED9 TMED10 TMED2 | COPI coating of Golgi vesicle |
| GO:0035964 | 0.0002304395259 | 0.3 | TMED9 TMED10 TMED2 | COPI-coated vesicle budding |
| GO:0048200 | 0.0002304395259 | 0.3 | TMED9 TMED10 TMED2 | Golgi transport vesicle coating |
| GO:0006886 | 0.000233697654719 | 0.7 | TMED10 TMED1 TMED2 TMED3 TMED5 TMED9 TMED4 | intracellular protein transport |
| REAC:R-HSA-8856688 | 0.000256657814131 | 0.4 | TMED9 TMED2 TMED3 TMED10 | Golgi-to-ER retrograde transport |
| HPA:0420053 | 0.000666737393287 | 0.7 | TMED5 TMED10 TMED2 TMED3 GOLGB1 TMED9 TMED4 | salivary gland; glandular cells[High] |
| GO:0033116 | 0.000889334569609 | 0.4 | TMED9 TMED2 TMED3 TMED10 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO:0048194 | 0.000966803032193 | 0.3 | TMED9 TMED10 TMED2 | Golgi vesicle budding |
| REAC:R-HSA-6811442 | 0.00140529487885 | 0.4 | TMED9 TMED2 TMED3 TMED10 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| WP:WP5380 | 0.00313738741595 | 0.3 | TMED9 TMED10 TMED2 | 5q35 copy number variation |
| GO:0000139 | 0.00411066763673 | 0.6 | TMED3 TMED10 TMED2 CHST8 GOLGB1 TMED9 | Golgi membrane |
| GO:0005798 | 0.00467585293512 | 0.4 | TMED9 TMED2 TMED3 TMED10 | Golgi-associated vesicle |
| REAC:R-HSA-199991 | 0.00470427579879 | 0.5 | TMED2 TMED10 TMED3 TMED9 GOLGB1 | Membrane Trafficking |
| GO:0015031 | 0.00552416206626 | 0.7 | TMED10 TMED1 TMED2 TMED3 TMED5 TMED9 TMED4 | protein transport |
| REAC:R-HSA-5653656 | 0.00612090797347 | 0.5 | TMED2 TMED10 TMED3 TMED9 GOLGB1 | Vesicle-mediated transport |
| HPA:0160053 | 0.0116051674312 | 0.6 | TMED10 TMED2 TMED3 GOLGB1 TMED9 TMED4 | endometrium 1; glandular cells[High] |
| GO:0030137 | 0.0130691170406 | 0.3 | TMED2 TMED3 TMED10 | COPI-coated vesicle |
| REAC:R-HSA-597592 | 0.0133621598082 | 0.6 | TMED3 TMED10 TMED2 CHST8 GOLGB1 TMED9 | Post-translational protein modification |
| GO:0045184 | 0.0348460317846 | 0.7 | TMED10 TMED1 TMED2 TMED3 TMED5 TMED9 TMED4 | establishment of protein localization |
| REAC:R-HSA-5694530 | 0.0354011801879 | 0.2 | TMED10 TMED2 | Cargo concentration in the ER |
| HPA:0180053 | 0.0381745282405 | 0.6 | TMED10 TMED2 TMED3 GOLGB1 TMED9 TMED4 | epididymis; glandular cells[High] |
| GO:0048199 | 0.0417546094154 | 0.3 | TMED9 TMED10 TMED2 | vesicle targeting, to, from or within Golgi |
| GO:0008104 | 0.0478453479677 | 0.8 | TMED5 TMED10 TMED1 TMED2 TMED3 GOLGB1 TMED9 TMED4 | protein localization |
| GO:0070727 | 0.0487556847657 | 0.8 | TMED5 TMED10 TMED1 TMED2 TMED3 GOLGB1 TMED9 TMED4 | cellular macromolecule localization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TMED2 | TMED9 | 1.0 | 0.92 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| TMED2 | TMED1 | 1.0 | 0.676 |
mutually_exclusive (P49755)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| TMED4 | TMED2 | 1.0 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| TMED9 | TMED5 | 1.0 | 0.386 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| TMED2 | TMED5 | 1.0 | 0.654 |
mutually_exclusive (P49755)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| TMED3 | TMED2 | 1.0 | 0.356 |
mutually_exclusive (P49755)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction |
| TMED2 | TMED10 | 1.0 | 0.858 |
mutually_exclusive (Q13445)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| TMED9 | TMED10 | 1.0 | 0.928 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| TMED10 | TMED1 | 1.0 | 0.508 |
mutually_exclusive (Q15363)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| TMED3 | TMED10 | 1.0 | 0.238 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction |
| TMED9 | TMED1 | 1.0 | 0.656 |
mutually_exclusive (Q15363)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| TMED10 | TMED5 | 0.999 | 0.676 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| TMED4 | TMED5 | 0.999 | 0.554 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| TMED3 | TMED9 | 0.999 | 0.212 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TMED4 | TMED1 | 0.999 | 0.578 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| TMED3 | TMED1 | 0.998 | 0.208 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TMED4 | TMED10 | 0.998 | 0.928 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () fraction boldt_WMM treiber_WMM | |
| TMED4 | TMED9 | 0.997 | 0.734 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM WMM_only | |
| TMED4 | TMED3 | 0.997 | 0.236 |
mutually_exclusive (Q9Y3B3)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TMED1 | TMED5 | 0.996 | 0.272 |
mutually_exclusive (P49755)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| TMED3 | TMED5 | 0.996 | 0.14 |
mutually_exclusive (P49755)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CHST8 | TMED5 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CTXN1 | TMED2 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GOLGB1 | TMED2 | 0.994 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| GOLGB1 | TMED9 | 0.992 | 0.2 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| TMED2 | CHST8 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GOLGB1 | TMED10 | 0.992 | 0.16 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| TMED9 | CHST8 | 0.988 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TMED4 | CHST8 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GOLGB1 | TMED5 | 0.981 | 0.072 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FGF3 | TMED1 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FGF3 | TMED2 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CHST8 | TMED10 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CHST8 | TMED1 | 0.972 |
mutually_exclusive (Q9BVK6)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CTXN1 | TMED10 | 0.965 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FGF3 | TMED9 | 0.949 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTXN1 | TMED9 | 0.949 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TMED3 | CHST8 | 0.943 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FGF3 | TMED4 | 0.93 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GOLGB1 | TMED1 | 0.894 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TMED4 | GOLGB1 | 0.89 | 0.178 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FGF3 | TMED10 | 0.862 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTXN1 | TMED3 | 0.857 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TMED3 | GOLGB1 | 0.844 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CTXN1 | TMED4 | 0.759 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FGF3 | TMED5 | 0.619 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTXN1 | TMED1 | 0.604 | bioplex3_WMM WMM_only | ||
| CTXN1 | TMED5 | 0.32 | bioplex3_WMM WMM_only | ||
| CTXN1 | GOLGB1 | 0.306 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes