hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08472.1
Complex Portal: CPX-10813
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MIB2 | E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) | 5 | UniProt NCBI |
| IKZF3 | Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) | 5 | UniProt NCBI |
| ELF2 | ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) | 5 | UniProt NCBI |
| CHD8 | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | 5 | UniProt NCBI |
| ZNF518B | Zinc finger protein 518B | 3 | UniProt NCBI |
| PEX14 | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | 5 | UniProt NCBI |
| IKZF4 | Zinc finger protein Eos (Ikaros family zinc finger protein 4) | 5 | UniProt NCBI |
| IKZF1 | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | 5 | UniProt NCBI |
| IKZF2 | Zinc finger protein Helios (Ikaros family zinc finger protein 2) | 5 | UniProt NCBI |
| IKZF5 | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140110 | 0.00942037447081 | 0.8 | ELF2 IKZF4 PEX14 IKZF5 ZNF518B IKZF2 IKZF3 IKZF1 | transcription regulator activity |
| GO:0003700 | 0.0209267384329 | 0.7 | ELF2 IKZF4 IKZF5 ZNF518B IKZF2 IKZF3 IKZF1 | DNA-binding transcription factor activity |
| GO:0003677 | 0.0226398277583 | 0.8 | ELF2 IKZF4 IKZF5 ZNF518B IKZF2 IKZF3 CHD8 IKZF1 | DNA binding |
| GO:0006355 | 0.0260722421898 | 0.9 | IKZF4 PEX14 IKZF5 ZNF518B IKZF2 IKZF3 CHD8 IKZF1 ELF2 | regulation of DNA-templated transcription |
| GO:2001141 | 0.0275042486783 | 0.9 | IKZF4 PEX14 IKZF5 ZNF518B IKZF2 IKZF3 CHD8 IKZF1 ELF2 | regulation of RNA biosynthetic process |
| GO:0006351 | 0.0396319173816 | 0.9 | IKZF4 PEX14 IKZF5 ZNF518B IKZF2 IKZF3 CHD8 IKZF1 ELF2 | DNA-templated transcription |
| GO:1990837 | 0.0409577072586 | 0.7 | ELF2 IKZF4 IKZF5 ZNF518B IKZF2 IKZF3 IKZF1 | sequence-specific double-stranded DNA binding |
| GO:0032774 | 0.0435543173798 | 0.9 | IKZF4 PEX14 IKZF5 ZNF518B IKZF2 IKZF3 CHD8 IKZF1 ELF2 | RNA biosynthetic process |
| CORUM:1984 | 0.0499436884912 | 0.1 | PEX14 | PEX14 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IKZF3 | IKZF4 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IKZF2 | IKZF1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IKZF1 | IKZF4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CHD8 | IKZF5 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IKZF1 | IKZF3 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF5 | IKZF2 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF5 | IKZF3 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PEX14 | IKZF5 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IKZF5 | IKZF1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MIB2 | IKZF5 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF5 | IKZF4 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZNF518B | IKZF5 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ELF2 | IKZF5 | 0.951 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MIB2 | IKZF1 | 0.948 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IKZF2 | IKZF4 | 0.797 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF518B | IKZF2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ELF2 | CHD8 | 0.469 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| IKZF2 | IKZF3 | 0.36 | 0.182 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF518B | IKZF4 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF518B | IKZF3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | IKZF2 | 0.211 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | IKZF4 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | IKZF3 | 0.202 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| PEX14 | IKZF4 | 0.2 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CHD8 | IKZF3 | 0.187 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| CHD8 | IKZF4 | 0.187 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ELF2 | MIB2 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MIB2 | ZNF518B | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PEX14 | ZNF518B | 0.162 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| MIB2 | CHD8 | 0.146 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| PEX14 | IKZF2 | 0.143 | 0.01 | bioplex_WMM bioplex3_WMM WMM_only | |
| ELF2 | IKZF4 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ELF2 | IKZF3 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CHD8 | IKZF2 | 0.143 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| ELF2 | IKZF2 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ELF2 | ZNF518B | 0.085 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| CHD8 | ZNF518B | 0.085 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PEX14 | CHD8 | 0.076 | 0.08 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PEX14 | IKZF3 | 0.076 | 0.074 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MIB2 | PEX14 | 0.005 | 0.112 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ELF2 | PEX14 | 0.003 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes