hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08480.1
Complex Portal: CPX-19369
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| YWHAH | 14-3-3 protein eta (Protein AS1) | 5 | UniProt NCBI |
| GRID2IP | Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1) | 3 | UniProt NCBI |
| ANKRD55 | Ankyrin repeat domain-containing protein 55 | 5 | UniProt NCBI |
| CDR2L | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | 5 | UniProt NCBI |
| YWHAZ | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | 5 | UniProt NCBI |
| PLEKHG5 | Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720) | 5 | UniProt NCBI |
| WEE1 | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | 5 | UniProt NCBI |
| GPSM3 | G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18) | 5 | UniProt NCBI |
| FOXO4 | Forkhead box protein O4 (Fork head domain transcription factor AFX1) | 5 | UniProt NCBI |
| SYDE2 | Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5199 | 0.00326883477195 | 0.222222222222 | YWHAH YWHAZ | Kinase maturation complex 1 |
| REAC:R-HSA-9614399 | 0.00525543712779 | 0.222222222222 | YWHAZ FOXO4 | Regulation of localization of FOXO transcription factors |
| REAC:R-HSA-9755779 | 0.00525543712779 | 0.222222222222 | YWHAH YWHAZ | SARS-CoV-2 targets host intracellular signalling and regulatory pathways |
| WP:WP5376 | 0.00581046009857 | 0.222222222222 | YWHAH YWHAZ | 17p13 3 YWHAE copy number variation |
| REAC:R-HSA-75035 | 0.00620898744994 | 0.222222222222 | YWHAH YWHAZ | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| REAC:R-HSA-111447 | 0.00835291407054 | 0.222222222222 | YWHAH YWHAZ | Activation of BAD and translocation to mitochondria |
| REAC:R-HSA-9735871 | 0.00835291407054 | 0.222222222222 | YWHAH YWHAZ | SARS-CoV-1 targets host intracellular signalling and regulatory pathways |
| REAC:R-HSA-114452 | 0.0344394959621 | 0.222222222222 | YWHAH YWHAZ | Activation of BH3-only proteins |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| YWHAZ | YWHAH | 1.0 | 0.724 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| YWHAZ | GPSM3 | 0.982 | 0.314 |
mutually_exclusive (P27348)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| YWHAZ | PLEKHG5 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CDR2L | YWHAH | 0.971 | 0.369797202797 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| YWHAZ | CDR2L | 0.97 | 0.574 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| YWHAZ | ANKRD55 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYDE2 | YWHAH | 0.965 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| YWHAH | GRID2IP | 0.956 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| YWHAH | WEE1 | 0.956 | 0.222523809524 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| YWHAH | FOXO4 | 0.954 |
mutually_exclusive (P31947)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PLEKHG5 | YWHAH | 0.951 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ANKRD55 | YWHAH | 0.936 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GPSM3 | YWHAH | 0.911 | 0.316 |
mutually_exclusive (P27348)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| YWHAZ | SYDE2 | 0.782 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| YWHAZ | FOXO4 | 0.449 |
mutually_exclusive (P31947)
|
bioplex3_WMM youn_WMM WMM_only | |
| SYDE2 | FOXO4 | 0.324 | bioplex3_WMM WMM_only | ||
| SYDE2 | GRID2IP | 0.283 | bioplex3_WMM WMM_only | ||
| GRID2IP | FOXO4 | 0.283 | bioplex3_WMM WMM_only | ||
| YWHAZ | GRID2IP | 0.232 | bioplex3_WMM boldt boldt_WMM WMM_only | ||
| CDR2L | WEE1 | 0.128 | 0.148 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| YWHAZ | WEE1 | 0.091 | 0.342715753425 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| PLEKHG5 | WEE1 | 0.079 | bioplex3_WMM WMM_only | ||
| GRID2IP | WEE1 | 0.079 | bioplex3_WMM WMM_only | ||
| WEE1 | FOXO4 | 0.079 | bioplex3_WMM WMM_only | ||
| PLEKHG5 | SYDE2 | 0.079 | bioplex3_WMM WMM_only | ||
| SYDE2 | WEE1 | 0.079 | bioplex3_WMM WMM_only | ||
| PLEKHG5 | GRID2IP | 0.079 | bioplex3_WMM WMM_only | ||
| PLEKHG5 | FOXO4 | 0.079 | bioplex3_WMM WMM_only | ||
| CDR2L | FOXO4 | 0.071 | bioplex3_WMM WMM_only | ||
| PLEKHG5 | CDR2L | 0.071 | bioplex3_WMM WMM_only | ||
| CDR2L | GRID2IP | 0.071 | bioplex3_WMM WMM_only | ||
| SYDE2 | CDR2L | 0.071 | bioplex3_WMM WMM_only |
Related Complexes