hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08485.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GYPB | Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b) | 5 | UniProt NCBI |
| BZW1 | eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) | 5 | UniProt NCBI |
| EIF2B1 | Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) | 5 | UniProt NCBI |
| EIF2B4 | Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta) | 5 | UniProt NCBI |
| EIF2B3 | Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) | 5 | UniProt NCBI |
| NOP9 | Nucleolar protein 9 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7292 | 4.675933868e-08 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex |
| REAC:R-HSA-72731 | 3.95483747683e-07 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Recycling of eIF2:GDP |
| GO:0005851 | 1.92180881975e-05 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | eukaryotic translation initiation factor 2B complex |
| WP:WP107 | 5.04563194767e-05 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Translation factors |
| CORUM:7291 | 0.000102488289015 | 0.333333333333 | EIF2B3 EIF2B4 | EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex |
| HP:0000869 | 0.000813158327929 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Secondary amenorrhea |
| GO:0014003 | 0.00130441648129 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | oligodendrocyte development |
| REAC:R-HSA-72613 | 0.00185327127259 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.00185327127259 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Cap-dependent Translation Initiation |
| GO:0006413 | 0.00186589865871 | 0.666666666667 | BZW1 EIF2B3 EIF2B4 EIF2B1 | translational initiation |
| GO:0048709 | 0.0125202207278 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | oligodendrocyte differentiation |
| HP:0000141 | 0.0153102613551 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Amenorrhea |
| KEGG:05168 | 0.0153678589488 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Herpes simplex virus 1 infection |
| GO:0003743 | 0.0252998897888 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | translation initiation factor activity |
| REAC:R-HSA-72766 | 0.0266429590673 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Translation |
| GO:0021782 | 0.037407051376 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | glial cell development |
| HP:0002352 | 0.0442030419385 | 0.5 | EIF2B1 EIF2B4 EIF2B3 | Leukoencephalopathy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF2B3 | EIF2B1 | 0.999 | 0.324 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| EIF2B4 | EIF2B1 | 0.998 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| EIF2B4 | EIF2B3 | 0.997 | 0.436 | bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| BZW1 | EIF2B4 | 0.983 | 0.11 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| NOP9 | EIF2B3 | 0.976 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| GYPB | EIF2B4 | 0.972 | bioplex3_HEK293 bioplex () | |
| GYPB | EIF2B3 | 0.972 | bioplex3_HEK293 bioplex () | |
| GYPB | BZW1 | 0.971 | bioplex3_HEK293 bioplex () | |
| EIF2B4 | NOP9 | 0.971 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| GYPB | EIF2B1 | 0.971 | bioplex3_HEK293 bioplex () | |
| BZW1 | EIF2B3 | 0.96 | 0.282 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| BZW1 | EIF2B1 | 0.656 | 0.244 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| NOP9 | EIF2B1 | 0.616 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| BZW1 | NOP9 | 0.22 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM |
Related Complexes