hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08486.1

Complex Portal: CPX-25313

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
SRSF7	Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)	5	UniProt NCBI
APOBEC3F	DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F)	5	UniProt NCBI
SNIP1	Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1)	5	UniProt NCBI
CLK3	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)	5	UniProt NCBI
FIP1L1	Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)	5	UniProt NCBI
SPEN	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	5	UniProt NCBI
SRSF10	Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)	5	UniProt NCBI
MKRN1	E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)	5	UniProt NCBI
CLK1	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)	5	UniProt NCBI
YTHDC1	YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)	5	UniProt NCBI
SRSF8	Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0003723	3.17467927449e-05	0.909090909091	SRSF10 YTHDC1 SRSF7 MKRN1 APOBEC3F SNIP1 SPEN SRSF8 FIP1L1 CLK3	RNA binding
GO:0008380	8.83222235795e-05	0.636363636364	SRSF10 SNIP1 SRSF7 SRSF8 CLK1 CLK3 YTHDC1	RNA splicing
WP:WP411	0.000152164166453	0.363636363636	SRSF10 CLK1 SRSF7 CLK3	mRNA processing
REAC:R-HSA-72203	0.000243736876409	0.454545454545	SRSF10 FIP1L1 SRSF8 SRSF7 SNIP1	Processing of Capped Intron-Containing Pre-mRNA
HPA:0570772	0.00184365374838	0.454545454545	SPEN CLK3 SRSF8 SRSF7 SNIP1	testis; peritubular cells[>=Medium]
REAC:R-HSA-72163	0.0027524806503	0.363636363636	SRSF10 SRSF8 SRSF7 SNIP1	mRNA Splicing - Major Pathway
GO:0043484	0.00285034652145	0.454545454545	SRSF10 CLK1 YTHDC1 SRSF7 CLK3	regulation of RNA splicing
REAC:R-HSA-72172	0.00315108221312	0.363636363636	SRSF10 SRSF8 SRSF7 SNIP1	mRNA Splicing
HPA:0570812	0.00380720510309	0.727272727273	YTHDC1 SRSF7 SRSF8 CLK1 CLK3 SPEN FIP1L1 SNIP1	testis; spermatogonia cells[>=Medium]
HPA:0570792	0.00480730276593	0.636363636364	YTHDC1 SRSF7 SRSF8 CLK3 SPEN FIP1L1 SNIP1	testis; round or early spermatids[>=Medium]
KEGG:03040	0.00488559896554	0.272727272727	SRSF8 SRSF7 SRSF10	Spliceosome
HPA:0570771	0.00785989125937	0.454545454545	SPEN CLK3 SRSF8 SRSF7 SNIP1	testis; peritubular cells[>=Low]
HPA:0570811	0.0135487431109	0.727272727273	YTHDC1 SRSF7 SRSF8 CLK1 CLK3 SPEN FIP1L1 SNIP1	testis; spermatogonia cells[>=Low]
GO:0006396	0.0146321583166	0.636363636364	SRSF10 SNIP1 SRSF7 SRSF8 CLK1 CLK3 YTHDC1	RNA processing
HPA:0570791	0.0178476756014	0.636363636364	YTHDC1 SRSF7 SRSF8 CLK3 SPEN FIP1L1 SNIP1	testis; round or early spermatids[>=Low]
HPA:0570782	0.018212843076	0.545454545455	YTHDC1 SRSF8 SRSF7 CLK3 SPEN FIP1L1	testis; preleptotene spermatocytes[>=Medium]
HPA:0570813	0.0184576858089	0.545454545455	YTHDC1 SRSF8 SNIP1 SPEN FIP1L1 CLK3	testis; spermatogonia cells[High]
REAC:R-HSA-8953854	0.0209237584293	0.454545454545	SRSF10 FIP1L1 SRSF8 SRSF7 SNIP1	Metabolism of RNA
GO:0003676	0.0259523693915	0.909090909091	SRSF10 YTHDC1 SRSF7 MKRN1 APOBEC3F SNIP1 SPEN SRSF8 FIP1L1 CLK3	nucleic acid binding
HPA:0570793	0.0290598498087	0.454545454545	SPEN FIP1L1 SRSF8 SRSF7 SNIP1	testis; round or early spermatids[High]
GO:0000398	0.0406309160605	0.454545454545	SRSF10 SRSF8 YTHDC1 SRSF7 SNIP1	mRNA splicing, via spliceosome
GO:0000377	0.0406309160605	0.454545454545	SRSF10 SRSF8 YTHDC1 SRSF7 SNIP1	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000375	0.0437430996842	0.454545454545	SRSF10 SRSF8 YTHDC1 SRSF7 SNIP1	RNA splicing, via transesterification reactions

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
SRSF8	CLK3	0.999	0.072	structurally_consistent (O00422)
SRSF10	CLK3	0.998		structurally_consistent (O00422)
SRSF10	SRSF7	0.997
CLK3	YTHDC1	0.997	0.144666666667
APOBEC3F	CLK3	0.993	0.088
CLK1	SRSF7	0.993	0.354
CLK3	SRSF7	0.991	0.344	structurally_consistent (O00422)
SRSF10	YTHDC1	0.987
SRSF10	MKRN1	0.978
SRSF8	CLK1	0.974	0.076
FIP1L1	CLK1	0.968	0.144
CLK3	CLK1	0.967	0.19
SPEN	CLK3	0.965	0.096
MKRN1	CLK3	0.964	0.122
SNIP1	SRSF7	0.964	0.762	mutually_exclusive (Q9Y383)
SRSF8	SRSF7	0.959	0.33775
FIP1L1	CLK3	0.957	0.395
APOBEC3F	SRSF7	0.957	0.148
SRSF8	SNIP1	0.955	0.16
CLK1	YTHDC1	0.946	0.134
APOBEC3F	CLK1	0.942	0.086
SRSF10	CLK1	0.935
SRSF8	YTHDC1	0.934	0.17
APOBEC3F	SRSF8	0.932	0.082
SRSF10	SNIP1	0.93		mutually_exclusive (Q13242)
MKRN1	SRSF7	0.927	0.158
APOBEC3F	YTHDC1	0.926	0.056
YTHDC1	SRSF7	0.923	0.494
MKRN1	SRSF8	0.92	0.112
SRSF10	APOBEC3F	0.909
SNIP1	YTHDC1	0.883	0.484
APOBEC3F	MKRN1	0.882	0.108
FIP1L1	SRSF8	0.86	0.483333333333	mutually_exclusive (P61326)
FIP1L1	SNIP1	0.852	0.576
FIP1L1	SRSF7	0.806	0.66	mutually_exclusive (P61326)
MKRN1	SNIP1	0.785	0.13
SRSF10	SRSF8	0.779
FIP1L1	SRSF10	0.71		mutually_exclusive (P61326)
MKRN1	YTHDC1	0.693	0.084
FIP1L1	MKRN1	0.633	0.03
SPEN	SRSF8	0.575	0.136
APOBEC3F	SPEN	0.563	0.068
FIP1L1	YTHDC1	0.367	0.428
FIP1L1	APOBEC3F	0.258	0.11
MKRN1	CLK1	0.208	0.092
SPEN	YTHDC1	0.183	0.238
SPEN	SNIP1	0.14	0.26
SPEN	CLK1	0.098	0.086
SPEN	SRSF7	0.036	0.138
CLK3	SNIP1	0.028	0.258
SRSF10	SPEN	0.019
FIP1L1	SPEN	0.018	0.284
MKRN1	SPEN	0.015	0.16

Related Complexes

Genename	Complexes
SRSF7	huMAP3_06081.1 huMAP3_06097.1 huMAP3_06391.1 huMAP3_07267.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
APOBEC3F	huMAP3_00714.1 huMAP3_06975.1 huMAP3_07291.1 huMAP3_07939.1 huMAP3_08105.1 huMAP3_08486.1 huMAP3_09113.1 huMAP3_09186.1 huMAP3_09587.1 huMAP3_10114.1 huMAP3_10625.1
SNIP1	huMAP3_03772.1 huMAP3_06391.1 huMAP3_06799.1 huMAP3_07248.1 huMAP3_07561.1 huMAP3_08365.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10139.1 huMAP3_10564.1 huMAP3_11073.1
CLK3	huMAP3_02831.1 huMAP3_06097.1 huMAP3_06523.1 huMAP3_07291.1 huMAP3_08087.1 huMAP3_08486.1 huMAP3_08824.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
FIP1L1	huMAP3_00102.1 huMAP3_08087.1 huMAP3_08486.1 huMAP3_09096.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_11073.1 huMAP3_11757.1
SPEN	huMAP3_02019.1 huMAP3_03970.1 huMAP3_05696.1 huMAP3_05995.1 huMAP3_07848.1 huMAP3_08302.1 huMAP3_08486.1 huMAP3_08820.1 huMAP3_09041.1 huMAP3_09156.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09943.1 huMAP3_10021.1 huMAP3_10524.1
SRSF10	huMAP3_00489.1 huMAP3_04780.1 huMAP3_06081.1 huMAP3_06097.1 huMAP3_06391.1 huMAP3_07267.1 huMAP3_07848.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
MKRN1	huMAP3_00714.1 huMAP3_03962.1 huMAP3_05745.1 huMAP3_05874.1 huMAP3_06081.1 huMAP3_06391.1 huMAP3_06975.1 huMAP3_07267.1 huMAP3_07661.1 huMAP3_07973.1 huMAP3_08087.1 huMAP3_08105.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09186.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_10114.1 huMAP3_10564.1 huMAP3_11047.1 huMAP3_11073.1
CLK1	huMAP3_03369.1 huMAP3_04705.1 huMAP3_05341.1 huMAP3_06081.1 huMAP3_06846.1 huMAP3_07724.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09279.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_11073.1
YTHDC1	huMAP3_05378.1 huMAP3_06081.1 huMAP3_06523.1 huMAP3_06975.1 huMAP3_07291.1 huMAP3_07724.1 huMAP3_08486.1 huMAP3_08824.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_10564.1 huMAP3_11073.1
SRSF8	huMAP3_02311.1 huMAP3_06081.1 huMAP3_06846.1 huMAP3_07910.1 huMAP3_08087.1 huMAP3_08486.1 huMAP3_09279.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09636.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08486.1

Complex Portal: CPX-25313