hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08489.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP43 | Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) | 5 | UniProt NCBI |
| NUP133 | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | 5 | UniProt NCBI |
| SEC13 | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | 5 | UniProt NCBI |
| AAAS | Aladin (Adracalin) | 5 | UniProt NCBI |
| NUP37 | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) | 5 | UniProt NCBI |
| NUP160 | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | 5 | UniProt NCBI |
| NUP85 | Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1) | 5 | UniProt NCBI |
| NUP188 | Nucleoporin NUP188 (hNup188) | 5 | UniProt NCBI |
| NUP107 | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | 5 | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:87 | 5.73645700663e-25 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | Nup 107-160 subcomplex |
| REAC:R-HSA-170822 | 1.99258889374e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 1.99258889374e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168333 | 2.88907565571e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 2.88907565571e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 2.88907565571e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-180910 | 5.81495418406e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 5.81495418406e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180746 | 5.81495418406e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Nuclear import of Rev protein |
| REAC:R-HSA-159230 | 8.08987184534e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 8.08987184534e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-4085377 | 8.08987184534e-22 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3301854 | 1.11228873965e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 1.51261933677e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 1.51261933677e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Interactions of Rev with host cellular proteins |
| WP:WP3998 | 1.95993439834e-21 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Prader Willi and Angelman syndrome |
| GO:0031080 | 1.96449738772e-21 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | nuclear pore outer ring |
| REAC:R-HSA-3232142 | 2.03609267563e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 3.58695857078e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 4.69986249304e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 6.1094440889e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 7.88266701529e-21 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Viral Messenger RNA Synthesis |
| KEGG:03013 | 7.91986720957e-21 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Nucleocytoplasmic transport |
| REAC:R-HSA-4615885 | 1.28525346452e-20 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 1.62536725391e-20 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 3.92653289e-20 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 8.76438980835e-20 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | snRNP Assembly |
| REAC:R-HSA-194441 | 8.76438980835e-20 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Metabolism of non-coding RNA |
| REAC:R-HSA-9615933 | 1.54843768026e-19 | 0.8 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP188 NUP107 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-6784531 | 1.83129595813e-19 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | tRNA processing in the nucleus |
| REAC:R-HSA-70171 | 9.20111767396e-19 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Glycolysis |
| REAC:R-HSA-3371453 | 9.20111767396e-19 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Regulation of HSF1-mediated heat shock response |
| GO:0005643 | 9.95646674359e-19 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | nuclear pore |
| REAC:R-HSA-4551638 | 1.06532669756e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-1169408 | 1.06532669756e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | ISG15 antiviral mechanism |
| REAC:R-HSA-5619102 | 1.87130739329e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SLC transporter disorders |
| REAC:R-HSA-159236 | 1.87130739329e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 2.14281624558e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 2.44878137379e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 5.91882719757e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Glucose metabolism |
| REAC:R-HSA-72202 | 5.91882719757e-18 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-3371556 | 1.18363896488e-17 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 2.25232424408e-17 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-72306 | 4.97202109512e-17 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | tRNA processing |
| REAC:R-HSA-9610379 | 4.97202109512e-17 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | HCMV Late Events |
| REAC:R-HSA-9705671 | 1.57692613405e-16 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-211000 | 2.56504028515e-16 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 2.99952749612e-16 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | HCMV Early Events |
| REAC:R-HSA-68875 | 3.49822459723e-16 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Mitotic Prophase |
| REAC:R-HSA-162909 | 4.38473110879e-16 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 6.31166630831e-16 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 6.776860293e-16 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-5619115 | 1.34005965111e-15 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Disorders of transmembrane transporters |
| REAC:R-HSA-2995410 | 1.36601353108e-15 | 0.8 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP188 NUP107 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-162587 | 1.43065149634e-15 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | HIV Life Cycle |
| REAC:R-HSA-9609646 | 1.43065149634e-15 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | HCMV Infection |
| REAC:R-HSA-168255 | 2.09786936827e-15 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Influenza Infection |
| REAC:R-HSA-3108232 | 3.83717398637e-15 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 5.11443995016e-15 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SUMOylation |
| REAC:R-HSA-913531 | 9.83862613374e-15 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Interferon Signaling |
| REAC:R-HSA-9705683 | 1.90124903034e-14 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SARS-CoV-2-host interactions |
| GO:0006913 | 6.43632255026e-14 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | nucleocytoplasmic transport |
| GO:0051169 | 6.43632255026e-14 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | nuclear transport |
| REAC:R-HSA-162906 | 8.37588129414e-14 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | HIV Infection |
| REAC:R-HSA-71387 | 3.21084436904e-13 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Metabolism of carbohydrates |
| KEGG:05014 | 5.72283793809e-13 | 0.9 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP188 NUP107 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-9694516 | 5.7722857031e-13 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SARS-CoV-2 Infection |
| REAC:R-HSA-72203 | 5.96795175418e-13 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0005635 | 2.81321206514e-12 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | nuclear envelope |
| REAC:R-HSA-141444 | 8.8618645324e-12 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 8.8618645324e-12 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | Amplification of signal from the kinetochores |
| REAC:R-HSA-9679506 | 1.06105690188e-11 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | SARS-CoV Infections |
| REAC:R-HSA-68886 | 1.37830467952e-11 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | M Phase |
| REAC:R-HSA-2262752 | 1.99793787088e-11 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 2.20134995186e-11 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Cellular responses to stimuli |
| REAC:R-HSA-68882 | 2.74474546119e-11 | 0.8 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP188 NUP107 | Mitotic Anaphase |
| REAC:R-HSA-69618 | 2.8124248425e-11 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2555396 | 2.84605173904e-11 | 0.8 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP188 NUP107 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-9648025 | 3.8918945844e-11 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 6.35365763928e-11 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | Resolution of Sister Chromatid Cohesion |
| GO:0000776 | 1.07427904153e-10 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | kinetochore |
| REAC:R-HSA-5663220 | 1.18354442719e-10 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | RHO GTPases Activate Formins |
| GO:0000779 | 1.35989321426e-10 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | condensed chromosome, centromeric region |
| REAC:R-HSA-69278 | 2.21720871216e-10 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Cell Cycle, Mitotic |
| REAC:R-HSA-1280215 | 8.32304697368e-10 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Cytokine Signaling in Immune system |
| REAC:R-HSA-2467813 | 1.25571830852e-09 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | Separation of Sister Chromatids |
| REAC:R-HSA-1640170 | 1.43657923965e-09 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Cell Cycle |
| HP:0031504 | 1.88087444075e-09 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Foamy urine |
| REAC:R-HSA-68877 | 1.89410381916e-09 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | Mitotic Prometaphase |
| GO:0000775 | 1.9944811062e-09 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | chromosome, centromeric region |
| REAC:R-HSA-8953854 | 2.37127813013e-09 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Metabolism of RNA |
| GO:0000793 | 2.75988205034e-09 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | condensed chromosome |
| REAC:R-HSA-9824446 | 3.03506176372e-09 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Viral Infection Pathways |
| HP:0012579 | 5.24761387425e-09 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Minimal change glomerulonephritis |
| HP:0001967 | 1.22781890016e-08 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Diffuse mesangial sclerosis |
| HP:0002586 | 1.4320462584e-08 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Peritonitis |
| REAC:R-HSA-5663205 | 1.94018726321e-08 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Infectious disease |
| REAC:R-HSA-69620 | 2.36646145604e-08 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | Cell Cycle Checkpoints |
| HP:0001966 | 3.30015072352e-08 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal glomerular mesangium morphology |
| REAC:R-HSA-195258 | 3.58483764252e-08 | 0.7 | SEC13 NUP85 NUP133 NUP37 NUP160 NUP43 NUP107 | RHO GTPase Effectors |
| GO:0031975 | 4.76824706502e-08 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | envelope |
| GO:0031967 | 4.76824706502e-08 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | organelle envelope |
| GO:0017056 | 5.94654868871e-08 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | structural constituent of nuclear pore |
| HP:0033072 | 6.02781895598e-08 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal macroscopic urine appearance |
| CORUM:1347 | 6.73299894294e-08 | 0.3 | NUP133 NUP107 NUP160 | NPC subcomplex (NUP98, NUP107, NUP133, NUP160) |
| GO:0098687 | 1.02313495819e-07 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | chromosomal region |
| REAC:R-HSA-194315 | 1.1494530141e-07 | 0.8 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP107 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 1.3693284286e-07 | 0.8 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP107 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| HP:0002585 | 1.38752031636e-07 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal peritoneum morphology |
| HP:0000097 | 1.52583598656e-07 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Focal segmental glomerulosclerosis |
| GO:0046907 | 2.35745919768e-07 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | intracellular transport |
| GO:0140513 | 2.96585252242e-07 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | nuclear protein-containing complex |
| REAC:R-HSA-597592 | 4.67336663847e-07 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Post-translational protein modification |
| REAC:R-HSA-74160 | 7.40196169193e-07 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Gene expression (Transcription) |
| HP:0000099 | 7.52703145767e-07 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Glomerulonephritis |
| HP:0045073 | 8.05479811927e-07 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Serositis |
| HP:0000096 | 1.11547151725e-06 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Glomerular sclerosis |
| HP:0100539 | 2.25487826191e-06 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Periorbital edema |
| REAC:R-HSA-1643685 | 2.48003679545e-06 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Disease |
| HP:0012116 | 2.79291706969e-06 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal circulating albumin concentration |
| HP:0003073 | 2.79291706969e-06 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Hypoalbuminemia |
| GO:0051649 | 2.8771422133e-06 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | establishment of localization in cell |
| HP:0000123 | 3.09784436921e-06 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Nephritis |
| HP:0000282 | 5.2843900126e-06 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Facial edema |
| HP:0003774 | 6.91308859209e-06 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Stage 5 chronic kidney disease |
| REAC:R-HSA-168256 | 7.73096015038e-06 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Immune System |
| REAC:R-HSA-392499 | 8.6312875687e-06 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Metabolism of proteins |
| REAC:R-HSA-1430728 | 1.1974924094e-05 | 0.9 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | Metabolism |
| HP:0000095 | 3.71614929054e-05 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal renal glomerulus morphology |
| HP:0031263 | 3.83264686787e-05 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal renal corpuscle morphology |
| HP:0012622 | 4.19968844164e-05 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Chronic kidney disease |
| GO:0006405 | 7.27476492791e-05 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | RNA export from nucleus |
| HP:0011035 | 9.89281749782e-05 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal renal cortex morphology |
| HP:0012588 | 0.00010246210866 | 0.3 | NUP133 NUP85 NUP160 | Steroid-resistant nephrotic syndrome |
| HP:0000093 | 0.000104046876262 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Proteinuria |
| HP:0020129 | 0.000156620199235 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal urine protein level |
| HP:0012575 | 0.000163982730868 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal nephron morphology |
| GO:0006606 | 0.000202848427867 | 0.5 | NUP133 NUP188 NUP107 NUP85 SEC13 | protein import into nucleus |
| HP:0000606 | 0.000214143701954 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormality of the periorbital region |
| GO:0050657 | 0.000234290959814 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | nucleic acid transport |
| GO:0050658 | 0.000234290959814 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | RNA transport |
| HP:0000737 | 0.000253858273237 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Irritability |
| HP:0003676 | 0.000253858273237 | 0.5 | NUP133 NUP85 NUP107 AAAS NUP160 | Progressive |
| GO:0051170 | 0.000257327488908 | 0.5 | NUP133 NUP188 NUP107 NUP85 SEC13 | import into nucleus |
| GO:0051236 | 0.000269503890643 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | establishment of RNA localization |
| CORUM:6216 | 0.000307240465423 | 0.2 | SEC13 SEH1L | GATOR2 complex |
| GO:0099080 | 0.00031468296732 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | supramolecular complex |
| HP:0002027 | 0.000539276850883 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abdominal pain |
| HP:0000100 | 0.000561088173901 | 0.4 | NUP133 NUP107 NUP85 NUP160 | Nephrotic syndrome |
| HP:0002315 | 0.000610261468582 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Headache |
| GO:0051641 | 0.000659170858169 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | cellular localization |
| CORUM:6753 | 0.000859331699025 | 0.2 | SEC13 SEH1L | SOG complex |
| CORUM:6217 | 0.000859331699025 | 0.2 | SEC13 SEH1L | GATOR complex |
| GO:0006403 | 0.000910280104063 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | RNA localization |
| GO:0051168 | 0.000977627874934 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | nuclear export |
| REAC:R-HSA-162582 | 0.00111876797815 | 0.8 | SEC13 NUP85 NUP133 NUP37 AAAS NUP160 NUP43 NUP107 | Signal Transduction |
| GO:0015931 | 0.00124525151289 | 0.5 | NUP133 NUP188 NUP107 NUP85 NUP160 | nucleobase-containing compound transport |
| HP:0001945 | 0.00152888822715 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Fever |
| HP:0000083 | 0.00173770036627 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Renal insufficiency |
| HP:0003679 | 0.00270398187329 | 0.5 | NUP133 NUP85 NUP107 AAAS NUP160 | Pace of progression |
| GO:0006810 | 0.00294091790142 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | transport |
| GO:0006406 | 0.00390203518198 | 0.4 | NUP133 NUP107 NUP85 NUP160 | mRNA export from nucleus |
| GO:0072006 | 0.00495760415907 | 0.4 | NUP133 NUP107 NUP85 NUP160 | nephron development |
| HP:0011799 | 0.00498518227246 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormality of facial soft tissue |
| GO:0006999 | 0.00522556754165 | 0.3 | NUP133 NUP107 SEH1L | nuclear pore organization |
| HP:0004370 | 0.00539037375737 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormality of temperature regulation |
| GO:0051028 | 0.00555894987576 | 0.4 | NUP133 NUP107 NUP85 NUP160 | mRNA transport |
| GO:0051234 | 0.00732138304297 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | establishment of localization |
| GO:0034504 | 0.00915616686316 | 0.5 | NUP133 NUP188 NUP107 NUP85 SEC13 | protein localization to nucleus |
| HP:0033354 | 0.00928086389026 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal urine metabolite level |
| HP:0003621 | 0.0099397796534 | 0.5 | NUP133 NUP85 NUP107 AAAS NUP160 | Juvenile onset |
| GO:0005694 | 0.0129065863791 | 0.8 | SEC13 NUP85 NUP133 NUP37 SEH1L NUP160 NUP43 NUP107 | chromosome |
| HP:0010876 | 0.0145757208267 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal circulating protein concentration |
| GO:0005198 | 0.0161551189904 | 0.6 | NUP133 NUP107 SEC13 NUP160 NUP188 NUP85 | structural molecule activity |
| HP:0000969 | 0.0181434317166 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Edema |
| GO:0012505 | 0.018998349123 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | endomembrane system |
| HP:0100851 | 0.0194191639886 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal emotion |
| HP:0012211 | 0.0221816097747 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormal renal physiology |
| HP:0003110 | 0.0262654339162 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormality of urine homeostasis |
| HP:0100720 | 0.0271664548802 | 0.2 | NUP133 NUP107 | Hypoplasia of the ear cartilage |
| WP:000000 | 0.029871335992 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | WIKIPATHWAYS |
| HP:0011032 | 0.0304481050468 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Abnormality of fluid regulation |
| HP:0002086 | 0.0338184970792 | 0.7 | NUP133 NUP85 NUP37 AAAS NUP160 NUP188 NUP107 | Abnormality of the respiratory system |
| GO:0051179 | 0.0339375137834 | 1.0 | SEC13 NUP85 NUP133 SEH1L NUP37 AAAS NUP160 NUP43 NUP188 NUP107 | localization |
| HP:0011947 | 0.0343604476418 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Respiratory tract infection |
| HP:0012531 | 0.0409559899961 | 0.5 | NUP133 NUP107 NUP85 NUP160 NUP37 | Pain |
| HP:0000252 | 0.0411798868894 | 0.6 | NUP133 NUP85 NUP37 AAAS NUP188 NUP107 | Microcephaly |
| GO:0001822 | 0.0422468474482 | 0.4 | NUP133 NUP107 NUP85 NUP160 | kidney development |
| HP:0040195 | 0.043435038871 | 0.6 | NUP133 NUP85 NUP37 AAAS NUP188 NUP107 | Decreased head circumference |
| GO:0072001 | 0.0482368973245 | 0.4 | NUP133 NUP107 NUP85 NUP160 | renal system development |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NUP160 | NUP133 | 1.0 | 0.986 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| NUP133 | NUP107 | 1.0 | 0.962 |
structurally_consistent (P55735)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| NUP43 | NUP133 | 0.999 | 0.804 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NUP43 | NUP37 | 0.999 | 0.942 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NUP43 | NUP107 | 0.999 | 0.818 |
structurally_consistent (Q8WUM0)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| SEH1L | NUP133 | 0.999 | 0.78 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| SEH1L | NUP43 | 0.999 | 0.938 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| NUP160 | NUP43 | 0.999 | 0.83 |
structurally_consistent (Q9BW27)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| NUP85 | NUP133 | 0.999 | 0.962 |
structurally_consistent (Q12769)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only |
| NUP133 | NUP37 | 0.999 | 0.806 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NUP85 | NUP43 | 0.999 | 0.874 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| NUP37 | NUP107 | 0.999 | 0.822 | hein_WMM bioplex_WMM Guru bioplex3_WMM hein () Malo fraction | |
| SEC13 | NUP133 | 0.999 | 0.472 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| SEC13 | NUP43 | 0.999 | 0.286 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| NUP160 | NUP85 | 0.998 | 0.974 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SEC13 | SEH1L | 0.997 | 0.172 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 boldt_WMM | |
| SEC13 | NUP107 | 0.997 | 0.448 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| SEC13 | NUP85 | 0.997 | 0.36 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| NUP85 | NUP107 | 0.997 | 0.972 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| SEH1L | NUP37 | 0.997 | 0.83 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| SEC13 | NUP37 | 0.996 | 0.248 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| NUP160 | NUP107 | 0.996 | 0.95 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM | |
| SEC13 | NUP160 | 0.995 | 0.3 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| SEH1L | NUP107 | 0.995 | 0.802 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| SEH1L | NUP160 | 0.994 | 0.892 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| NUP85 | NUP37 | 0.994 | 0.798 |
structurally_consistent (Q12769)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| NUP160 | NUP37 | 0.994 | 0.674 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SEC13 | AAAS | 0.993 | 0.118 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SEH1L | NUP85 | 0.988 | 0.938 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| NUP188 | NUP133 | 0.987 | 0.858 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| SEH1L | AAAS | 0.983 | 0.176 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| NUP188 | NUP107 | 0.98 | 0.868 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM | |
| AAAS | NUP37 | 0.975 | 0.158 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NUP188 | NUP37 | 0.973 | 0.468 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NUP188 | AAAS | 0.957 | 0.468 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| AAAS | NUP107 | 0.957 | 0.382 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| NUP160 | NUP188 | 0.954 | 0.846 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| NUP85 | AAAS | 0.948 | 0.364 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| NUP85 | NUP188 | 0.924 | 0.842 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | |
| NUP188 | NUP43 | 0.91 | 0.488 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM | |
| NUP43 | AAAS | 0.759 | 0.41 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NUP160 | AAAS | 0.735 | 0.384 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SEC13 | NUP188 | 0.614 | 0.32 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| SEH1L | NUP188 | 0.6 | 0.652 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| NUP133 | AAAS | 0.329 | 0.484 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes