hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08500.1
Complex Portal: CPX-25027
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRP10 | Low-density lipoprotein receptor-related protein 10 (LRP-10) | 5 | UniProt NCBI |
| TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | 5 | UniProt NCBI |
| PROKR1 | Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) | 4 | UniProt NCBI |
| UGCG | Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) | 5 | UniProt NCBI |
| PTPRS | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) | 5 | UniProt NCBI |
| IL20RB | Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2) | 5 | UniProt NCBI |
| GPR3 | G-protein coupled receptor 3 (ACCA orphan receptor) | 5 | UniProt NCBI |
| SYT11 | Synaptotagmin-11 (Synaptotagmin XI) (SytXI) | 5 | UniProt NCBI |
| KCNE4 | Potassium voltage-gated channel subfamily E member 4 (MinK-related peptide 3) (Minimum potassium ion channel-related peptide 3) (Potassium channel subunit beta MiRP3) | 5 | UniProt NCBI |
| TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04061 | 0.000351394323482 | 0.3 | IL20RB TNFRSF10A TNFRSF10B | Viral protein interaction with cytokine and cytokine receptor |
| REAC:R-HSA-75158 | 0.00213354034849 | 0.2 | TNFRSF10B TNFRSF10A | TRAIL signaling |
| REAC:R-HSA-5218900 | 0.00456686801865 | 0.2 | TNFRSF10B TNFRSF10A | CASP8 activity is inhibited |
| REAC:R-HSA-69416 | 0.00456686801865 | 0.2 | TNFRSF10B TNFRSF10A | Dimerization of procaspase-8 |
| REAC:R-HSA-3371378 | 0.00456686801865 | 0.2 | TNFRSF10B TNFRSF10A | Regulation by c-FLIP |
| REAC:R-HSA-6803211 | 0.00669318453569 | 0.2 | TNFRSF10B TNFRSF10A | TP53 Regulates Transcription of Death Receptors and Ligands |
| REAC:R-HSA-140534 | 0.00790724004214 | 0.2 | TNFRSF10B TNFRSF10A | Caspase activation via Death Receptors in the presence of ligand |
| KEGG:04060 | 0.0135920515349 | 0.3 | IL20RB TNFRSF10A TNFRSF10B | Cytokine-cytokine receptor interaction |
| REAC:R-HSA-5357769 | 0.0172971739669 | 0.2 | TNFRSF10B TNFRSF10A | Caspase activation via extrinsic apoptotic signalling pathway |
| GO:0045569 | 0.0210690324038 | 0.2 | TNFRSF10B TNFRSF10A | TRAIL binding |
| KEGG:04115 | 0.0418172146224 | 0.2 | TNFRSF10B TNFRSF10A | p53 signaling pathway |
| REAC:R-HSA-5213460 | 0.04382523057 | 0.2 | TNFRSF10B TNFRSF10A | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.04382523057 | 0.2 | TNFRSF10B TNFRSF10A | Regulation of necroptotic cell death |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TNFRSF10B | LRP10 | 0.998 | 0.236 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PTPRS | KCNE4 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | UGCG | 0.991 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PTPRS | IL20RB | 0.987 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | TNFRSF10A | 0.986 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRP10 | UGCG | 0.986 | 0.186 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP10 | TNFRSF10A | 0.985 | 0.178 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PTPRS | SYT11 | 0.98 | 0.07 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LRP10 | IL20RB | 0.979 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LRP10 | KCNE4 | 0.979 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LRP10 | SYT11 | 0.97 | 0.13 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TNFRSF10B | KCNE4 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | SYT11 | 0.963 | 0.066 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TNFRSF10B | PROKR1 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10B | IL20RB | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GPR3 | TNFRSF10B | 0.962 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TNFRSF10A | UGCG | 0.953 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRP10 | PTPRS | 0.952 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| TNFRSF10B | PTPRS | 0.951 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| PTPRS | UGCG | 0.88 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| PTPRS | TNFRSF10A | 0.546 | 0.09 | bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes