hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08503.1
Complex Portal: CPX-11027
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAB7A | Ras-related protein Rab-7a (EC 3.6.5.2) | 5 | UniProt NCBI |
| RAB6A | Ras-related protein Rab-6A (Rab-6) | 5 | UniProt NCBI |
| ARL8B | ADP-ribosylation factor-like protein 8B (EC 3.6.5.2) (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1) | 5 | UniProt NCBI |
| RAB5A | Ras-related protein Rab-5A (EC 3.6.5.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8854214 | 1.28002609524e-05 | 0.75 | RAB7A RAB6A RAB5A | TBC/RABGAPs |
| REAC:R-HSA-8873719 | 5.2908776296e-05 | 0.75 | RAB7A RAB6A RAB5A | RAB geranylgeranylation |
| REAC:R-HSA-8876198 | 0.000119242757257 | 0.75 | RAB7A RAB6A RAB5A | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 0.000284930280132 | 0.75 | RAB7A RAB6A RAB5A | Rab regulation of trafficking |
| REAC:R-HSA-9636383 | 0.000368856835097 | 0.5 | RAB7A RAB5A | Prevention of phagosomal-lysosomal fusion |
| KEGG:05132 | 0.000627272119201 | 0.75 | RAB7A RAB5A ARL8B | Salmonella infection |
| REAC:R-HSA-9637687 | 0.000798898068561 | 0.5 | RAB7A RAB5A | Suppression of phagosomal maturation |
| GO:0005525 | 0.000993378785041 | 1.0 | RAB7A RAB5A RAB6A ARL8B | GTP binding |
| GO:0032561 | 0.00156892706691 | 1.0 | RAB7A RAB5A RAB6A ARL8B | guanyl ribonucleotide binding |
| GO:0019001 | 0.00160144369006 | 1.0 | RAB7A RAB5A RAB6A ARL8B | guanyl nucleotide binding |
| REAC:R-HSA-9637690 | 0.00258893271292 | 0.5 | RAB7A RAB5A | Response of Mtb to phagocytosis |
| REAC:R-HSA-9635486 | 0.00332479301982 | 0.5 | RAB7A RAB5A | Infection with Mycobacterium tuberculosis |
| GO:0003924 | 0.00366770658506 | 1.0 | RAB7A RAB5A RAB6A ARL8B | GTPase activity |
| KEGG:05146 | 0.00909742323246 | 0.5 | RAB7A RAB5A | Amoebiasis |
| KEGG:04137 | 0.0118173906169 | 0.5 | RAB7A RAB5A | Mitophagy - animal |
| GO:0019003 | 0.0152210712647 | 0.75 | RAB7A RAB5A ARL8B | GDP binding |
| WP:WP4217 | 0.0168573248614 | 0.5 | RAB7A RAB5A | Ebola virus infection in host |
| REAC:R-HSA-9824439 | 0.0174510452107 | 0.5 | RAB7A RAB5A | Bacterial Infection Pathways |
| KEGG:04148 | 0.0189154103852 | 0.5 | RAB7A RAB5A | Efferocytosis |
| GO:0017111 | 0.0191409054275 | 1.0 | RAB7A RAB5A RAB6A ARL8B | ribonucleoside triphosphate phosphatase activity |
| KEGG:04145 | 0.0214296747035 | 0.5 | RAB7A RAB5A | Phagosome |
| KEGG:05152 | 0.02620193588 | 0.5 | RAB7A RAB5A | Tuberculosis |
| GO:0016818 | 0.0305291540849 | 1.0 | RAB7A RAB5A RAB6A ARL8B | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 0.0305291540849 | 1.0 | RAB7A RAB5A RAB6A ARL8B | hydrolase activity, acting on acid anhydrides |
| GO:0016462 | 0.0305291540849 | 1.0 | RAB7A RAB5A RAB6A ARL8B | pyrophosphatase activity |
| HPA:0020053 | 0.0309381158894 | 1.0 | RAB7A RAB5A RAB6A ARL8B | adrenal gland; glandular cells[High] |
| GO:0035639 | 0.0326761482103 | 1.0 | RAB7A RAB5A RAB6A ARL8B | purine ribonucleoside triphosphate binding |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | RAB7A RAB6A RAB5A | Membrane Trafficking |
| CORUM:2572 | 0.049938562206 | 0.25 | RAB5A | RAB5-EEA1 complex |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | RAB7A RAB6A RAB5A | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ARL8B | RAB7A | 0.97 | 0.482 | bioplex_WMM Guru bioplex3_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM | |
| RAB5A | RAB7A | 0.968 | 0.346 | bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| RAB7A | RAB6A | 0.96 | 0.396 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| RAB5A | RAB6A | 0.953 | 0.342 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| ARL8B | RAB6A | 0.415 | 0.25 | bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| ARL8B | RAB5A | 0.001 | 0.366 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes