hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08525.1

Complex Portal: CPX-17513

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PIGR	Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]	5	UniProt NCBI
MUC5AC	Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM)	5	UniProt NCBI
JCHAIN	Immunoglobulin J chain (Joining chain of multimeric IgA and IgM)	5	UniProt NCBI
LYZ	Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)	5	UniProt NCBI
PABIR3	PABIR family member 1	4	UniProt NCBI
SPNS3	Protein spinster homolog 3	4	UniProt NCBI
BPIFA1	BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl)	5	UniProt NCBI
MUC5B	Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin)	5	UniProt NCBI
BPIFB1	BPI fold-containing family B member 1 (Long palate, lung and nasal epithelium carcinoma-associated protein 1) (von Ebner minor salivary gland protein) (VEMSGP)	5	UniProt NCBI
LTF	Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C]	5	UniProt NCBI
DMBT1	Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	5	UniProt NCBI
ZG16B	Pancreatic adenocarcinoma up-regulated factor (Zymogen granule protein 16 homolog B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04970	8.37906789245e-06	0.333333333333	DMBT1 MUC5B MUC5AC LYZ	Salivary secretion
REAC:R-HSA-6803157	2.73190159893e-05	0.333333333333	BPIFB1 LYZ LTF BPIFA1	Antimicrobial peptides
GO:0019730	0.000255001844134	0.416666666667	LTF DMBT1 BPIFA1 JCHAIN LYZ	antimicrobial humoral response
REAC:R-HSA-168249	0.000490887344577	0.583333333333	BPIFB1 PIGR MUC5B LTF LYZ BPIFA1 MUC5AC	Innate Immune System
GO:0019731	0.00227976807463	0.333333333333	LTF DMBT1 JCHAIN BPIFA1	antibacterial humoral response
GO:0042742	0.00622029696174	0.416666666667	LTF DMBT1 BPIFA1 JCHAIN LYZ	defense response to bacterium
GO:0006959	0.0068098021003	0.416666666667	LTF DMBT1 BPIFA1 JCHAIN LYZ	humoral immune response
REAC:R-HSA-5083625	0.00752983260265	0.166666666667	MUC5AC MUC5B	Defective GALNT3 causes HFTC
REAC:R-HSA-5083636	0.00752983260265	0.166666666667	MUC5AC MUC5B	Defective GALNT12 causes CRCS1
REAC:R-HSA-5083632	0.00919893032747	0.166666666667	MUC5AC MUC5B	Defective C1GALT1C1 causes TNPS
REAC:R-HSA-977068	0.0200246560632	0.166666666667	MUC5AC MUC5B	Termination of O-glycan biosynthesis
REAC:R-HSA-5621480	0.0200246560632	0.166666666667	MUC5AC MUC5B	Dectin-2 family
GO:1900229	0.0309012475255	0.166666666667	BPIFA1 LTF	negative regulation of single-species biofilm formation in or on host organism
GO:1900228	0.0309012475255	0.166666666667	BPIFA1 LTF	regulation of single-species biofilm formation in or on host organism
GO:0071745	0.0309012475255	0.166666666667	PIGR JCHAIN	IgA immunoglobulin complex
GO:0098630	0.0309012475255	0.166666666667	BPIFA1 LTF	aggregation of unicellular organisms
GO:0044407	0.0309012475255	0.166666666667	BPIFA1 LTF	single-species biofilm formation in or on host organism
GO:0044010	0.0309012475255	0.166666666667	BPIFA1 LTF	single-species biofilm formation
GO:0042710	0.0309012475255	0.166666666667	BPIFA1 LTF	biofilm formation
GO:0071751	0.0309012475255	0.166666666667	PIGR JCHAIN	secretory IgA immunoglobulin complex
GO:0071749	0.0309012475255	0.166666666667	PIGR JCHAIN	polymeric IgA immunoglobulin complex
GO:0071746	0.0309012475255	0.166666666667	PIGR JCHAIN	IgA immunoglobulin complex, circulating
GO:1900191	0.0309012475255	0.166666666667	BPIFA1 LTF	negative regulation of single-species biofilm formation
GO:1900190	0.0309012475255	0.166666666667	BPIFA1 LTF	regulation of single-species biofilm formation
REAC:R-HSA-168256	0.0342645501665	0.583333333333	BPIFB1 PIGR MUC5B LTF LYZ BPIFA1 MUC5AC	Immune System

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PIGR	BPIFA1	0.994
PIGR	ZG16B	0.993		structurally_consistent (Q6B0K9)
DMBT1	SPNS3	0.992
DMBT1	PABIR3	0.992
PIGR	JCHAIN	0.992	0.17	structurally_consistent (dimer)
BPIFA1	LTF	0.989
PIGR	LTF	0.988	0.148
PIGR	LYZ	0.988	0.162
BPIFA1	MUC5B	0.985
MUC5B	SPNS3	0.983
BPIFA1	ZG16B	0.981
BPIFA1	PABIR3	0.981
PIGR	MUC5B	0.98	0.1166
PIGR	DMBT1	0.979	0.182
BPIFA1	MUC5AC	0.978
PIGR	BPIFB1	0.977
DMBT1	JCHAIN	0.976	0.368
PIGR	MUC5AC	0.976	0.1706
BPIFA1	BPIFB1	0.975
BPIFA1	DMBT1	0.975
LTF	JCHAIN	0.974	0.342
JCHAIN	PABIR3	0.974
MUC5B	BPIFB1	0.973
BPIFA1	SPNS3	0.973
BPIFB1	SPNS3	0.972
MUC5B	DMBT1	0.971	0.102
LTF	BPIFB1	0.971
ZG16B	JCHAIN	0.97		structurally_consistent (Q6B0K9)
BPIFA1	JCHAIN	0.968
ZG16B	LYZ	0.968
DMBT1	MUC5AC	0.968	0.236
LYZ	PABIR3	0.966
PIGR	SPNS3	0.966
LTF	MUC5AC	0.965	0.152
BPIFA1	LYZ	0.965
MUC5B	LTF	0.963	0.084
ZG16B	LTF	0.963		structurally_consistent (Q6B0K9)
JCHAIN	BPIFB1	0.96
MUC5B	LYZ	0.959	0.024
DMBT1	LTF	0.958	0.406
MUC5B	MUC5AC	0.956	0.264
LYZ	SPNS3	0.956
LTF	LYZ	0.955	0.114
MUC5AC	LYZ	0.952	0.066
ZG16B	BPIFB1	0.95		structurally_consistent (Q6B0K9)
ZG16B	MUC5AC	0.947
MUC5AC	JCHAIN	0.946	0.168
MUC5B	ZG16B	0.942
DMBT1	BPIFB1	0.929
DMBT1	ZG16B	0.928
ZG16B	SPNS3	0.928
LTF	PABIR3	0.927
LTF	SPNS3	0.924
MUC5B	JCHAIN	0.911	0.104
DMBT1	LYZ	0.893	0.202
MUC5AC	BPIFB1	0.891
JCHAIN	LYZ	0.792	0.246
LYZ	BPIFB1	0.612
MUC5B	PABIR3	0.059
PIGR	PABIR3	0.021
ZG16B	PABIR3	0.017

Related Complexes

Genename	Complexes
PIGR	huMAP3_00693.1 huMAP3_02710.1 huMAP3_06906.1 huMAP3_07637.1 huMAP3_08525.1 huMAP3_08928.1 huMAP3_10720.1 huMAP3_11343.1 huMAP3_13577.1
MUC5AC	huMAP3_01756.1 huMAP3_06906.1 huMAP3_08525.1 huMAP3_11343.1
JCHAIN	huMAP3_02710.1 huMAP3_06906.1 huMAP3_07637.1 huMAP3_08525.1 huMAP3_08928.1 huMAP3_10720.1 huMAP3_11343.1 huMAP3_13577.1
LYZ	huMAP3_02710.1 huMAP3_08525.1 huMAP3_08928.1 huMAP3_10720.1 huMAP3_11343.1 huMAP3_13577.1
PABIR3	huMAP3_05272.1 huMAP3_06906.1 huMAP3_07001.1 huMAP3_08525.1 huMAP3_11343.1
SPNS3	huMAP3_08525.1 huMAP3_11343.1 huMAP3_11475.1 huMAP3_14701.1
BPIFA1	huMAP3_00693.1 huMAP3_06906.1 huMAP3_08525.1 huMAP3_11343.1
MUC5B	huMAP3_00693.1 huMAP3_06906.1 huMAP3_08525.1 huMAP3_11343.1 huMAP3_13577.1
BPIFB1	huMAP3_06906.1 huMAP3_08525.1 huMAP3_11343.1
LTF	huMAP3_01756.1 huMAP3_08525.1 huMAP3_11343.1
DMBT1	huMAP3_00693.1 huMAP3_06906.1 huMAP3_08525.1 huMAP3_11343.1
ZG16B	huMAP3_00693.1 huMAP3_02710.1 huMAP3_06906.1 huMAP3_07637.1 huMAP3_08525.1 huMAP3_08928.1 huMAP3_10720.1 huMAP3_11343.1 huMAP3_13577.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08525.1

Complex Portal: CPX-17513