hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08540.1

Complex Portal: CPX-20393

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
AP2M1	AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)	5	UniProt NCBI
RALBP1	RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1)	5	UniProt NCBI
AP2S1	AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)	5	UniProt NCBI
AP2A2	AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)	5	UniProt NCBI
ITSN2	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)	5	UniProt NCBI
AAGAB	Alpha- and gamma-adaptin-binding protein p34	5	UniProt NCBI
EPS15L1	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	5	UniProt NCBI
EPS15	Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)	5	UniProt NCBI
AP1S1	AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)	5	UniProt NCBI
AP1B1	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	5	UniProt NCBI
AP2B1	AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)	5	UniProt NCBI
CCDC32	Coiled-coil domain-containing protein 32	5	UniProt NCBI
CALCOCO1	Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)	5	UniProt NCBI
NECAP2	Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)	4	UniProt NCBI
FCHO2	F-BAR domain only protein 2	5	UniProt NCBI
ITSN1	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)	5	UniProt NCBI
AP2A1	AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)	5	UniProt NCBI
NECAP1	Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1)	4	UniProt NCBI
STON2	Stonin-2 (Stoned B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0030118	4.93266426195e-23	0.631578947368	EPS15L1 STON2 NECAP1 AP2A2 NECAP2 AP2S1 AP2A1 AP1S1 AP2B1 AP2M1 AP1B1 EPS15	clathrin coat
GO:0005905	7.04354008307e-23	0.631578947368	EPS15L1 STON2 ITSN1 AP2A2 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 CCDC32 EPS15 FCHO2	clathrin-coated pit
REAC:R-HSA-8856825	1.06997615005e-22	0.684210526316	ITSN2 STON2 ITSN1 EPS15L1 NECAP2 AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 NECAP1 EPS15 FCHO2	Cargo recognition for clathrin-mediated endocytosis
REAC:R-HSA-8856828	1.3831063641e-20	0.684210526316	ITSN2 STON2 ITSN1 EPS15L1 NECAP2 AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 NECAP1 EPS15 FCHO2	Clathrin-mediated endocytosis
GO:0030125	7.49386289734e-19	0.526315789474	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1	clathrin vesicle coat
GO:0048475	2.18994703351e-18	0.631578947368	EPS15L1 STON2 NECAP1 AP2A2 NECAP2 AP2S1 AP2A1 AP1S1 AP2B1 AP2M1 AP1B1 EPS15	coated membrane
GO:0030117	2.18994703351e-18	0.631578947368	EPS15L1 STON2 NECAP1 AP2A2 NECAP2 AP2S1 AP2A1 AP1S1 AP2B1 AP2M1 AP1B1 EPS15	membrane coat
GO:0030132	3.6206988023e-17	0.421052631579	EPS15L1 STON2 AP2A2 AP2S1 AP2A1 AP2B1 AP2M1 EPS15	clathrin coat of coated pit
GO:0072583	4.16623903453e-17	0.526315789474	ITSN2 STON2 ITSN1 AP2A2 AP2S1 AP2A1 AP2B1 AP2M1 CCDC32 FCHO2	clathrin-dependent endocytosis
REAC:R-HSA-199991	6.67504759039e-16	0.789473684211	ITSN2 STON2 ITSN1 EPS15L1 NECAP2 AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 NECAP1 AP1B1 AP1S1 EPS15 FCHO2	Membrane Trafficking
REAC:R-HSA-5653656	1.51022151469e-15	0.789473684211	ITSN2 STON2 ITSN1 EPS15L1 NECAP2 AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 NECAP1 AP1B1 AP1S1 EPS15 FCHO2	Vesicle-mediated transport
GO:0030120	1.59041527024e-15	0.526315789474	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1	vesicle coat
GO:0030131	3.18785971213e-15	0.421052631579	AP2A2 STON2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	clathrin adaptor complex
GO:0006897	3.56440664382e-15	0.789473684211	AP2A2 STON2 ITSN1 ITSN2 NECAP2 AP2S1 AP2A1 EPS15L1 AP1S1 RALBP1 AP2B1 AP2M1 CCDC32 EPS15 FCHO2	endocytosis
GO:0006898	3.82223929123e-14	0.631578947368	ITSN2 STON2 ITSN1 AP2A2 AP2S1 AP2A1 AP1S1 AP2B1 AP2M1 CCDC32 EPS15 FCHO2	receptor-mediated endocytosis
REAC:R-HSA-164938	6.15425268714e-14	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
GO:0030136	2.03720808768e-13	0.578947368421	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1 FCHO2	clathrin-coated vesicle
GO:0098657	2.06510349605e-13	0.789473684211	AP2A2 STON2 ITSN1 ITSN2 NECAP2 AP2S1 AP2A1 EPS15L1 AP1S1 RALBP1 AP2B1 AP2M1 CCDC32 EPS15 FCHO2	import into cell
GO:0030665	2.6038947621e-13	0.526315789474	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1	clathrin-coated vesicle membrane
REAC:R-HSA-164952	4.67975106326e-13	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	The role of Nef in HIV-1 replication and disease pathogenesis
GO:0016192	5.10076001246e-13	0.894736842105	AP2A2 STON2 ITSN1 ITSN2 NECAP2 AP2S1 AP2A1 EPS15L1 AP1S1 RALBP1 AP2B1 CCDC32 AP2M1 NECAP1 AP1B1 EPS15 FCHO2	vesicle-mediated transport
GO:0030119	1.6952063256e-12	0.421052631579	AP2A2 STON2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	AP-type membrane coat adaptor complex
GO:0030122	2.80499724506e-12	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	AP-2 adaptor complex
GO:0030128	2.80499724506e-12	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	clathrin coat of endocytic vesicle
REAC:R-HSA-182218	1.3145233151e-11	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Nef Mediated CD8 Down-regulation
GO:0030135	2.76832388958e-11	0.578947368421	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1 FCHO2	coated vesicle
GO:0030662	3.32415217576e-11	0.526315789474	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1	coated vesicle membrane
REAC:R-HSA-167590	7.87454740223e-11	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Nef Mediated CD4 Down-regulation
GO:0099003	2.03207553689e-10	0.473684210526	ITSN2 STON2 ITSN1 AP2A2 AP2S1 AP2A1 AP2B1 FCHO2 AP2M1	vesicle-mediated transport in synapse
GO:0035615	2.99461549368e-10	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	clathrin adaptor activity
REAC:R-HSA-177504	4.93786522115e-10	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Retrograde neurotrophin signalling
GO:0140312	4.98721763204e-10	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	cargo adaptor activity
REAC:R-HSA-5140745	8.01762186962e-10	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
REAC:R-HSA-5099900	1.8677909382e-09	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	WNT5A-dependent internalization of FZD4
GO:0140239	2.19525393622e-09	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	postsynaptic endocytosis
GO:0098884	2.19525393622e-09	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	postsynaptic neurotransmitter receptor internalization
REAC:R-HSA-8866427	2.71461657983e-09	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	VLDLR internalisation and degradation
GO:0048488	3.94224435976e-09	0.368421052632	ITSN1 STON2 ITSN2 AP2S1 AP2B1 FCHO2 AP2M1	synaptic vesicle endocytosis
GO:0140238	3.94224435976e-09	0.368421052632	ITSN1 STON2 ITSN2 AP2S1 AP2B1 FCHO2 AP2M1	presynaptic endocytosis
REAC:R-HSA-8964038	5.31632055653e-09	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	LDL clearance
WP:WP4159	1.09855621301e-08	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	GABA receptor signaling
GO:0036465	1.52857337681e-08	0.368421052632	ITSN1 STON2 ITSN2 AP2S1 AP2B1 FCHO2 AP2M1	synaptic vesicle recycling
REAC:R-HSA-2132295	2.44926574751e-08	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	MHC class II antigen presentation
REAC:R-HSA-162909	3.91532549012e-08	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	Host Interactions of HIV factors
WP:WP437	4.45305972214e-08	0.368421052632	EPS15L1 AP2B1 AP2S1 AP2A1 RALBP1 AP2M1 EPS15	EGF EGFR signaling pathway
GO:0099590	8.24623491931e-08	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	neurotransmitter receptor internalization
REAC:R-HSA-8964043	1.23560273413e-07	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Plasma lipoprotein clearance
KEGG:04961	1.80797373271e-07	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Endocrine and other factor-regulated calcium reabsorption
REAC:R-HSA-2682334	1.98501168112e-07	0.315789473684	AP2A1 ITSN1 AP2S1 AP2A2 AP2B1 AP2M1	EPH-Ephrin signaling
WP:WP2267	2.45041121261e-07	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Synaptic vesicle pathway
KEGG:04144	5.61599143962e-07	0.368421052632	EPS15L1 AP2A2 AP2S1 AP2A1 AP2B1 AP2M1 EPS15	Endocytosis
KEGG:04721	6.37057978032e-07	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Synaptic vesicle cycle
REAC:R-HSA-3928665	6.59988021608e-07	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	EPH-ephrin mediated repulsion of cells
REAC:R-HSA-437239	8.31701893893e-07	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Recycling pathway of L1
GO:0036020	8.87825532941e-07	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	endolysosome membrane
GO:0099504	1.89351842345e-06	0.368421052632	ITSN1 STON2 ITSN2 AP2S1 AP2B1 FCHO2 AP2M1	synaptic vesicle cycle
REAC:R-HSA-162906	2.12569205172e-06	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	HIV Infection
GO:0006810	2.89933718131e-06	0.894736842105	AP2A2 STON2 ITSN1 ITSN2 NECAP2 AP2S1 AP2A1 EPS15L1 AP1S1 RALBP1 AP2B1 CCDC32 AP2M1 NECAP1 AP1B1 EPS15 FCHO2	transport
REAC:R-HSA-174824	3.27684313251e-06	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Plasma lipoprotein assembly, remodeling, and clearance
GO:0030669	4.81998998358e-06	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	clathrin-coated endocytic vesicle membrane
GO:0098796	6.26285523919e-06	0.631578947368	EPS15L1 STON2 NECAP1 AP2A2 NECAP2 AP2S1 AP2A1 AP1S1 AP2B1 AP2M1 AP1B1 EPS15	membrane protein complex
GO:0036019	8.30536578803e-06	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	endolysosome
GO:0051234	1.31304386291e-05	0.894736842105	AP2A2 STON2 ITSN1 ITSN2 NECAP2 AP2S1 AP2A1 EPS15L1 AP1S1 RALBP1 AP2B1 CCDC32 AP2M1 NECAP1 AP1B1 EPS15 FCHO2	establishment of localization
GO:0045334	1.62270563855e-05	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	clathrin-coated endocytic vesicle
GO:0099072	1.74243417512e-05	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	regulation of postsynaptic membrane neurotransmitter receptor levels
REAC:R-HSA-9679191	1.92904532615e-05	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Potential therapeutics for SARS
REAC:R-HSA-4086400	2.72179442897e-05	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	PCP/CE pathway
REAC:R-HSA-187037	3.75377856081e-05	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Signaling by NTRK1 (TRKA)
REAC:R-HSA-373760	4.8320739781e-05	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	L1CAM interactions
CORUM:3231	6.11162772017e-05	0.105263157895	STON2 EPS15	Eps15-stonin2 complex
REAC:R-HSA-166520	8.4350807918e-05	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Signaling by NTRKs
GO:0051179	0.000164476524435	0.894736842105	AP2A2 STON2 ITSN1 ITSN2 NECAP2 AP2S1 AP2A1 EPS15L1 AP1S1 RALBP1 AP2B1 CCDC32 AP2M1 NECAP1 AP1B1 EPS15 FCHO2	localization
REAC:R-HSA-3858494	0.000203193656595	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Beta-catenin independent WNT signaling
REAC:R-HSA-9006934	0.000208287630876	0.368421052632	EPS15L1 AP2A2 AP2S1 AP2A1 AP2B1 AP2M1 EPS15	Signaling by Receptor Tyrosine Kinases
GO:0097708	0.000353740173911	0.684210526316	ITSN2 STON2 ITSN1 AP2A2 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 NECAP1 AP1B1 AP1S1 FCHO2	intracellular vesicle
CORUM:247	0.000366129100924	0.105263157895	RALBP1 AP2A1	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex
CORUM:7476	0.000366129100924	0.105263157895	AP1B1 AP1S1	AP1B1-AP1G2-AP1M-1AP1S1 complex
GO:0030659	0.00036630669734	0.526315789474	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1	cytoplasmic vesicle membrane
GO:0012506	0.000426630196151	0.526315789474	AP2A2 STON2 NECAP1 NECAP2 AP2S1 AP2A1 AP2B1 AP2M1 AP1B1 AP1S1	vesicle membrane
WP:WP4829	0.000834942166448	0.157894736842	AP2A2 AP2A1 AP2B1	mBDNF and proBDNF regulation of GABA neurotransmission
GO:0098797	0.000975545267946	0.421052631579	EPS15L1 STON2 AP2A2 AP2S1 AP2A1 AP2B1 AP2M1 EPS15	plasma membrane protein complex
GO:0030666	0.00109268877839	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	endocytic vesicle membrane
KEGG:05016	0.00115556985084	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Huntington disease
WP:WP4549	0.00135245186565	0.210526315789	AP2S1 AP2A1 AP2M1 AP2B1	Fragile X syndrome
CORUM:36	0.00170330895109	0.105263157895	AP1B1 AP1S1	AP1 adaptor complex
REAC:R-HSA-5663205	0.00182133108374	0.421052631579	AP2A2 AP2A1 AP2S1 AP1S1 AP2B1 AP2M1 AP1B1 EPS15	Infectious disease
CORUM:144	0.00218827065477	0.105263157895	AP1B1 AP1S1	Gamma-BAR-AP1 complex
REAC:R-HSA-1280218	0.00361813067917	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	Adaptive Immune System
GO:0031623	0.00429909303122	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	receptor internalization
GO:0098852	0.00515567773167	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	lytic vacuole membrane
GO:0005765	0.00515567773167	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	lysosomal membrane
REAC:R-HSA-9824446	0.00525013019277	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	Viral Infection Pathways
REAC:R-HSA-422475	0.00702618619237	0.315789473684	AP2A1 ITSN1 AP2S1 AP2A2 AP2B1 AP2M1	Axon guidance
GO:0005829	0.00780731889926	0.894736842105	FCHO2 AP2A2 STON2 ITSN1 ITSN2 AP2S1 AP2A1 CALCOCO1 EPS15L1 AP1S1 RALBP1 AP2B1 AAGAB NECAP1 AP1B1 EPS15 AP2M1	cytosol
REAC:R-HSA-9675108	0.00864282892595	0.315789473684	AP2A1 ITSN1 AP2S1 AP2A2 AP2B1 AP2M1	Nervous system development
GO:0005774	0.00869763520718	0.368421052632	AP2A2 AP2A1 AP2S1 AP2B1 AP2M1 AP1B1 AP1S1	vacuolar membrane
REAC:R-HSA-195721	0.00923246215338	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	Signaling by WNT
GO:0051649	0.00996978427252	0.578947368421	ITSN2 STON2 ITSN1 EPS15L1 AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 EPS15 FCHO2	establishment of localization in cell
REAC:R-HSA-432722	0.0132661818612	0.157894736842	AP1B1 AP1S1 NECAP1	Golgi Associated Vesicle Biogenesis
HPA:0050011	0.0135429290043	0.578947368421	AP2A2 ITSN1 EPS15L1 NECAP2 AP1B1 AP2A1 CALCOCO1 AP1S1 STON2 AAGAB EPS15	breast; adipocytes[>=Low]
GO:0030130	0.0203399151593	0.157894736842	AP1B1 AP1S1 AP2A1	clathrin coat of trans-Golgi network vesicle
REAC:R-HSA-162582	0.0212190849404	0.526315789474	AP2A2 ITSN1 ITSN2 AP2S1 AP2A1 EPS15L1 RALBP1 AP2B1 AP2M1 EPS15	Signal Transduction
REAC:R-HSA-164940	0.0214402096475	0.105263157895	AP1B1 AP1S1	Nef mediated downregulation of MHC class I complex cell surface expression
GO:0031503	0.0223068838654	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	protein-containing complex localization
GO:0048268	0.0264201745208	0.157894736842	AP2S1 EPS15 FCHO2	clathrin coat assembly
REAC:R-HSA-9679506	0.0283692302195	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	SARS-CoV Infections
GO:0051641	0.0288703937757	0.684210526316	ITSN2 STON2 ITSN1 EPS15L1 AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 AP1B1 AP1S1 EPS15 FCHO2	cellular localization
REAC:R-HSA-199992	0.0288948400375	0.157894736842	AP1B1 AP1S1 NECAP1	trans-Golgi Network Vesicle Budding
GO:0060090	0.0290648766826	0.473684210526	ITSN2 STON2 ITSN1 AP2A2 AP2S1 AP2A1 AP2B1 AP2M1 CALCOCO1	molecular adaptor activity
GO:0030139	0.0305221156219	0.315789473684	AP2A1 STON2 AP2S1 AP2A2 AP2B1 AP2M1	endocytic vesicle
GO:0012510	0.0335980618564	0.157894736842	AP1B1 AP1S1 AP2A1	trans-Golgi network transport vesicle membrane
HPA:0100212	0.0365814358307	0.526315789474	ITSN2 EPS15L1 AP1B1 AP2A1 CALCOCO1 AP2A2 RALBP1 AP2B1 AAGAB EPS15	cerebral cortex; neuropil[>=Medium]
GO:0009898	0.0405921692043	0.263157894737	AP2A1 AP2S1 AP2B1 AP2M1 AP2A2	cytoplasmic side of plasma membrane
HP:0011967	0.0495852161318	0.105263157895	AP1B1 AP1S1	Decreased circulating copper concentration

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
AP2A2	AP2M1	1.0	0.418	mixed_interface
AP2S1	AP2A1	1.0	0.71	structurally_consistent (dimer)
AP2B1	AP2A1	1.0	0.93	structurally_consistent (dimer)
AP2M1	EPS15	1.0	0.25
AP2A2	AP2B1	1.0	0.336153846154
AP2S1	AP2M1	1.0	0.706	mixed_interface
AP2B1	AP2S1	1.0	0.7	structurally_consistent (O95782)
NECAP2	AP2M1	1.0	0.1	structurally_consistent (dimer)
AP2A2	AP2S1	1.0	0.282	structurally_consistent (dimer)
ITSN1	AP2M1	1.0
CCDC32	AP2S1	1.0	0.13	structurally_consistent (dimer)
AP2S1	EPS15	1.0	0.104	structurally_consistent (dimer)
AP2B1	EPS15	1.0	0.186
AP2B1	AP2M1	1.0	0.826	structurally_consistent (dimer)
AP2B1	NECAP2	1.0	0.09	mutually_exclusive (Q96CW1)
AP2S1	AP1B1	1.0	0.258
NECAP2	AP2A1	1.0	0.184
EPS15L1	AP2M1	1.0	0.186
AP2M1	AP1B1	1.0	0.384	structurally_consistent (dimer)
AP2M1	CALCOCO1	1.0	0.102
NECAP2	AP1B1	0.999	0.14	mutually_exclusive (Q96CW1)
EPS15L1	EPS15	0.999	0.182	mutually_exclusive (Q59EK9)
AP2B1	AP1B1	0.999	0.718	mutually_exclusive (Q9Y6Q5)
EPS15L1	AP2S1	0.999	0.222
EPS15L1	AP2A1	0.999	0.32
AP2A2	NECAP2	0.999	0.138416666667
AP1B1	AP2A1	0.999	0.49
ITSN1	AP2S1	0.999
CCDC32	AAGAB	0.999	0.11	mutually_exclusive (P53680)
AP2B1	ITSN1	0.999
NECAP2	AP2S1	0.999	0.076	structurally_consistent (dimer)
AP2M1	AP2A1	0.999	0.956	mutually_exclusive (P53680)
AP2A2	AAGAB	0.999	0.1305
EPS15L1	FCHO2	0.999	0.138
AP2B1	STON2	0.999	0.134
AP2A2	EPS15L1	0.999	0.313555555556
AP2B1	EPS15L1	0.999	0.446
EPS15	AP2A1	0.999	0.186
AP2S1	FCHO2	0.999	0.074	structurally_consistent (dimer)
AP2B1	FCHO2	0.999	0.114
FCHO2	EPS15	0.998	0.142545454545
AAGAB	AP2S1	0.998	0.058	structurally_consistent (dimer)
AP2A2	AP1B1	0.998	0.266	mutually_exclusive (O43747)
EPS15L1	ITSN1	0.998
FCHO2	AP2A1	0.998	0.188275862069
AP2S1	STON2	0.998	0.09
AP2A2	CCDC32	0.998	0.13
RALBP1	AP2A1	0.998	0.14
AAGAB	AP2A1	0.998	0.1085
AP2M1	RALBP1	0.997	0.116	structurally_consistent (dimer)
FCHO2	STON2	0.997	0.066
AP1B1	EPS15	0.997	0.198
AP2A1	STON2	0.997	0.162
ITSN2	EPS15L1	0.997	0.118
EPS15L1	AP1B1	0.997	0.38
ITSN1	AP1B1	0.996
ITSN2	AP2M1	0.996	0.166
AP2A2	EPS15	0.996	0.218
NECAP2	NECAP1	0.996	0.076
EPS15	STON2	0.995	0.11
FCHO2	AP1B1	0.994	0.208
AP2A2	AP2A1	0.994	0.3585
CCDC32	AP2A1	0.994	0.132
AP2M1	STON2	0.994	0.138
AP2S1	RALBP1	0.993	0.204
CALCOCO1	RALBP1	0.992	0.14
AP2M1	AP1S1	0.992	0.078
AP2M1	NECAP1	0.99	0.158	structurally_consistent (dimer)
AAGAB	AP2M1	0.99	0.086	mutually_exclusive (P53680)
AP2B1	NECAP1	0.989	0.108
AP2B1	AP1S1	0.989	0.186
CCDC32	AP2M1	0.989	0.104	mutually_exclusive (P53680)
FCHO2	AP2M1	0.987	0.104	structurally_consistent (dimer)
RALBP1	EPS15	0.986	0.09
AP1S1	AP1B1	0.985	0.112	mutually_exclusive (O43747)
FCHO2	NECAP1	0.985	0.102
EPS15L1	RALBP1	0.985	0.126
AP2B1	RALBP1	0.985	0.124	mutually_exclusive (Q96CW1)
ITSN2	ITSN1	0.985
AP1B1	NECAP1	0.984	0.278	structurally_consistent (dimer)
AP1B1	RALBP1	0.983	0.16	mutually_exclusive (Q96CW1)
ITSN2	AP2S1	0.982	0.084
AP2A2	STON2	0.982	0.166
FCHO2	AP1S1	0.982	0.068
AP2B1	AAGAB	0.981	0.13
RALBP1	STON2	0.98	0.138
AP2B1	CALCOCO1	0.98	0.068
AP2A2	RALBP1	0.978	0.168
AP2A2	ITSN1	0.976
ITSN2	AP2A1	0.975	0.18
ITSN1	RALBP1	0.975
AP1B1	STON2	0.974	0.174
AP2B1	CCDC32	0.974	0.06
ITSN2	AP1B1	0.973	0.126
NECAP1	STON2	0.97	0.108
EPS15L1	STON2	0.97	0.122
AP1S1	NECAP1	0.968	0.048	structurally_consistent (Q9Y6Q5)
NECAP1	EPS15	0.965	0.146
AP2A2	ITSN2	0.963	0.36
AP2A2	FCHO2	0.959	0.146
ITSN1	EPS15	0.959
AP1S1	RALBP1	0.958	0.062
ITSN1	STON2	0.957
ITSN2	AP2B1	0.957	0.082
ITSN1	AP2A1	0.955
AAGAB	AP1S1	0.948	0.038	mutually_exclusive (O75843) structurally_consistent (dimer)
FCHO2	RALBP1	0.947	0.078
AP1S1	STON2	0.945	0.074
ITSN2	EPS15	0.935	0.15
ITSN2	FCHO2	0.932	0.052
AP1S1	AP2A1	0.929	0.204	structurally_consistent (dimer)
AP2A2	AP1S1	0.929	0.158235294118	structurally_consistent (O43747) structurally_consistent (dimer)
NECAP2	EPS15L1	0.927	0.096
NECAP1	RALBP1	0.924	0.142	mutually_exclusive (Q96CW1)
NECAP2	ITSN1	0.913
AAGAB	AP1B1	0.907	0.066
NECAP1	AP2A1	0.898	0.168	mutually_exclusive (P53680)
AP2S1	AP1S1	0.876	0.1
NECAP2	RALBP1	0.846	0.138	mutually_exclusive (Q96CW1)
CCDC32	AP1B1	0.845	0.092
ITSN1	FCHO2	0.831
NECAP2	EPS15	0.81	0.17
AP2S1	CALCOCO1	0.781	0.078
NECAP2	FCHO2	0.761	0.042	structurally_consistent (Q96CW1)
ITSN1	AP1S1	0.732
NECAP2	CALCOCO1	0.722	0.026
AP1B1	CALCOCO1	0.717	0.11
AAGAB	FCHO2	0.702	0.04
AAGAB	ITSN1	0.656
CCDC32	ITSN1	0.617
AP2S1	NECAP1	0.615	0.082	structurally_consistent (dimer)
CALCOCO1	EPS15	0.605	0.078
ITSN2	STON2	0.595	0.1
CCDC32	FCHO2	0.572	0.052
AP1S1	EPS15	0.569	0.096
CCDC32	EPS15	0.563	0.026
AP2A2	CALCOCO1	0.552	0.120597222222
ITSN1	CALCOCO1	0.51
NECAP2	STON2	0.487	0.064
CALCOCO1	AP2A1	0.479	0.112
CCDC32	EPS15L1	0.475	0.202
AP2A2	NECAP1	0.475	0.16	mutually_exclusive (P53680)
ITSN2	AP1S1	0.471	0.074
EPS15L1	NECAP1	0.43	0.158
AAGAB	EPS15	0.427	0.038
AAGAB	EPS15L1	0.415	0.066
ITSN1	NECAP1	0.36
NECAP2	AP1S1	0.353	0.048
ITSN2	NECAP1	0.353	0.092
EPS15L1	AP1S1	0.322	0.068
CCDC32	STON2	0.305	0.06
ITSN2	CALCOCO1	0.29	0.044
EPS15L1	CALCOCO1	0.258	0.088
AAGAB	RALBP1	0.24	0.034
ITSN2	RALBP1	0.231	0.07
AAGAB	NECAP2	0.18	0.03	mutually_exclusive (P53680)
CCDC32	NECAP2	0.172	0.086	mutually_exclusive (P53680)
CCDC32	RALBP1	0.164	0.128
NECAP1	CALCOCO1	0.163	0.142
AP1S1	CALCOCO1	0.162	0.064
AAGAB	STON2	0.138	0.082
CALCOCO1	STON2	0.105	0.086
FCHO2	CALCOCO1	0.105	0.04
AAGAB	NECAP1	0.102	0.118	mutually_exclusive (P53680)
CCDC32	AP1S1	0.043	0.06
ITSN2	NECAP2	0.029	0.07
ITSN2	CCDC32	0.024	0.05
ITSN2	AAGAB	0.02	0.042

Related Complexes

Genename	Complexes
AP2M1	huMAP3_00631.1 huMAP3_02419.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
RALBP1	huMAP3_02704.1 huMAP3_02942.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11054.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
AP2S1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
AP2A2	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11624.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
ITSN2	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
AAGAB	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11624.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1 huMAP3_13969.1
EPS15L1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
EPS15	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
AP1S1	huMAP3_00819.1 huMAP3_04311.1 huMAP3_04842.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_06911.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_08695.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1B1	huMAP3_00819.1 huMAP3_04311.1 huMAP3_04842.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_06911.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_08695.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP2B1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
CCDC32	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11624.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13969.1
CALCOCO1	huMAP3_02419.1 huMAP3_06283.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_13906.1
NECAP2	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12582.1 huMAP3_12918.1
FCHO2	huMAP3_00631.1 huMAP3_02419.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
ITSN1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
AP2A1	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
NECAP1	huMAP3_00819.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
STON2	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08540.1

Complex Portal: CPX-20393