hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08546.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MT-CYB | Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) | 5 | UniProt NCBI |
| UQCR10 | Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) | 5 | UniProt NCBI |
| UQCRQ | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | 5 | UniProt NCBI |
| COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L) | 5 | UniProt NCBI |
| UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | 5 | UniProt NCBI |
| COX7A2L | Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1) | 4 | UniProt NCBI |
| UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | 5 | UniProt NCBI |
| PTGES2 | Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] | 5 | UniProt NCBI |
| UQCRB | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4921 | 7.72026313534e-10 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | Mitochondrial complex III assembly |
| KEGG:04260 | 7.79527128226e-10 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Cardiac muscle contraction |
| WP:WP111 | 5.23603068389e-09 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.15158142094e-08 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Oxidative phosphorylation |
| REAC:R-HSA-611105 | 1.41302060093e-08 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Respiratory electron transport |
| KEGG:04932 | 2.23152734084e-08 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Non-alcoholic fatty liver disease |
| WP:WP4396 | 2.87381650686e-08 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Nonalcoholic fatty liver disease |
| REAC:R-HSA-163200 | 3.92241770227e-08 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05415 | 8.71637435553e-08 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Diabetic cardiomyopathy |
| GO:0006122 | 1.30147699894e-07 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | mitochondrial electron transport, ubiquinol to cytochrome c |
| KEGG:05208 | 1.47446779161e-07 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 1.58815149831e-07 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Thermogenesis |
| GO:0045275 | 1.9520016395e-07 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | respiratory chain complex III |
| GO:0005750 | 1.9520016395e-07 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | mitochondrial respiratory chain complex III |
| REAC:R-HSA-1428517 | 2.12950310477e-07 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05012 | 3.36633846427e-07 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Parkinson disease |
| KEGG:05020 | 3.89453467336e-07 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Prion disease |
| KEGG:05016 | 6.46455868087e-07 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Huntington disease |
| KEGG:05014 | 1.58391086806e-06 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Amyotrophic lateral sclerosis |
| GO:0005746 | 1.7640596292e-06 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | mitochondrial respirasome |
| GO:0070469 | 1.7640596292e-06 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | respirasome |
| KEGG:05010 | 2.01666118798e-06 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Alzheimer disease |
| KEGG:05022 | 5.40342215478e-06 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | Pathways of neurodegeneration - multiple diseases |
| GO:0008121 | 7.68841921772e-06 | 0.5 | MT-CYB UQCRC1 UQCR10 | ubiquinol-cytochrome-c reductase activity |
| GO:0070069 | 9.34862345773e-06 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | cytochrome complex |
| GO:0006119 | 9.39170949702e-06 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | oxidative phosphorylation |
| GO:0016679 | 1.92180881975e-05 | 0.5 | MT-CYB UQCRC1 UQCR10 | oxidoreductase activity, acting on diphenols and related substances as donors |
| KEGG:01100 | 2.50181856894e-05 | 1.0 | MT-CYB UQCRQ UQCR10 PTGES2 UQCRC1 COX7A2L | Metabolic pathways |
| GO:0009060 | 3.06428171392e-05 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | aerobic respiration |
| GO:0045333 | 5.79224844498e-05 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | cellular respiration |
| GO:0015453 | 0.000166466176189 | 0.666666666667 | MT-CYB UQCRC1 COX7A2L UQCR10 | oxidoreduction-driven active transmembrane transporter activity |
| GO:0015980 | 0.000234372796223 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | energy derivation by oxidation of organic compounds |
| GO:0019646 | 0.000502392288512 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | aerobic electron transport chain |
| REAC:R-HSA-1430728 | 0.000579637081746 | 1.0 | MT-CYB UQCRQ UQCR10 PTGES2 UQCRC1 COX7A2L | Metabolism |
| GO:0098803 | 0.000588161116581 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | respiratory chain complex |
| GO:0042775 | 0.000684451996602 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.000684451996602 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | ATP synthesis coupled electron transport |
| GO:0022904 | 0.00104484947805 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | respiratory electron transport chain |
| GO:0015078 | 0.00109222246905 | 0.666666666667 | MT-CYB UQCRC1 COX7A2L UQCR10 | proton transmembrane transporter activity |
| GO:0009055 | 0.00135364525546 | 0.666666666667 | MT-CYB UQCRC1 COX7A2L UQCR10 | electron transfer activity |
| GO:0022900 | 0.00147034444981 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | electron transport chain |
| GO:0006091 | 0.0018359440657 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | generation of precursor metabolites and energy |
| GO:1990204 | 0.00242244235372 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | oxidoreductase complex |
| GO:0005743 | 0.00402322779151 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | mitochondrial inner membrane |
| GO:0015399 | 0.00415357355124 | 0.666666666667 | MT-CYB UQCRC1 COX7A2L UQCR10 | primary active transmembrane transporter activity |
| GO:0019866 | 0.00534701059771 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | organelle inner membrane |
| GO:0098800 | 0.00725468131599 | 0.666666666667 | MT-CYB UQCRC1 UQCRQ UQCR10 | inner mitochondrial membrane protein complex |
| GO:0022853 | 0.00808243366695 | 0.666666666667 | MT-CYB UQCRC1 COX7A2L UQCR10 | active monoatomic ion transmembrane transporter activity |
| GO:0031966 | 0.0215578343109 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | mitochondrial membrane |
| GO:0005739 | 0.022429776518 | 1.0 | MT-CYB UQCRQ UQCR10 PTGES2 UQCRC1 COX7A2L | mitochondrion |
| GO:0005740 | 0.0298219178279 | 0.833333333333 | MT-CYB COX7A2L UQCRC1 UQCRQ UQCR10 | mitochondrial envelope |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UQCRB | UQCRC1 | 0.999 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| UQCRC2 | UQCRC1 | 0.999 | 0.958 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| UQCRC2 | UQCRQ | 0.999 | 0.96 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM fraction boldt_WMM |
| UQCRQ | PTGES2 | 0.998 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| UQCRQ | UQCRC1 | 0.998 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| UQCRC2 | UQCRB | 0.997 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction boldt_WMM |
| UQCRB | UQCRQ | 0.996 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| COX7A2L | UQCRQ | 0.995 | 0.726 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| MT-CYB | UQCRQ | 0.995 | 0.77 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| UQCR10 | UQCRQ | 0.994 | 0.766 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM |
| UQCRB | PTGES2 | 0.993 | 0.122 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PTGES2 | UQCRC1 | 0.99 | 0.228 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| COX7A2L | UQCRB | 0.989 | 0.882 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UQCR10 | UQCRC1 | 0.989 | 0.758 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| UQCRC2 | PTGES2 | 0.988 | 0.296 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| MT-CYB | PTGES2 | 0.985 | 0.276 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| UQCRC2 | UQCR10 | 0.984 | 0.58 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| COX7A2L | MT-CYB | 0.983 | 0.652 | bioplex_WMM bioplex3_WMM WMM_only |
| MT-CYB | UQCRB | 0.981 | 0.814 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UQCRC2 | COX7A2L | 0.979 | 0.828 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only |
| COX7A2L | UQCRC1 | 0.979 | 0.584 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| UQCRC2 | COX6A1 | 0.974 | 0.526 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only |
| COX7A2L | PTGES2 | 0.973 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| COX7A2L | COX6A1 | 0.972 | 0.784 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| MT-CYB | UQCR10 | 0.966 | 0.612 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| UQCRB | UQCR10 | 0.965 | 0.914 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UQCRC2 | MT-CYB | 0.958 | 0.78 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM fraction |
| UQCRC1 | COX6A1 | 0.955 | 0.466 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only |
| UQCRB | COX6A1 | 0.953 | 0.836 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UQCRQ | COX6A1 | 0.952 | 0.756 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| MT-CYB | UQCRC1 | 0.944 | 0.762 | bioplex_WMM bioplex3_WMM WMM_only |
| COX7A2L | UQCR10 | 0.925 | 0.53 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only |
| UQCR10 | PTGES2 | 0.858 | 0.314 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| UQCR10 | COX6A1 | 0.523 | 0.272 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only |
| PTGES2 | COX6A1 | 0.01 | 0.22 | bioplex3_WMM WMM_only |
Related Complexes