hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08554.1

Complex Portal: CPX-20933

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
TIMELESS	Protein timeless homolog (hTIM)	5	UniProt NCBI
MCM3	DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)	5	UniProt NCBI
GINS1	DNA replication complex GINS protein PSF1 (GINS complex subunit 1)	5	UniProt NCBI
MCMBP	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	5	UniProt NCBI
MCM2	DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)	5	UniProt NCBI
MCM5	DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)	5	UniProt NCBI
MCM6	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	5	UniProt NCBI
CLSPN	Claspin (hClaspin)	5	UniProt NCBI
GINS2	DNA replication complex GINS protein PSF2 (GINS complex subunit 2)	5	UniProt NCBI
GINS4	DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]	5	UniProt NCBI
MCM7	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	5	UniProt NCBI
GINS3	DNA replication complex GINS protein PSF3 (GINS complex subunit 3)	5	UniProt NCBI
TIPIN	TIMELESS-interacting protein	5	UniProt NCBI
MCM4	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	5	UniProt NCBI
CDC45	Cell division control protein 45 homolog (PORC-PI-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-176974	2.39659330548e-18	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	Unwinding of DNA
GO:0071162	1.9277224274e-16	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	CMG complex
GO:0031261	4.62542507958e-16	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	DNA replication preinitiation complex
GO:0006261	2.75753371498e-15	0.909090909091	GINS4 MCMBP CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	DNA-templated DNA replication
REAC:R-HSA-69190	1.01363506516e-14	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	DNA strand elongation
GO:0006268	6.77632780639e-14	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	DNA unwinding involved in DNA replication
GO:0006260	2.09050518858e-13	0.909090909091	GINS4 MCMBP CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	DNA replication
GO:0000228	9.97505777325e-12	0.818181818182	GINS4 CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	nuclear chromosome
CORUM:678	1.15314319164e-11	0.363636363636	GINS1 GINS3 GINS4 GINS2	GINS complex
GO:0032508	2.62935356194e-11	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	DNA duplex unwinding
GO:0032392	8.91410311319e-11	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	DNA geometric change
REAC:R-HSA-69239	1.65203940223e-10	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	Synthesis of DNA
GO:0071103	2.22968319304e-10	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	DNA conformation change
REAC:R-HSA-69242	1.30225076353e-09	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	S Phase
GO:0033260	1.87726203329e-09	0.545454545455	CDC45 TIPIN MCM2 GINS1 MCM6 GINS3	nuclear DNA replication
GO:0000727	1.91798962418e-09	0.454545454545	MCM2 CDC45 MCM6 GINS4 GINS2	double-strand break repair via break-induced replication
REAC:R-HSA-69306	2.46752656426e-09	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	DNA Replication
GO:0044786	3.93574205546e-09	0.545454545455	CDC45 TIPIN MCM2 GINS1 MCM6 GINS3	cell cycle DNA replication
GO:1902969	5.3393134954e-09	0.454545454545	GINS1 CDC45 GINS3 MCM6 MCM2	mitotic DNA replication
GO:0000811	8.68316823302e-09	0.363636363636	GINS1 GINS3 GINS4 GINS2	GINS complex
GO:0006259	7.55235167618e-08	0.909090909091	GINS4 MCMBP CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	DNA metabolic process
REAC:R-HSA-1640170	5.37098041829e-07	0.727272727273	GINS4 CDC45 GINS2 GINS3 CLSPN GINS1 MCM2 MCM6	Cell Cycle
REAC:R-HSA-176187	2.61783426947e-06	0.363636363636	MCM2 CDC45 MCM6 CLSPN	Activation of ATR in response to replication stress
REAC:R-HSA-69278	5.67054332852e-06	0.636363636364	GINS4 CDC45 GINS2 GINS3 MCM2 GINS1 MCM6	Cell Cycle, Mitotic
GO:0051276	1.381738007e-05	0.727272727273	GINS4 MCMBP GINS2 GINS3 MCM2 GINS1 MCM6 CDC45	chromosome organization
GO:0000076	2.64282390746e-05	0.363636363636	CLSPN CDC45 TIMELESS TIPIN	DNA replication checkpoint signaling
GO:0000724	3.20658375744e-05	0.545454545455	GINS4 CDC45 TIMELESS GINS2 MCM2 MCM6	double-strand break repair via homologous recombination
CORUM:1452	3.41979277617e-05	0.181818181818	MCM2 MCM6	MCM2-MCM6-MCM7 complex
CORUM:387	3.41979277617e-05	0.181818181818	MCM2 MCM6	MCM complex
CORUM:2792	3.41979277617e-05	0.181818181818	MCM2 MCM6	MCM2-MCM4-MCM6-MCM7 complex
GO:0000725	3.73008049403e-05	0.545454545455	GINS4 CDC45 TIMELESS GINS2 MCM2 MCM6	recombinational repair
GO:0022402	6.4368790623e-05	0.818181818182	MCMBP CLSPN CDC45 TIMELESS GINS3 MCM2 GINS1 MCM6 TIPIN	cell cycle process
GO:0032993	0.000101124435349	0.818181818182	GINS4 CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	protein-DNA complex
GO:0140513	0.000188828148492	0.818181818182	GINS4 CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	nuclear protein-containing complex
GO:0006974	0.000236254717533	0.727272727273	GINS4 CDC45 TIMELESS GINS2 TIPIN CLSPN MCM2 MCM6	DNA damage response
GO:0006270	0.000308911252354	0.363636363636	MCM2 CDC45 MCM6 GINS3	DNA replication initiation
WP:WP466	0.000374062639208	0.272727272727	MCM2 MCM6 CDC45	DNA replication
REAC:R-HSA-68962	0.000442855259632	0.272727272727	MCM2 MCM6 CDC45	Activation of the pre-replicative complex
GO:0006310	0.000472025665839	0.545454545455	GINS4 CDC45 TIMELESS GINS2 MCM2 MCM6	DNA recombination
GO:0007049	0.000583751039853	0.818181818182	MCMBP CLSPN CDC45 TIMELESS GINS3 MCM2 GINS1 MCM6 TIPIN	cell cycle
GO:0090329	0.000704674168151	0.363636363636	MCM2 TIPIN TIMELESS MCM6	regulation of DNA-templated DNA replication
GO:0006302	0.000804034472938	0.545454545455	GINS4 CDC45 TIMELESS GINS2 MCM2 MCM6	double-strand break repair
REAC:R-HSA-69481	0.00108667895748	0.363636363636	MCM2 CDC45 MCM6 CLSPN	G2/M Checkpoints
WP:WP45	0.00134534612351	0.272727272727	MCM2 MCM6 CDC45	G1 to S cell cycle control
GO:0005694	0.00149673440926	0.818181818182	GINS4 CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	chromosome
CORUM:5611	0.00187394691988	0.181818181818	MCM2 MCM6	Emerin complex 24
WP:WP4016	0.0023494401904	0.272727272727	MCM2 CDC45 CLSPN	DNA IR damage and cellular response via ATR
GO:0042555	0.00260828330546	0.272727272727	MCM2 MCMBP MCM6	MCM complex
GO:1903047	0.00265189841342	0.636363636364	CDC45 TIPIN CLSPN GINS1 MCM2 MCM6 GINS3	mitotic cell cycle process
WP:WP179	0.0080109788171	0.272727272727	MCM2 MCM6 CDC45	Cell cycle
KEGG:04110	0.00855620189561	0.272727272727	MCM2 MCM6 CDC45	Cell cycle
REAC:R-HSA-5693607	0.00931468951254	0.272727272727	CLSPN TIMELESS TIPIN	Processing of DNA double-strand break ends
GO:0000278	0.00976698516068	0.636363636364	CDC45 TIPIN CLSPN GINS1 MCM2 MCM6 GINS3	mitotic cell cycle
REAC:R-HSA-69620	0.00999783931495	0.363636363636	MCM2 CDC45 MCM6 CLSPN	Cell Cycle Checkpoints
GO:0005654	0.0105448660706	1.0	GINS4 MCMBP CLSPN CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	nucleoplasm
KEGG:03030	0.0163080582055	0.181818181818	MCM2 MCM6	DNA replication
TF:M00431_1	0.0187664525781	0.818181818182	MCMBP CLSPN CDC45 TIMELESS GINS3 MCM2 GINS1 MCM6 TIPIN	Factor: E2F-1; motif: TTTSGCGS; match class: 1
GO:0031981	0.0214587900711	1.0	GINS4 MCMBP CLSPN CDC45 TIMELESS GINS2 GINS3 MCM2 GINS1 MCM6 TIPIN	nuclear lumen
GO:0033554	0.0233588405222	0.727272727273	GINS4 CDC45 TIMELESS GINS2 TIPIN CLSPN MCM2 MCM6	cellular response to stress
REAC:R-HSA-5693567	0.0236701449349	0.272727272727	CLSPN TIMELESS TIPIN	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
GO:0006281	0.0256521953742	0.545454545455	GINS4 CDC45 TIMELESS GINS2 MCM2 MCM6	DNA repair
REAC:R-HSA-5693538	0.0272696927821	0.272727272727	CLSPN TIMELESS TIPIN	Homology Directed Repair
REAC:R-HSA-69206	0.027902357559	0.272727272727	MCM2 MCM6 CDC45	G1/S Transition
GO:0006275	0.0302538127526	0.363636363636	MCM2 TIPIN TIMELESS MCM6	regulation of DNA replication
REAC:R-HSA-69002	0.0401691573103	0.272727272727	MCM2 MCM6 CDC45	DNA Replication Pre-Initiation
REAC:R-HSA-453279	0.0401691573103	0.272727272727	MCM2 MCM6 CDC45	Mitotic G1 phase and G1/S transition
REAC:R-HSA-5693532	0.0497239830603	0.272727272727	CLSPN TIMELESS TIPIN	DNA Double-Strand Break Repair
CORUM:2791	0.049976851631	0.0909090909091	MCM6	MCM4-MCM6-MCM7 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GINS2	GINS4	1.0	0.93
MCMBP	MCM5	1.0	0.314	mixed_interface
GINS3	GINS1	1.0	0.93	structurally_consistent (dimer)
TIPIN	TIMELESS	1.0	0.216
GINS2	GINS1	1.0	0.838	structurally_consistent (O75419) structurally_consistent (dimer)
MCM6	MCM4	1.0	0.986	structurally_consistent (dimer)
GINS2	GINS3	1.0	0.908
MCM2	MCM6	1.0	0.992	mutually_exclusive (Q9BTE3)
GINS4	GINS1	1.0	0.836
GINS4	GINS3	1.0	0.922
MCM2	MCM4	1.0	0.992
MCM4	MCM7	1.0	0.988	structurally_consistent (dimer)
MCM3	MCMBP	0.999	0.254486486486	mutually_exclusive (Q14566) structurally_consistent (dimer)
MCM3	MCM5	0.999	0.962
MCM4	MCM5	0.999	0.97
MCM6	MCM7	0.999	0.974	mutually_exclusive (Q9BTE3)
MCM2	MCM7	0.999	0.98
MCM3	MCM4	0.999	0.988
MCM3	MCM6	0.999	0.974	mutually_exclusive (Q9BTE3) structurally_consistent (dimer)
MCM4	TIPIN	0.999	0.384
MCM5	MCM7	0.998	0.98
MCMBP	MCM6	0.998	0.304	mixed_interface
MCM2	TIPIN	0.998	0.378
GINS4	TIMELESS	0.998	0.204
MCM3	MCM7	0.998	0.986
MCM2	GINS4	0.997	0.572
MCM2	MCM5	0.997	0.978
MCM6	MCM5	0.997	0.98	structurally_consistent (dimer)
GINS4	TIPIN	0.997	0.09
MCM3	MCM2	0.996	0.986	mutually_exclusive (Q9BTE3)
MCMBP	MCM7	0.996	0.396	mutually_exclusive (P33991) structurally_consistent (dimer)
CLSPN	GINS4	0.996	0.12
TIPIN	GINS3	0.996	0.084
CLSPN	TIMELESS	0.995	0.124
MCM2	TIMELESS	0.995	0.512
TIMELESS	CDC45	0.995	0.416
GINS3	TIMELESS	0.995	0.158
MCM6	TIMELESS	0.995	0.476
TIPIN	MCM7	0.994	0.402
MCM3	GINS4	0.994	0.256
MCM3	GINS3	0.993	0.646
MCM3	TIPIN	0.992	0.236
MCM6	TIPIN	0.991	0.374
MCM4	TIMELESS	0.991	0.382
MCM6	GINS3	0.991	0.764
MCM6	GINS4	0.989	0.54
MCM4	GINS3	0.989	0.642
GINS4	MCM7	0.989	0.59
CLSPN	TIPIN	0.988	0.22
MCM7	TIMELESS	0.988	0.464
MCMBP	MCM2	0.987	0.207047619048	structurally_consistent (dimer)
GINS3	CDC45	0.984	0.474	structurally_consistent (Q14691)
MCMBP	MCM4	0.98	0.436	mutually_exclusive (Q14566) structurally_consistent (dimer)
MCM3	TIMELESS	0.979	0.342
MCM7	CDC45	0.978	0.49
CLSPN	GINS3	0.978	0.154
GINS1	CDC45	0.976	0.316	structurally_consistent (dimer)
TIPIN	MCM5	0.974	0.26
MCM4	GINS4	0.969	0.554
MCM5	TIMELESS	0.967	0.502
MCM3	CLSPN	0.965	0.384
GINS2	MCM5	0.963	0.472
GINS3	MCM5	0.957	0.578
GINS4	MCM5	0.953	0.328
GINS2	TIMELESS	0.952	0.092
GINS2	MCM7	0.939	0.47
MCM2	CLSPN	0.936	0.434
MCM6	CLSPN	0.927	0.504
CLSPN	MCM7	0.925	0.516
MCM2	GINS3	0.92	0.686
GINS3	MCM7	0.915	0.516
GINS4	CDC45	0.91	0.198
GINS1	TIMELESS	0.908	0.128
TIPIN	GINS1	0.896	0.104
MCM3	GINS2	0.879	0.302
GINS1	MCM5	0.877	0.594
MCM6	CDC45	0.859	0.418
GINS2	CDC45	0.857	0.124	structurally_consistent (Q14691) structurally_consistent (dimer)
MCM3	GINS1	0.841	0.404
GINS1	MCM7	0.835	0.592
MCM5	CDC45	0.832	0.426
MCM2	GINS2	0.828	0.556
MCM4	GINS2	0.825	0.614
MCM4	CDC45	0.822	0.476
MCM2	CDC45	0.764	0.47
MCM6	GINS2	0.759	0.666
MCM3	CDC45	0.754	0.354
MCM6	GINS1	0.704	0.412
GINS2	TIPIN	0.699	0.098
CLSPN	CDC45	0.694	0.22
MCM4	GINS1	0.632	0.736
TIPIN	CDC45	0.594	0.122
CLSPN	GINS1	0.568	0.074
GINS2	CLSPN	0.401	0.078
MCM4	CLSPN	0.372	0.576
MCM2	GINS1	0.202	0.622
MCMBP	GINS2	0.105	0.078
MCMBP	TIPIN	0.093	0.09
CLSPN	MCM5	0.064	0.34
MCMBP	GINS1	0.038	0.124
MCMBP	GINS4	0.038	0.166
MCMBP	TIMELESS	0.024	0.074
MCMBP	CLSPN	0.022	0.118
MCMBP	GINS3	0.022	0.084
MCMBP	CDC45	0.01	0.202

Related Complexes

Genename	Complexes
TIMELESS	huMAP3_06136.1 huMAP3_06417.1 huMAP3_07113.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM3	huMAP3_00154.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS1	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCMBP	huMAP3_00154.1 huMAP3_02113.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_09860.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM2	huMAP3_00154.1 huMAP3_02113.1 huMAP3_02289.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_07824.1 huMAP3_08554.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
MCM5	huMAP3_05529.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM6	huMAP3_00154.1 huMAP3_02602.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10862.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
CLSPN	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS2	huMAP3_03896.1 huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_13708.1 huMAP3_14758.1
GINS4	huMAP3_04079.1 huMAP3_04983.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_06922.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM7	huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
GINS3	huMAP3_05447.1 huMAP3_06136.1 huMAP3_06278.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
TIPIN	huMAP3_04079.1 huMAP3_06136.1 huMAP3_06417.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14758.1
MCM4	huMAP3_00154.1 huMAP3_02602.1 huMAP3_05529.1 huMAP3_06061.1 huMAP3_07113.1 huMAP3_08554.1 huMAP3_08848.1 huMAP3_09466.1 huMAP3_09860.1 huMAP3_10862.1 huMAP3_11119.1 huMAP3_11832.1 huMAP3_12180.1 huMAP3_14306.1 huMAP3_14758.1
CDC45	huMAP3_06136.1 huMAP3_06278.1 huMAP3_08399.1 huMAP3_08554.1 huMAP3_09238.1 huMAP3_11119.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08554.1

Complex Portal: CPX-20933