hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08568.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIMM50 | Mitochondrial import inner membrane translocase subunit TIM50 | 5 | UniProt NCBI |
| OXA1L | Mitochondrial inner membrane protein OXA1L (Hsa) (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein) | 5 | UniProt NCBI |
| AFG3L2 | AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein) | 5 | UniProt NCBI |
| UNC45A | Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) | 5 | UniProt NCBI |
| AASS | Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)] | 5 | UniProt NCBI |
| GCDH | Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6) | 5 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0002921 | 0.00099333681464 | 0.714285714286 | AASS PYCR1 GCDH TIMM50 UNC45A | Abnormal cerebrospinal fluid morphology |
| REAC:R-HSA-71064 | 0.00209171533568 | 0.285714285714 | AASS GCDH | Lysine catabolism |
| HPA:0530721 | 0.0102359031903 | 1.0 | UNC45A AFG3L2 GCDH PYCR1 OXA1L TIMM50 AASS | spleen; cells in white pulp[>=Low] |
| HP:0004305 | 0.0135180057092 | 0.714285714286 | AFG3L2 PYCR1 GCDH TIMM50 AASS | Involuntary movements |
| HP:0001508 | 0.0161496482753 | 0.714285714286 | AASS PYCR1 GCDH TIMM50 UNC45A | Failure to thrive |
| KEGG:00310 | 0.0167496959508 | 0.285714285714 | AASS GCDH | Lysine degradation |
| HP:0012719 | 0.0275736169282 | 0.714285714286 | AFG3L2 PYCR1 GCDH UNC45A AASS | Functional abnormality of the gastrointestinal tract |
| HP:0002305 | 0.0281302035428 | 0.428571428571 | PYCR1 TIMM50 GCDH | Athetosis |
| HP:0033354 | 0.0352692462778 | 0.571428571429 | AASS GCDH TIMM50 UNC45A | Abnormal urine metabolite level |
| HPA:0430052 | 0.037183614591 | 1.0 | UNC45A AFG3L2 GCDH PYCR1 OXA1L TIMM50 AASS | seminal vesicle; glandular cells[>=Medium] |
| HP:0012372 | 0.0445065262832 | 0.857142857143 | AASS AFG3L2 GCDH PYCR1 TIMM50 UNC45A | Abnormal eye morphology |
| HPA:0630221 | 0.0477522154514 | 1.0 | UNC45A AFG3L2 GCDH PYCR1 OXA1L TIMM50 AASS | cervix; squamous epithelial cells[>=Low] |
| CORUM:3098 | 0.0499958217778 | 0.142857142857 | TIMM50 | TIM50-SMN1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PYCR1 | AFG3L2 | 0.99 | 0.078 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM |
| OXA1L | AFG3L2 | 0.979 | 0.232 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| TIMM50 | AFG3L2 | 0.971 | 0.292 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| OXA1L | TIMM50 | 0.967 | 0.384 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| AFG3L2 | UNC45A | 0.967 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| AASS | AFG3L2 | 0.962 | 0.02 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| GCDH | AFG3L2 | 0.961 | 0.224 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| GCDH | UNC45A | 0.858 | 0.0554 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PYCR1 | GCDH | 0.85 | 0.064 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| AASS | GCDH | 0.748 | 0.048 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM |
| TIMM50 | GCDH | 0.707 | 0.084 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| AASS | UNC45A | 0.641 | 0.06 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| OXA1L | PYCR1 | 0.473 | 0.16 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PYCR1 | AASS | 0.426 | 0.07 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| OXA1L | UNC45A | 0.278 | 0.06 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PYCR1 | UNC45A | 0.208 | 0.1 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| TIMM50 | UNC45A | 0.136 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM |
| TIMM50 | AASS | 0.111 | 0.0701165048544 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| OXA1L | GCDH | 0.087 | 0.046 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| OXA1L | AASS | 0.052 | 0.01 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| TIMM50 | PYCR1 | 0.009 | 0.278 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only |
Related Complexes