hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08591.1

Complex Portal: CPX-13592

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
SMPDL3B	Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-)	5	UniProt NCBI
RGS12	Regulator of G-protein signaling 12 (RGS12)	5	UniProt NCBI
RGS14	Regulator of G-protein signaling 14 (RGS14)	5	UniProt NCBI
GNAT2	Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain)	5	UniProt NCBI
GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	5	UniProt NCBI
GNB4	Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)	5	UniProt NCBI
GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)	5	UniProt NCBI
GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)	5	UniProt NCBI
GNAI3	Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)	5	UniProt NCBI
GNG4	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	5	UniProt NCBI
GNAO1	Guanine nucleotide-binding protein G(o) subunit alpha	5	UniProt NCBI
GNG7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	4	UniProt NCBI
RIC8A	Synembryn-A (Protein Ric-8A)	5	UniProt NCBI
GNG12	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	5	UniProt NCBI
GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005834	2.28792976429e-23	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	heterotrimeric G-protein complex
GO:1905360	2.51253152625e-22	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	GTPase complex
GO:0031234	1.42452104419e-19	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	extrinsic component of cytoplasmic side of plasma membrane
REAC:R-HSA-392518	2.54378230033e-19	0.6	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Signal amplification
WP:WP536	4.78435217001e-19	0.733333333333	GNG12 GNAO1 GNAQ GNG4 RGS14 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Calcium regulation in cardiac cells
KEGG:04713	8.53933977549e-19	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Circadian entrainment
REAC:R-HSA-418594	1.66342955939e-18	0.8	GNG12 GNG7 GNAQ GNAT2 GNG11 RGS14 GNB4 GNG4 GNB1 GNAI3 RGS12 GNAI2	G alpha (i) signalling events
KEGG:04724	2.5751706339e-18	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Glutamatergic synapse
KEGG:04726	3.78166319704e-18	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Serotonergic synapse
REAC:R-HSA-392170	4.68608557219e-18	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	ADP signalling through P2Y purinoceptor 12
KEGG:04725	6.9538585441e-18	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Cholinergic synapse
GO:0019897	2.21639706168e-17	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	extrinsic component of plasma membrane
KEGG:04728	5.79393267016e-17	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Dopaminergic synapse
KEGG:04727	1.42791554812e-16	0.6	GNG12 GNAO1 GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	GABAergic synapse
KEGG:04723	1.44138322335e-16	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Retrograde endocannabinoid signaling
KEGG:05032	1.64512265724e-16	0.6	GNG12 GNAO1 GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Morphine addiction
GO:0007186	1.89216317781e-16	0.933333333333	GNG12 GNAO1 GNAQ GNAT2 GNG11 RGS14 RIC8A GNB4 GNG4 GNG7 GNB1 GNAI3 RGS12 GNAI2	G protein-coupled receptor signaling pathway
REAC:R-HSA-977444	5.13635029073e-16	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	GABA B receptor activation
REAC:R-HSA-991365	5.13635029073e-16	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Activation of GABAB receptors
REAC:R-HSA-9660821	8.6994916427e-16	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	ADORA2B mediated anti-inflammatory cytokines production
REAC:R-HSA-418597	8.6994916427e-16	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	G alpha (z) signalling events
REAC:R-HSA-9634597	1.11802888728e-15	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	GPER1 signaling
WP:WP35	1.18206888696e-15	0.6	GNG12 GNAO1 GNAQ GNG7 GNG11 GNG4 GNAI2 GNAI3 GNB1	G protein signaling pathways
GO:0019898	2.99469729656e-15	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	extrinsic component of membrane
GO:0009898	2.99469729656e-15	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	cytoplasmic side of plasma membrane
REAC:R-HSA-111885	3.18521556365e-15	0.6	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Opioid Signalling
REAC:R-HSA-977443	3.52269611356e-15	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	GABA receptor activation
REAC:R-HSA-388396	6.70093180238e-15	0.8	GNG12 GNG7 GNAQ GNAT2 GNG11 RGS14 GNB4 GNG4 GNB1 GNAI3 RGS12 GNAI2	GPCR downstream signalling
REAC:R-HSA-202040	1.15605340366e-14	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	G-protein activation
REAC:R-HSA-428930	1.15605340366e-14	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	Thromboxane signalling through TP receptor
REAC:R-HSA-400042	1.15605340366e-14	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNB1	Adrenaline,noradrenaline inhibits insulin secretion
REAC:R-HSA-418592	1.15605340366e-14	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	ADP signalling through P2Y purinoceptor 1
KEGG:04926	1.28648706185e-14	0.6	GNG12 GNAO1 GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Relaxin signaling pathway
KEGG:04371	1.66012742957e-14	0.6	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Apelin signaling pathway
KEGG:05163	1.95721947456e-14	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Human cytomegalovirus infection
KEGG:05170	2.06352182547e-14	0.666666666667	GNG12 GNAO1 GNAQ GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Human immunodeficiency virus 1 infection
GO:0098562	3.03914433393e-14	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	cytoplasmic side of membrane
REAC:R-HSA-372790	3.23351908771e-14	0.8	GNG12 GNG7 GNAQ GNAT2 GNG11 RGS14 GNB4 GNG4 GNB1 GNAI3 RGS12 GNAI2	Signaling by GPCR
REAC:R-HSA-4086398	3.25101567232e-14	0.533333333333	GNG12 GNAO1 GNG4 GNG11 GNB4 GNAT2 GNB1 GNG7	Ca2+ pathway
REAC:R-HSA-456926	6.00519826551e-14	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	Thrombin signalling through proteinase activated receptors (PARs)
REAC:R-HSA-9662851	1.23542124701e-13	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Anti-inflammatory response favouring Leishmania parasite infection
REAC:R-HSA-9009391	1.23542124701e-13	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Extra-nuclear estrogen signaling
REAC:R-HSA-9664433	1.23542124701e-13	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Leishmania parasite growth and survival
KEGG:04062	1.33225576496e-13	0.6	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Chemokine signaling pathway
REAC:R-HSA-422356	1.84190207047e-13	0.533333333333	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNB1	Regulation of insulin secretion
KEGG:05034	2.52564502533e-13	0.6	GNG12 GNAO1 GNG4 GNG11 GNB4 GNG7 GNAI2 GNAI3 GNB1	Alcoholism
REAC:R-HSA-6814122	4.52995244346e-13	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
REAC:R-HSA-8964315	8.82820979305e-13	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	G beta:gamma signalling through BTK
REAC:R-HSA-392851	8.82820979305e-13	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Prostacyclin signalling through prostacyclin receptor
REAC:R-HSA-500657	1.36363889256e-12	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Presynaptic function of Kainate receptors
REAC:R-HSA-418217	1.36363889256e-12	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	G beta:gamma signalling through PLC beta
REAC:R-HSA-8964616	2.04437765311e-12	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	G beta:gamma signalling through CDC42
REAC:R-HSA-163685	3.06706154542e-12	0.533333333333	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNB1	Integration of energy metabolism
REAC:R-HSA-418555	3.35772501234e-12	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	G alpha (s) signalling events
REAC:R-HSA-392451	5.96640544248e-12	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	G beta:gamma signalling through PI3Kgamma
REAC:R-HSA-451326	8.19947228315e-12	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Activation of kainate receptors upon glutamate binding
REAC:R-HSA-1296041	1.10875412191e-11	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Activation of G protein gated Potassium channels
REAC:R-HSA-420092	1.10875412191e-11	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Glucagon-type ligand receptors
REAC:R-HSA-997272	1.10875412191e-11	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REAC:R-HSA-1296059	1.10875412191e-11	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	G protein gated Potassium channels
WP:WP3929	1.18963660037e-11	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Chemokine signaling pathway
WP:WP289	2.27735003998e-11	0.533333333333	GNG12 GNG7 GNG4 RGS14 GNG11 GNB4 GNB1 GNAQ	Myometrial relaxation and contraction pathways
REAC:R-HSA-1296065	3.24436586573e-11	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Inwardly rectifying K+ channels
REAC:R-HSA-397795	3.24436586573e-11	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	G-protein beta:gamma signalling
REAC:R-HSA-163359	3.24436586573e-11	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Glucagon signaling in metabolic regulation
REAC:R-HSA-76002	4.12154669695e-11	0.6	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Platelet activation, signaling and aggregation
REAC:R-HSA-3858494	8.33069440344e-11	0.533333333333	GNG12 GNAO1 GNG4 GNG11 GNB4 GNAT2 GNB1 GNG7	Beta-catenin independent WNT signaling
REAC:R-HSA-9824443	8.33069440344e-11	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Parasitic Infection Pathways
REAC:R-HSA-9658195	8.33069440344e-11	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Leishmania infection
REAC:R-HSA-432040	1.46861213053e-10	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Vasopressin regulates renal water homeostasis via Aquaporins
REAC:R-HSA-381676	1.77152568462e-10	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REAC:R-HSA-445717	2.12470668343e-10	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Aquaporin-mediated transport
REAC:R-HSA-112314	2.82108857897e-10	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-390466	3.24606300162e-10	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	Chaperonin-mediated protein folding
GO:0098552	3.89152477161e-10	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	side of membrane
GO:0098797	4.2225177998e-10	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	plasma membrane protein complex
REAC:R-HSA-391251	5.74200256613e-10	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	Protein folding
REAC:R-HSA-8939211	1.01173062561e-09	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	ESR-mediated signaling
REAC:R-HSA-112315	2.13932610253e-09	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Transmission across Chemical Synapses
KEGG:05200	5.13925390983e-09	0.6	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Pathways in cancer
REAC:R-HSA-416482	6.61416461566e-09	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	G alpha (12/13) signalling events
REAC:R-HSA-416476	7.17854644063e-09	0.466666666667	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1 GNAQ	G alpha (q) signalling events
REAC:R-HSA-1296071	9.75498398074e-09	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Potassium Channels
REAC:R-HSA-9006931	1.03409129456e-08	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Signaling by Nuclear Receptors
REAC:R-HSA-373080	1.17389326848e-08	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Class B/2 (Secretin family receptors)
REAC:R-HSA-418346	1.67212353284e-08	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Platelet homeostasis
GO:0003924	1.85158186714e-08	0.6	GNAO1 GNAQ GNG11 RGS14 GNAT2 GNAI2 GNAI3 RGS12 GNB1	GTPase activity
REAC:R-HSA-195721	4.50909103042e-08	0.533333333333	GNG12 GNAO1 GNG4 GNG11 GNB4 GNAT2 GNB1 GNG7	Signaling by WNT
REAC:R-HSA-112316	4.63147343486e-08	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Neuronal System
GO:0031683	8.07396144441e-08	0.333333333333	GNAT2 GNAO1 GNAI2 GNAQ GNAI3	G-protein beta/gamma-subunit complex binding
REAC:R-HSA-109582	1.15051270773e-07	0.6	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Hemostasis
REAC:R-HSA-162582	1.59417051326e-07	0.866666666667	GNG12 GNAO1 GNAQ GNAT2 GNG11 RGS14 GNB4 GNG4 GNG7 GNB1 GNAI3 RGS12 GNAI2	Signal Transduction
WP:WP2032	2.03151292118e-07	0.333333333333	GNAO1 GNAI3 GNB1 GNAQ GNAI2	Thyroid stimulating hormone TSH signaling pathway
WP:WP4223	4.82374728696e-07	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Ras signaling
KEGG:05167	5.52546377787e-07	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Kaposi sarcoma-associated herpesvirus infection
GO:0017111	7.51530901324e-07	0.6	GNAO1 GNAQ GNG11 RGS14 GNAT2 GNAI2 GNAI3 RGS12 GNB1	ribonucleoside triphosphate phosphatase activity
WP:WP4900	8.37953025287e-07	0.266666666667	GNAT2 GNAO1 GNAI2 GNAI3	Purinergic signaling
KEGG:04014	9.53154081662e-07	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Ras signaling pathway
WP:WP722	1.17751762325e-06	0.266666666667	GNAO1 GNAI2 GNAQ GNAI3	Serotonin HTR1 group and FOS pathway
GO:0016462	2.12690158776e-06	0.6	GNAO1 GNAQ GNG11 RGS14 GNAT2 GNAI2 GNAI3 RGS12 GNB1	pyrophosphatase activity
GO:0016818	2.12690158776e-06	0.6	GNAO1 GNAQ GNG11 RGS14 GNAT2 GNAI2 GNAI3 RGS12 GNB1	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016817	2.12690158776e-06	0.6	GNAO1 GNAQ GNG11 RGS14 GNAT2 GNAI2 GNAI3 RGS12 GNB1	hydrolase activity, acting on acid anhydrides
GO:0098796	3.2497150192e-06	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	membrane protein complex
GO:0005886	7.24550215397e-06	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	plasma membrane
KEGG:04730	7.76023940409e-06	0.266666666667	GNAO1 GNAI2 GNAQ GNAI3	Long-term depression
WP:WP3932	1.09956142813e-05	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Focal adhesion PI3K Akt mTOR signaling pathway
KEGG:04151	1.31107928055e-05	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	PI3K-Akt signaling pathway
REAC:R-HSA-500792	1.84592026816e-05	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	GPCR ligand binding
WP:WP4172	1.85885242865e-05	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	PI3K Akt signaling pathway
KEGG:04015	2.77931995429e-05	0.333333333333	GNAO1 GNAI3 RGS14 GNAQ GNAI2	Rap1 signaling pathway
GO:0071944	3.12270071434e-05	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	cell periphery
GO:0007165	3.46871773026e-05	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	signal transduction
CORUM:7204	4.77291996201e-05	0.133333333333	GNG12 GNB1	GNAS-L-GNB1-GNG12 complex
CORUM:7160	4.77291996201e-05	0.133333333333	GNG4 GNB1	GNAS-L-GNB1-GNG4 complex
CORUM:7207	4.77291996201e-05	0.133333333333	GNB4 GNG12	GNAS-L-GNB4-GNG12 complex
CORUM:7202	4.77291996201e-05	0.133333333333	GNB4 GNG11	GNAS-L-GNB4-GNG11 complex
CORUM:7163	4.77291996201e-05	0.133333333333	GNB4 GNG4	GNAS-L-GNB4-GNG4 complex
CORUM:7170	4.77291996201e-05	0.133333333333	GNB1 GNG7	GNAS-L-GNB1-GNG7 complex
CORUM:7173	4.77291996201e-05	0.133333333333	GNB4 GNG7	GNAS-L-GNB4-GNG7 complex
CORUM:7195	4.77291996201e-05	0.133333333333	GNG11 GNB1	GNAS-L-GNB1-GNG11 complex
GO:0007188	6.69287756738e-05	0.4	GNAO1 GNAI2 GNAT2 GNB1 GNAI3 GNAQ	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
KEGG:04916	7.1755826708e-05	0.266666666667	GNAO1 GNAI2 GNAQ GNAI3	Melanogenesis
GO:0031681	8.4814831801e-05	0.266666666667	GNG12 GNG4 GNG11 GNG7	G-protein beta-subunit binding
KEGG:05142	9.07816173144e-05	0.266666666667	GNAO1 GNAI2 GNAQ GNAI3	Chagas disease
WP:WP2355	9.29445188113e-05	0.266666666667	GNAO1 GNB1 GNAQ GNAI2	Corticotropin releasing hormone signaling pathway
KEGG:04915	0.000108515284803	0.266666666667	GNAO1 GNAI2 GNAQ GNAI3	Estrogen signaling pathway
GO:0023052	0.000114167333166	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	signaling
GO:0007154	0.00013730926927	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	cell communication
CORUM:7066	0.000143102677271	0.133333333333	GNB1 GNG7	GNAI1-GNB1-GNG7 complex
CORUM:7089	0.000143102677271	0.133333333333	GNB4 GNG12	GNAI1-GNB4-GNG12 complex
CORUM:7034	0.000143102677271	0.133333333333	GNB4 GNG4	GNAI1-GNB4-GNG4 complex
CORUM:7069	0.000143102677271	0.133333333333	GNB4 GNG7	GNAI1-GNB4-GNG7 complex
CORUM:7081	0.000143102677271	0.133333333333	GNG11 GNB1	GNAI1-GNB1-GNG11 complex
CORUM:7084	0.000143102677271	0.133333333333	GNB4 GNG11	GNAI1-GNB4-GNG11 complex
CORUM:7031	0.000143102677271	0.133333333333	GNG4 GNB1	GNAI1-GNB1-GNG4 complex
REAC:R-HSA-5663205	0.000191833594165	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Infectious disease
GO:0007212	0.000212770750591	0.266666666667	GNAO1 GNB1 GNAQ GNAI3	dopamine receptor signaling pathway
CORUM:6806	0.000286035615974	0.133333333333	GNB1 GNAI2	IGF1R-CXCR4-GNAI2-GNB1 complex
CORUM:117	0.000286035615974	0.133333333333	GNB1 GNAQ	GPR56-CD81-Galpha(q/11)-Gbeta complex
KEGG:04921	0.000293378531494	0.266666666667	GNAO1 GNAI2 GNAQ GNAI3	Oxytocin signaling pathway
GO:1902494	0.000722767747102	0.733333333333	GNG12 GNAO1 GNAQ GNB4 GNG11 GNG4 GNAT2 GNG7 GNAI2 GNAI3 GNB1	catalytic complex
KEGG:04924	0.000838932125106	0.2	GNAI2 GNAQ GNAI3	Renin secretion
GO:1903350	0.000840301455925	0.266666666667	GNAO1 GNB1 GNAQ GNAI3	response to dopamine
GO:1903351	0.000840301455925	0.266666666667	GNAO1 GNB1 GNAQ GNAI3	cellular response to dopamine
GO:0071868	0.000968994174115	0.266666666667	GNAO1 GNB1 GNAQ GNAI3	cellular response to monoamine stimulus
GO:0071867	0.000968994174115	0.266666666667	GNAO1 GNB1 GNAQ GNAI3	response to monoamine
GO:0071869	0.000968994174115	0.266666666667	GNAO1 GNB1 GNAQ GNAI3	response to catecholamine
GO:0071870	0.000968994174115	0.266666666667	GNAO1 GNB1 GNAQ GNAI3	cellular response to catecholamine stimulus
KEGG:04971	0.00113276690566	0.2	GNAI2 GNAQ GNAI3	Gastric acid secretion
GO:0051716	0.00122286486278	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	cellular response to stimulus
REAC:R-HSA-382551	0.00258792430482	0.4	GNG12 GNG7 GNG4 GNG11 GNB4 GNB1	Transport of small molecules
KEGG:04540	0.00273323184262	0.2	GNAI2 GNAQ GNAI3	Gap junction
REAC:R-HSA-112040	0.00413284350139	0.2	GNAI2 GNAQ GNAI3	G-protein mediated events
KEGG:04928	0.00436147999209	0.2	GNAI2 GNAQ GNAI3	Parathyroid hormone synthesis, secretion and action
KEGG:05145	0.00573836066261	0.2	GNAO1 GNAI2 GNAI3	Toxoplasmosis
KEGG:04611	0.00715332046344	0.2	GNAI2 GNAQ GNAI3	Platelet activation
KEGG:04744	0.00755608093358	0.133333333333	GNAT2 GNB1	Phototransduction
KEGG:04935	0.00759563488001	0.2	GNAI2 GNAQ GNAI3	Growth hormone synthesis, secretion and action
WP:WP4540	0.00819786414524	0.2	GNAI2 GNAQ GNAI3	Hippo signaling regulation pathways
KEGG:04071	0.00829197171089	0.2	GNAI2 GNAQ GNAI3	Sphingolipid signaling pathway
REAC:R-HSA-1643685	0.0111590520674	0.533333333333	GNG12 GNG7 GNG4 GNG11 GNB4 GNAI2 GNAI3 GNB1	Disease
KEGG:04261	0.0127123721346	0.2	GNAI2 GNAQ GNAI3	Adrenergic signaling in cardiomyocytes
GO:0050896	0.0127437607462	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	response to stimulus
WP:WP5380	0.0131124614751	0.2	GNAI3 RGS14 GNAI2	5q35 copy number variation
REAC:R-HSA-170670	0.0131842796061	0.133333333333	GNAI2 GNAI3	Adenylate cyclase inhibitory pathway
GO:0016787	0.0138175453029	0.666666666667	SMPDL3B GNAO1 GNAQ RGS14 GNG11 GNAT2 GNB1 GNAI3 RGS12 GNAI2	hydrolase activity
KEGG:04022	0.0146974039013	0.2	GNAI2 GNAQ GNAI3	cGMP-PKG signaling pathway
KEGG:04934	0.0146974039013	0.2	GNAI2 GNAQ GNAI3	Cushing syndrome
WP:WP26	0.0272973213504	0.133333333333	GNAI2 GNAI3	S1P receptor signal transduction
GO:0016020	0.0378885221644	1.0	SMPDL3B GNAO1 GNAQ GNB4 RGS14 GNG11 RIC8A GNAT2 GNG4 GNG7 GNB1 GNAI3 GNG12 RGS12 GNAI2	membrane
REAC:R-HSA-1430728	0.0402252851312	0.533333333333	GNG12 GNG7 GNAQ GNG4 GNG11 GNB4 GNAI2 GNB1	Metabolism
GO:0001664	0.0417107879377	0.333333333333	GNAT2 GNAO1 GNAI2 GNAQ GNAI3	G protein-coupled receptor binding
KEGG:05030	0.0449150412235	0.133333333333	GNAI2 GNAI3	Cocaine addiction
KEGG:04923	0.0494027221414	0.133333333333	GNAI2 GNAI3	Regulation of lipolysis in adipocytes
CORUM:7209	0.0498224659463	0.0666666666667	GNB1	GNAS-L-GNB1-GNG13 complex
CORUM:7212	0.0498224659463	0.0666666666667	GNB4	GNAS-L-GNB4-GNG13 complex
CORUM:7201	0.0498224659463	0.0666666666667	GNG11	GNAS-L-GNB3-GNG11 complex
CORUM:7172	0.0498224659463	0.0666666666667	GNG7	GNAS-L-GNB3-GNG7 complex
CORUM:7162	0.0498224659463	0.0666666666667	GNG4	GNAS-L-GNB3-GNG4 complex
CORUM:7206	0.0498224659463	0.0666666666667	GNG12	GNAS-L-GNB3-GNG12 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GNAI3	RIC8A	1.0	0.06
GNAI3	GNAI2	0.999	0.286
GNAO1	RIC8A	0.999	0.068
GNG7	GNB1	0.999	0.150619047619
GNAO1	GNAI2	0.999	0.082
GNAI3	GNAO1	0.999	0.106
GNAI2	RIC8A	0.999	0.042
RGS12	GNAI3	0.998	0.068
GNAI3	GNG12	0.997	0.086
GNG7	GNAI2	0.997	0.126	structurally_consistent (dimer)
GNAI2	GNB1	0.997	0.244
GNAI3	GNG7	0.997	0.13
GNAI3	GNB1	0.997	0.23	structurally_consistent (P16520)
GNG12	GNAI2	0.997	0.056
GNAI3	GNAQ	0.996	0.14
GNAI3	GNG4	0.996	0.082
GNAI2	GNAQ	0.996	0.28
GNAI3	GNB4	0.995	0.488
GNB4	GNAI2	0.994	0.458	mutually_exclusive (O60262)
GNAI3	GNAT2	0.994		structurally_consistent (dimer)
GNG4	GNB1	0.994	0.154	structurally_consistent (P16520) structurally_consistent (dimer)
GNG12	GNB1	0.994	0.162	structurally_consistent (P16520) structurally_consistent (dimer)
GNB4	GNAQ	0.993	0.356	structurally_consistent (dimer)
GNAQ	GNB1	0.993	0.37	structurally_consistent (P16520)
GNG12	GNAQ	0.99	0.126
GNG4	GNG7	0.99	0.152
GNB4	GNG12	0.989	0.228	structurally_consistent (dimer)
GNG11	GNAI3	0.987	0.156	structurally_consistent (dimer)
GNAT2	GNAO1	0.986		structurally_consistent (dimer)
GNG4	GNAI2	0.983	0.076
GNG4	RIC8A	0.981	0.062
GNB4	GNB1	0.98	0.788
GNAQ	RIC8A	0.979	0.032
GNAO1	GNG4	0.979	0.288
RGS14	GNAI3	0.968	0.096	mutually_exclusive (P63096) structurally_consistent (dimer)
GNB4	GNG4	0.964	0.294	structurally_consistent (dimer)
SMPDL3B	GNAI3	0.964	0.108
GNAO1	GNB1	0.962	0.126
GNAO1	GNG7	0.956	0.098	structurally_consistent (dimer)
GNG4	GNG12	0.951	0.106
GNG7	RIC8A	0.942	0.06
RGS12	GNAT2	0.936
RIC8A	GNB1	0.929	0.068	mutually_exclusive (P63096)
GNAT2	GNG4	0.921
RGS12	GNG4	0.899	0.114
GNAT2	GNG7	0.877		mutually_exclusive (P09471)
SMPDL3B	GNAQ	0.868	0.064	structurally_consistent (Q8IYP9)
GNAT2	RIC8A	0.854
GNG7	GNG12	0.844	0.184
RGS14	GNG11	0.825	0.092	mutually_exclusive (P08754)
RGS12	GNG7	0.809	0.118
RGS12	GNAO1	0.809	0.152
RGS12	RIC8A	0.803	0.09
SMPDL3B	GNAI2	0.778	0.09
GNAO1	GNAQ	0.715	0.126
GNG12	RIC8A	0.709	0.044
GNG11	GNB1	0.704	0.306
SMPDL3B	GNAO1	0.681	0.092
RGS12	GNAI2	0.596	0.124
GNB4	GNG7	0.595	0.146	structurally_consistent (dimer)
SMPDL3B	GNG12	0.563	0.116
GNG4	GNAQ	0.532	0.124
RGS14	GNAT2	0.513		mutually_exclusive (P08754)
RGS14	RIC8A	0.476	0.068	mutually_exclusive (P63096)
RGS14	RGS12	0.476	0.08
GNAT2	GNAI2	0.46
GNG11	GNAO1	0.445	0.09
GNAO1	GNB4	0.431	0.176	mutually_exclusive (O60262) structurally_consistent (dimer)
RGS12	GNB1	0.431	0.27
RGS14	GNB4	0.424	0.204
GNG11	GNG7	0.42	0.144
RGS14	GNB1	0.414	0.13
RGS14	GNAO1	0.411	0.088
GNG11	GNG4	0.4	0.148
RGS14	GNG7	0.4	0.108	mutually_exclusive (P04899)
GNG11	RIC8A	0.4	0.074
GNB4	RIC8A	0.389	0.106	mutually_exclusive (P63096)
GNG11	GNB4	0.388	0.294	structurally_consistent (dimer)
GNG11	GNAT2	0.378
RGS14	GNG4	0.367	0.154
RGS12	GNG11	0.367	0.114
RGS12	GNB4	0.337	0.13
GNAO1	GNG12	0.286	0.088
RGS12	GNG12	0.283	0.078
GNG7	GNAQ	0.269	0.112
GNAT2	GNB4	0.185
RGS14	GNAI2	0.18	0.048	structurally_consistent (dimer)
GNAT2	GNB1	0.168
GNAT2	GNG12	0.162
RGS14	GNG12	0.151	0.162
GNG11	GNG12	0.143	0.124
GNAT2	GNAQ	0.13
SMPDL3B	GNB4	0.118	0.168
GNG11	GNAI2	0.088	0.14
SMPDL3B	GNG7	0.087	0.104315789474
SMPDL3B	GNG4	0.046	0.094
SMPDL3B	GNB1	0.033	0.1
SMPDL3B	RIC8A	0.007	0.06

Related Complexes

Genename	Complexes
SMPDL3B	huMAP3_01486.1 huMAP3_03550.1 huMAP3_07033.1 huMAP3_07209.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_12658.1 huMAP3_14897.1
RGS12	huMAP3_01199.1 huMAP3_01486.1 huMAP3_03550.1 huMAP3_07033.1 huMAP3_07243.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1 huMAP3_15303.1
RGS14	huMAP3_00466.1 huMAP3_01486.1 huMAP3_05502.1 huMAP3_07209.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12381.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNAT2	huMAP3_02643.1 huMAP3_08140.1 huMAP3_08591.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG11	huMAP3_01486.1 huMAP3_03550.1 huMAP3_07033.1 huMAP3_07209.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12381.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNB4	huMAP3_03550.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNB1	huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNAI2	huMAP3_05473.1 huMAP3_05901.1 huMAP3_08591.1 huMAP3_08713.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1
GNAI3	huMAP3_01486.1 huMAP3_03550.1 huMAP3_07033.1 huMAP3_07209.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG4	huMAP3_03550.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNAO1	huMAP3_02643.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG7	huMAP3_03550.1 huMAP3_05901.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
RIC8A	huMAP3_05901.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG12	huMAP3_03550.1 huMAP3_05674.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1
GNAQ	huMAP3_05502.1 huMAP3_08591.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12658.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08591.1

Complex Portal: CPX-13592