hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08596.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EDRF1 | Erythroid differentiation-related factor 1 | 5 | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | 5 | UniProt NCBI |
| CDC37L1 | Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) | 5 | UniProt NCBI |
| HSP90AA1 | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | 5 | UniProt NCBI |
| UNC45B | Protein unc-45 homolog B (Unc-45B) (SMUNC45) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2112 | 4.09448956317e-05 | 0.4 | HSP90AB1 HSP90AA1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:5234 | 0.000136445626745 | 0.4 | HSP90AB1 HSP90AA1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:5269 | 0.000204640425412 | 0.4 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 8 |
| REAC:R-HSA-5336415 | 0.000227895019208 | 0.4 | HSP90AB1 HSP90AA1 | Uptake and function of diphtheria toxin |
| CORUM:5212 | 0.00038189088864 | 0.4 | HSP90AB1 HSP90AA1 | Kinase maturation complex 2 |
| CORUM:5268 | 0.00038189088864 | 0.4 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5286 | 0.000613585186048 | 0.4 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 10 |
| REAC:R-HSA-3371511 | 0.00100191474811 | 0.4 | HSP90AB1 HSP90AA1 | HSF1 activation |
| CORUM:5266 | 0.00106311089559 | 0.4 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 6 |
| REAC:R-HSA-3371568 | 0.0011839189519 | 0.4 | HSP90AB1 HSP90AA1 | Attenuation phase |
| REAC:R-HSA-399954 | 0.001593300657 | 0.4 | HSP90AB1 HSP90AA1 | Sema3A PAK dependent Axon repulsion |
| CORUM:5199 | 0.00163488349218 | 0.4 | HSP90AB1 HSP90AA1 | Kinase maturation complex 1 |
| REAC:R-HSA-5339562 | 0.00259338296865 | 0.4 | HSP90AB1 HSP90AA1 | Uptake and actions of bacterial toxins |
| REAC:R-HSA-9613829 | 0.00318398402781 | 0.4 | HSP90AB1 HSP90AA1 | Chaperone Mediated Autophagy |
| REAC:R-HSA-9013418 | 0.00383489202506 | 0.4 | HSP90AB1 HSP90AA1 | RHOBTB2 GTPase cycle |
| REAC:R-HSA-3371571 | 0.00383489202506 | 0.4 | HSP90AB1 HSP90AA1 | HSF1-dependent transactivation |
| GO:0006457 | 0.00397811315054 | 0.8 | UNC45B HSP90AB1 HSP90AA1 CDC37L1 | protein folding |
| GO:1902949 | 0.00468200720083 | 0.4 | HSP90AB1 HSP90AA1 | positive regulation of tau-protein kinase activity |
| KEGG:04612 | 0.00825154536734 | 0.4 | HSP90AB1 HSP90AA1 | Antigen processing and presentation |
| REAC:R-HSA-9706574 | 0.00900400267976 | 0.4 | HSP90AB1 HSP90AA1 | RHOBTB GTPase Cycle |
| KEGG:04657 | 0.0131645270498 | 0.4 | HSP90AB1 HSP90AA1 | IL-17 signaling pathway |
| KEGG:04914 | 0.0149314441262 | 0.4 | HSP90AB1 HSP90AA1 | Progesterone-mediated oocyte maturation |
| KEGG:05215 | 0.0179869923441 | 0.4 | HSP90AB1 HSP90AA1 | Prostate cancer |
| KEGG:04659 | 0.0179869923441 | 0.4 | HSP90AB1 HSP90AA1 | Th17 cell differentiation |
| KEGG:04915 | 0.0187947263105 | 0.4 | HSP90AB1 HSP90AA1 | Estrogen signaling pathway |
| REAC:R-HSA-3371497 | 0.0200193611976 | 0.4 | HSP90AB1 HSP90AA1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-2029482 | 0.0232374901507 | 0.4 | HSP90AB1 HSP90AA1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-9824439 | 0.0258071378099 | 0.4 | HSP90AB1 HSP90AA1 | Bacterial Infection Pathways |
| REAC:R-HSA-373755 | 0.0258071378099 | 0.4 | HSP90AB1 HSP90AA1 | Semaphorin interactions |
| KEGG:05418 | 0.0303640260346 | 0.4 | HSP90AB1 HSP90AA1 | Fluid shear stress and atherosclerosis |
| WP:WP2884 | 0.0360146352745 | 0.4 | HSP90AB1 HSP90AA1 | NRF2 pathway |
| KEGG:04217 | 0.0415700968186 | 0.4 | HSP90AB1 HSP90AA1 | Necroptosis |
| REAC:R-HSA-168928 | 0.0417637628913 | 0.4 | HSP90AB1 HSP90AA1 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| REAC:R-HSA-8852276 | 0.0428866281036 | 0.4 | HSP90AB1 HSP90AA1 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-2029480 | 0.0451765626421 | 0.4 | HSP90AB1 HSP90AA1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:1902947 | 0.0468008499735 | 0.4 | HSP90AB1 HSP90AA1 | regulation of tau-protein kinase activity |
| GO:0044294 | 0.0468008499735 | 0.4 | HSP90AB1 HSP90AA1 | dendritic growth cone |
| GO:0030911 | 0.0468008499735 | 0.4 | HSP90AB1 HSP90AA1 | TPR domain binding |
| KEGG:04621 | 0.0471742362289 | 0.4 | HSP90AB1 HSP90AA1 | NOD-like receptor signaling pathway |
| CORUM:5716 | 0.0498708842806 | 0.2 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSP90AB1 | HSP90AA1 | 1.0 | 0.954 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| EDRF1 | HSP90AB1 | 0.995 | 0.32305 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| CDC37L1 | HSP90AB1 | 0.986 | 0.351110091582 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EDRF1 | HSP90AA1 | 0.983 | 0.474 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| CDC37L1 | HSP90AA1 | 0.966 | 0.479316479401 | hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| HSP90AB1 | UNC45B | 0.963 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| HSP90AA1 | UNC45B | 0.952 | 0.207431818182 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CDC37L1 | EDRF1 | 0.667 | 0.082 | bioplex3_WMM WMM_only |
Related Complexes