hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08597.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | 5 | UniProt NCBI |
| SLX4 | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03460 | 0.000191181960701 | 1.0 | SLX4 ERCC4 | Fanconi anemia pathway |
| HP:0005522 | 0.000789447929484 | 1.0 | SLX4 ERCC4 | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 0.000864633446577 | 1.0 | SLX4 ERCC4 | Absent testis |
| REAC:R-HSA-6783310 | 0.00101671324252 | 1.0 | SLX4 ERCC4 | Fanconi Anemia Pathway |
| WP:WP5114 | 0.00111857408398 | 1.0 | SLX4 ERCC4 | Nucleotide excision repair in xeroderma pigmentosum |
| HP:0010293 | 0.00119955074999 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia of the uvula |
| HP:0100867 | 0.00119955074999 | 1.0 | SLX4 ERCC4 | Duodenal stenosis |
| HP:0012848 | 0.00119955074999 | 1.0 | SLX4 ERCC4 | Small intestinal stenosis |
| HP:0002245 | 0.00129182388461 | 1.0 | SLX4 ERCC4 | Meckel diverticulum |
| HP:0100760 | 0.00129182388461 | 1.0 | SLX4 ERCC4 | Clubbing of toes |
| GO:0070522 | 0.00140460216025 | 1.0 | SLX4 ERCC4 | ERCC4-ERCC1 complex |
| HP:0100587 | 0.00148662272435 | 1.0 | SLX4 ERCC4 | Abnormal preputium morphology |
| HP:0001924 | 0.00169509165811 | 1.0 | SLX4 ERCC4 | Sideroblastic anemia |
| HP:0040012 | 0.00227607065384 | 1.0 | SLX4 ERCC4 | Chromosome breakage |
| HP:0001549 | 0.00227607065384 | 1.0 | SLX4 ERCC4 | Abnormal ileum morphology |
| HP:0000813 | 0.00338334826922 | 1.0 | SLX4 ERCC4 | Bicornuate uterus |
| HP:0007874 | 0.0038549665128 | 1.0 | SLX4 ERCC4 | Almond-shaped palpebral fissure |
| HP:0100026 | 0.00401900764101 | 1.0 | SLX4 ERCC4 | Arteriovenous malformation |
| HP:0003022 | 0.00435734246793 | 1.0 | SLX4 ERCC4 | Hypoplasia of the ulna |
| HP:0003220 | 0.00453163616665 | 1.0 | SLX4 ERCC4 | Abnormality of chromosome stability |
| HP:0200005 | 0.00470934738887 | 1.0 | SLX4 ERCC4 | Abnormal shape of the palpebral fissure |
| HP:0009777 | 0.00470934738887 | 1.0 | SLX4 ERCC4 | Absent thumb |
| HP:0006495 | 0.00507502240382 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia of the ulna |
| HP:0007565 | 0.0054543675128 | 1.0 | SLX4 ERCC4 | Multiple cafe-au-lait spots |
| HP:0002860 | 0.00604901660254 | 1.0 | SLX4 ERCC4 | Squamous cell carcinoma |
| HP:0001199 | 0.00688972738458 | 1.0 | SLX4 ERCC4 | Triphalangeal thumb |
| HP:0000072 | 0.00733058791663 | 1.0 | SLX4 ERCC4 | Hydroureter |
| HP:0009821 | 0.00825331926278 | 1.0 | SLX4 ERCC4 | Forearm undergrowth |
| HP:0006501 | 0.00849254590808 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia of the radius |
| HP:0008572 | 0.00948362772432 | 1.0 | SLX4 ERCC4 | External ear malformation |
| HP:0009380 | 0.00973994198714 | 1.0 | SLX4 ERCC4 | Aplasia of the fingers |
| HP:0009824 | 0.0105293899166 | 1.0 | SLX4 ERCC4 | Upper limb undergrowth |
| HP:0002246 | 0.0105293899166 | 1.0 | SLX4 ERCC4 | Abnormal duodenum morphology |
| HP:0005344 | 0.0110727761538 | 1.0 | SLX4 ERCC4 | Abnormal carotid artery morphology |
| HP:0002575 | 0.0122005589102 | 1.0 | SLX4 ERCC4 | Tracheoesophageal fistula |
| HP:0000027 | 0.0127849554294 | 1.0 | SLX4 ERCC4 | Azoospermia |
| REAC:R-HSA-5693567 | 0.0128208394262 | 1.0 | SLX4 ERCC4 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| HP:0006503 | 0.0130822799743 | 1.0 | SLX4 ERCC4 | Aplasia/hypoplasia involving forearm bones |
| REAC:R-HSA-5693538 | 0.0141075370256 | 1.0 | SLX4 ERCC4 | Homology Directed Repair |
| HP:0012745 | 0.0172584936965 | 1.0 | SLX4 ERCC4 | Short palpebral fissure |
| HP:0002863 | 0.0190185183012 | 1.0 | SLX4 ERCC4 | Myelodysplasia |
| HP:0008669 | 0.0190185183012 | 1.0 | SLX4 ERCC4 | Abnormal spermatogenesis |
| HP:0001053 | 0.0193807757926 | 1.0 | SLX4 ERCC4 | Hypopigmented skin patches |
| HP:0010161 | 0.0193807757926 | 1.0 | SLX4 ERCC4 | Abnormal toe phalanx morphology |
| GO:0000712 | 0.0210690324038 | 1.0 | SLX4 ERCC4 | resolution of meiotic recombination intermediates |
| REAC:R-HSA-5693532 | 0.0211937720117 | 1.0 | SLX4 ERCC4 | DNA Double-Strand Break Repair |
| HP:0000957 | 0.0212433261025 | 1.0 | SLX4 ERCC4 | Cafe-au-lait spot |
| HP:0008053 | 0.0216260887349 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia of the iris |
| HP:0008055 | 0.0216260887349 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia affecting the uvea |
| HP:0000453 | 0.0216260887349 | 1.0 | SLX4 ERCC4 | Choanal atresia |
| HP:0002414 | 0.0220122688909 | 1.0 | SLX4 ERCC4 | Spina bifida |
| HP:0001217 | 0.0224018665704 | 1.0 | SLX4 ERCC4 | Clubbing |
| HP:0000415 | 0.0248112206409 | 1.0 | SLX4 ERCC4 | Abnormality of the choanae |
| HP:0008062 | 0.0252247409849 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia affecting the anterior segment of the eye |
| HP:0000324 | 0.0256416788524 | 1.0 | SLX4 ERCC4 | Facial asymmetry |
| GO:0000109 | 0.0257510396046 | 1.0 | SLX4 ERCC4 | nucleotide-excision repair complex |
| HP:0010301 | 0.0260620342435 | 1.0 | SLX4 ERCC4 | Spinal dysraphism |
| HP:0009601 | 0.026485807158 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia of the thumb |
| HP:0002023 | 0.026912997596 | 1.0 | SLX4 ERCC4 | Anal atresia |
| HP:0000010 | 0.0295479082178 | 1.0 | SLX4 ERCC4 | Recurrent urinary tract infections |
| HP:0004362 | 0.0299990213204 | 1.0 | SLX4 ERCC4 | Abnormal enteric ganglion morphology |
| HP:0002251 | 0.0299990213204 | 1.0 | SLX4 ERCC4 | Aganglionic megacolon |
| HP:0031105 | 0.0299990213204 | 1.0 | SLX4 ERCC4 | Abnormal uterus morphology |
| HP:0012331 | 0.0304535519464 | 1.0 | SLX4 ERCC4 | Abnormal autonomic nervous system morphology |
| HP:0025633 | 0.0304535519464 | 1.0 | SLX4 ERCC4 | Abnormal ureter morphology |
| HP:0025028 | 0.0304535519464 | 1.0 | SLX4 ERCC4 | Abnormal enteric nervous system morphology |
| HP:0040071 | 0.030911500096 | 1.0 | SLX4 ERCC4 | Abnormal morphology of ulna |
| HP:0001882 | 0.0313728657691 | 1.0 | SLX4 ERCC4 | Leukopenia |
| HP:0012041 | 0.0318376489657 | 1.0 | SLX4 ERCC4 | Decreased fertility in males |
| HP:0002778 | 0.0381908251601 | 1.0 | SLX4 ERCC4 | Abnormal tracheal morphology |
| HP:0001646 | 0.0392194997349 | 1.0 | SLX4 ERCC4 | Abnormal aortic valve morphology |
| HP:0012145 | 0.0397389633075 | 1.0 | SLX4 ERCC4 | Abnormality of multiple cell lineages in the bone marrow |
| HP:0010468 | 0.0418509928331 | 1.0 | SLX4 ERCC4 | Aplasia/Hypoplasia of the testes |
| HP:0001562 | 0.0440177027348 | 1.0 | SLX4 ERCC4 | Oligohydramnios |
| HP:0001636 | 0.0456786191579 | 1.0 | SLX4 ERCC4 | Tetralogy of Fallot |
| HP:0010972 | 0.0473702932925 | 1.0 | SLX4 ERCC4 | Anemia of inadequate production |
| HP:0000340 | 0.0473702932925 | 1.0 | SLX4 ERCC4 | Sloping forehead |
| HP:0000172 | 0.0479410197177 | 1.0 | SLX4 ERCC4 | Abnormal uvula morphology |
| HP:0045058 | 0.0496737041344 | 1.0 | SLX4 ERCC4 | Abnormality of the testis size |
| CORUM:2220 | 0.0499419797295 | 0.5 | ERCC4 | RAD52-ERCC4-ERCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ERCC4 | SLX4 | 0.968 | 0.166 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes