hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08604.1
Complex Portal: CPX-22870
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TFAP2D | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | 5 | UniProt NCBI |
| TFAP2B | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | 5 | UniProt NCBI |
| TFAP2C | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | 5 | UniProt NCBI |
| TFAP2A | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8866904 | 1.20999690042e-11 | 1.0 | TFAP2D TFAP2B TFAP2A TFAP2C | Negative regulation of activity of TFAP2 (AP-2) family transcription factors |
| REAC:R-HSA-8866907 | 2.0166615007e-11 | 1.0 | TFAP2D TFAP2B TFAP2A TFAP2C | Activation of the TFAP2 (AP-2) family of transcription factors |
| REAC:R-HSA-8864260 | 3.92960898137e-09 | 1.0 | TFAP2D TFAP2B TFAP2A TFAP2C | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| REAC:R-HSA-8866910 | 3.0856409449e-07 | 0.75 | TFAP2C TFAP2B TFAP2A | TFAP2 (AP-2) family regulates transcription of growth factors and their receptors |
| WP:WP4352 | 1.84759822159e-06 | 1.0 | TFAP2D TFAP2B TFAP2A TFAP2C | Ciliary landscape |
| REAC:R-HSA-8866906 | 6.15041976665e-05 | 0.5 | TFAP2C TFAP2A | TFAP2 (AP-2) family regulates transcription of other transcription factors |
| REAC:R-HSA-8866911 | 0.000102497642323 | 0.5 | TFAP2C TFAP2A | TFAP2 (AP-2) family regulates transcription of cell cycle factors |
| HPA:0410552 | 0.000195847962419 | 0.5 | TFAP2B TFAP2A | retina; ganglion cells [>=Medium] |
| HPA:0410551 | 0.000395903520345 | 0.5 | TFAP2B TFAP2A | retina; ganglion cells [>=Low] |
| HPA:0411232 | 0.000591517957266 | 0.5 | TFAP2B TFAP2A | retina; inner nuclear layer[>=Medium] |
| HPA:0411231 | 0.000826159052053 | 0.5 | TFAP2B TFAP2A | retina; inner nuclear layer[>=Low] |
| REAC:R-HSA-3232118 | 0.00107524337392 | 0.5 | TFAP2C TFAP2B | SUMOylation of transcription factors |
| REAC:R-HSA-212436 | 0.00439089268099 | 1.0 | TFAP2D TFAP2B TFAP2A TFAP2C | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.00681752083972 | 1.0 | TFAP2D TFAP2B TFAP2A TFAP2C | RNA Polymerase II Transcription |
| WP:WP2064 | 0.00685264055756 | 0.5 | TFAP2B TFAP2A | Neural crest differentiation |
| HPA:0410000 | 0.00957267319752 | 0.5 | TFAP2B TFAP2A | retina |
| REAC:R-HSA-74160 | 0.0112707156575 | 1.0 | TFAP2D TFAP2B TFAP2A TFAP2C | Gene expression (Transcription) |
| HPA:0461462 | 0.0163259099541 | 0.75 | TFAP2C TFAP2B TFAP2A | skin 1; langerhans cells[>=Medium] |
| WP:WP2858 | 0.0165681999049 | 0.5 | TFAP2C TFAP2A | Ectoderm differentiation |
| HPA:0461412 | 0.017037547013 | 0.75 | TFAP2C TFAP2B TFAP2A | skin 1; cells in spinous layer[>=Medium] |
| HPA:0471462 | 0.0233681465302 | 0.75 | TFAP2C TFAP2B TFAP2A | skin 2; langerhans cells[>=Medium] |
| HPA:0471412 | 0.025307719873 | 0.75 | TFAP2C TFAP2B TFAP2A | skin 2; cells in spinous layer[>=Medium] |
| HPA:0461453 | 0.0292462264975 | 0.5 | TFAP2C TFAP2B | skin 1; hair follicles[High] |
| HPA:0461461 | 0.0306799890508 | 0.75 | TFAP2C TFAP2B TFAP2A | skin 1; langerhans cells[>=Low] |
| HPA:0461411 | 0.0364546459466 | 0.75 | TFAP2C TFAP2B TFAP2A | skin 1; cells in spinous layer[>=Low] |
| HP:0002558 | 0.0391604009626 | 0.5 | TFAP2B TFAP2A | Supernumerary nipple |
| HPA:0471461 | 0.0392002139957 | 0.75 | TFAP2C TFAP2B TFAP2A | skin 2; langerhans cells[>=Low] |
| CORUM:5146 | 0.049938562206 | 0.25 | TFAP2A | RB1-TFAP2A complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TFAP2A | TFAP2D | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TFAP2B | TFAP2A | 0.988 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TFAP2B | TFAP2D | 0.977 |
mutually_exclusive (P05549)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TFAP2C | TFAP2D | 0.973 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TFAP2A | TFAP2C | 0.415 | 0.12 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| TFAP2D | huMAP3_01365.1 huMAP3_03193.1 huMAP3_08604.1 |
| TFAP2B | huMAP3_01365.1 huMAP3_02506.1 huMAP3_03193.1 huMAP3_06567.1 huMAP3_07334.1 huMAP3_08604.1 huMAP3_12543.1 |
| TFAP2C | huMAP3_01365.1 huMAP3_08604.1 |
| TFAP2A | huMAP3_01365.1 huMAP3_03193.1 huMAP3_08604.1 |