hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08605.1

Complex Portal: CPX-15325

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PHF12	PHD finger protein 12 (PHD factor 1) (Pf1)	5	UniProt NCBI
PHF21A	PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)	5	UniProt NCBI
SFMBT1	Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1)	5	UniProt NCBI
HDAC1	Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)	5	UniProt NCBI
MIDEAS	Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)	4	UniProt NCBI
CCDC71	Coiled-coil domain-containing protein 71	2	UniProt NCBI
GSE1	Genetic suppressor element 1	5	UniProt NCBI
PHF21B	PHD finger protein 21B	3	UniProt NCBI
TRERF1	Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132)	5	UniProt NCBI
RREB1	Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1)	5	UniProt NCBI
EMSY	BRCA2-interacting transcriptional repressor EMSY	5	UniProt NCBI
CASP8AP2	CASP8-associated protein 2 (FLICE-associated huge protein)	5	UniProt NCBI
PWWP2A	PWWP domain-containing protein 2A	5	UniProt NCBI
DNTTIP1	Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1)	5	UniProt NCBI
RERE	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)	5	UniProt NCBI
RCOR1	REST corepressor 1 (Protein CoREST)	5	UniProt NCBI
KDM5A	Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)	5	UniProt NCBI
GATAD1	GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:626	6.09562332881e-11	0.294117647059	PHF21A RREB1 HDAC1 RCOR1 PHF21B	LSD1 complex
CORUM:1492	1.11922940843e-08	0.235294117647	PHF21A RCOR1 HDAC1 GSE1	BHC110 complex
CORUM:633	1.75753697224e-08	0.235294117647	PHF21A RCOR1 HDAC1 GSE1	anti-BHC110 complex
GO:0000118	2.06869779679e-08	0.411764705882	DNTTIP1 MIDEAS PHF21A TRERF1 HDAC1 RCOR1 PHF12	histone deacetylase complex
CORUM:632	1.26215176664e-07	0.235294117647	PHF21A RCOR1 HDAC1 GSE1	Anti-HDAC2 complex
CORUM:6373	2.23297982515e-07	0.176470588235	DNTTIP1 HDAC1 MIDEAS	MiDAC complex
CORUM:636	1.11488588145e-06	0.176470588235	PHF21A HDAC1 RCOR1	BHC complex
CORUM:620	1.94964826371e-06	0.176470588235	PHF21A HDAC1 RCOR1	CoREST-HDAC complex
CORUM:871	1.94964826371e-06	0.176470588235	PHF21A HDAC1 RCOR1	BRAF53-BRCA2 complex
GO:0003714	1.40214579447e-05	0.411764705882	SFMBT1 MIDEAS TRERF1 HDAC1 RCOR1 RERE PHF12	transcription corepressor activity
CORUM:642	3.76075506667e-05	0.176470588235	RCOR1 HDAC1 RREB1	CtBP complex
CORUM:6421	0.000163158265417	0.117647058824	DNTTIP1 HDAC1	DNTTIP1-ZNF541-HDAC1-HDAC2 complex
CORUM:648	0.000163158265417	0.117647058824	RCOR1 HDAC1	HDAC1-associated core complex cI
CORUM:643	0.00194987488536	0.117647058824	RCOR1 HDAC1	CtBP core complex
CORUM:646	0.00194987488536	0.117647058824	RCOR1 HDAC1	HDAC1-associated protein complex
CORUM:649	0.00194987488536	0.117647058824	RCOR1 HDAC1	HDAC1-associated core complex cII
CORUM:5614	0.00919874420385	0.117647058824	RCOR1 HDAC1	Emerin complex 32
GO:0003712	0.0111179812739	0.411764705882	SFMBT1 MIDEAS TRERF1 HDAC1 RCOR1 RERE PHF12	transcription coregulator activity
REAC:R-HSA-3214815	0.0327798548488	0.176470588235	PHF21A HDAC1 RCOR1	HDACs deacetylate histones
WP:WP2853	0.0338393919987	0.176470588235	SFMBT1 TRERF1 EMSY	Endoderm differentiation
REAC:R-HSA-9679191	0.0392653910943	0.176470588235	PHF21A HDAC1 RCOR1	Potential therapeutics for SARS

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
HDAC1	RCOR1	1.0	0.164	structurally_consistent (dimer)
GSE1	RCOR1	1.0	0.066
PHF12	GATAD1	1.0	0.168
KDM5A	GATAD1	1.0	0.192
EMSY	GATAD1	1.0	0.094
HDAC1	GSE1	1.0	0.088	structurally_consistent (dimer)
PHF12	KDM5A	1.0	0.294
PHF12	HDAC1	0.999	0.208
PHF21A	RCOR1	0.999	0.076
MIDEAS	DNTTIP1	0.999	0.378	mutually_exclusive (Q92769)
PHF12	EMSY	0.999	0.646
EMSY	KDM5A	0.999	0.174
MIDEAS	HDAC1	0.998	0.128	structurally_consistent (dimer)
HDAC1	RREB1	0.998	0.162	structurally_consistent (dimer)
EMSY	HDAC1	0.997	0.062
HDAC1	TRERF1	0.997		structurally_consistent (dimer)
HDAC1	DNTTIP1	0.997	0.344	mutually_exclusive (Q92769) structurally_consistent (dimer)
GATAD1	HDAC1	0.995	0.142
TRERF1	DNTTIP1	0.994
PHF21A	GSE1	0.994	0.1	mutually_exclusive (Q13547)
RERE	HDAC1	0.992	0.318
PHF21A	HDAC1	0.992	0.196	mutually_exclusive (O60341) structurally_consistent (dimer)
MIDEAS	PWWP2A	0.992	0.092
KDM5A	HDAC1	0.991	0.228
MIDEAS	TRERF1	0.99		mutually_exclusive (Q13547)
RCOR1	RREB1	0.99	0.078
TRERF1	PWWP2A	0.987
PWWP2A	DNTTIP1	0.984	0.212
SFMBT1	HDAC1	0.984	0.17106122449
HDAC1	PWWP2A	0.981	0.11
PHF12	RCOR1	0.978	0.104
HDAC1	CASP8AP2	0.977	0.256
HDAC1	PHF21B	0.976
PHF12	TRERF1	0.968
CCDC71	HDAC1	0.967	0.118	structurally_consistent (dimer)
PWWP2A	RCOR1	0.965	0.17
RERE	PWWP2A	0.965	0.108
PHF12	GSE1	0.964	0.172
GSE1	PWWP2A	0.957	0.058
RERE	PHF12	0.956	0.276
PHF21B	RCOR1	0.942
KDM5A	TRERF1	0.924
CASP8AP2	RCOR1	0.901	0.116
PWWP2A	RREB1	0.898	0.086
KDM5A	RCOR1	0.882	0.114
RERE	KDM5A	0.878	0.32
TRERF1	RREB1	0.876
RERE	TRERF1	0.87
RERE	EMSY	0.862	0.206
PHF12	RREB1	0.853	0.062
TRERF1	RCOR1	0.841
KDM5A	GSE1	0.838	0.154
PHF12	PWWP2A	0.835	0.108
GATAD1	PWWP2A	0.83	0.134
GSE1	TRERF1	0.806
SFMBT1	RCOR1	0.805	0.104
EMSY	TRERF1	0.803
PHF21A	SFMBT1	0.803	0.06
RERE	GSE1	0.793	0.096
KDM5A	PWWP2A	0.766	0.162
RERE	RCOR1	0.735	0.17
EMSY	PWWP2A	0.727	0.048
RERE	DNTTIP1	0.71	0.07
GSE1	RREB1	0.7	0.084
RERE	RREB1	0.687	0.098
EMSY	DNTTIP1	0.675	0.038
KDM5A	RREB1	0.675	0.148
MIDEAS	RCOR1	0.667	0.136
EMSY	GSE1	0.661	0.084
RERE	PHF21A	0.658	0.23
RERE	MIDEAS	0.657	0.052
PHF21A	TRERF1	0.637		mutually_exclusive (Q13547)
MIDEAS	RREB1	0.626	0.018
PHF12	CCDC71	0.622	0.2
KDM5A	CCDC71	0.622	0.184
GATAD1	CCDC71	0.622	0.078
SFMBT1	GSE1	0.61	0.056
MIDEAS	PHF21A	0.61	0.04
DNTTIP1	RCOR1	0.604	0.062	mutually_exclusive (Q92769)
GSE1	DNTTIP1	0.594	0.096
KDM5A	PHF21A	0.591	0.162
MIDEAS	GSE1	0.537	0.052
PHF21A	RREB1	0.535	0.06
PHF21B	TRERF1	0.516
CCDC71	TRERF1	0.502		mutually_exclusive (Q13547)
SFMBT1	TRERF1	0.502
TRERF1	CASP8AP2	0.502
PHF21B	CASP8AP2	0.497
PHF12	MIDEAS	0.488	0.088
DNTTIP1	RREB1	0.475	0.04
EMSY	MIDEAS	0.468	0.07
PHF21A	DNTTIP1	0.443	0.072
PHF12	PHF21A	0.44	0.222
PHF12	DNTTIP1	0.412	0.134
EMSY	RREB1	0.409	0.052
SFMBT1	PHF21B	0.406
KDM5A	DNTTIP1	0.396	0.126
PHF21A	PWWP2A	0.396	0.118
EMSY	CCDC71	0.392	0.1
MIDEAS	CASP8AP2	0.391	0.08
KDM5A	MIDEAS	0.385	0.16
CCDC71	PWWP2A	0.359	0.134
PHF21B	RREB1	0.336
GATAD1	TRERF1	0.333
CCDC71	PHF21B	0.333
PHF21B	PWWP2A	0.333
MIDEAS	PHF21B	0.333
RERE	PHF21B	0.333
CCDC71	CASP8AP2	0.333	0.096
CASP8AP2	PWWP2A	0.333	0.102
RERE	CASP8AP2	0.333	0.118
GSE1	CASP8AP2	0.306	0.06
CCDC71	RREB1	0.303	0.126
CCDC71	SFMBT1	0.303	0.068
MIDEAS	SFMBT1	0.303	0.094
CCDC71	MIDEAS	0.303	0.1	mutually_exclusive (Q13547)
SFMBT1	PWWP2A	0.303	0.126
SFMBT1	CASP8AP2	0.265	0.188
SFMBT1	RREB1	0.265	0.15
PHF21A	PHF21B	0.265
GSE1	PHF21B	0.262
GATAD1	PHF21A	0.262	0.192
PHF21A	CASP8AP2	0.262	0.08
EMSY	RCOR1	0.248	0.032
CASP8AP2	RREB1	0.207	0.086
EMSY	PHF21A	0.2	0.3
PHF12	CASP8AP2	0.2	0.104
GATAD1	GSE1	0.187	0.114
EMSY	CASP8AP2	0.184	0.05
CCDC71	DNTTIP1	0.172	0.068
RERE	CCDC71	0.172	0.092
KDM5A	SFMBT1	0.172	0.166
GATAD1	SFMBT1	0.172	0.146
GATAD1	MIDEAS	0.172	0.06
PHF12	PHF21B	0.172
SFMBT1	DNTTIP1	0.172	0.084
PHF21B	DNTTIP1	0.172
CASP8AP2	DNTTIP1	0.172	0.096
GATAD1	CASP8AP2	0.172	0.09
KDM5A	CASP8AP2	0.172	0.162
KDM5A	PHF21B	0.172
GATAD1	PHF21B	0.172
RERE	SFMBT1	0.172	0.11
EMSY	SFMBT1	0.164	0.082
GATAD1	RREB1	0.164	0.086
EMSY	PHF21B	0.164
GATAD1	DNTTIP1	0.164	0.102
RERE	GATAD1	0.164	0.258
CCDC71	PHF21A	0.164	0.096
PHF12	SFMBT1	0.164	0.208
GATAD1	RCOR1	0.146	0.098
CCDC71	GSE1	0.143	0.078
CCDC71	RCOR1	0.141	0.068

Related Complexes

Genename	Complexes
PHF12	huMAP3_00411.1 huMAP3_01287.1 huMAP3_05699.1 huMAP3_06457.1 huMAP3_07709.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09513.1 huMAP3_09515.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1
PHF21A	huMAP3_01287.1 huMAP3_02683.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_08880.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09692.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
SFMBT1	huMAP3_01287.1 huMAP3_01666.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_08955.1 huMAP3_09232.1 huMAP3_10311.1 huMAP3_10505.1 huMAP3_15128.1
HDAC1	huMAP3_01287.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10311.1 huMAP3_15128.1
MIDEAS	huMAP3_01026.1 huMAP3_01287.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_06587.1 huMAP3_07709.1 huMAP3_08377.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09319.1 huMAP3_09513.1 huMAP3_10311.1 huMAP3_10449.1 huMAP3_14722.1
CCDC71	huMAP3_00429.1 huMAP3_01287.1 huMAP3_06889.1 huMAP3_07299.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10118.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1
GSE1	huMAP3_01287.1 huMAP3_05107.1 huMAP3_05699.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_08865.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09692.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
PHF21B	huMAP3_01287.1 huMAP3_01504.1 huMAP3_06860.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_09232.1 huMAP3_10122.1 huMAP3_10311.1 huMAP3_15128.1
TRERF1	huMAP3_01287.1 huMAP3_02407.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_07709.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09513.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
RREB1	huMAP3_04507.1 huMAP3_05107.1 huMAP3_05699.1 huMAP3_06993.1 huMAP3_08605.1 huMAP3_08697.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10094.1 huMAP3_10311.1 huMAP3_12062.1 huMAP3_14584.1 huMAP3_15128.1
EMSY	huMAP3_00411.1 huMAP3_06457.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09515.1 huMAP3_13482.1 huMAP3_15128.1
CASP8AP2	huMAP3_01287.1 huMAP3_06889.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_10311.1 huMAP3_14162.1 huMAP3_15009.1 huMAP3_15128.1
PWWP2A	huMAP3_01287.1 huMAP3_05396.1 huMAP3_05699.1 huMAP3_07709.1 huMAP3_08463.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09499.1 huMAP3_09513.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_10472.1 huMAP3_15128.1
DNTTIP1	huMAP3_01287.1 huMAP3_02407.1 huMAP3_05396.1 huMAP3_06334.1 huMAP3_07709.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09513.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_11690.1
RERE	huMAP3_00047.1 huMAP3_01287.1 huMAP3_07585.1 huMAP3_08605.1 huMAP3_08776.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09422.1 huMAP3_09513.1 huMAP3_10027.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_13482.1 huMAP3_15128.1
RCOR1	huMAP3_04507.1 huMAP3_05107.1 huMAP3_05699.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_08865.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09692.1 huMAP3_10258.1 huMAP3_10311.1 huMAP3_15128.1
KDM5A	huMAP3_00411.1 huMAP3_06457.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09515.1 huMAP3_13482.1 huMAP3_15128.1
GATAD1	huMAP3_00411.1 huMAP3_06457.1 huMAP3_08605.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09232.1 huMAP3_09515.1 huMAP3_13482.1 huMAP3_15128.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08605.1

Complex Portal: CPX-15325