hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08618.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP4S1 | AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) | 5 | UniProt NCBI |
| AP4E1 | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | 5 | UniProt NCBI |
| AP4B1 | AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) | 5 | UniProt NCBI |
| DISC1 | Disrupted in schizophrenia 1 protein | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:67 | 2.80628050973e-09 | 0.75 | AP4E1 AP4S1 AP4B1 | AP4 adaptor complex |
| HP:5200020 | 5.49060032847e-07 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal interest in others |
| HP:0100962 | 5.49060032847e-07 | 0.75 | AP4E1 AP4S1 AP4B1 | Shyness |
| GO:0030124 | 1.53784171933e-06 | 0.75 | AP4E1 AP4S1 AP4B1 | AP-4 adaptor complex |
| HP:0008807 | 5.21339206211e-06 | 0.75 | AP4E1 AP4S1 AP4B1 | Acetabular dysplasia |
| HP:0002464 | 6.08197827663e-06 | 0.75 | AP4E1 AP4S1 AP4B1 | Spastic dysarthria |
| HP:0010803 | 7.04192883742e-06 | 0.75 | AP4E1 AP4S1 AP4B1 | Everted upper lip vermilion |
| REAC:R-HSA-432720 | 7.64413736449e-06 | 0.75 | AP4E1 AP4S1 AP4B1 | Lysosome Vesicle Biogenesis |
| HP:0007020 | 1.49754852965e-05 | 0.75 | AP4E1 AP4S1 AP4B1 | Progressive spastic paraplegia |
| HP:0002816 | 2.49344480699e-05 | 0.75 | AP4E1 AP4S1 AP4B1 | Genu recurvatum |
| HP:0025502 | 3.55023502799e-05 | 0.75 | AP4E1 AP4S1 AP4B1 | Overweight |
| HP:0002761 | 3.55023502799e-05 | 0.75 | AP4E1 AP4S1 AP4B1 | Generalized joint hypermobility |
| HP:0010500 | 3.85434269704e-05 | 0.75 | AP4E1 AP4S1 AP4B1 | Hyperextensibility of the knee |
| HP:0000297 | 5.63705712181e-05 | 0.75 | AP4E1 AP4S1 AP4B1 | Facial hypotonia |
| REAC:R-HSA-199992 | 7.65476877178e-05 | 0.75 | AP4E1 AP4S1 AP4B1 | trans-Golgi Network Vesicle Budding |
| KEGG:04142 | 0.00010324564632 | 0.75 | AP4E1 AP4S1 AP4B1 | Lysosome |
| HP:0003170 | 0.000320567621517 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal acetabulum morphology |
| HP:0034670 | 0.000333546420735 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal knee physiology |
| HP:0002307 | 0.000671598193523 | 0.75 | AP4E1 AP4S1 AP4B1 | Drooling |
| HP:0000646 | 0.000714383064062 | 0.75 | AP4E1 AP4S1 AP4B1 | Amblyopia |
| HP:0001258 | 0.000781902282316 | 0.75 | AP4E1 AP4S1 AP4B1 | Spastic paraplegia |
| HP:0003781 | 0.000853539408528 | 0.75 | AP4E1 AP4S1 AP4B1 | Excessive salivation |
| HP:0002515 | 0.000903644973001 | 0.75 | AP4E1 AP4S1 AP4B1 | Waddling gait |
| GO:0031904 | 0.000998468305694 | 0.75 | AP4E1 AP4S1 AP4B1 | endosome lumen |
| HP:0002518 | 0.00155250227532 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal periventricular white matter morphology |
| HP:0010550 | 0.00155250227532 | 0.75 | AP4E1 AP4S1 AP4B1 | Paraplegia |
| HP:0012433 | 0.00207834768342 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal social behavior |
| GO:0030119 | 0.0025122894873 | 0.75 | AP4E1 AP4S1 AP4B1 | AP-type membrane coat adaptor complex |
| HP:0000341 | 0.00260627971198 | 0.75 | AP4E1 AP4S1 AP4B1 | Narrow forehead |
| HP:0007370 | 0.00274984731609 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Aplasia/Hypoplasia of the corpus callosum |
| HP:0012472 | 0.00276430324972 | 0.75 | AP4E1 AP4S1 AP4B1 | Eclabion |
| HP:0002538 | 0.00298428444273 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Abnormal cerebral cortex morphology |
| HP:0100755 | 0.00371547168799 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormality of salivation |
| HP:0000414 | 0.00378123102664 | 0.75 | AP4E1 AP4S1 AP4B1 | Bulbous nose |
| HP:0002465 | 0.00378123102664 | 0.75 | AP4E1 AP4S1 AP4B1 | Poor speech |
| HP:0033725 | 0.00418502298343 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Thin corpus callosum |
| HP:0010551 | 0.00526378291815 | 0.75 | AP4E1 AP4S1 AP4B1 | Paraplegia/paraparesis |
| HP:0000154 | 0.00543031495837 | 0.75 | AP4E1 AP4S1 AP4B1 | Wide mouth |
| HP:0001273 | 0.00568807850398 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Abnormal corpus callosum morphology |
| HP:0002061 | 0.00613143375936 | 0.75 | AP4E1 AP4S1 AP4B1 | Lower limb spasticity |
| HP:0000280 | 0.00669499673868 | 0.75 | AP4E1 AP4S1 AP4B1 | Coarse facial features |
| HP:0002352 | 0.00698923937258 | 0.75 | AP4E1 AP4S1 AP4B1 | Leukoencephalopathy |
| HP:0001317 | 0.00795240650999 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Abnormal cerebellum morphology |
| HP:0011282 | 0.00809740415548 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Abnormal hindbrain morphology |
| HP:0011283 | 0.00809740415548 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Abnormal metencephalon morphology |
| HP:0000322 | 0.00881998427789 | 0.75 | AP4E1 AP4S1 AP4B1 | Short philtrum |
| HP:0000733 | 0.0104167341589 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal repetitive mannerisms |
| HP:0031432 | 0.0104167341589 | 0.75 | AP4E1 AP4S1 AP4B1 | Restricted or repetitive behaviors or interests |
| HP:0002500 | 0.0112014831127 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Abnormal cerebral white matter morphology |
| HP:0031936 | 0.011350921992 | 0.75 | AP4E1 AP4S1 AP4B1 | Delayed ability to walk |
| HP:0003487 | 0.0124847721541 | 0.75 | AP4E1 AP4S1 AP4B1 | Babinski sign |
| HP:0031828 | 0.0124847721541 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal superficial reflex |
| HP:0002355 | 0.0130788400566 | 0.75 | AP4E1 AP4S1 AP4B1 | Difficulty walking |
| REAC:R-HSA-432722 | 0.0146019089592 | 0.5 | AP4E1 AP4B1 | Golgi Associated Vesicle Biogenesis |
| HP:0010993 | 0.0151809428209 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Abnormal cerebral subcortex morphology |
| HP:0031815 | 0.0161575597254 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal oral physiology |
| HP:0000301 | 0.0161575597254 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormality of facial musculature |
| HP:0002120 | 0.0210996257365 | 0.75 | AP4E1 AP4S1 AP4B1 | Cerebral cortical atrophy |
| HP:0001763 | 0.0217270761582 | 0.75 | AP4E1 AP4S1 AP4B1 | Pes planus |
| HP:0002540 | 0.0219389426652 | 0.75 | AP4E1 AP4S1 AP4B1 | Inability to walk |
| HP:0010864 | 0.0243605289659 | 0.75 | AP4E1 AP4S1 AP4B1 | Intellectual disability, severe |
| HP:0000252 | 0.0246674560744 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Microcephaly |
| CORUM:7235 | 0.0249718442456 | 0.25 | DISC1 | DISC1-DRD2 complex |
| HP:0001384 | 0.0255174052948 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal hip joint morphology |
| HP:0040195 | 0.025606252379 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Decreased head circumference |
| HP:0000436 | 0.0269530199508 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal nasal tip morphology |
| HP:0034353 | 0.0305087012549 | 0.75 | AP4E1 AP4S1 AP4B1 | Appendicular spasticity |
| HP:0002815 | 0.0315787867362 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormality of the knee |
| HP:0001762 | 0.0318501377451 | 0.75 | AP4E1 AP4S1 AP4B1 | Talipes equinovarus |
| HP:0011337 | 0.0376062786913 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormality of mouth size |
| GO:0048475 | 0.0405772675542 | 0.75 | AP4E1 AP4S1 AP4B1 | coated membrane |
| GO:0030117 | 0.0405772675542 | 0.75 | AP4E1 AP4S1 AP4B1 | membrane coat |
| HP:0007256 | 0.0416942448541 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormal pyramidal sign |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | AP4E1 AP4S1 AP4B1 | Membrane Trafficking |
| HP:0001272 | 0.0433416366127 | 0.75 | AP4E1 AP4S1 AP4B1 | Cerebellar atrophy |
| HP:0011339 | 0.0464144688579 | 0.75 | AP4E1 AP4S1 AP4B1 | Abnormality of upper lip vermillion |
| GO:0032588 | 0.0464975978221 | 0.75 | AP4E1 AP4S1 AP4B1 | trans-Golgi network membrane |
| HP:0002194 | 0.0481822683014 | 0.75 | AP4E1 AP4S1 AP4B1 | Delayed gross motor development |
| HP:0007364 | 0.0483732370923 | 1.0 | AP4E1 DISC1 AP4S1 AP4B1 | Aplasia/Hypoplasia of the cerebrum |
| HP:0004324 | 0.0489016791407 | 0.75 | AP4E1 AP4S1 AP4B1 | Increased body weight |
| HP:0001883 | 0.0496281638505 | 0.75 | AP4E1 AP4S1 AP4B1 | Talipes |
| CORUM:7345 | 0.049938562206 | 0.25 | DISC1 | DISC1-TRAK1 complex |
| CORUM:6041 | 0.049938562206 | 0.25 | DISC1 | DISC1-FEZ1 complex |
| CORUM:6043 | 0.049938562206 | 0.25 | DISC1 | DISC-FEZ1-F-actin complex |
| CORUM:6046 | 0.049938562206 | 0.25 | DISC1 | PDE4B-DISC1 complex |
| CORUM:6061 | 0.049938562206 | 0.25 | DISC1 | DISC1-ZNF365 complex |
| CORUM:7346 | 0.049938562206 | 0.25 | DISC1 | DISC1-RHOT1 complex |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | AP4E1 AP4S1 AP4B1 | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AP4S1 | AP4B1 | 1.0 | 0.172 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4E1 | AP4B1 | 1.0 | 0.284 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4S1 | AP4E1 | 0.999 | 0.166342857143 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4S1 | DISC1 | 0.994 | 0.066 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4E1 | DISC1 | 0.993 | 0.154 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4B1 | DISC1 | 0.978 | 0.134 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes