List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_08622.1

Confidence: High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
RNF2	E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)	5	UniProt   NCBI
CBX8	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	5	UniProt   NCBI
BCOR	BCL-6 corepressor (BCoR)	5	UniProt   NCBI
YAF2	YY1-associated factor 2	5	UniProt   NCBI
RING1	E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)	5	UniProt   NCBI
RYBP	RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)	5	UniProt   NCBI
KDM2B	Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)	5	UniProt   NCBI
PCGF6	Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)	5	UniProt   NCBI
PCGF3	Polycomb group RING finger protein 3 (RING finger protein 3A)	5	UniProt   NCBI
BCORL1	BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1)	5	UniProt   NCBI
FBRS	Probable fibrosin-1	2	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03083	3.81027603547e-24	1.0	BCORL1 RNF2 PCGF3 RYBP FBRS BCOR KDM2B RING1 PCGF6 YAF2 CBX8	Polycomb repressive complex
CORUM:1178	1.15937335921e-13	0.454545454545	RING1 RYBP RNF2 KDM2B BCOR	BCOR complex
GO:0031519	1.56428545762e-11	0.636363636364	RNF2 PCGF3 RYBP PCGF6 KDM2B RING1 CBX8	PcG protein complex
CORUM:1194	5.69057779739e-09	0.363636363636	RING1 PCGF6 RNF2 YAF2	E2F-6 complex
REAC:R-HSA-8953750	5.93840217276e-09	0.454545454545	RING1 PCGF6 RYBP RNF2 YAF2	Transcriptional Regulation by E2F6
REAC:R-HSA-8939243	8.04006323532e-09	0.454545454545	RING1 RYBP RNF2 YAF2 CBX8	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
GO:0000152	1.19260547778e-08	0.545454545455	CBX8 RNF2 PCGF3 PCGF6 RING1 BCOR	nuclear ubiquitin ligase complex
GO:0035102	1.81026995552e-08	0.454545454545	RING1 PCGF6 RNF2 PCGF3 CBX8	PRC1 complex
CORUM:116	3.46385565135e-06	0.272727272727	RING1 RNF2 CBX8	Polycomb repressive complex 1 (PRC1, hPRC-H)
CORUM:115	3.46385565135e-06	0.272727272727	RING1 RNF2 CBX8	Polycomb repressive complex 1 (PRC1, hPRC-H)
REAC:R-HSA-4655427	3.7205851709e-05	0.272727272727	RING1 RNF2 CBX8	SUMOylation of DNA methylation proteins
REAC:R-HSA-8878171	6.67209829562e-05	0.454545454545	RING1 RYBP RNF2 YAF2 CBX8	Transcriptional regulation by RUNX1
CORUM:929	0.000124440815824	0.272727272727	RING1 RNF2 CBX8	CEN complex
GO:0006338	0.000155563544425	0.636363636364	RNF2 PCGF3 RYBP PCGF6 KDM2B RING1 BCOR	chromatin remodeling
WP:WP4553	0.000162281654186	0.272727272727	KDM2B RNF2 BCOR	FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma
CORUM:1462	0.000205019103882	0.181818181818	RING1 RNF2	hPRC1L complex
GO:0006325	0.000401078542902	0.636363636364	RNF2 PCGF3 RYBP PCGF6 KDM2B RING1 BCOR	chromatin organization
GO:0010605	0.000565996941917	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of macromolecule metabolic process
REAC:R-HSA-3899300	0.000683331436742	0.272727272727	RING1 RNF2 CBX8	SUMOylation of transcription cofactors
GO:0000151	0.000957261005082	0.545454545455	CBX8 RNF2 PCGF3 PCGF6 RING1 BCOR	ubiquitin ligase complex
REAC:R-HSA-4570464	0.000997590822835	0.272727272727	RING1 RNF2 CBX8	SUMOylation of RNA binding proteins
GO:0045892	0.00102609437145	0.727272727273	BCORL1 RNF2 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of DNA-templated transcription
GO:0071824	0.001108873533	0.636363636364	RNF2 PCGF3 RYBP PCGF6 KDM2B RING1 BCOR	protein-DNA complex organization
GO:1902679	0.00112317878821	0.727272727273	BCORL1 RNF2 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of RNA biosynthetic process
GO:0009892	0.00122454461031	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of metabolic process
REAC:R-HSA-8943724	0.00235166852176	0.272727272727	RING1 RNF2 CBX8	Regulation of PTEN gene transcription
GO:0051253	0.0024230510168	0.727272727273	BCORL1 RNF2 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of RNA metabolic process
GO:0010558	0.00278851019654	0.818181818182	BCORL1 RNF2 PCGF3 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of macromolecule biosynthetic process
GO:0031327	0.00339832845459	0.818181818182	BCORL1 RNF2 PCGF3 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of cellular biosynthetic process
GO:0051172	0.00355787517831	0.818181818182	BCORL1 RNF2 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of nitrogen compound metabolic process
GO:0009890	0.00357827645649	0.818181818182	BCORL1 RNF2 PCGF3 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of biosynthetic process
REAC:R-HSA-4551638	0.00366420663692	0.272727272727	RING1 RNF2 CBX8	SUMOylation of chromatin organization proteins
GO:0006355	0.00451084211889	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	regulation of DNA-templated transcription
REAC:R-HSA-3108214	0.00456724968844	0.272727272727	RING1 RNF2 CBX8	SUMOylation of DNA damage response and repair proteins
GO:2001141	0.00478749411208	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	regulation of RNA biosynthetic process
GO:0045934	0.00532192710495	0.727272727273	BCORL1 RNF2 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of nucleobase-containing compound metabolic process
GO:0140513	0.00704522774331	0.727272727273	RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 CBX8	nuclear protein-containing complex
GO:0006351	0.0071899107241	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	DNA-templated transcription
GO:0032774	0.00798646080955	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	RNA biosynthetic process
REAC:R-HSA-212436	0.0103316302063	0.545454545455	RNF2 RYBP PCGF6 RING1 YAF2 CBX8	Generic Transcription Pathway
GO:0051252	0.0135387581616	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	regulation of RNA metabolic process
REAC:R-HSA-2559580	0.0156275919478	0.272727272727	RING1 RNF2 CBX8	Oxidative Stress Induced Senescence
GO:0031324	0.0166701656886	0.818181818182	BCORL1 RNF2 PCGF3 BCOR KDM2B RING1 PCGF6 YAF2 CBX8	negative regulation of cellular metabolic process
REAC:R-HSA-73857	0.0192733308151	0.545454545455	RNF2 RYBP PCGF6 RING1 YAF2 CBX8	RNA Polymerase II Transcription
GO:0034654	0.0273693774831	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	nucleobase-containing compound biosynthetic process
REAC:R-HSA-6807070	0.0312099533255	0.272727272727	RING1 RNF2 CBX8	PTEN Regulation
GO:0018130	0.0327201680984	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	heterocycle biosynthetic process
GO:0019438	0.0330622518626	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	aromatic compound biosynthetic process
GO:0019219	0.0331769891161	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	regulation of nucleobase-containing compound metabolic process
HP:0000577	0.0367275982991	0.272727272727	BCORL1 RNF2 BCOR	Exotropia
REAC:R-HSA-74160	0.0390724328074	0.545454545455	RNF2 RYBP PCGF6 RING1 YAF2 CBX8	Gene expression (Transcription)
GO:1901362	0.0438918850918	0.909090909091	BCORL1 RNF2 PCGF3 RYBP BCOR KDM2B RING1 PCGF6 YAF2 CBX8	organic cyclic compound biosynthetic process
REAC:R-HSA-3108232	0.0497239830603	0.272727272727	RING1 RNF2 CBX8	SUMO E3 ligases SUMOylate target proteins



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
YAF2	RNF2	1.0	0.124
RYBP	PCGF6	1.0	0.21
RING1	PCGF6	1.0	0.244
RNF2	PCGF6	1.0	0.064
YAF2	RING1	1.0	0.112
RING1	FBRS	1.0	0.07
YAF2	PCGF6	1.0	0.11
RYBP	RNF2	1.0	0.142
YAF2	FBRS	1.0	0.19
RYBP	FBRS	1.0	0.118
RYBP	RING1	1.0	0.146
RYBP	PCGF3	1.0	0.124
YAF2	PCGF3	0.999	0.12
RNF2	FBRS	0.999	0.1
RYBP	BCOR	0.999	0.148
YAF2	RYBP	0.999	0.078
RING1	PCGF3	0.998	0.08
CBX8	RING1	0.998	0.248
RNF2	CBX8	0.998	0.228
RNF2	RING1	0.998	0.174
KDM2B	RYBP	0.998	0.108
PCGF3	FBRS	0.998	0.144
RNF2	PCGF3	0.997	0.096
BCORL1	RING1	0.997	0.066
YAF2	BCOR	0.996	0.158
KDM2B	YAF2	0.995	0.126
BCORL1	BCOR	0.994	0.196
FBRS	PCGF6	0.993	0.142
KDM2B	BCOR	0.993	0.254
CBX8	BCOR	0.992	0.28
CBX8	FBRS	0.992	0.134
RNF2	BCOR	0.99	0.172
BCORL1	RYBP	0.987	0.14
BCORL1	PCGF6	0.986	0.126
KDM2B	RING1	0.985	0.142
BCOR	PCGF6	0.982	0.172
BCOR	RING1	0.982	0.166
BCORL1	YAF2	0.982	0.098
KDM2B	RNF2	0.979	0.15
CBX8	PCGF6	0.973	0.16
KDM2B	BCORL1	0.967	0.18
BCORL1	RNF2	0.952	0.11
PCGF3	PCGF6	0.945	0.136
BCOR	FBRS	0.941	0.194
KDM2B	FBRS	0.937	0.092
RYBP	CBX8	0.937	0.126
YAF2	CBX8	0.845	0.078
BCORL1	FBRS	0.755	0.156
KDM2B	PCGF6	0.577	0.162
KDM2B	PCGF3	0.291	0.13
BCOR	PCGF3	0.254	0.16
BCORL1	CBX8	0.222	0.172
BCORL1	PCGF3	0.209	0.14
KDM2B	CBX8	0.063	0.14





Related Complexes

Genename	Complexes
RNF2	huMAP3_02464.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
CBX8	huMAP3_02464.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09551.1 huMAP3_10162.1 huMAP3_14051.1
BCOR	huMAP3_02464.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
YAF2	huMAP3_01807.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
RING1	huMAP3_04542.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
RYBP	huMAP3_01807.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
KDM2B	huMAP3_00161.1 huMAP3_00839.1 huMAP3_04542.1 huMAP3_05528.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09623.1 huMAP3_09719.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1 huMAP3_14622.1
PCGF6	huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
PCGF3	huMAP3_04542.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_11527.1 huMAP3_11826.1 huMAP3_14051.1
BCORL1	huMAP3_01807.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_13766.1 huMAP3_14051.1
FBRS	huMAP3_04542.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_11527.1 huMAP3_11826.1 huMAP3_14051.1