hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08633.1
Complex Portal: CPX-19665
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GDF10 | Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP) | 5 | UniProt NCBI |
| LDLR | Low-density lipoprotein receptor (LDL receptor) | 5 | UniProt NCBI |
| LRP4 | Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2846 | 0.0165527833611 | 0.333333333333 | LDLR | PCSK9 mediated LDL receptor degradation |
| WP:WP3408 | 0.0165527833611 | 0.333333333333 | LDLR | Evolocumab mechanism to reduce LDL cholesterol |
| GO:0150094 | 0.0393180950424 | 0.666666666667 | LRP4 LDLR | amyloid-beta clearance by cellular catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRP4 | LDLR | 0.96 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| GDF10 | LRP4 | 0.958 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| GDF10 | huMAP3_03683.1 huMAP3_08633.1 huMAP3_10712.1 |
| LDLR | huMAP3_04974.1 huMAP3_08633.1 huMAP3_10712.1 |
| LRP4 | huMAP3_03683.1 huMAP3_06423.1 huMAP3_08633.1 huMAP3_10712.1 |