hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08640.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HOMER3 | Homer protein homolog 3 (Homer-3) | 5 | UniProt NCBI |
| TRAF5 | TNF receptor-associated factor 5 (RING finger protein 84) | 5 | UniProt NCBI |
| HOMER1 | Homer protein homolog 1 (Homer-1) | 5 | UniProt NCBI |
| HOMER2 | Homer protein homolog 2 (Homer-2) (Cupidin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0007216 | 7.68841921772e-06 | 0.75 | HOMER3 HOMER2 HOMER1 | G protein-coupled glutamate receptor signaling pathway |
| GO:2001256 | 7.68841921772e-06 | 0.75 | HOMER3 HOMER2 HOMER1 | regulation of store-operated calcium entry |
| GO:0035256 | 1.34540429244e-05 | 0.75 | HOMER3 HOMER2 HOMER1 | G protein-coupled glutamate receptor binding |
| REAC:R-HSA-6794361 | 2.12537496865e-05 | 0.75 | HOMER3 HOMER2 HOMER1 | Neurexins and neuroligins |
| KEGG:04724 | 2.91718888289e-05 | 0.75 | HOMER3 HOMER2 HOMER1 | Glutamatergic synapse |
| WP:WP5417 | 3.5618246416e-05 | 0.75 | HOMER3 HOMER2 HOMER1 | Cell lineage map for neuronal differentiation |
| GO:0002115 | 4.61210427592e-05 | 0.75 | HOMER3 HOMER2 HOMER1 | store-operated calcium entry |
| REAC:R-HSA-6794362 | 7.65476877178e-05 | 0.75 | HOMER3 HOMER2 HOMER1 | Protein-protein interactions at synapses |
| KEGG:04068 | 7.99217742683e-05 | 0.75 | HOMER3 HOMER2 HOMER1 | FoxO signaling pathway |
| GO:0035254 | 0.000261258639543 | 0.75 | HOMER3 HOMER2 HOMER1 | glutamate receptor binding |
| GO:0007215 | 0.000998468305694 | 0.75 | HOMER3 HOMER2 HOMER1 | glutamate receptor signaling pathway |
| WP:WP5420 | 0.00101030857977 | 0.75 | HOMER3 HOMER2 HOMER1 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-112316 | 0.00603406960129 | 0.75 | HOMER3 HOMER2 HOMER1 | Neuronal System |
| CORUM:74 | 0.049938562206 | 0.25 | HOMER3 | HOMER3-IP3R-TRPC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HOMER3 | HOMER1 | 1.0 | 0.048 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| HOMER2 | HOMER1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HOMER3 | HOMER2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TRAF5 | HOMER1 | 0.973 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TRAF5 | HOMER3 | 0.358 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
| TRAF5 | HOMER2 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes