hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08641.1
Complex Portal: CPX-23411
Confidence: High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
RGPD5 | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | 4 | UniProt   NCBI |
NUSAP1 | Nucleolar and spindle-associated protein 1 (NuSAP) | 5 | UniProt   NCBI |
POM121 | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | 5 | UniProt   NCBI |
SUMO1 | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | 5 | UniProt   NCBI |
KPNB1 | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | 5 | UniProt   NCBI |
RANGAP1 | Ran GTPase-activating protein 1 (RanGAP1) | 5 | UniProt   NCBI |
CDCA2 | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | 5 | UniProt   NCBI |
KPNA4 | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | 5 | UniProt   NCBI |
NUP214 | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | 5 | UniProt   NCBI |
RAN | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) | 5 | UniProt   NCBI |
RANBP1 | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | 5 | UniProt   NCBI |
RCC1 | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | 5 | UniProt   NCBI |
SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | 5 | UniProt   NCBI |
RANBP2 | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | 5 | UniProt   NCBI |
RGPD8 | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | 3 | UniProt   NCBI |
KPNA3 | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) | 5 | UniProt   NCBI |
UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | 5 | UniProt   NCBI |
NEMP1 | Nuclear envelope integral membrane protein 1 | 5 | UniProt   NCBI |
B2M | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0005643 | 4.43339738863e-19 | 0.666666666667 | POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN | nuclear pore |
  KEGG:03013 | 1.7632715156e-18 | 0.611111111111 | POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 SUMO2 RAN | Nucleocytoplasmic transport |
  REAC:R-HSA-177243 | 4.68405015184e-15 | 0.444444444444 | POM121 RCC1 NUP214 KPNB1 RANBP2 RAN RANBP1 RANGAP1 | Interactions of Rev with host cellular proteins |
  REAC:R-HSA-9615933 | 1.19127265355e-13 | 0.388888888889 | POM121 RCC1 KPNB1 RANGAP1 SUMO1 UBE2I RAN | Postmitotic nuclear pore complex (NPC) reformation |
  GO:0005635 | 2.72848355067e-13 | 0.722222222222 | POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 NEMP1 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN | nuclear envelope |
  REAC:R-HSA-165054 | 1.15241197107e-12 | 0.388888888889 | POM121 RCC1 RANBP1 RANBP2 RAN NUP214 RANGAP1 | Rev-mediated nuclear export of HIV RNA |
  REAC:R-HSA-162909 | 2.57212140756e-12 | 0.5 | POM121 RCC1 NUP214 KPNB1 RANBP2 RAN RANBP1 B2M RANGAP1 | Host Interactions of HIV factors |
  REAC:R-HSA-4615885 | 9.17615104548e-12 | 0.388888888889 | POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I RANGAP1 | SUMOylation of DNA replication proteins |
  REAC:R-HSA-9824446 | 1.40220937287e-11 | 0.722222222222 | POM121 KPNA4 NUP214 KPNB1 RANBP2 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 B2M UBE2I RAN | Viral Infection Pathways |
  GO:0051169 | 2.93753104585e-11 | 0.611111111111 | POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | nuclear transport |
  GO:0006913 | 2.93753104585e-11 | 0.611111111111 | POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | nucleocytoplasmic transport |
  GO:0006606 | 7.57554943603e-11 | 0.5 | POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 SUMO1 RGPD8 KPNA3 | protein import into nucleus |
  GO:0051170 | 1.17227063012e-10 | 0.5 | POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 SUMO1 RGPD8 KPNA3 | import into nucleus |
  REAC:R-HSA-5663205 | 1.98058900315e-10 | 0.722222222222 | POM121 KPNA4 NUP214 KPNB1 RANBP2 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 B2M UBE2I RAN | Infectious disease |
  REAC:R-HSA-2995410 | 2.9094844415e-10 | 0.388888888889 | POM121 RCC1 KPNB1 RANGAP1 SUMO1 UBE2I RAN | Nuclear Envelope (NE) Reassembly |
  REAC:R-HSA-180746 | 3.06552144851e-10 | 0.333333333333 | POM121 RCC1 RANBP2 KPNB1 RAN NUP214 | Nuclear import of Rev protein |
  REAC:R-HSA-4085377 | 3.77029006285e-10 | 0.333333333333 | POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I | SUMOylation of SUMOylation proteins |
  REAC:R-HSA-162906 | 4.68414960712e-10 | 0.5 | POM121 RCC1 NUP214 KPNB1 RANBP2 RAN RANBP1 B2M RANGAP1 | HIV Infection |
  REAC:R-HSA-168276 | 9.63841917568e-10 | 0.333333333333 | POM121 KPNA3 NUP214 KPNB1 RANBP2 KPNA4 | NS1 Mediated Effects on Host Pathways |
  GO:0034504 | 1.05062060587e-09 | 0.555555555556 | POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | protein localization to nucleus |
  REAC:R-HSA-4570464 | 2.51687960257e-09 | 0.333333333333 | POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I | SUMOylation of RNA binding proteins |
  REAC:R-HSA-913531 | 4.38944149202e-09 | 0.444444444444 | POM121 KPNA4 RANBP2 KPNB1 NUP214 SUMO1 B2M KPNA3 | Interferon Signaling |
  REAC:R-HSA-68882 | 3.06953227531e-08 | 0.444444444444 | POM121 RCC1 RANBP2 KPNB1 RANGAP1 SUMO1 UBE2I RAN | Mitotic Anaphase |
  REAC:R-HSA-2555396 | 3.1812588662e-08 | 0.444444444444 | POM121 RCC1 RANBP2 KPNB1 RANGAP1 SUMO1 UBE2I RAN | Mitotic Metaphase and Anaphase |
  REAC:R-HSA-162599 | 3.38980372261e-08 | 0.388888888889 | POM121 RCC1 RANBP1 RANBP2 RAN NUP214 RANGAP1 | Late Phase of HIV Life Cycle |
  REAC:R-HSA-1169408 | 3.69063811566e-08 | 0.333333333333 | POM121 KPNA3 NUP214 KPNB1 RANBP2 KPNA4 | ISG15 antiviral mechanism |
  REAC:R-HSA-4551638 | 3.69063811566e-08 | 0.333333333333 | POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I | SUMOylation of chromatin organization proteins |
  REAC:R-HSA-3108214 | 5.79697679434e-08 | 0.333333333333 | POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I | SUMOylation of DNA damage response and repair proteins |
  REAC:R-HSA-1169410 | 6.31950909177e-08 | 0.333333333333 | POM121 KPNA3 NUP214 KPNB1 RANBP2 KPNA4 | Antiviral mechanism by IFN-stimulated genes |
  CORUM:1554 | 6.32531883213e-08 | 0.166666666667 | RANBP1 KPNB1 RAN | RANBP1-RAN-KPNB1 complex |
  REAC:R-HSA-162587 | 6.32786417704e-08 | 0.388888888889 | POM121 RCC1 RANBP1 RANBP2 RAN NUP214 RANGAP1 | HIV Life Cycle |
  REAC:R-HSA-68886 | 7.09253793878e-08 | 0.5 | POM121 RCC1 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 UBE2I RAN | M Phase |
  GO:0031975 | 7.36458663568e-08 | 0.722222222222 | POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 NEMP1 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN | envelope |
  GO:0031967 | 7.36458663568e-08 | 0.722222222222 | POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 NEMP1 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN | organelle envelope |
  REAC:R-HSA-168255 | 8.472774739e-08 | 0.388888888889 | POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 KPNA3 | Influenza Infection |
  REAC:R-HSA-3108232 | 1.34253040655e-07 | 0.388888888889 | POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I RANGAP1 | SUMO E3 ligases SUMOylate target proteins |
  REAC:R-HSA-3232142 | 1.51196027559e-07 | 0.277777777778 | NUP214 POM121 RANBP2 UBE2I SUMO1 | SUMOylation of ubiquitinylation proteins |
  REAC:R-HSA-2990846 | 1.67114983174e-07 | 0.388888888889 | POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I RANGAP1 | SUMOylation |
  REAC:R-HSA-1643685 | 1.89945895009e-07 | 0.722222222222 | POM121 KPNA4 NUP214 KPNB1 RANBP2 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 B2M UBE2I RAN | Disease |
  REAC:R-HSA-9793242 | 4.84160206904e-07 | 0.166666666667 | SUMO1 RANGAP1 UBE2I | SUMOylation of nuclear envelope proteins |
  GO:0006607 | 6.54672911896e-07 | 0.277777777778 | RANBP2 KPNA3 RGPD8 KPNB1 KPNA4 | NLS-bearing protein import into nucleus |
  REAC:R-HSA-69278 | 1.0634937167e-06 | 0.5 | POM121 RCC1 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 UBE2I RAN | Cell Cycle, Mitotic |
  GO:0008139 | 2.0061917853e-06 | 0.277777777778 | NUP214 POM121 KPNA3 KPNB1 KPNA4 | nuclear localization sequence binding |
  GO:0006886 | 2.54701325467e-06 | 0.555555555556 | POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | intracellular protein transport |
  GO:0072594 | 3.53755355942e-06 | 0.5 | POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 SUMO1 RGPD8 KPNA3 | establishment of protein localization to organelle |
  GO:0140142 | 6.12743447997e-06 | 0.277777777778 | NUP214 KPNA3 RAN KPNB1 KPNA4 | nucleocytoplasmic carrier activity |
  REAC:R-HSA-1640170 | 6.47866253615e-06 | 0.5 | POM121 RCC1 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 UBE2I RAN | Cell Cycle |
  REAC:R-HSA-3065678 | 9.66085554184e-06 | 0.166666666667 | SUMO1 SUMO2 UBE2I | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
  REAC:R-HSA-168333 | 1.15804178979e-05 | 0.222222222222 | POM121 RANBP2 RAN NUP214 | NEP/NS2 Interacts with the Cellular Export Machinery |
  REAC:R-HSA-168271 | 1.15804178979e-05 | 0.222222222222 | POM121 RANBP2 KPNB1 NUP214 | Transport of Ribonucleoproteins into the Host Nucleus |
  REAC:R-HSA-168274 | 1.15804178979e-05 | 0.222222222222 | POM121 RANBP2 RAN NUP214 | Export of Viral Ribonucleoproteins from Nucleus |
  WP:WP4657 | 1.27955349774e-05 | 0.277777777778 | RAN RANBP1 RCC1 KPNB1 RANGAP1 | 22q11 2 copy number variation syndrome |
  GO:0140513 | 2.01617113895e-05 | 0.666666666667 | POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN | nuclear protein-containing complex |
  GO:0031074 | 2.64282390746e-05 | 0.222222222222 | RAN KPNA3 KPNB1 KPNA4 | nucleocytoplasmic transport complex |
  REAC:R-HSA-3215018 | 4.04819448703e-05 | 0.166666666667 | SUMO1 SUMO2 UBE2I | Processing and activation of SUMO |
  GO:0005048 | 4.33124926153e-05 | 0.277777777778 | NUP214 POM121 KPNA3 KPNB1 KPNA4 | signal sequence binding |
  REAC:R-HSA-9679506 | 5.42687446114e-05 | 0.388888888889 | POM121 B2M NUP214 KPNB1 RANBP2 SUMO1 UBE2I | SARS-CoV Infections |
  CORUM:6143 | 5.77699275587e-05 | 0.111111111111 | KPNB1 RAN | KPNB1-RAN complex |
  REAC:R-HSA-1280215 | 8.0973503206e-05 | 0.444444444444 | POM121 KPNA4 RANBP2 KPNB1 NUP214 SUMO1 B2M KPNA3 | Cytokine Signaling in Immune system |
  GO:0033365 | 0.00014573961935 | 0.555555555556 | POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | protein localization to organelle |
  REAC:R-HSA-6784531 | 0.000163004566241 | 0.222222222222 | POM121 RANBP2 RAN NUP214 | tRNA processing in the nucleus |
  CORUM:7050 | 0.000173183276299 | 0.111111111111 | SUMO1 UBE2I | PIAS1-SUMO1-UBC9 complex |
  REAC:R-HSA-9694516 | 0.000190796005136 | 0.333333333333 | POM121 B2M NUP214 RANBP2 SUMO1 UBE2I | SARS-CoV-2 Infection |
  REAC:R-HSA-3232118 | 0.00021826617171 | 0.166666666667 | SUMO1 SUMO2 UBE2I | SUMOylation of transcription factors |
  GO:0015031 | 0.000220187260834 | 0.555555555556 | POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | protein transport |
  GO:0016925 | 0.000258604542679 | 0.277777777778 | SUMO1 RANBP2 UBE2I RANGAP1 SUMO2 | protein sumoylation |
  GO:0140014 | 0.000265298967356 | 0.388888888889 | RCC1 CDCA2 RANBP1 KPNB1 NUSAP1 RAN UBE2I | mitotic nuclear division |
  GO:0051649 | 0.000275166022089 | 0.666666666667 | POM121 KPNA4 NUP214 KPNB1 UBE2I NUSAP1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | establishment of localization in cell |
  REAC:R-HSA-4090294 | 0.000325697873067 | 0.166666666667 | SUMO1 SUMO2 UBE2I | SUMOylation of intracellular receptors |
  GO:0046907 | 0.000338396054235 | 0.611111111111 | POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | intracellular transport |
  GO:0051168 | 0.000637995490753 | 0.333333333333 | POM121 RANBP2 RAN NUP214 UBE2I RANGAP1 | nuclear export |
  HPA:0471391 | 0.000933538599002 | 0.444444444444 | B2M CDCA2 RANBP1 KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2 | skin 2; cells in basal layer[>=Low] |
  REAC:R-HSA-5578749 | 0.001242542042 | 0.222222222222 | POM121 RANBP2 RAN NUP214 | Transcriptional regulation by small RNAs |
  REAC:R-HSA-170822 | 0.00155585884203 | 0.166666666667 | POM121 RANBP2 NUP214 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
  REAC:R-HSA-5619107 | 0.00155585884203 | 0.166666666667 | POM121 RANBP2 NUP214 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
  REAC:R-HSA-72306 | 0.00173935614951 | 0.222222222222 | POM121 RANBP2 RAN NUP214 | tRNA processing |
  GO:0140104 | 0.00175417898685 | 0.277777777778 | NUP214 KPNA3 RAN KPNB1 KPNA4 | molecular carrier activity |
  REAC:R-HSA-159227 | 0.00212986666664 | 0.166666666667 | POM121 RANBP2 NUP214 | Transport of the SLBP independent Mature mRNA |
  REAC:R-HSA-180910 | 0.00212986666664 | 0.166666666667 | POM121 RANBP2 NUP214 | Vpr-mediated nuclear import of PICs |
  REAC:R-HSA-159230 | 0.0023483880889 | 0.166666666667 | POM121 RANBP2 NUP214 | Transport of the SLBP Dependant Mature mRNA |
  REAC:R-HSA-3301854 | 0.00258123785128 | 0.166666666667 | POM121 RANBP2 NUP214 | Nuclear Pore Complex (NPC) Disassembly |
  GO:0000280 | 0.00262378069272 | 0.388888888889 | RCC1 CDCA2 RANBP1 KPNB1 NUSAP1 RAN UBE2I | nuclear division |
  REAC:R-HSA-176033 | 0.00282885520127 | 0.166666666667 | POM121 RANBP2 NUP214 | Interactions of Vpr with host cellular proteins |
  REAC:R-HSA-9705671 | 0.00284121587273 | 0.222222222222 | POM121 RANBP2 B2M NUP214 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
  GO:0045184 | 0.00289363658448 | 0.555555555556 | POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | establishment of protein localization |
  REAC:R-HSA-211000 | 0.00349433149635 | 0.222222222222 | POM121 RANBP2 RAN NUP214 | Gene Silencing by RNA |
  REAC:R-HSA-159231 | 0.00397573632974 | 0.166666666667 | POM121 RANBP2 NUP214 | Transport of Mature mRNA Derived from an Intronless Transcript |
  REAC:R-HSA-3899300 | 0.00397573632974 | 0.166666666667 | SUMO1 SUMO2 UBE2I | SUMOylation of transcription cofactors |
  REAC:R-HSA-8957322 | 0.00398729060425 | 0.222222222222 | SUMO2 UBE2I KPNB1 RAN | Metabolism of steroids |
  REAC:R-HSA-159234 | 0.00430373127092 | 0.166666666667 | POM121 RANBP2 NUP214 | Transport of Mature mRNAs Derived from Intronless Transcripts |
  REAC:R-HSA-3065676 | 0.00441221993888 | 0.111111111111 | SUMO1 SUMO2 | SUMO is conjugated to E1 (UBA2:SAE1) |
  REAC:R-HSA-168325 | 0.00464909988722 | 0.166666666667 | POM121 RANBP2 NUP214 | Viral Messenger RNA Synthesis |
  REAC:R-HSA-5696395 | 0.00539367465473 | 0.166666666667 | SUMO1 SUMO2 UBE2I | Formation of Incision Complex in GG-NER |
  HPA:0471411 | 0.00545409388564 | 0.388888888889 | B2M RANBP1 KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2 | skin 2; cells in spinous layer[>=Low] |
  GO:0031965 | 0.00554647204036 | 0.333333333333 | POM121 KPNA4 RANBP2 KPNB1 RANGAP1 SUMO1 | nuclear membrane |
  GO:0071705 | 0.00569130188568 | 0.555555555556 | POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | nitrogen compound transport |
  GO:0048285 | 0.00582987312534 | 0.388888888889 | RCC1 CDCA2 RANBP1 KPNB1 NUSAP1 RAN UBE2I | organelle fission |
  GO:0042564 | 0.00655807506899 | 0.166666666667 | KPNA3 KPNB1 KPNA4 | NLS-dependent protein nuclear import complex |
  GO:0042277 | 0.00658610304733 | 0.333333333333 | POM121 KPNA3 NUP214 KPNB1 KPNA4 B2M | peptide binding |
  REAC:R-HSA-3065679 | 0.00661349948055 | 0.111111111111 | SUMO1 SUMO2 | SUMO is proteolytically processed |
  REAC:R-HSA-2980766 | 0.00758904467698 | 0.166666666667 | POM121 RANBP2 NUP214 | Nuclear Envelope Breakdown |
  REAC:R-HSA-194441 | 0.00971665961503 | 0.166666666667 | POM121 RANBP2 NUP214 | Metabolism of non-coding RNA |
  REAC:R-HSA-191859 | 0.00971665961503 | 0.166666666667 | POM121 RANBP2 NUP214 | snRNP Assembly |
  GO:0018205 | 0.0118938365231 | 0.277777777778 | SUMO1 RANBP2 UBE2I RANGAP1 SUMO2 | peptidyl-lysine modification |
  WP:WP138 | 0.0154515808248 | 0.166666666667 | SUMO1 RAN UBE2I | Androgen receptor signaling pathway |
  REAC:R-HSA-9683610 | 0.0158376732004 | 0.111111111111 | SUMO1 UBE2I | Maturation of nucleoprotein |
  REAC:R-HSA-8866904 | 0.0158376732004 | 0.111111111111 | SUMO1 UBE2I | Negative regulation of activity of TFAP2 (AP-2) family transcription factors |
  WP:WP3998 | 0.0160186699353 | 0.166666666667 | POM121 RANBP2 NUP214 | Prader Willi and Angelman syndrome |
  REAC:R-HSA-4755510 | 0.0197826447946 | 0.111111111111 | SUMO1 UBE2I | SUMOylation of immune response proteins |
  REAC:R-HSA-196791 | 0.0197826447946 | 0.111111111111 | SUMO2 UBE2I | Vitamin D (calciferol) metabolism |
  REAC:R-HSA-70171 | 0.0201618733033 | 0.166666666667 | POM121 RANBP2 NUP214 | Glycolysis |
  REAC:R-HSA-3371453 | 0.0201618733033 | 0.166666666667 | POM121 RANBP2 NUP214 | Regulation of HSF1-mediated heat shock response |
  HPA:0470671 | 0.0215771797059 | 0.333333333333 | B2M KPNB1 CDCA2 SUMO2 SUMO1 RANGAP1 | skin 2; melanocytes[>=Low] |
  GO:0033218 | 0.0216846317109 | 0.333333333333 | POM121 KPNA3 NUP214 KPNB1 KPNA4 B2M | amide binding |
  REAC:R-HSA-9705683 | 0.0217484076162 | 0.222222222222 | POM121 RANBP2 B2M NUP214 | SARS-CoV-2-host interactions |
  GO:0106068 | 0.0222599970629 | 0.166666666667 | RANBP2 RANGAP1 UBE2I | SUMO ligase complex |
  REAC:R-HSA-159236 | 0.0251698279425 | 0.166666666667 | POM121 RANBP2 NUP214 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
  REAC:R-HSA-5619102 | 0.0251698279425 | 0.166666666667 | POM121 RANBP2 NUP214 | SLC transporter disorders |
  HPA:0471461 | 0.0318843230377 | 0.333333333333 | B2M KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2 | skin 2; langerhans cells[>=Low] |
  REAC:R-HSA-9694631 | 0.0342149103932 | 0.111111111111 | SUMO1 UBE2I | Maturation of nucleoprotein |
  HPA:0030431 | 0.0350392915935 | 0.222222222222 | NUSAP1 B2M RANBP1 CDCA2 | appendix; germinal center cells[>=Low] |
  HPA:0471471 | 0.0353094132865 | 0.333333333333 | B2M KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2 | skin 2; lymphocytes[>=Low] |
  REAC:R-HSA-72202 | 0.0361098379174 | 0.166666666667 | POM121 RANBP2 NUP214 | Transport of Mature Transcript to Cytoplasm |
  REAC:R-HSA-70326 | 0.0361098379174 | 0.166666666667 | POM121 RANBP2 NUP214 | Glucose metabolism |
  GO:0071702 | 0.0380444333041 | 0.555555555556 | POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN | organic substance transport |
  REAC:R-HSA-5696399 | 0.0418265270532 | 0.166666666667 | SUMO1 SUMO2 UBE2I | Global Genome Nucleotide Excision Repair (GG-NER) |
  HPA:0090962 | 0.0425879582014 | 0.166666666667 | SUMO1 KPNB1 KPNA4 | cerebellum; Purkinje cells - nucleus[>=Medium] |
  GO:0061608 | 0.0434854095061 | 0.166666666667 | KPNA3 KPNB1 KPNA4 | nuclear import signal receptor activity |
  HPA:0460201 | 0.0448574812638 | 0.333333333333 | B2M KPNB1 CDCA2 SUMO2 SUMO1 RANGAP1 | skin 1; endothelial cells[>=Low] |
  REAC:R-HSA-3371556 | 0.044893348853 | 0.166666666667 | POM121 RANBP2 NUP214 | Cellular response to heat stress |
  GO:0005634 | 0.0449589173992 | 0.944444444444 | POM121 KPNA4 CDCA2 NUP214 UBE2I RGPD8 KPNB1 RANBP2 NUSAP1 NEMP1 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 SUMO2 RAN | nucleus |
  REAC:R-HSA-4655427 | 0.0459913485254 | 0.111111111111 | SUMO1 UBE2I | SUMOylation of DNA methylation proteins |
  WP:WP366 | 0.0464322118282 | 0.166666666667 | SUMO1 UBE2I NUP214 | TGF beta signaling pathway |
  CORUM:7543 | 0.0496617483143 | 0.0555555555556 | KPNB1 | KPNB1-SMN-SPN complex |
  CORUM:7567 | 0.0496617483143 | 0.0555555555556 | SUMO1 | SUMO1-SYT7 complex |
  CORUM:680 | 0.0496617483143 | 0.0555555555556 | RANBP1 | RANBMP-CD39 complex |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
---|---|---|---|---|
 RAN |  RANGAP1 | 1.0 | 0.242           |
mutually_exclusive (P61970)        
structurally_consistent (dimer)         |
 UBE2I |  SUMO1 | 1.0 | 0.234           |
structurally_consistent (dimer)        
|
 UBE2I |  RCC1 | 1.0 | 0.07           |
structurally_consistent (dimer)        
|
 UBE2I |  RANGAP1 | 1.0 | 0.202           |
structurally_consistent (dimer)        
|
 RCC1 |  RANGAP1 | 1.0 | 0.254           |          |
 RCC1 |  RANBP2 | 1.0 | 0.238           |          |
 RANGAP1 |  RGPD5 | 1.0 | 0.14           |          |
 RANBP1 |  RCC1 | 1.0 | 0.136           |
structurally_consistent (P62826)        
|
 KPNB1 |  RCC1 | 1.0 | 0.258           |          |
 RAN |  RCC1 | 1.0 | 0.16           |
structurally_consistent (dimer)        
|
 RAN |  RGPD8 | 1.0 |            |
structurally_consistent (dimer)        
|
 RCC1 |  SUMO1 | 1.0 | 0.086           |
structurally_consistent (dimer)        
|
 RANGAP1 |  RANBP2 | 1.0 | 0.426           |          |
 RAN |  RGPD5 | 1.0 | 0.142130434783           |
structurally_consistent (dimer)        
|
 KPNB1 |  NEMP1 | 1.0 | 0.212           |          |
 KPNA3 |  RCC1 | 0.999 | 0.182           |
mutually_exclusive (P62826)        
|
 RAN |  RANBP1 | 0.999 | 0.398           |
mixed_interface        
|
 UBE2I |  NEMP1 | 0.999 | 0.11           |
mutually_exclusive (P62826)        
|
 UBE2I |  RANBP2 | 0.999 | 0.264           |          |
 RCC1 |  RGPD8 | 0.999 |            |
mutually_exclusive (P62826)        
|
 SUMO2 |  UBE2I | 0.999 | 0.436           |
structurally_consistent (Q9UBT2)        
structurally_consistent (dimer)         |
 KPNA3 |  KPNA4 | 0.999 | 0.44           |          |
 KPNB1 |  UBE2I | 0.999 | 0.364           |          |
 RAN |  NEMP1 | 0.999 | 0.09           |
structurally_consistent (dimer)        
|
 RCC1 |  RGPD5 | 0.999 | 0.068           |          |
 RCC1 |  NEMP1 | 0.999 | 0.138           |
mutually_exclusive (P62826)        
|
 RGPD5 |  RGPD8 | 0.999 |            |          |
 SUMO2 |  RCC1 | 0.999 | 0.161           |
structurally_consistent (P63279)        
|
 RCC1 |  KPNA4 | 0.999 | 0.166           |
mutually_exclusive (P62826)        
structurally_consistent (dimer)         |
 RANBP2 |  SUMO1 | 0.999 | 0.44           |          |
 RANBP2 |  NEMP1 | 0.998 | 0.19           |          |
 NUSAP1 |  RCC1 | 0.998 | 0.212           |          |
 RGPD5 |  NEMP1 | 0.998 | 0.086           |
mutually_exclusive (P62826)        
|
 RANGAP1 |  NEMP1 | 0.998 | 0.11           |
mutually_exclusive (P62826)        
|
 UBE2I |  KPNA4 | 0.998 | 0.124           |
mutually_exclusive (P18754)        
|
 KPNA4 |  CDCA2 | 0.998 | 0.104           |
mutually_exclusive (Q14974)        
|
 UBE2I |  RGPD5 | 0.998 | 0.114           |          |
 UBE2I |  RGPD8 | 0.998 |            |          |
 RAN |  CDCA2 | 0.998 | 0.111           |          |
 KPNA4 |  SUMO1 | 0.998 | 0.176           |
mutually_exclusive (P18754)        
|
 RANGAP1 |  SUMO1 | 0.998 | 0.454           |
structurally_consistent (dimer)        
|
 RAN |  SUMO1 | 0.998 | 0.416           |
structurally_consistent (dimer)        
|
 KPNB1 |  RANBP1 | 0.997 | 0.182           |
mutually_exclusive (P62826)        
|
 RGPD5 |  SUMO1 | 0.997 | 0.104           |          |
 KPNB1 |  CDCA2 | 0.996 | 0.104           |
structurally_consistent (dimer)        
|
 KPNA3 |  UBE2I | 0.996 | 0.13           |          |
 RANBP2 |  RGPD8 | 0.996 |            |          |
 RANGAP1 |  RGPD8 | 0.996 |            |          |
 SUMO1 |  NEMP1 | 0.996 | 0.062           |          |
 KPNA3 |  CDCA2 | 0.995 | 0.146           |
mutually_exclusive (Q14974)        
|
 RAN |  NUSAP1 | 0.995 | 0.282           |          |
 KPNA3 |  SUMO1 | 0.995 | 0.144           |          |
 KPNA4 |  RGPD5 | 0.994 | 0.104           |          |
 NUP214 |  RANBP2 | 0.994 | 0.622           |          |
 NUP214 |  POM121 | 0.994 | 0.438           |          |
 RAN |  UBE2I | 0.994 | 0.45           |
structurally_consistent (dimer)        
|
 KPNB1 |  RANBP2 | 0.993 | 0.54           |          |
 KPNA4 |  RANBP2 | 0.993 | 0.412           |          |
 SUMO2 |  SUMO1 | 0.993 | 0.278           |          |
 KPNB1 |  RAN | 0.992 | 0.38           |
structurally_consistent (dimer)        
|
 NEMP1 |  RGPD8 | 0.992 |            |
mutually_exclusive (P62826)        
|
 B2M |  NEMP1 | 0.992 | 0.056           |          |
 RANBP2 |  RGPD5 | 0.991 | 0.224           |          |
 B2M |  RANGAP1 | 0.991 | 0.088           |
mutually_exclusive (P63279)        
|
 RAN |  B2M | 0.99 | 0.066           |          |
 KPNA3 |  RAN | 0.99 | 0.274           |
structurally_consistent (dimer)        
|
 RANBP1 |  RANBP2 | 0.989 | 0.182           |          |
 SUMO1 |  RGPD8 | 0.989 |            |          |
 SUMO2 |  RANBP2 | 0.989 | 0.382           |          |
 NUP214 |  RAN | 0.989 | 0.352           |          |
 KPNA4 |  NEMP1 | 0.987 | 0.112           |          |
 KPNB1 |  RANGAP1 | 0.987 | 0.346           |          |
 KPNA3 |  RANGAP1 | 0.987 | 0.272           |          |
 RAN |  KPNA4 | 0.987 | 0.4           |
mutually_exclusive (P18754)        
structurally_consistent (dimer)         |
 KPNA3 |  RANBP2 | 0.986 | 0.314           |          |
 KPNB1 |  RGPD5 | 0.986 | 0.153692307692           |          |
 NUP214 |  KPNB1 | 0.985 | 0.254           |          |
 KPNA4 |  RGPD8 | 0.985 |            |
mutually_exclusive (P62826)        
|
 RANGAP1 |  CDCA2 | 0.984 | 0.13           |          |
 RGPD5 |  CDCA2 | 0.983 | 0.156           |          |
 KPNB1 |  SUMO1 | 0.982 | 0.404           |          |
 KPNB1 |  KPNA4 | 0.982 | 0.656           |
structurally_consistent (dimer)        
|
 B2M |  RANBP2 | 0.982 | 0.076           |          |
 NUP214 |  RCC1 | 0.981 | 0.18           |          |
 KPNA3 |  RGPD8 | 0.981 |            |
mutually_exclusive (P62826)        
|
 KPNB1 |  KPNA3 | 0.981 | 0.236           |
structurally_consistent (dimer)        
|
 RAN |  RANBP2 | 0.981 | 0.31           |          |
 KPNA3 |  NEMP1 | 0.981 | 0.07           |
mutually_exclusive (P62826)        
|
 KPNB1 |  POM121 | 0.981 | 0.084           |          |
 SUMO2 |  RAN | 0.98 | 0.49           |          |
 KPNA4 |  POM121 | 0.977 | 0.12           |          |
 B2M |  RCC1 | 0.976 | 0.154           |
structurally_consistent (dimer)        
|
 B2M |  SUMO1 | 0.975 | 0.044           |          |
 KPNB1 |  B2M | 0.973 | 0.196           |          |
 KPNB1 |  RGPD8 | 0.972 |            |          |
 CDCA2 |  POM121 | 0.971 | 0.098431372549           |          |
 RCC1 |  CDCA2 | 0.966 | 0.108           |          |
 B2M |  UBE2I | 0.965 | 0.05           |
structurally_consistent (dimer)        
|
 NUSAP1 |  RANGAP1 | 0.96 | 0.254           |          |
 KPNB1 |  NUSAP1 | 0.957 | 0.2916           |
structurally_consistent (dimer)        
|
 SUMO2 |  KPNB1 | 0.955 | 0.642           |          |
 UBE2I |  CDCA2 | 0.955 | 0.144           |          |
 NUSAP1 |  NEMP1 | 0.955 | 0.066           |          |
 NUSAP1 |  RANBP2 | 0.951 | 0.38           |          |
 RANBP1 |  RANGAP1 | 0.949 | 0.258           |          |
 SUMO1 |  CDCA2 | 0.947 | 0.112           |          |
 RANBP2 |  CDCA2 | 0.944 | 0.248           |          |
 KPNA3 |  POM121 | 0.942 | 0.068           |          |
 RANGAP1 |  POM121 | 0.942 | 0.276           |          |
 SUMO1 |  POM121 | 0.938 | 0.118           |          |
 RANGAP1 |  KPNA4 | 0.937 | 0.174           |          |
 NUP214 |  RANBP1 | 0.932 | 0.24           |          |
 SUMO2 |  KPNA4 | 0.928 | 0.116           |          |
 NUP214 |  SUMO1 | 0.922 | 0.41           |          |
 SUMO2 |  KPNA3 | 0.911 | 0.134           |          |
 B2M |  KPNA4 | 0.909 | 0.044           |
mutually_exclusive (P18754)        
|
 NUP214 |  NEMP1 | 0.905 | 0.1           |          |
 RANBP1 |  KPNA4 | 0.904 | 0.238           |          |
 NUSAP1 |  SUMO1 | 0.901 | 0.094           |          |
 RANBP2 |  POM121 | 0.898 | 0.452           |          |
 NEMP1 |  CDCA2 | 0.89 | 0.052           |          |
 NUP214 |  KPNA3 | 0.885 | 0.192           |          |
 NUP214 |  RGPD5 | 0.884 | 0.154           |          |
 NUP214 |  RANGAP1 | 0.881 | 0.262           |          |
 SUMO2 |  NEMP1 | 0.878 | 0.2674           |          |
 KPNA3 |  RGPD5 | 0.875 | 0.124           |          |
 NUP214 |  RGPD8 | 0.875 |            |          |
 KPNA3 |  RANBP1 | 0.865 | 0.296           |          |
 NUP214 |  UBE2I | 0.865 | 0.172           |
mutually_exclusive (P61956)        
|
 RANBP1 |  POM121 | 0.858 | 0.108           |          |
 SUMO2 |  RANGAP1 | 0.851 | 0.45           |          |
 CDCA2 |  RGPD8 | 0.848 |            |          |
 RANBP1 |  CDCA2 | 0.83 | 0.167333333333           |          |
 RANBP1 |  SUMO1 | 0.818 | 0.112333333333           |
mutually_exclusive (P62826)        
|
 B2M |  RGPD5 | 0.8 | 0.068           |          |
 SUMO2 |  CDCA2 | 0.785 | 0.254           |          |
 NUSAP1 |  UBE2I | 0.761 | 0.164           |          |
 NUSAP1 |  RGPD8 | 0.744 |            |          |
 POM121 |  RGPD8 | 0.731 |            |          |
 RANBP1 |  RGPD5 | 0.731 | 0.07           |
mutually_exclusive (P62826)        
|
 NUP214 |  KPNA4 | 0.721 | 0.322           |          |
 RCC1 |  POM121 | 0.717 | 0.144           |          |
 RANBP1 |  RGPD8 | 0.695 |            |          |
 UBE2I |  POM121 | 0.658 | 0.106           |          |
 SUMO2 |  RGPD5 | 0.632 | 0.1           |          |
 RAN |  POM121 | 0.623 | 0.178           |          |
 SUMO2 |  RGPD8 | 0.599 |            |          |
 NEMP1 |  POM121 | 0.565 | 0.044431372549           |          |
 NUP214 |  CDCA2 | 0.535 | 0.122           |          |
 RANBP1 |  NEMP1 | 0.52 | 0.05           |
mutually_exclusive (P62826)        
|
 RANBP1 |  UBE2I | 0.456 | 0.168           |          |
 RANBP1 |  NUSAP1 | 0.434 | 0.17           |          |
 KPNA3 |  B2M | 0.429 | 0.054           |          |
 NUP214 |  SUMO2 | 0.403 | 0.348           |
structurally_consistent (dimer)        
|
 NUSAP1 |  B2M | 0.375 | 0.074           |          |
 NUP214 |  NUSAP1 | 0.328 | 0.296           |          |
 NUSAP1 |  CDCA2 | 0.307 | 0.244           |
mutually_exclusive (Q14974)        
|
 NUSAP1 |  KPNA4 | 0.194 | 0.152           |
mutually_exclusive (Q14974)        
|
 NUSAP1 |  RGPD5 | 0.162 | 0.088           |          |
 RGPD5 |  POM121 | 0.144 | 0.05           |          |
 KPNA3 |  NUSAP1 | 0.13 | 0.154           |
mutually_exclusive (Q14974)        
|
 B2M |  CDCA2 | 0.109 | 0.058           |          |
 SUMO2 |  NUSAP1 | 0.099 | 0.3           |          |
 NUSAP1 |  POM121 | 0.096 | 0.116           |          |
 SUMO2 |  RANBP1 | 0.072 | 0.276           |          |
 B2M |  POM121 | 0.048 | 0.034           |          |
 SUMO2 |  POM121 | 0.036 | 0.298           |          |
 SUMO2 |  B2M | 0.004 | 0.128           |
structurally_consistent (P63279)        
|
 RANBP1 |  B2M | 0.003 | 0.216           |          |
 NUP214 |  B2M | 0.002 | 0.062           |          |
Related Complexes