hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08641.1

Complex Portal: CPX-23411

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
RGPD5	RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)	4	UniProt NCBI
NUSAP1	Nucleolar and spindle-associated protein 1 (NuSAP)	5	UniProt NCBI
POM121	Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)	5	UniProt NCBI
SUMO1	Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)	5	UniProt NCBI
KPNB1	Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)	5	UniProt NCBI
RANGAP1	Ran GTPase-activating protein 1 (RanGAP1)	5	UniProt NCBI
CDCA2	Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man)	5	UniProt NCBI
KPNA4	Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)	5	UniProt NCBI
NUP214	Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)	5	UniProt NCBI
RAN	GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)	5	UniProt NCBI
RANBP1	Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)	5	UniProt NCBI
RCC1	Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)	5	UniProt NCBI
SUMO2	Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)	5	UniProt NCBI
RANBP2	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	5	UniProt NCBI
RGPD8	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	3	UniProt NCBI
KPNA3	Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)	5	UniProt NCBI
UBE2I	SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)	5	UniProt NCBI
NEMP1	Nuclear envelope integral membrane protein 1	5	UniProt NCBI
B2M	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005643	4.43339738863e-19	0.666666666667	POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN	nuclear pore
KEGG:03013	1.7632715156e-18	0.611111111111	POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 SUMO2 RAN	Nucleocytoplasmic transport
REAC:R-HSA-177243	4.68405015184e-15	0.444444444444	POM121 RCC1 NUP214 KPNB1 RANBP2 RAN RANBP1 RANGAP1	Interactions of Rev with host cellular proteins
REAC:R-HSA-9615933	1.19127265355e-13	0.388888888889	POM121 RCC1 KPNB1 RANGAP1 SUMO1 UBE2I RAN	Postmitotic nuclear pore complex (NPC) reformation
GO:0005635	2.72848355067e-13	0.722222222222	POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 NEMP1 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN	nuclear envelope
REAC:R-HSA-165054	1.15241197107e-12	0.388888888889	POM121 RCC1 RANBP1 RANBP2 RAN NUP214 RANGAP1	Rev-mediated nuclear export of HIV RNA
REAC:R-HSA-162909	2.57212140756e-12	0.5	POM121 RCC1 NUP214 KPNB1 RANBP2 RAN RANBP1 B2M RANGAP1	Host Interactions of HIV factors
REAC:R-HSA-4615885	9.17615104548e-12	0.388888888889	POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I RANGAP1	SUMOylation of DNA replication proteins
REAC:R-HSA-9824446	1.40220937287e-11	0.722222222222	POM121 KPNA4 NUP214 KPNB1 RANBP2 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 B2M UBE2I RAN	Viral Infection Pathways
GO:0051169	2.93753104585e-11	0.611111111111	POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	nuclear transport
GO:0006913	2.93753104585e-11	0.611111111111	POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	nucleocytoplasmic transport
GO:0006606	7.57554943603e-11	0.5	POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 SUMO1 RGPD8 KPNA3	protein import into nucleus
GO:0051170	1.17227063012e-10	0.5	POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 SUMO1 RGPD8 KPNA3	import into nucleus
REAC:R-HSA-5663205	1.98058900315e-10	0.722222222222	POM121 KPNA4 NUP214 KPNB1 RANBP2 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 B2M UBE2I RAN	Infectious disease
REAC:R-HSA-2995410	2.9094844415e-10	0.388888888889	POM121 RCC1 KPNB1 RANGAP1 SUMO1 UBE2I RAN	Nuclear Envelope (NE) Reassembly
REAC:R-HSA-180746	3.06552144851e-10	0.333333333333	POM121 RCC1 RANBP2 KPNB1 RAN NUP214	Nuclear import of Rev protein
REAC:R-HSA-4085377	3.77029006285e-10	0.333333333333	POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I	SUMOylation of SUMOylation proteins
REAC:R-HSA-162906	4.68414960712e-10	0.5	POM121 RCC1 NUP214 KPNB1 RANBP2 RAN RANBP1 B2M RANGAP1	HIV Infection
REAC:R-HSA-168276	9.63841917568e-10	0.333333333333	POM121 KPNA3 NUP214 KPNB1 RANBP2 KPNA4	NS1 Mediated Effects on Host Pathways
GO:0034504	1.05062060587e-09	0.555555555556	POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	protein localization to nucleus
REAC:R-HSA-4570464	2.51687960257e-09	0.333333333333	POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I	SUMOylation of RNA binding proteins
REAC:R-HSA-913531	4.38944149202e-09	0.444444444444	POM121 KPNA4 RANBP2 KPNB1 NUP214 SUMO1 B2M KPNA3	Interferon Signaling
REAC:R-HSA-68882	3.06953227531e-08	0.444444444444	POM121 RCC1 RANBP2 KPNB1 RANGAP1 SUMO1 UBE2I RAN	Mitotic Anaphase
REAC:R-HSA-2555396	3.1812588662e-08	0.444444444444	POM121 RCC1 RANBP2 KPNB1 RANGAP1 SUMO1 UBE2I RAN	Mitotic Metaphase and Anaphase
REAC:R-HSA-162599	3.38980372261e-08	0.388888888889	POM121 RCC1 RANBP1 RANBP2 RAN NUP214 RANGAP1	Late Phase of HIV Life Cycle
REAC:R-HSA-1169408	3.69063811566e-08	0.333333333333	POM121 KPNA3 NUP214 KPNB1 RANBP2 KPNA4	ISG15 antiviral mechanism
REAC:R-HSA-4551638	3.69063811566e-08	0.333333333333	POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I	SUMOylation of chromatin organization proteins
REAC:R-HSA-3108214	5.79697679434e-08	0.333333333333	POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I	SUMOylation of DNA damage response and repair proteins
REAC:R-HSA-1169410	6.31950909177e-08	0.333333333333	POM121 KPNA3 NUP214 KPNB1 RANBP2 KPNA4	Antiviral mechanism by IFN-stimulated genes
CORUM:1554	6.32531883213e-08	0.166666666667	RANBP1 KPNB1 RAN	RANBP1-RAN-KPNB1 complex
REAC:R-HSA-162587	6.32786417704e-08	0.388888888889	POM121 RCC1 RANBP1 RANBP2 RAN NUP214 RANGAP1	HIV Life Cycle
REAC:R-HSA-68886	7.09253793878e-08	0.5	POM121 RCC1 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 UBE2I RAN	M Phase
GO:0031975	7.36458663568e-08	0.722222222222	POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 NEMP1 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN	envelope
GO:0031967	7.36458663568e-08	0.722222222222	POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 NEMP1 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN	organelle envelope
REAC:R-HSA-168255	8.472774739e-08	0.388888888889	POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 KPNA3	Influenza Infection
REAC:R-HSA-3108232	1.34253040655e-07	0.388888888889	POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I RANGAP1	SUMO E3 ligases SUMOylate target proteins
REAC:R-HSA-3232142	1.51196027559e-07	0.277777777778	NUP214 POM121 RANBP2 UBE2I SUMO1	SUMOylation of ubiquitinylation proteins
REAC:R-HSA-2990846	1.67114983174e-07	0.388888888889	POM121 NUP214 SUMO2 RANBP2 SUMO1 UBE2I RANGAP1	SUMOylation
REAC:R-HSA-1643685	1.89945895009e-07	0.722222222222	POM121 KPNA4 NUP214 KPNB1 RANBP2 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 B2M UBE2I RAN	Disease
REAC:R-HSA-9793242	4.84160206904e-07	0.166666666667	SUMO1 RANGAP1 UBE2I	SUMOylation of nuclear envelope proteins
GO:0006607	6.54672911896e-07	0.277777777778	RANBP2 KPNA3 RGPD8 KPNB1 KPNA4	NLS-bearing protein import into nucleus
REAC:R-HSA-69278	1.0634937167e-06	0.5	POM121 RCC1 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 UBE2I RAN	Cell Cycle, Mitotic
GO:0008139	2.0061917853e-06	0.277777777778	NUP214 POM121 KPNA3 KPNB1 KPNA4	nuclear localization sequence binding
GO:0006886	2.54701325467e-06	0.555555555556	POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	intracellular protein transport
GO:0072594	3.53755355942e-06	0.5	POM121 KPNA4 NUP214 KPNB1 RAN RANBP2 SUMO1 RGPD8 KPNA3	establishment of protein localization to organelle
GO:0140142	6.12743447997e-06	0.277777777778	NUP214 KPNA3 RAN KPNB1 KPNA4	nucleocytoplasmic carrier activity
REAC:R-HSA-1640170	6.47866253615e-06	0.5	POM121 RCC1 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 UBE2I RAN	Cell Cycle
REAC:R-HSA-3065678	9.66085554184e-06	0.166666666667	SUMO1 SUMO2 UBE2I	SUMO is transferred from E1 to E2 (UBE2I, UBC9)
REAC:R-HSA-168333	1.15804178979e-05	0.222222222222	POM121 RANBP2 RAN NUP214	NEP/NS2 Interacts with the Cellular Export Machinery
REAC:R-HSA-168271	1.15804178979e-05	0.222222222222	POM121 RANBP2 KPNB1 NUP214	Transport of Ribonucleoproteins into the Host Nucleus
REAC:R-HSA-168274	1.15804178979e-05	0.222222222222	POM121 RANBP2 RAN NUP214	Export of Viral Ribonucleoproteins from Nucleus
WP:WP4657	1.27955349774e-05	0.277777777778	RAN RANBP1 RCC1 KPNB1 RANGAP1	22q11 2 copy number variation syndrome
GO:0140513	2.01617113895e-05	0.666666666667	POM121 KPNA4 NUP214 UBE2I KPNB1 RANBP2 RANGAP1 RANBP1 SUMO1 KPNA3 RGPD8 RAN	nuclear protein-containing complex
GO:0031074	2.64282390746e-05	0.222222222222	RAN KPNA3 KPNB1 KPNA4	nucleocytoplasmic transport complex
REAC:R-HSA-3215018	4.04819448703e-05	0.166666666667	SUMO1 SUMO2 UBE2I	Processing and activation of SUMO
GO:0005048	4.33124926153e-05	0.277777777778	NUP214 POM121 KPNA3 KPNB1 KPNA4	signal sequence binding
REAC:R-HSA-9679506	5.42687446114e-05	0.388888888889	POM121 B2M NUP214 KPNB1 RANBP2 SUMO1 UBE2I	SARS-CoV Infections
CORUM:6143	5.77699275587e-05	0.111111111111	KPNB1 RAN	KPNB1-RAN complex
REAC:R-HSA-1280215	8.0973503206e-05	0.444444444444	POM121 KPNA4 RANBP2 KPNB1 NUP214 SUMO1 B2M KPNA3	Cytokine Signaling in Immune system
GO:0033365	0.00014573961935	0.555555555556	POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	protein localization to organelle
REAC:R-HSA-6784531	0.000163004566241	0.222222222222	POM121 RANBP2 RAN NUP214	tRNA processing in the nucleus
CORUM:7050	0.000173183276299	0.111111111111	SUMO1 UBE2I	PIAS1-SUMO1-UBC9 complex
REAC:R-HSA-9694516	0.000190796005136	0.333333333333	POM121 B2M NUP214 RANBP2 SUMO1 UBE2I	SARS-CoV-2 Infection
REAC:R-HSA-3232118	0.00021826617171	0.166666666667	SUMO1 SUMO2 UBE2I	SUMOylation of transcription factors
GO:0015031	0.000220187260834	0.555555555556	POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	protein transport
GO:0016925	0.000258604542679	0.277777777778	SUMO1 RANBP2 UBE2I RANGAP1 SUMO2	protein sumoylation
GO:0140014	0.000265298967356	0.388888888889	RCC1 CDCA2 RANBP1 KPNB1 NUSAP1 RAN UBE2I	mitotic nuclear division
GO:0051649	0.000275166022089	0.666666666667	POM121 KPNA4 NUP214 KPNB1 UBE2I NUSAP1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	establishment of localization in cell
REAC:R-HSA-4090294	0.000325697873067	0.166666666667	SUMO1 SUMO2 UBE2I	SUMOylation of intracellular receptors
GO:0046907	0.000338396054235	0.611111111111	POM121 KPNA4 NUP214 KPNB1 UBE2I RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	intracellular transport
GO:0051168	0.000637995490753	0.333333333333	POM121 RANBP2 RAN NUP214 UBE2I RANGAP1	nuclear export
HPA:0471391	0.000933538599002	0.444444444444	B2M CDCA2 RANBP1 KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2	skin 2; cells in basal layer[>=Low]
REAC:R-HSA-5578749	0.001242542042	0.222222222222	POM121 RANBP2 RAN NUP214	Transcriptional regulation by small RNAs
REAC:R-HSA-170822	0.00155585884203	0.166666666667	POM121 RANBP2 NUP214	Regulation of Glucokinase by Glucokinase Regulatory Protein
REAC:R-HSA-5619107	0.00155585884203	0.166666666667	POM121 RANBP2 NUP214	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
REAC:R-HSA-72306	0.00173935614951	0.222222222222	POM121 RANBP2 RAN NUP214	tRNA processing
GO:0140104	0.00175417898685	0.277777777778	NUP214 KPNA3 RAN KPNB1 KPNA4	molecular carrier activity
REAC:R-HSA-159227	0.00212986666664	0.166666666667	POM121 RANBP2 NUP214	Transport of the SLBP independent Mature mRNA
REAC:R-HSA-180910	0.00212986666664	0.166666666667	POM121 RANBP2 NUP214	Vpr-mediated nuclear import of PICs
REAC:R-HSA-159230	0.0023483880889	0.166666666667	POM121 RANBP2 NUP214	Transport of the SLBP Dependant Mature mRNA
REAC:R-HSA-3301854	0.00258123785128	0.166666666667	POM121 RANBP2 NUP214	Nuclear Pore Complex (NPC) Disassembly
GO:0000280	0.00262378069272	0.388888888889	RCC1 CDCA2 RANBP1 KPNB1 NUSAP1 RAN UBE2I	nuclear division
REAC:R-HSA-176033	0.00282885520127	0.166666666667	POM121 RANBP2 NUP214	Interactions of Vpr with host cellular proteins
REAC:R-HSA-9705671	0.00284121587273	0.222222222222	POM121 RANBP2 B2M NUP214	SARS-CoV-2 activates/modulates innate and adaptive immune responses
GO:0045184	0.00289363658448	0.555555555556	POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	establishment of protein localization
REAC:R-HSA-211000	0.00349433149635	0.222222222222	POM121 RANBP2 RAN NUP214	Gene Silencing by RNA
REAC:R-HSA-159231	0.00397573632974	0.166666666667	POM121 RANBP2 NUP214	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-3899300	0.00397573632974	0.166666666667	SUMO1 SUMO2 UBE2I	SUMOylation of transcription cofactors
REAC:R-HSA-8957322	0.00398729060425	0.222222222222	SUMO2 UBE2I KPNB1 RAN	Metabolism of steroids
REAC:R-HSA-159234	0.00430373127092	0.166666666667	POM121 RANBP2 NUP214	Transport of Mature mRNAs Derived from Intronless Transcripts
REAC:R-HSA-3065676	0.00441221993888	0.111111111111	SUMO1 SUMO2	SUMO is conjugated to E1 (UBA2:SAE1)
REAC:R-HSA-168325	0.00464909988722	0.166666666667	POM121 RANBP2 NUP214	Viral Messenger RNA Synthesis
REAC:R-HSA-5696395	0.00539367465473	0.166666666667	SUMO1 SUMO2 UBE2I	Formation of Incision Complex in GG-NER
HPA:0471411	0.00545409388564	0.388888888889	B2M RANBP1 KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2	skin 2; cells in spinous layer[>=Low]
GO:0031965	0.00554647204036	0.333333333333	POM121 KPNA4 RANBP2 KPNB1 RANGAP1 SUMO1	nuclear membrane
GO:0071705	0.00569130188568	0.555555555556	POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	nitrogen compound transport
GO:0048285	0.00582987312534	0.388888888889	RCC1 CDCA2 RANBP1 KPNB1 NUSAP1 RAN UBE2I	organelle fission
GO:0042564	0.00655807506899	0.166666666667	KPNA3 KPNB1 KPNA4	NLS-dependent protein nuclear import complex
GO:0042277	0.00658610304733	0.333333333333	POM121 KPNA3 NUP214 KPNB1 KPNA4 B2M	peptide binding
REAC:R-HSA-3065679	0.00661349948055	0.111111111111	SUMO1 SUMO2	SUMO is proteolytically processed
REAC:R-HSA-2980766	0.00758904467698	0.166666666667	POM121 RANBP2 NUP214	Nuclear Envelope Breakdown
REAC:R-HSA-194441	0.00971665961503	0.166666666667	POM121 RANBP2 NUP214	Metabolism of non-coding RNA
REAC:R-HSA-191859	0.00971665961503	0.166666666667	POM121 RANBP2 NUP214	snRNP Assembly
GO:0018205	0.0118938365231	0.277777777778	SUMO1 RANBP2 UBE2I RANGAP1 SUMO2	peptidyl-lysine modification
WP:WP138	0.0154515808248	0.166666666667	SUMO1 RAN UBE2I	Androgen receptor signaling pathway
REAC:R-HSA-9683610	0.0158376732004	0.111111111111	SUMO1 UBE2I	Maturation of nucleoprotein
REAC:R-HSA-8866904	0.0158376732004	0.111111111111	SUMO1 UBE2I	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
WP:WP3998	0.0160186699353	0.166666666667	POM121 RANBP2 NUP214	Prader Willi and Angelman syndrome
REAC:R-HSA-4755510	0.0197826447946	0.111111111111	SUMO1 UBE2I	SUMOylation of immune response proteins
REAC:R-HSA-196791	0.0197826447946	0.111111111111	SUMO2 UBE2I	Vitamin D (calciferol) metabolism
REAC:R-HSA-70171	0.0201618733033	0.166666666667	POM121 RANBP2 NUP214	Glycolysis
REAC:R-HSA-3371453	0.0201618733033	0.166666666667	POM121 RANBP2 NUP214	Regulation of HSF1-mediated heat shock response
HPA:0470671	0.0215771797059	0.333333333333	B2M KPNB1 CDCA2 SUMO2 SUMO1 RANGAP1	skin 2; melanocytes[>=Low]
GO:0033218	0.0216846317109	0.333333333333	POM121 KPNA3 NUP214 KPNB1 KPNA4 B2M	amide binding
REAC:R-HSA-9705683	0.0217484076162	0.222222222222	POM121 RANBP2 B2M NUP214	SARS-CoV-2-host interactions
GO:0106068	0.0222599970629	0.166666666667	RANBP2 RANGAP1 UBE2I	SUMO ligase complex
REAC:R-HSA-159236	0.0251698279425	0.166666666667	POM121 RANBP2 NUP214	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-5619102	0.0251698279425	0.166666666667	POM121 RANBP2 NUP214	SLC transporter disorders
HPA:0471461	0.0318843230377	0.333333333333	B2M KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2	skin 2; langerhans cells[>=Low]
REAC:R-HSA-9694631	0.0342149103932	0.111111111111	SUMO1 UBE2I	Maturation of nucleoprotein
HPA:0030431	0.0350392915935	0.222222222222	NUSAP1 B2M RANBP1 CDCA2	appendix; germinal center cells[>=Low]
HPA:0471471	0.0353094132865	0.333333333333	B2M KPNB1 NUSAP1 RANGAP1 SUMO1 SUMO2	skin 2; lymphocytes[>=Low]
REAC:R-HSA-72202	0.0361098379174	0.166666666667	POM121 RANBP2 NUP214	Transport of Mature Transcript to Cytoplasm
REAC:R-HSA-70326	0.0361098379174	0.166666666667	POM121 RANBP2 NUP214	Glucose metabolism
GO:0071702	0.0380444333041	0.555555555556	POM121 KPNA4 NUP214 KPNB1 RANGAP1 RANBP2 SUMO1 KPNA3 RGPD8 RAN	organic substance transport
REAC:R-HSA-5696399	0.0418265270532	0.166666666667	SUMO1 SUMO2 UBE2I	Global Genome Nucleotide Excision Repair (GG-NER)
HPA:0090962	0.0425879582014	0.166666666667	SUMO1 KPNB1 KPNA4	cerebellum; Purkinje cells - nucleus[>=Medium]
GO:0061608	0.0434854095061	0.166666666667	KPNA3 KPNB1 KPNA4	nuclear import signal receptor activity
HPA:0460201	0.0448574812638	0.333333333333	B2M KPNB1 CDCA2 SUMO2 SUMO1 RANGAP1	skin 1; endothelial cells[>=Low]
REAC:R-HSA-3371556	0.044893348853	0.166666666667	POM121 RANBP2 NUP214	Cellular response to heat stress
GO:0005634	0.0449589173992	0.944444444444	POM121 KPNA4 CDCA2 NUP214 UBE2I RGPD8 KPNB1 RANBP2 NUSAP1 NEMP1 RCC1 RANGAP1 RANBP1 SUMO1 KPNA3 SUMO2 RAN	nucleus
REAC:R-HSA-4655427	0.0459913485254	0.111111111111	SUMO1 UBE2I	SUMOylation of DNA methylation proteins
WP:WP366	0.0464322118282	0.166666666667	SUMO1 UBE2I NUP214	TGF beta signaling pathway
CORUM:7543	0.0496617483143	0.0555555555556	KPNB1	KPNB1-SMN-SPN complex
CORUM:7567	0.0496617483143	0.0555555555556	SUMO1	SUMO1-SYT7 complex
CORUM:680	0.0496617483143	0.0555555555556	RANBP1	RANBMP-CD39 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RAN	RANGAP1	1.0	0.242	mutually_exclusive (P61970) structurally_consistent (dimer)
UBE2I	SUMO1	1.0	0.234	structurally_consistent (dimer)
UBE2I	RCC1	1.0	0.07	structurally_consistent (dimer)
UBE2I	RANGAP1	1.0	0.202	structurally_consistent (dimer)
RCC1	RANGAP1	1.0	0.254
RCC1	RANBP2	1.0	0.238
RANGAP1	RGPD5	1.0	0.14
RANBP1	RCC1	1.0	0.136	structurally_consistent (P62826)
KPNB1	RCC1	1.0	0.258
RAN	RCC1	1.0	0.16	structurally_consistent (dimer)
RAN	RGPD8	1.0		structurally_consistent (dimer)
RCC1	SUMO1	1.0	0.086	structurally_consistent (dimer)
RANGAP1	RANBP2	1.0	0.426
RAN	RGPD5	1.0	0.142130434783	structurally_consistent (dimer)
KPNB1	NEMP1	1.0	0.212
KPNA3	RCC1	0.999	0.182	mutually_exclusive (P62826)
RAN	RANBP1	0.999	0.398	mixed_interface
UBE2I	NEMP1	0.999	0.11	mutually_exclusive (P62826)
UBE2I	RANBP2	0.999	0.264
RCC1	RGPD8	0.999		mutually_exclusive (P62826)
SUMO2	UBE2I	0.999	0.436	structurally_consistent (Q9UBT2) structurally_consistent (dimer)
KPNA3	KPNA4	0.999	0.44
KPNB1	UBE2I	0.999	0.364
RAN	NEMP1	0.999	0.09	structurally_consistent (dimer)
RCC1	RGPD5	0.999	0.068
RCC1	NEMP1	0.999	0.138	mutually_exclusive (P62826)
RGPD5	RGPD8	0.999
SUMO2	RCC1	0.999	0.161	structurally_consistent (P63279)
RCC1	KPNA4	0.999	0.166	mutually_exclusive (P62826) structurally_consistent (dimer)
RANBP2	SUMO1	0.999	0.44
RANBP2	NEMP1	0.998	0.19
NUSAP1	RCC1	0.998	0.212
RGPD5	NEMP1	0.998	0.086	mutually_exclusive (P62826)
RANGAP1	NEMP1	0.998	0.11	mutually_exclusive (P62826)
UBE2I	KPNA4	0.998	0.124	mutually_exclusive (P18754)
KPNA4	CDCA2	0.998	0.104	mutually_exclusive (Q14974)
UBE2I	RGPD5	0.998	0.114
UBE2I	RGPD8	0.998
RAN	CDCA2	0.998	0.111
KPNA4	SUMO1	0.998	0.176	mutually_exclusive (P18754)
RANGAP1	SUMO1	0.998	0.454	structurally_consistent (dimer)
RAN	SUMO1	0.998	0.416	structurally_consistent (dimer)
KPNB1	RANBP1	0.997	0.182	mutually_exclusive (P62826)
RGPD5	SUMO1	0.997	0.104
KPNB1	CDCA2	0.996	0.104	structurally_consistent (dimer)
KPNA3	UBE2I	0.996	0.13
RANBP2	RGPD8	0.996
RANGAP1	RGPD8	0.996
SUMO1	NEMP1	0.996	0.062
KPNA3	CDCA2	0.995	0.146	mutually_exclusive (Q14974)
RAN	NUSAP1	0.995	0.282
KPNA3	SUMO1	0.995	0.144
KPNA4	RGPD5	0.994	0.104
NUP214	RANBP2	0.994	0.622
NUP214	POM121	0.994	0.438
RAN	UBE2I	0.994	0.45	structurally_consistent (dimer)
KPNB1	RANBP2	0.993	0.54
KPNA4	RANBP2	0.993	0.412
SUMO2	SUMO1	0.993	0.278
KPNB1	RAN	0.992	0.38	structurally_consistent (dimer)
NEMP1	RGPD8	0.992		mutually_exclusive (P62826)
B2M	NEMP1	0.992	0.056
RANBP2	RGPD5	0.991	0.224
B2M	RANGAP1	0.991	0.088	mutually_exclusive (P63279)
RAN	B2M	0.99	0.066
KPNA3	RAN	0.99	0.274	structurally_consistent (dimer)
RANBP1	RANBP2	0.989	0.182
SUMO1	RGPD8	0.989
SUMO2	RANBP2	0.989	0.382
NUP214	RAN	0.989	0.352
KPNA4	NEMP1	0.987	0.112
KPNB1	RANGAP1	0.987	0.346
KPNA3	RANGAP1	0.987	0.272
RAN	KPNA4	0.987	0.4	mutually_exclusive (P18754) structurally_consistent (dimer)
KPNA3	RANBP2	0.986	0.314
KPNB1	RGPD5	0.986	0.153692307692
NUP214	KPNB1	0.985	0.254
KPNA4	RGPD8	0.985		mutually_exclusive (P62826)
RANGAP1	CDCA2	0.984	0.13
RGPD5	CDCA2	0.983	0.156
KPNB1	SUMO1	0.982	0.404
KPNB1	KPNA4	0.982	0.656	structurally_consistent (dimer)
B2M	RANBP2	0.982	0.076
NUP214	RCC1	0.981	0.18
KPNA3	RGPD8	0.981		mutually_exclusive (P62826)
KPNB1	KPNA3	0.981	0.236	structurally_consistent (dimer)
RAN	RANBP2	0.981	0.31
KPNA3	NEMP1	0.981	0.07	mutually_exclusive (P62826)
KPNB1	POM121	0.981	0.084
SUMO2	RAN	0.98	0.49
KPNA4	POM121	0.977	0.12
B2M	RCC1	0.976	0.154	structurally_consistent (dimer)
B2M	SUMO1	0.975	0.044
KPNB1	B2M	0.973	0.196
KPNB1	RGPD8	0.972
CDCA2	POM121	0.971	0.098431372549
RCC1	CDCA2	0.966	0.108
B2M	UBE2I	0.965	0.05	structurally_consistent (dimer)
NUSAP1	RANGAP1	0.96	0.254
KPNB1	NUSAP1	0.957	0.2916	structurally_consistent (dimer)
SUMO2	KPNB1	0.955	0.642
UBE2I	CDCA2	0.955	0.144
NUSAP1	NEMP1	0.955	0.066
NUSAP1	RANBP2	0.951	0.38
RANBP1	RANGAP1	0.949	0.258
SUMO1	CDCA2	0.947	0.112
RANBP2	CDCA2	0.944	0.248
KPNA3	POM121	0.942	0.068
RANGAP1	POM121	0.942	0.276
SUMO1	POM121	0.938	0.118
RANGAP1	KPNA4	0.937	0.174
NUP214	RANBP1	0.932	0.24
SUMO2	KPNA4	0.928	0.116
NUP214	SUMO1	0.922	0.41
SUMO2	KPNA3	0.911	0.134
B2M	KPNA4	0.909	0.044	mutually_exclusive (P18754)
NUP214	NEMP1	0.905	0.1
RANBP1	KPNA4	0.904	0.238
NUSAP1	SUMO1	0.901	0.094
RANBP2	POM121	0.898	0.452
NEMP1	CDCA2	0.89	0.052
NUP214	KPNA3	0.885	0.192
NUP214	RGPD5	0.884	0.154
NUP214	RANGAP1	0.881	0.262
SUMO2	NEMP1	0.878	0.2674
KPNA3	RGPD5	0.875	0.124
NUP214	RGPD8	0.875
KPNA3	RANBP1	0.865	0.296
NUP214	UBE2I	0.865	0.172	mutually_exclusive (P61956)
RANBP1	POM121	0.858	0.108
SUMO2	RANGAP1	0.851	0.45
CDCA2	RGPD8	0.848
RANBP1	CDCA2	0.83	0.167333333333
RANBP1	SUMO1	0.818	0.112333333333	mutually_exclusive (P62826)
B2M	RGPD5	0.8	0.068
SUMO2	CDCA2	0.785	0.254
NUSAP1	UBE2I	0.761	0.164
NUSAP1	RGPD8	0.744
POM121	RGPD8	0.731
RANBP1	RGPD5	0.731	0.07	mutually_exclusive (P62826)
NUP214	KPNA4	0.721	0.322
RCC1	POM121	0.717	0.144
RANBP1	RGPD8	0.695
UBE2I	POM121	0.658	0.106
SUMO2	RGPD5	0.632	0.1
RAN	POM121	0.623	0.178
SUMO2	RGPD8	0.599
NEMP1	POM121	0.565	0.044431372549
NUP214	CDCA2	0.535	0.122
RANBP1	NEMP1	0.52	0.05	mutually_exclusive (P62826)
RANBP1	UBE2I	0.456	0.168
RANBP1	NUSAP1	0.434	0.17
KPNA3	B2M	0.429	0.054
NUP214	SUMO2	0.403	0.348	structurally_consistent (dimer)
NUSAP1	B2M	0.375	0.074
NUP214	NUSAP1	0.328	0.296
NUSAP1	CDCA2	0.307	0.244	mutually_exclusive (Q14974)
NUSAP1	KPNA4	0.194	0.152	mutually_exclusive (Q14974)
NUSAP1	RGPD5	0.162	0.088
RGPD5	POM121	0.144	0.05
KPNA3	NUSAP1	0.13	0.154	mutually_exclusive (Q14974)
B2M	CDCA2	0.109	0.058
SUMO2	NUSAP1	0.099	0.3
NUSAP1	POM121	0.096	0.116
SUMO2	RANBP1	0.072	0.276
B2M	POM121	0.048	0.034
SUMO2	POM121	0.036	0.298
SUMO2	B2M	0.004	0.128	structurally_consistent (P63279)
RANBP1	B2M	0.003	0.216
NUP214	B2M	0.002	0.062

Related Complexes

Genename	Complexes
RGPD5	huMAP3_05030.1 huMAP3_05712.1 huMAP3_07331.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
NUSAP1	huMAP3_01999.1 huMAP3_02813.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07763.1 huMAP3_08641.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1
POM121	huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_12581.1
SUMO1	huMAP3_05712.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
KPNB1	huMAP3_00976.1 huMAP3_07479.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
RANGAP1	huMAP3_02264.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07828.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
CDCA2	huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
KPNA4	huMAP3_03376.1 huMAP3_07479.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_13201.1
NUP214	huMAP3_00209.1 huMAP3_05948.1 huMAP3_06369.1 huMAP3_08641.1 huMAP3_09220.1 huMAP3_10000.1 huMAP3_12581.1
RAN	huMAP3_01999.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07763.1 huMAP3_08641.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_15098.1
RANBP1	huMAP3_01999.1 huMAP3_03516.1 huMAP3_07032.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
RCC1	huMAP3_02264.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07828.1 huMAP3_08641.1 huMAP3_09597.1 huMAP3_10000.1 huMAP3_12581.1
SUMO2	huMAP3_00864.1 huMAP3_01999.1 huMAP3_02554.1 huMAP3_05860.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07649.1 huMAP3_07958.1 huMAP3_08641.1 huMAP3_10000.1 huMAP3_12375.1 huMAP3_12581.1
RANBP2	huMAP3_05030.1 huMAP3_05712.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
RGPD8	huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
KPNA3	huMAP3_00976.1 huMAP3_07479.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
UBE2I	huMAP3_02057.1 huMAP3_02554.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_07649.1 huMAP3_08641.1 huMAP3_10000.1 huMAP3_12581.1
NEMP1	huMAP3_07331.1 huMAP3_07828.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
B2M	huMAP3_01999.1 huMAP3_06494.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_08363.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1 huMAP3_13569.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08641.1

Complex Portal: CPX-23411