hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08647.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CWC22 | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | 5 | UniProt NCBI |
| EPB41L3 | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | 5 | UniProt NCBI |
| EPB41L2 | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | 5 | UniProt NCBI |
| EPB41 | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | 5 | UniProt NCBI |
| CWC27 | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | 5 | UniProt NCBI |
| NAF1 | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | 5 | UniProt NCBI |
| EPB41L1 | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4148 | 2.13184989952e-05 | 0.5 | EPB41L2 EPB41L3 EPB41L1 | Splicing factor NOVA regulated synaptic proteins |
| REAC:R-HSA-6794361 | 0.000106578184795 | 0.5 | EPB41L2 EPB41L3 EPB41L1 | Neurexins and neuroligins |
| REAC:R-HSA-6794362 | 0.00038290615081 | 0.5 | EPB41L2 EPB41L3 EPB41L1 | Protein-protein interactions at synapses |
| REAC:R-HSA-9662361 | 0.0161658624528 | 0.333333333333 | EPB41L1 EPB41L3 | Sensory processing of sound by outer hair cells of the cochlea |
| REAC:R-HSA-112316 | 0.0294801014222 | 0.5 | EPB41L2 EPB41L3 EPB41L1 | Neuronal System |
| REAC:R-HSA-9662360 | 0.0326270815028 | 0.333333333333 | EPB41L1 EPB41L3 | Sensory processing of sound by inner hair cells of the cochlea |
| REAC:R-HSA-9659379 | 0.0379731829042 | 0.333333333333 | EPB41L1 EPB41L3 | Sensory processing of sound |
| HPA:0100212 | 0.0490347745154 | 0.833333333333 | EPB41L2 NAF1 EPB41L1 CWC22 EPB41L3 | cerebral cortex; neuropil[>=Medium] |
| CORUM:1181 | 0.0493179573456 | 0.333333333333 | CWC22 CWC27 | C complex spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EPB41L2 | EPB41L1 | 0.999 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| EPB41L3 | EPB41L2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| CWC22 | EPB41L2 | 0.998 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EPB41L3 | EPB41L1 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| EPB41L3 | CWC22 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| EPB41L3 | EPB41 | 0.991 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only | |
| EPB41L1 | NAF1 | 0.99 | 0.12 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CWC22 | EPB41L1 | 0.962 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CWC22 | NAF1 | 0.961 | 0.292 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CWC22 | CWC27 | 0.96 | 0.316 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EPB41L3 | CWC27 | 0.954 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EPB41L2 | NAF1 | 0.95 | 0.076 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| EPB41L3 | NAF1 | 0.928 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| EPB41 | EPB41L2 | 0.887 | 0.054 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| CWC27 | NAF1 | 0.848 | 0.112 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EPB41L1 | CWC27 | 0.835 | 0.028 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EPB41L2 | CWC27 | 0.511 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EPB41 | EPB41L1 | 0.336 | 0.228 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| EPB41 | CWC22 | 0.073 | 0.038 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EPB41 | CWC27 | 0.055 | 0.032 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EPB41 | NAF1 | 0.007 | 0.048 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes