hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08660.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SSMEM1 | Serine-rich single-pass membrane protein 1 | 5 | UniProt NCBI |
| MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (NADH dehydrogenase subunit 3) | 5 | UniProt NCBI |
| FAM185A | Protein FAM185A | 2 | UniProt NCBI |
| NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4) | 5 | UniProt NCBI |
| NDUFB2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:178 | 3.4441742414e-05 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Respiratory chain complex I (holoenzyme), mitochondrial |
| WP:WP623 | 3.90305291366e-05 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Oxidative phosphorylation |
| REAC:R-HSA-6799198 | 9.08085842447e-05 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Complex I biogenesis |
| WP:WP111 | 0.000181875223355 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:04723 | 0.0002524957978 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Retrograde endocannabinoid signaling |
| KEGG:00190 | 0.000272164365812 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Oxidative phosphorylation |
| REAC:R-HSA-611105 | 0.000484679960429 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Respiratory electron transport |
| REAC:R-HSA-163200 | 0.000887870732144 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05415 | 0.000905384445946 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Diabetic cardiomyopathy |
| KEGG:05208 | 0.00123733747112 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 0.00129317041782 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Thermogenesis |
| KEGG:05012 | 0.00202081325994 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Parkinson disease |
| KEGG:05020 | 0.00220361322689 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Prion disease |
| REAC:R-HSA-1428517 | 0.00242434232497 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05016 | 0.0029777279627 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Huntington disease |
| KEGG:05014 | 0.00506998141773 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.00585158514735 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Alzheimer disease |
| WP:WP4324 | 0.00867145853418 | 0.4 | NDUFV3 NDUFB2 | Mitochondrial complex I assembly model OXPHOS system |
| GO:0008137 | 0.0094606249379 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 0.0102064666638 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | NADH dehydrogenase (quinone) activity |
| KEGG:05022 | 0.0104994491245 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | Pathways of neurodegeneration - multiple diseases |
| GO:0003954 | 0.0109904490822 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | NADH dehydrogenase activity |
| GO:0003955 | 0.0126766174236 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | NAD(P)H dehydrogenase (quinone) activity |
| GO:0006120 | 0.0135806930791 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | mitochondrial electron transport, NADH to ubiquinone |
| GO:0045271 | 0.0176256341648 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | respiratory chain complex I |
| GO:0030964 | 0.0176256341648 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | NADH dehydrogenase complex |
| GO:0005747 | 0.0176256341648 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | mitochondrial respiratory chain complex I |
| GO:0016655 | 0.0264997162634 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0015453 | 0.0294915925302 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | oxidoreduction-driven active transmembrane transporter activity |
| GO:0042776 | 0.0379355065545 | 0.6 | NDUFV3 MT-ND3 NDUFB2 | proton motive force-driven mitochondrial ATP synthesis |
| KEGG:04932 | 0.0427854405203 | 0.4 | NDUFV3 NDUFB2 | Non-alcoholic fatty liver disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDUFB2 | NDUFV3 | 0.998 | 0.208 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| FAM185A | NDUFV3 | 0.996 | 0.056 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| MT-ND3 | NDUFV3 | 0.958 | 0.248 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| NDUFV3 | SSMEM1 | 0.953 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NDUFB2 | FAM185A | 0.87 | 0.136 | bioplex3_WMM WMM_only |
| FAM185A | MT-ND3 | 0.415 | 0.0845038216561 | bioplex3_WMM WMM_only |
| NDUFB2 | MT-ND3 | 0.274 | 0.734 | bioplex3_WMM WMM_only |
Related Complexes