hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08670.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | 5 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6710 | 3.41752350426e-06 | 0.666666666667 | CAPN1 CAPNS1 | Calpain 1 |
| GO:0004198 | 1.58598067776e-05 | 1.0 | CAPN8 CAPNS1 CAPN1 | calcium-dependent cysteine-type endopeptidase activity |
| REAC:R-HSA-1474228 | 8.74692373796e-05 | 1.0 | CAPN8 CAPNS1 CAPN1 | Degradation of the extracellular matrix |
| REAC:R-HSA-1474244 | 0.000909629675716 | 1.0 | CAPN8 CAPNS1 CAPN1 | Extracellular matrix organization |
| REAC:R-HSA-8862803 | 0.00143063482691 | 0.666666666667 | CAPN1 CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00143063482691 | 0.666666666667 | CAPN1 CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 0.00188000535098 | 0.666666666667 | CAPN1 CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| WP:WP185 | 0.0039339723602 | 0.666666666667 | CAPN1 CAPNS1 | Integrin mediated cell adhesion |
| GO:0004197 | 0.00526161104852 | 1.0 | CAPN8 CAPNS1 CAPN1 | cysteine-type endopeptidase activity |
| GO:0110158 | 0.00842684400117 | 0.666666666667 | CAPN1 CAPNS1 | calpain complex |
| REAC:R-HSA-6809371 | 0.0150309034717 | 0.666666666667 | CAPN1 CAPNS1 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.0159472060247 | 0.666666666667 | CAPN1 CAPNS1 | Keratinization |
| KEGG:05131 | 0.0193802248568 | 0.666666666667 | CAPN1 CAPNS1 | Shigellosis |
| GO:0008234 | 0.0276806494292 | 1.0 | CAPN8 CAPNS1 CAPN1 | cysteine-type peptidase activity |
| REAC:R-HSA-9645723 | 0.0278082114556 | 0.666666666667 | CAPN1 CAPNS1 | Diseases of programmed cell death |
| CORUM:6706 | 0.0499402709677 | 0.333333333333 | CAPN1 | CAPN1-HSP90AB1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAPN1 | CAPNS1 | 1.0 | 0.604 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CAPN8 | CAPN1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPNS1 | 0.987 | 0.336 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN8 | CAPNS1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPN2 | CAPN1 | 0.963 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| CAPN8 | CAPN2 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes